Ran GTPase Cycle and Nuclear Transport | Importins and Exportins
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- Опубликовано: 8 сен 2024
- Lesson on the Ran GTPase Cycle and the mechanism of Nuclear Transport involving importins and exportins. The Ran GTPase cycle is critically important for nuclear transportation of transcription factors and other proteins into and out of the nucleus. The RanGTPase cycle induces a Ran gradient, which leads to increased levels of RanGDP in the cytosol and RanGTP in the nucleus. Importins and their cargo, along with RanGDP enter the nucleus through nuclear pore complexes. Once inside the nucleus, RanGDP gets processed to RanGTP.
Hey everyone. In this lesson you will be introduced to the Ran GTPase cycle, what it is and why it is important. You will also learn about how proteins such as transcription factors can enter and exit the nucleus with the help of proteins known as importins and exportins, respectively.
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This was a very Importin video
Great video! But correction, the "RCC1" protein known as GEF does not add a phosphate to the GDP. It trades the Ran-GDP for a Ran-GTP
Yes, a very important detail
Since GEF just swaps Ran-GDP with Ran-GTP, are GEF and Ran-GDP still relevant to the import cycle? What happens with Ran-GDP in the nucleus after its swapped?
i paused the video here and facepalmed--glad someone else caught it
@@manyakonkalmattback into the cytosol and disintegrated.
Please pin
Thank you very much an excellent video! Im from Germany and study medicine and your video was very simple to understand. There is just one thing i`d like to say, in the nucleus the Ran-GDP is not made to Ran-GTP by adding anorganic phosphate, the enzyme replaces the GDP by GTP.
Greetings from Germany!
This is the most beautiful video I have ever seen. You made a very difficult concept very understandable.
you just saved me 3 hours of studying. I love you xxx
bless your soul, saving my life in prep for molecular cell biology final exam in med school
That was awesome. Thank you so much. I was having a horrific time with the slide handed out. Your video made it crystal clear in just a few minutes!
I've been trying to figure this out for days but this video was very understandable. Other videos have made sense of the process, but still left me with a loose understanding of the process. This is the only video that made me understand it. So lucky this wasn't on my quiz yesterday lol.
You just explained such a complex process in the most simplest way and I am forever thankful I found this very IMPORTIN video
Thanks for the concise explanation. This is way more useful than a prof pointing at a still picture in a lecture.
Look forward to seeing other videos you've put together.
Thank you so much for explaining nuclear import and export! The microbiology textbook over complicates these pathways! You literally took a concept that took my professor at least an hour to explain into 7 minutes lol. Thank you again!!!
Really so helpful thank you so much for this video 😭❤
The video is so easy to understand. Thank you :)
Thank you, this thoroughly explained both processes step by step and clarified some previous diagrams I had visited
so helpful! thank you
its really helpfull.......... Well explained with proper labelled diagrams
This channel deserves way more subs! Thanks for your effort :D
so helpfull!!!!! thank you
Thanks for the explanation💙..you really saved me😌
Very clearly explained...thanku🤗
Super, I can further my studies now. Thank you...
You rock!!! Thanks so much and do I sense a Canadian accent?? I love it
thank you so much! It was a great video and it helped me a lot
You’re greattttttt
Great video!
This.was.amazing
Excellent
This my favorite video on this, thanks. But can you upload a higher quality, because I can’t read the labels on my phone?
good job thank you.
Thanks
wow, you are the best :)
I'm a bit confused. So proteins who are typically
I hoped this video would tell me whether RNA nucleotides are actively transported from the cytosol into the nucleus. Diffusion is a possibility, but I don't think that's how the nucleus can get a high concentration of nucleotides needed for transcription since diffusion operates on a concentration gradient. So, the cytoplasm would have to have a much higher concentration of nucleotides than the nucleus. I can see the possibility that a specific importin would be useful for bringing nucleotides into the nucleus. Can you steer me in the right direction. Has there been studies done on this?
I guess RANGTP transfers the beta subunit of importin outside the nucleus and the alpha subunit is exported by exportins. Plz tell me whether I am right or wrong.😊
Arent the NLS attached to the Cargo Protein to be Specific?? and then to Importin??
wow
What is rcc1
please work on jj bartley music again
Explanation of the year goes to................
noocular