Role of the sarcoplasmic reticulum in muscle cells | NCLEX-RN | Khan Academy
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- Опубликовано: 7 сен 2024
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The role of the sarcoplasmic reticulum in controlling calcium ion concentrations within the muscle cell. Created by Sal Khan.
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I'm a first year Medical student. I just want to thank you for these great videos that make the difficult things you read on the slide shows from school, seem so easy...
Davíð Jónsson nice lol so how was med school, did u graduate ?
ya, touche´how was med school? things going good? :)
yea i wanna know too~
So? Did you graduate? How did it go?
@@martinajaya975 Yes I did graduate 2 months ago :) - working full time as a doctor now.. best of luck to all of you!
You are a life saver. I'm trying to squeeze 8 months worth of study into 3 days before my exam (bad idea kids never miss your classes/ lectures) and your videos are literally helping me power through my syllabus.
how did it go ? did you pass?
omg this was a year ago haha. Yes I did pass now I'm revising for my exams next month. And I didn't follow my own advice and left everything till the last minute again lol
HAHA Nina you are horrible just like me but this does not work in medical school :( I studied my ass off the last two weeks still can't keep up
how could you pass with 3 days of studying?
I hope I'm never your patient
when we die and meet god, Ill make sure to say something nice about you. Thank you
My physiology professor spent two weeks on muscle contraction. I never understood it, and two ~10 minute videos made it SO much clearer. Thank you.
Can I just say that I actually love you. You are genuinely saving lives with these videos that are so fantastically explained and illustrated. Thank you.
Can't express how much this video has helped me! I might actually do decent in my first year :') thank you!
You have just saved me from a cell bio teacher with a thick German accent and no understanding of how to explain concepts or teach. Kudos to you, my fine fellow.
I finally understand this concept. Thank you!
this is amazing...nothing in my textbook or on the internet explained what exactly the sacroplasmic reticulum is for. Beautiful explanation, you just helped me get 20 points on my final! :)
I read my books and its all just word floating round my head! Then I watch these vids and they all settle in place! Its like I can actually here them clicking in to place!ha Thanks so much you're doing a great job!
great video but I think its time now to update the information of the mystery box is actually called triad complex composed of dihydropyridine receptors (DHPR) voltage sensing channels of the T-tubule and the sarcoplasmic reticulum calcium channels ryanodine receptors (RyR)
I learnt more in this series about the neuromuscular system in 30 minutes than my 4 hour graduate level exercise physiology class. You are a genius Sal.
most effective use of paint i've ever seen.
He's good, isn't he? I was very impressed with his quick illustrations and swapping out colors like a pro. Mad skills.
For those curious:
The "mystery box" is now understood to be a co-op of two proteins. The 1st, bound to the t-tubule, is called a "DHP-receptor". It is a modified version of a Ca2+ voltage gated channel, altered to serve as a volt-meter. Ryanodine, the 2nd protein, is embedded in the SR. As an action potential moves into the t-tubule, charged amino acids in the DHP receptor signal the ryanodine receptor, itself changing shape to allow Ca2+ ions to flow into the cytosol, then to the troponin.
Sitting in Starbucks studying for my Animal physiology test on Monday and I go “ahhhhh!” Really loudly because I finally get how the Ca2+ gets into SR
Yeah this is skeletal muscle, people sometimes get confused.. yet, just remember smooth muscle and striated muscle (Skeletal muscle and Cardiac muscle)! :D
This video indirectly answered my question about how malignant hyperthermia works. Strong work.
Your videos have the same subjects as my lessons! I'm studying medicine, and this stuff is amazing!!
Selin B. How is your studying going now? I’m a potential studier lol
thank you so much you make it so easy
Great lecture Khan! Just a small correction. When referring to the "mystery box," you mentioned the possibility that "ryanodine" may be involved. I believe you meant to say ryanodine receptor. The ryanodine receptor is a selective calcium channel which operates via a process known as calcium induced calcium release. Ryanodine, on the other hand, is a plank alkaloid and a high affinity binding partner of the ryanodine receptor and is able to inhibit or activate this calcium channel (depending on the concentration). Ryanodine receptors are prevalent throughout skeletal and cardiac muscle and are crucial in the physiologic processes you're describing here. Great work!
Agreed! Just went over this in lecture, and apparently the Ryanodine receptor acts much like the calcium channel of the pre-synaptic neuron in that it is stimulated by the sodium from the action potential carried across the t-tubule. This channel then opens up and releases calcium which stimulates calcium channels on the sarcoplasmic reticulum to open up and release even more calcium to the surrounding muscle myofibrils. According to our 2007 textbook that is! This protein bridge could be an even more recent discovery
MadelMac Good point! To be completely accurate, ryanodine receptors (RyR-; located on the SR) are indirectly activated by sodium. The RyR is a prototypic Ca2+ induced Ca2+ release channel, which means that the most potent activator of RyR Ca2+ channel is Ca2+ itself. Other direct activators include the second messenger cyclic ADP ribose (cADPR).
Super helpful! You should remake this video with the new findings about these structures and processes (e.g. ryanodine as a receptor to stimulate calcium ion release).
YOU'RE BRILLIANT!! Thank you thank you!!
This helps understand the protein complex aspect of the muscle cell a little better. I am still trying to understand the terminal cisternae of the SR in more depth and their receptors that push against each other and excite each other to release the stored calcium ions.
now that we have a better understanding of the mystery box can someone do a follow-up video explaining it?
Beautiful-- Clear-- Explanation. Thank you.
Thank u so much Sal...Love ur videos ❤❤
excellent. now if you are so inclined, time for some genetics and microbiology, and organic chemistry :(
these videos are great for review though an excellent complimentary source for the curriculum. i will probably be using the calculus videos next semester for a refresher and physics as well to keep my edge. thanks again splendid job as always.
Wow. Great explanation. They say the mark of great intelligence is the ability to explain highly complex subject matter in a very simple, concise, and easily relatable manner. You sir, are an intelligent man.
I suppose we all need heroes nerded out about certain topics. Everyone who watches this video will be happy to know that in the case of Saroplasmic roles, it's not me.
The "mystery box" is related to DHP and Ryanodine Receptor.
You're the man! BTW As stated in the comments below learned that ryanodine communicates with DHP (Dihydropyridine ) receptors (the big question mark in the video). Easy for me to say 8 years later
youre the greatest man on the earth
Thank you so much Sal Sir
I also LOVE YOU !!!! What knowledge you - you're so comfortable explaining the most complex things in the most clearest way :) - you make biology and biochem good fun
thanks million times,u save my misunderstood lecture.God bless u,
Masha Allah...
Thank you thank you. This really pulled it all together for me.
Great video. Thank you for the explanation and the enthusiasm.
I am a MBBS first year student...
And I'm still taking help from khan academy ❤❤❤❤
GREAT job explaining. Keep it up- you're helping a lot of people.
Great... Thank you.. really great
Amazing and easy explanation thx man
you are a fabulous teacher! I never once got lost (as I have in many other videos) and your voice is great:)
This just solved a question I've been confusing for weeks !!
This video helped me a lot in my studies! Thank you SO much!
You are absolutely incredible. Thank you 🙏
This is amazing.. You helped me so much with the diagram of sarcoplasmic reticulum
Just perfect anything cant be better than a perfect concept.
I love you Kahn, you're doing gods work.
learning this for my exams at the beginning of second year as we didn't have first year exams due to covid 19. ask me how im doing in 5 years :)
Awesome video. Very informative .-therapist
thank you❤
I like how you make all this stuff easy to understand, by the way can you make oremvideos regarding human anatomy
You saved my ass. Oh my God, you are the savior of the common student!
I'm confused on what is the purpose of T tubuls, please help
What happens to the calcium after its pumped back into the SR? Is it re used over and over again for muscle contraction? How many times can the same calcium ions be reused? Are they eventually metabolized and replaced by more calcium ions from the extracellular fluid???
i was watching this in the living room. There was kind of an argument going on. When you raised your voice when you said sarcoplasmic reticulum it suddenly got quiet in the room. :] It was a really funny moment
AMAZINGLY CLEAR
Wait, the mystery box ISN'T DHP and ryanodine receptors?
+cez reloj It is! The video is from 2010, so the research at that time hasn't discovered that yet. Dihydropyridine receptors senses the electrical signals, which then trigger the opening of Ryanodine receptors, which in turn release Ca2+ across all the membrane of SR.
+Alexandr Pulbere I have an interview next week on the same topic, if you know can you suggest a couple of reviews on this topic..? Its all very new to me, cheers
You make us all geniuses !! Thumbs up ;)
You have a good handwriting and very artistic as well
Awesome explanation! Thank you!
wowowow thank you. you're a lifesaver.
Thank you, you are a fantastic teacher :))
Omg he’s so excited LOL
What happens if the calcium was not return back into the sarcoplasmic reticulum?
Sounds good mate, see you in the next video :) Cheers!
Do you need ATP to pump Calcium ions out of the sarcoplasmic reticulum? :)
My teacher don’t even explain. Am learning what I paid For🤦🏻♀️🤦🏻♀️
YOURE A LEGEND
So what will be the voltage here?
@hould6611 Could you please make it more clear for me.. It might not get more simple than this but could you please try? I have exams in 3 weeks so it would be perfect if I add something that I didnt hear from the lectures.. I just lost it a bit after the second protein.. The second protein is replacing what??? Thank you for your help!:)
I love you man. you're the best.
Awesome ! Love you
you're videos are GREAT btw!
I apologize for being terse on my previous post. There's a word limit!
Anyone know what happens if the the DHPR is not activated
keep up d good work
God watching this video: "No way I could design that, man."
So can you do a bicep curl without any utilization of the tricep
All your muscles are slightly flexed for the most part you arent using triceps when bicep curling
for flexion (actually curling part)-no, but for extension (lowering of your arm to relax and begin the next curl), yes.
WOW 👍👍
is the cytoplasm the same term used for sarcoplasm?
yeah its the same thing just that it is for the muscle so its sarcoplasm
I'm enrolled in an Anatomy course at community college with a crappy professor who links to your videos instead of making her own lectures. I love your vids, but I would much rather give you my money than the college.
don't muscle cell's only have voltage gated Ca2+ channels?
Noor J no
dom rolfe your wrong. there are Voltage gated ca channels - im pretty sure thats what activate the ryanodine receptors
Ev Mannion dihydroperidine receptors are the voltage gated ca receptros Noor J was asking about. had to look that up, but makes sense - they are the target of DHP ca channel blockers on smooth muscle :P fucker
Ev Mannion No, your wrong
ya ya. get some references or explanations to back up your Nos
I love you too :)
Im sure the mystery box is a ryanodine receptor
greaaaaaaaaaaaaaaaaaaat
Is that...is that "gym douchebag" style advertising spam? Only here cause the word muscle is in the title? I find this amusing!
WHO ARE YOU???????
will you marry me?