What Causes Sickle Cell...and How Are We Treating It?
HTML-код
- Опубликовано: 25 июл 2024
- Sickle cell disease got its name from mutated, misshapen red blood cells.
» Subscribe to Seeker! bit.ly/subscribeseeker
» Watch more SICK | bit.ly/SICKplaylist
Sickle cell was the first molecular disease ever and the disease was identified in Chicago in 1910.
Sickle cell disease is a group of inherited blood disorders. In fact, it's the most commonly inherited blood disorder in the world, affecting millions of people worldwide. Once upon a time sickle cell was almost impossible to live with but today, we know a lot more about it and it turns out, something as simple as H2O can help keep it in check.
Seeker sat down with Marsha Treadwell a clinical psychologist and scientists at UCSF Benioff Children’s Hospital in Oakland, California. Treadwell has worked with the sickle cell community for nearly 20 years.
According to Treadwell, sickle cell disease, the disorder is related to the hemoglobin-the molecule in red blood cells that delivers oxygen to cells throughout the body. Atypical hemoglobin molecules called hemoglobin S distort red blood cells into that sickle or crescent shape.
When red blood cells-which are normally round, like balloons-take on the sickled or misshapen and rigid shape they also become sticky and cause damage throughout the body.
Sickle Cell is common all over the world, but there are populations that are more often affected, such as those originating from Africa, India, the Mediterranean, Middle East and South America.
Find out more about sickle cell, its 4 different forms, sickle cell symptoms, and a potential cure for the disease on this episode of SICK.
#SickleCell #Disease #Symptoms #Health #Seeker #Science #SICK
____________________
Read More
Patient Hopes Gene-Editing Can Help With Pain Of Sickle Cell:
www.npr.org/sections/health-s...
NIH researchers create new viral vector for improved gene therapy in sickle cell disease:
www.nih.gov/news-events/news-...
New treatment targets for pulmonary inflammation in sickle cell disease:
www.news-medical.net/news/201...
____________________
SICK is a new series that looks at how diseases actually work inside our body. We'll be visiting medical centers and talking to top researchers and doctors to uncover the mysteries of viruses, bacteria, fungi and our own immune system. Come back every Tuesday for a new episode and let us know in the comments which diseases you think we should cover next.
____________________
Visit the Seeker website www.seeker.com/videos
Subscribe now! / subscription_c. .
Seeker on Twitter / seeker
Seeker on Instagram / seeker
Seeker on Facebook / seekermedia 
Наука
i feel sorry for those born with this illness, i wish you a healthy and long life
Please Pray For Me
Thank you!
4:15 that's quite a cheerful background song for such severe symptoms..
Lol right, this is like james bond music
I didn't really notice the music....until now....I was concentrating on the information that was the most important part....then I listened to it....it was a type of music that I dislike so I reckon that was why I could ignore it
Wow. Was not expecting this one. I currently have this disease as I was born with it, and let me tell y'all, IT SUCKS. But not many people know about it. And it doesn't get as much spotlight and medical treatment like other blood disorders or sicknesses in general. The fact that a pretty big channel is doing a whole video specifically on Sickle Cell makes me happy. Thank you guys.
Dwayne Jones people don’t realize how serious and severe it can be. Hopefully the new therapies that are on the horizon will be able to help people like you Dwayne!
@@1bwash thank you very much my brotha! I VERY much appreciate it. Yeah it can be rough but I never let it get me down. I still live a great productive life. It's all about what you make outta the cards you are dealt you know?
Dwayne Jones I'm sorry that you inherited that. Years ago, when I worked in a navy hospital, I remember a boy that was in the ER and he was in crisis. Apparently, he had a pretty fragile system and was going into crisis a lot for a while. I worked in the lab and when I tested his blood, it was pretty bad. I took the results over to the doctor and I'll never forget how he cried from the pain and begged his mom to let the doctor kill him to put him out of his misery. I'm glad that they're working on it. When I learned about gene editing, sickle cell was the first thing that I thought of. It sounds like a perfect use of such a tool. It would be so great if they could come up with a cure like that.
I actually learned about it in school. I think in 10th grade and again in the 12 th grade in biology when we learned about genetic illnesses. Sadly the symptoms were greatly downplayed. Until I watched this video, I didn't know about the pain and the serious possible complications which is disappointing. I wish you good luck with your illness and hope the development of the new therapies go well, so people like you can get help and don't have to deal with the symptoms anymore.
I have sickle cell anemia. Thank yall for spreading awareness for us. On behalf of the sickle cell community, I say thank you
queen!!! i wish for your good health❤️🌸🌸
@@zack7122 thank youu 💖💖💖🙏🏽
sickle- shape of a cell
cell - cell
anemia - presence in blood
sickle cell anemia- sickle cell presence in blood
Wrong background music
100% I was like wtf
×2
I love dying it is so calming
shoulda used crab rave instead
No kidding, it's so upbeat and proactive! Good track but wrong context.
Yo @Seeker team, if you need music hit me up, I'd love to help out with some fresh tunes! 💎
I was born with Sickle Cell and it’s why I wear glasses, blood vessels in my eyes were damaged when I was younger. Thank you for bringing more attention to this community!
I read this is an adaptation against malaria which if you look at the main population makes perfect sense
Yeah, you are right. I have it and when I found out that I couldn't get malaria I was like "oh wow, cool". Lol Sickle Cell doesn't have many positives about it so I'll take what I can get 😅
Yeah there’s 4 variants of sickle cell I think. I’m was diagnosed with alpha thalassemia minor. I’m just more anemic then usual but I really don’t feel it’s affects.
@@DwayneIsKing Wait how beneficial is this in actuality
Thank you Seeker....you are really a channel of note....
I look for your channel every time that I log into YT....
Interesting information!! Thanks you and keep it up!!👍
The way she re-presented sickle cell is like it's just a flu it will fly away. I have seen sickling patent and their life is a pain from morning to night.
im just halfway through and this music is so inappropriate wow
Naw its a pretty sick beat signifying the seriousness of this sickness.
Great video
When you said "South America" , you meant Brazil only on the map.
It only happens to black folk
@@aztlanwarrior1983Not true. That is a myth that we have here in the US because of the people mainly affected here. Unless you consider India, the middle east, Mediterranean and Jewish people Black folk. The disease mainly affects people in/from hot humid environments. Some even believe early that it is a mutation that came about as a defense against certain types of mosquitoes and other blood sucking insects in those areas. A few generations removed from those environments, diets, and so on, may have caused it to mutate into a more debilitating disease for certain people.
Brazil makes up over 50% of the population of South America. The map was showing where the people with this blood disease predominantly live.
Thank God science is homing in on a cure for this, and other genetic conditions. Why is a psychologist explaining this and not a biologist?
I'd love to see a video on type one diabetes
I've been with sickle cell all my life it hurts me that some people don't realize how painful this disease is for us the sickle cell patients
I have Sickle Cell SS, so thank you for informing people about this illness. The part about "it feels like a muscle cramp all over" is underrated. Imagine that x5-10. Or imagine someone takes glass, melts it down, and injects it into your veins. It pretty much feels just like that.
You are doing great work...just keep on guyzz... We really need knowledge about several filed...and yes i can trust on you thanks for beaing loyal with your information....and also its a humble request to make a video in entrepreneurship ( some business model that really work in india n other countries i.e. that we can apply this knowledge in any field ) anyway love from India ❤️🙏
Weird i was Googling this the other day
Omg I have sickle cell this will help a lot
2:04 wrong trait marked
Hope they find cure
Anyone else pees at the sides of the toilet bowl as to not make a sound?
😁 you're not alone lol
It's uncivilized to pee loudly!
That and to not splash it all over me
Stealth mode activated
Me, especially at night.
I have this disease too, my mother told me they had to give me lots of medicines when i was little..like alot of medicines
8 to 10 glasses of water. Very confusing. Do you have standard sizes of glasses all over world? Use the capacity i.e. liters.
No timeframe either, Like per day? week? hour? I got to know
A glass of water is 8oz
@@filmzen281 in metric
@@rajeevarts398 .23 liters
@@rajeevarts398 8 cups is almost 2 liters.
Wish there was a mention of sickle cell trait
Finally, someone had done a good video about sickle cell but still the cure in the title lacks.
Inappropriate background music for such a serious condition.
Pretty interesting that having sickle cell might help protect against malaria from mosquitoes.
im guessing that's why it evolved in the first place, considering people from equatorial regions, aka where malaria spreads, are at greater risks for the disease.
@@GabZonY wouldn't it be the other way around
@@shadowrealm8014 i dont understand what you mean... the theory is that it evolved as a protection against malaria, the trade - off being worth it because of how common malaria is, and probably the diets and habits of the people living in malaria - stricken regions leading to way less people suffering the negative health effects of having sickle cell (or not living long enough to experience them) than we do in the 21st century.
It sucks 😞
Going to live with it whole life .
CRISPR Gene Editing the future for the cure of Genetic Disorders !
Thank you for covering this, sickle cell is a huge problem that feels like it's too often brushed under the carpet. 💙
That's not necessarily true, sickle cell is discussed quite often every year, maybe you're not around the right people.
@@HShango Am in the UK, and worked in the NHS research and development, sickle cell is rarely discussed any more. I dearly hope people are discussing it and that's it's just me not hearing about it. 💙
@@catalinacurio Its more commonly covered in America where there is a much larger african population.
I think this disease have some relationship with maleriya ?
I'm a carrier of sickle cell, so I do not have the disease but mine is benign basically.
Moses Jonson wouldn’t that be sickle cell trait?
@@hoopsonwheels yep, it is.
Good news: You're basically immune to malaria, right?
Bad news: If you have kids with someone who also has sickle cell trait, each kid had a 25% chance of having the disease :(
@@Master_Therion I know, which is soo unfortunate in terms of the kids issue, so yes that means I sort of have to be picky with which women I want to have kids with one day, in terms of the malaria case I have not exposed my body to mosquitos yet, if it is true that my body is sort of immune to malaria then I am a lucky person indeed.
so youre black?
R.I.P Prodigy of Mobb Deep
Simple glutamic acid replaced by valine
How does gene-editing work? I can understand editing DNA in one cell, so how does that transform every cell in the body afterwards?
Stem cells are the cells that don't have a function yet and differentiate to become functional cells. What they will do is edit stem cells to not produce sickle cells and then put them in the bone marrow of the patient. This bone marrow will produce new cells that are ok. The old sickle cells will just die off. At least that's what I understood, I would have to look at the exact procedure to give a more informed response.
@@shkhrvarshney Thanks, that makes sense as the hematogenesis of the RBCs takes place in the marrow. I suspect that the lab uses the CRISPR to do the editing. Cheers, Bob
Early squad
👇
Did vox do this one 4 u guys?
I don't like the way she explained it at 4:00. She put the cart b4 the horse. Or the horse was never there in the first place.
Let me explain.
She said the cut off of air causes pain. What she should have said is the cut off of air starves the body of oxygen and it starts to die which then causes pain.
The pain is a result of a response that is caused by the effects of the oxygen being cut off.
These are important details because every word matters when it comes to science and health.
What about the school research, like what is the perfect school is? What knowledge actually needed for learning effectively? Do we need another study program for a single course (ex: engineering)? etc.
am i the only one who saw a closed eye in the thumbnail?
Get your bowls flushed.
exactly! i dont like shitpoop stuck in my belly. it dosent feel good.
Hi
Hello
I wish I could live my life normal😴😭
I when it takes our own stem blood cells reader then someone else's ...
Just saying is better I suppose 😉
crispr! Not just for editing babies.
Its a long way of from being viable mass market application.
You drew me here with the "16-year-old Helen Obando is the youngest person in the U.S. to have her DNA reset in an attempt to cure her sickle cell disease" line, but you say absolutely nothing about it. I've learned my lesson, by now. No more Seeker for me.
Wtf a muscle cramp through your whole body?! That would be constant agony
a family member lived to 65 with sickle cell....
Then he went back out of retirement to pay for his childrens college and died on the job...workplace accident..
Ratus damn forreal? Did he have life insurance
@@Gabriel.4190 Yeah he did.
The two main symptoms of Sickle Cell Disease are being sick and feeling ill.
Sick + ill = sickle.
Dude. C’mon mang 🤦🏿♂️
Me, my mom, and dad have sickle cell disease but my father have crisis almost every month now that puts him in the hospital. My mom never really had crisis but she was diagnosed with multiple myeloma and couldn't get half of the treatments to try to cure the cancer which she ened up passing away from it last year. Me on the other hand, i am 29 and only had to be hospitalized once because of it. All of my kids have the trait and if they have a child by someone with the trait as well it gives the baby a greater chance of getting the disease. Crazy stuff.
Wow, im the same age as you & have Sickle cell!!! You've only been in the hospital once?!?! That's AMAZING!!! I've only been in the hospital once this year alone & that's better than I've ever done. I used to have to go in every 3-4 months at one point. Stay hydrated & stress free!!!
At least it have a positive thing about it that it makes you immune against Malaria .
thats why it exists, and primarily in africa and parts of brazil.
If red blood cells don't have DNA then how do they get mutations?
Im assuming with my limited knowledge that its a source issue, in that the marrow begins to produce incomplete blood cells for whatever reason.
DNA reset
Weeaboos suffer from the same disease but instead of sickle shaped bloodcells, they have shuriken and kunai shaped bloodcells
Spy!
Who edited this hot mess? Great topics, horrible delivery.
Whole food Plant based vegan diët will make you the healthiest you can be! #Govegan
Lies
Not true, being a vegan does not mean you will be healthier, homo sapiens become healthy through mixing their diet from dairy/meat to plants etc. So please keep your vegan cult to your self and stop forcing that ideology down people screens, throats and lives.
@ Robbert van Haaften. Very true! Ignorance is bliss?
#Govegan you can toss my salad for a starter
Lol. Most of Indians are vegan, and they suffer from poor muscle growth due to not being able to ingest enough protein during their adolescent years. If you want the world to go vegan get ready for the subsequent generations to be more and more physically weak.