Thomas A. Rando at ARDD2023: Epigenetic control of stem cell aging and rejuvenation

Thomas A. Rando, MD, PhD,Deputy Director, Stanford Center on Longevity presents at the 10th Aging Research and Drug Discovery conference: Epigenetic control of stem cell aging and rejuvenation.

[@medicinefuture]

I hope we do not overestimate the cellular reprogramming by Yamanaka factors, because DNA damage or loss cannot be reversed except for the lengthening of telomere which is a repetitive sequence that is expected process is done by repeating certain codons in a sequence, but genes which are more complicated than telomeres when got damaged are so hard to repair by the reprogramming process, but in my opinion, there is still a probability of the existence of nonmaterialistic or virtual template of DNA we have to find, if we did this, the problem will be solved easy

[@coffeebreakchat2450]

If DNA damage was as prevalent & hard to repair as we are lead to believe, no species would survive past ten generations.
I agree, nature must have a backup of DNA somewhere, like it has a backup of the epigenome.