Hey, great stuff. I have question regarding the backside attack of the second thiolate in 5:22. Why does the sulfor kicks out the brom? Which are the characteristics to see who kicks out whom? keep it up, greetings from Germany
Hey there! Sorry for the late response. The sulfur kicks out the bromine because it only wants to have two bonds. It's bonded to carbon and bromine, but then it makes a bond to another sulfur, so it has to kick out the best leaving group. Hope that helps!
@@Clutchprep Bromine is not a catalyst in this reaction because it gets reduced (at the beginning it was in oxidation state 0, and after the reaction it's -1), and catalyst go through the catalytic circle and exit totally unchanged.
Hi, there's a very simple procedure to make Al alcoholates by basically heating Al in the respective alcohol, often with something to help get through the oxide layer on the Al (like HgCl2 and/or I2) . Do you think this same procedure would work with the thiol equivalent?
Hey there! The stereochemistry of the compound containing the thiol will be retained, but the stereochemistry of the alkyl halide group will be inverted. This is just an application of SN2 to form a sulfide. Hope that helps! :)
Great work. Thank you 🎉
Hey, great stuff. I have question regarding the backside attack of the second thiolate in 5:22. Why does the sulfor kicks out the brom? Which are the characteristics to see who kicks out whom? keep it up, greetings from Germany
Hey there! Sorry for the late response.
The sulfur kicks out the bromine because it only wants to have two bonds. It's bonded to carbon and bromine, but then it makes a bond to another sulfur, so it has to kick out the best leaving group. Hope that helps!
Is the bromine technically a catalyst here? It gets regenerated here but picks up the electrons (bromide ions).
Hi there! Technically, yes! Br2 here will serve as a catalyst for this reaction.
@@Clutchprep Bromine is not a catalyst in this reaction because it gets reduced (at the beginning it was in oxidation state 0, and after the reaction it's -1), and catalyst go through the catalytic circle and exit totally unchanged.
Imine is normally considered as a acid-sensitive one, do you think there will be a problem when imine and thiol meet each other?
Hey there! Imine can possibly react with thiols due to both's acid/basic properties but its very unlikely that you'll encounter it.
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Thank u so much that was easy now that u put it that way !!!!
You're welcome! Lmk if you have questions :)
@@Clutchprep I love u dude
Nice I from India
I appreciate your helpful video!
Thanks! Glad to help :)
Hi, there's a very simple procedure to make Al alcoholates by basically heating Al in the respective alcohol, often with something to help get through the oxide layer on the Al (like HgCl2 and/or I2) . Do you think this same procedure would work with the thiol equivalent?
what a bout the stereo-chemistry, will it be inversed?
Hey there!
The stereochemistry of the compound containing the thiol will be retained, but the stereochemistry of the alkyl halide group will be inverted. This is just an application of SN2 to form a sulfide. Hope that helps! :)
thank you a lot for making this video
You're welcome 😊