13. Mullarian Agenisis

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊
𝐘𝐨𝐮𝐭𝐮𝐛𝐞 : / @draishwaryakelkar
📌𝗙𝗮𝗰𝗲𝗯𝗼𝗼𝗸 : / draishwaryakelkar
📌𝗧𝘄𝗶𝘁𝘁𝗲𝗿: / aishwayadr
📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 : / clinical.learning
Mayer-Rokitansky-Küster-Hauser syndrome, also known as Müllerian agenesis, Müllerian aplasia, or vaginal agenesis, is a congenital malformation characterized by a failure of the Müllerian duct to develop, resulting in a missing uterus and variable degrees of vaginal hypoplasia of its upper portion. Müllerian agenesis (including absence of the uterus, cervix and/or vagina) is the cause in 15% of cases of primary amenorrhoea. Because most of the vagina does not develop from the Müllerian duct, instead developing from the urogenital sinus, along with the bladder and urethra, it is present even when the Müllerian duct is completely absent. Because ovaries do not develop from the Müllerian ducts, affected people might have normal secondary sexual characteristics but are infertile due to the lack of a functional uterus. However, parenthood is possible through use of gestational surrogates.
Mayer-Rokitansky-Küster-Hauser syndrome is hypothesized to be a result of autosomal dominant inheritance with incomplete penetrance and variable expressivity, which contributes to the complexity involved in identifying of the underlying mechanisms causing the condition. Because of the variance in inheritance, penetrance and expressivity patterns, MRKH is subdivided into two types: type 1, in which only the structures developing from the Müllerian duct are affected (the upper vagina, cervix, and uterus), and type 2, where the same structures are affected, but is characterized by the additional malformations of other body systems most often including the renal and skeletal systems. MRKH type 2 includes MURCS (Müllerian Renal Cervical Somite).
The majority of MRKH syndrome cases are characterized as sporadic, but familial cases have provided evidence that, at least for some patients, MRKH is an inherited disorder. The underlying causes of MRKH syndrome is still being investigated, but several causative genes have been studied for their possible association with the syndrome. Most of these studies have served to rule-out genes as causative factors in MRKH, but thus far, only WNT4 has been associated with MRKH with hyperandrogenism.

[@medschoolsimplified007]

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊
𝐘𝐨𝐮𝐭𝐮𝐛𝐞 : www.youtube.com/@DrAishwaryaKelkar
📌𝗙𝗮𝗰𝗲𝗯𝗼𝗼𝗸 : facebook.com/draishwaryakelkar
📌𝗧𝘄𝗶𝘁𝘁𝗲𝗿: twitter.com/AishwayaDr
📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 : instagram.com/clinical.learning/

[@surrt1145]

U r way of teaching is wonderful sir....ur teaching skills makes any topic easy to remember for long....keep making such videos ...u r the best teacher...and I can't thank you enough 🙏

[@medschoolsimplified007]

Keep watching

[@sheerinmumtaj6238]

Thank you sir❤ 🙏

[@medschoolsimplified007]

So nice of you

[@mangalgiri6096]

Great explanation

[@medschoolsimplified007]

Glad it was helpful!

[@narahariedukuda3837]

Excellent teaching, but please clarify that ..after vaginoplasty she can participate in intercourse???

[@zalasagar9077]

Kya ye video aap hindi me bana sakte he