Thank you very much an excellent video! Im from Germany and study medicine and your video was very simple to understand. There is just one thing i`d like to say, in the nucleus the Ran-GDP is not made to Ran-GTP by adding anorganic phosphate, the enzyme replaces the GDP by GTP. Greetings from Germany!
Since GEF just swaps Ran-GDP with Ran-GTP, are GEF and Ran-GDP still relevant to the import cycle? What happens with Ran-GDP in the nucleus after its swapped?
I've been trying to figure this out for days but this video was very understandable. Other videos have made sense of the process, but still left me with a loose understanding of the process. This is the only video that made me understand it. So lucky this wasn't on my quiz yesterday lol.
Thanks for the concise explanation. This is way more useful than a prof pointing at a still picture in a lecture. Look forward to seeing other videos you've put together.
Thank you so much for explaining nuclear import and export! The microbiology textbook over complicates these pathways! You literally took a concept that took my professor at least an hour to explain into 7 minutes lol. Thank you again!!!
I guess RANGTP transfers the beta subunit of importin outside the nucleus and the alpha subunit is exported by exportins. Plz tell me whether I am right or wrong.😊
I hoped this video would tell me whether RNA nucleotides are actively transported from the cytosol into the nucleus. Diffusion is a possibility, but I don't think that's how the nucleus can get a high concentration of nucleotides needed for transcription since diffusion operates on a concentration gradient. So, the cytoplasm would have to have a much higher concentration of nucleotides than the nucleus. I can see the possibility that a specific importin would be useful for bringing nucleotides into the nucleus. Can you steer me in the right direction. Has there been studies done on this?
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This was a very Importin video
Thank you very much an excellent video! Im from Germany and study medicine and your video was very simple to understand. There is just one thing i`d like to say, in the nucleus the Ran-GDP is not made to Ran-GTP by adding anorganic phosphate, the enzyme replaces the GDP by GTP.
Greetings from Germany!
Great video! But correction, the "RCC1" protein known as GEF does not add a phosphate to the GDP. It trades the Ran-GDP for a Ran-GTP
Yes, a very important detail
Since GEF just swaps Ran-GDP with Ran-GTP, are GEF and Ran-GDP still relevant to the import cycle? What happens with Ran-GDP in the nucleus after its swapped?
i paused the video here and facepalmed--glad someone else caught it
@@manyakonkalmattback into the cytosol and disintegrated.
Please pin
you just saved me 3 hours of studying. I love you xxx
This is the most beautiful video I have ever seen. You made a very difficult concept very understandable.
That was awesome. Thank you so much. I was having a horrific time with the slide handed out. Your video made it crystal clear in just a few minutes!
You just explained such a complex process in the most simplest way and I am forever thankful I found this very IMPORTIN video
I've been trying to figure this out for days but this video was very understandable. Other videos have made sense of the process, but still left me with a loose understanding of the process. This is the only video that made me understand it. So lucky this wasn't on my quiz yesterday lol.
Thanks for the concise explanation. This is way more useful than a prof pointing at a still picture in a lecture.
Look forward to seeing other videos you've put together.
bless your soul, saving my life in prep for molecular cell biology final exam in med school
Thank you so much for explaining nuclear import and export! The microbiology textbook over complicates these pathways! You literally took a concept that took my professor at least an hour to explain into 7 minutes lol. Thank you again!!!
This channel deserves way more subs! Thanks for your effort :D
Thank you, this thoroughly explained both processes step by step and clarified some previous diagrams I had visited
The video is so easy to understand. Thank you :)
its really helpfull.......... Well explained with proper labelled diagrams
Really so helpful thank you so much for this video 😭❤
Thanks for the explanation💙..you really saved me😌
Very clearly explained...thanku🤗
Super, I can further my studies now. Thank you...
thank you so much! It was a great video and it helped me a lot
so helpful! thank you
Great video!
so helpfull!!!!! thank you
You rock!!! Thanks so much and do I sense a Canadian accent?? I love it
This my favorite video on this, thanks. But can you upload a higher quality, because I can’t read the labels on my phone?
Excellent
This.was.amazing
I'm a bit confused. So proteins who are typically
You’re greattttttt
Thanks
good job thank you.
wow, you are the best :)
I guess RANGTP transfers the beta subunit of importin outside the nucleus and the alpha subunit is exported by exportins. Plz tell me whether I am right or wrong.😊
Arent the NLS attached to the Cargo Protein to be Specific?? and then to Importin??
Hmm…. I think that GEF/RCC1 exchanges GDP to a new GTP molecule and not just phosphorylate it as u describe it here.
wow
What is rcc1
please work on jj bartley music again
Explanation of the year goes to................
noocular
I hoped this video would tell me whether RNA nucleotides are actively transported from the cytosol into the nucleus. Diffusion is a possibility, but I don't think that's how the nucleus can get a high concentration of nucleotides needed for transcription since diffusion operates on a concentration gradient. So, the cytoplasm would have to have a much higher concentration of nucleotides than the nucleus. I can see the possibility that a specific importin would be useful for bringing nucleotides into the nucleus. Can you steer me in the right direction. Has there been studies done on this?