15. Testicular Feminization Syndrome
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- Опубликовано: 10 окт 2024
- 𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩⚕ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊
𝐘𝐨𝐮𝐭𝐮𝐛𝐞 : / @draishwaryakelkar
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Introduction and objectives: Testicular feminization is the syndrome when a male, genetically XY, because of various abnormalities of the X chromosome, is resistant to the actions of the androgen hormones, which in turn stops the forming of the male genitalia and gives a female phenotype. The androgen insensitivity syndrome occurs in one out of 20,000 births and can be incomplete (various sexual ambiguities) or complete (the person appears to be a woman). The aim of this paper is to present the diagnosis and treatment of a case of testicular feminization.
Patient and methods: A 22-year-old patient is admitted at Gynecology for primary amenorrhea. The clinical examination shows a female phenotype: the breasts are normally developed, but there is no hair in the groins and axillary areas, the labia are small and hypoplastic, the urinary meatus is normally inserted, and the vulva is unpigmented. The gynecological exam reveals that the hymen is present, the vagina has 1.5 cm in length, while the uterus is absent. At Endocrinology, the levels of gonadotropins were measured and found normal (FSH 3.18 mU/mL, LH 15 mU/mL), the progesterone was 5.79 nmol/L, estradiol was 82.39 pmol/L and the testosterone was 4.27 nmol/L. The karyotype was mapped in order to differentiate the androgen insensitivity syndrome from other genetic abnormalities, like the Klinefelter syndrome (46XXY), Turner syndrome (45XO), mixed gonadal dyssynergia (45XO/46XY) or tetragametic chimerism (46XX/46XY). These tests confirmed the suspected diagnosis - testicular feminization (46XY). The pelvic CT scan revealed the lack of uterus and ovaries, hypoplastic vagina, and intra-abdominal prepsoic testes. The testes were removed in order to avoid the malignant risk. We performed laparoscopic bilateral orchiectomy.
Results: Surgically, the patient had a simple evolution, being discharged in the second day postoperatory, and estrogen therapy was started from that moment on. Mentally, the patient kept thinking she was a woman, so the decision of telling her the truth was left to the parents.
Conclusions: Testicular feminization is a rare disease that must be diagnosed and treated through close work between gynecologists, endocrinologists, geneticians, urologists, and psychiatrists. Bilateral laparoscopic orchiectomy is the best procedure to remove the intra-abdominal testes, in order to avoid their malignant transformation.
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greeeeeat explanation, finally I got it. You saved my time, thank you very much!
You are a very gifted teacher. Thank you so much, u explain excellently
𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩⚕ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊
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Thank you so much
Good explain 😄
Very impressive 😊
Very good.
Check spelling of *Sertoli* & Leydig
Kindly do a video about xy gonadal agenesis female.
You are great ❤
Sir in mullarian agenisis and testicular feminization s. Both produce estrogen but why TFS male having breast development as weel as no axillary hair
And how to differentiate these 2 conditions
This is little bit confused me 😞😲
I have a intersex condition that happens in early gestation we’re my germ cells failed to full reach the glands. Resulting Int one testis remaining as a fetal gonad with a partially attached germ cell teratoma. The other testis did develop but only remained small, never growing to adult size. A number of years ago a doctor suggested that I may also have a mild form of AIS androgen insensitivity syndrome. I appear male but often seen as female when I was younger. Ironically I did marry and we managed to have two children after many years. Speculation has suggested I was exposed to DES during my gestation. This synthetic estrogen was often given to women to prevent miscarriages and other complications during pregnancy.
,,,, congrats,,,,🎉
❤❤❤genus
I came here after controversy of imane khalif at the olympic boxing
How this people feel it?do yhey suffer mentally illnesses ? What are they? Can they get a sergery to replace uterus and overy.
Just recently uterine transplantation was done in the UK
❤
👍👍👍
Question: On a fully developed male. From the scrotum back to the anus, is a curious looking stitch. I have heard it is called "Natures Stitch". Is this a fact?
বুঝলাম না
Its a he looking like a she but its not she its a he 😅😅😅 what a simpler explanation
𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩⚕ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊
𝐘𝐨𝐮𝐭𝐮𝐛𝐞 : www.youtube.com/@DrAishwaryaKelkar
📌𝗙𝗮𝗰𝗲𝗯𝗼𝗼𝗸 : facebook.com/draishwaryakelkar
📌𝗧𝘄𝗶𝘁𝘁𝗲𝗿: twitter.com/AishwayaDr
📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 : instagram.com/clinical.learning/