Finasteride and dutasteride in androgenetic alopecia - selected topics
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- Опубликовано: 27 авг 2024
- Finasteride and dutasteride in androgenetic alopecia - selected topics
The basic mechanism of action, history, adverse effects, 0.25% topical finasteride spray
A book about androgenetic alopecia:
Androgenetic Alopecia From A to Z: Vol. 2 Drugs, Herbs, Nutrition and Supplements
by Konstantinos Anastassakis
amzn.to/3YDM4hy
* Introduction
* 5 alpha reductase inhibitors
* finasteride and dutasteride
* sexual adverse effects & finasteride or dutasteride
* finasteride & the breast abnormalities
* topical finasteride
💐💐💐💐💐
🙂
Thank you!
Underrated videos. Thanks for posting. I hope the video about efficacy of these drugs is still in the pipeline.
I miss you soooooo much
Thank you Madam. Very useful please post more research about oral minoxidil and finasteride and how much dutesteride dose is better
Thank you! Everyone is different, so there is no dose that is best for everyone….
I hope you are fine
Dziękuję Pani Profesor
Dziękuję bardzo za feedback! 🙂
Very Very excellent
Thanks a lil 🙂
The end of this video gets me because I don't know what to do anymore. I wish dr. Rudnicka could see me herself. I've been to more than 10 doctors, 05 being 'specialists' who sent me back home telling me 'there's not patterns, there's nothing wrong with your hair'. No one will close a diagnosis so won't let me try a DHT blocker. I've been losing hair globally in my entire scalp, especially sides and even on the back, however this has been happening for years (progressively) and not in clumps, so it's not alopecia areata or telogen effluvium. I believe genetic hairloss is the only possibility left. I feel neglected and like I've wasted too much time already, losing ground.
Where do you live? Maybe I know a hair expert in the area
Do you No an expert in Germany for female androgenetic Hair loss?
Thanks professor 🎉🎉
Thank you 😊
can you please make video on lichen plano pillairs LPP/ scarring alopecia
I will! As soon as I get some time to put it together! Thanks for the suggestion :-)
Can U Please make ur Expert opinion Post for Safe Donor Area Thanks
i watched this video again. can u please do a video on the difference between oral spironolactone versus oral finasteride in adrogenetic alopecia in women? and if spironolactone affects every part of body and if finasteride affects on;y hair follicles or breast tissue as well?
Thank you. It is a complex issue to compare these two treatment methods, because there are no head-to-head data. I will see what is possible.
Very informative video, thank you Prof!
Thank you!
Thank you got an informative video. I didn’t realise that type 3 isoform of 5-alpha reductase was present in significant levels in hair follicles (always thought that it’s preferred substrate would be androstenedione instead of testosterone. I also thought both finasteride and dutasteride were quite potent inhibitors of type 3 anyway, so in my mind it’s always been finasteride against type 2, and dutasteride against type 1 and 2 as far as AGA goes. So I’ve learned something new.
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Good program thinks madam ❤
Thank you!
Hey doc, i would love a video talking about how these medications affects the hair cycle, because when you are suffering hair miniaturization the sync of how this happens on each hair is different, so when using these types of dht blockers these miniaturized hairs are putten into the anagen phase for longer time. The question is i've seen people saying that their hair starts synchronizing again and they start experiencing a "seasonal shedding" that makes their hair looks thinner before getting thicker again, especially close at one year and two year mark after starting these medications. Would love to know what you think of this topic :). Thank you!
This may be the case with another medication, not finasteride
Dobry wieczór, dzisiaj natrafiłem na kanał Pani profesor i muszę tak ja przedmówcy serdecznie podziękować za cenne materiały jakie Pani tworzy. Ze względu na to że problem AGA dot. mnie osobiście i mojej narzeczonej (narzeczona w trakcie diagnozy) to interesuję się tematem dosyć intensywnie jak na amatora, ale nadal mam jeszcze zagwozdki o które chciałbym zapytać. Obecnie przyjmuję finasteryd w dawce 1,25mg dziennie z w miarę dobrymi efektami, miałem epizody w których próbowałem stosować na skórę głowy minoxidil, ale z mało zauważalnym efektem. Zainteresowałem się fragmentem w którym wspomniała Pani o doustnym minoxidilu który wydaje mi się wygodniejszą formą do regularnego stosowania. Czy minoxidil doustnie stosuje się także u kobiet? I czy w polskich aptekach minoxidil doustny jest dostępny, ew. pod jaką nazwą? Pozdrawiam serdecznie
Bardzo dziękuję. Zachęcam do innych filmów na moich kanałach, które zapewne odpowiedzą na te pytania, w szczególności pierwsza cześć tego materiału: ruclips.net/video/R686IxJQ0Ck/видео.html
@@profLidiaRudnicka dziękuję za odpowiedź, wydaje mi się że to nie ten link
Excellent post, thank you. Can you suggest appropriate dosage for using finasteride in women? My doctor has prescribed 1 x 5mg tablet per WEEK (not day).
That's correct. He's having you take it just once a week instead of daily. I mean you can cut your pill into 5 pieces and take it 5 times a week.
Does finastrade works in women ? Please reply
It is frequently used by women with female pattern hair loss as a DHT blocker. @@mirasingh7428
Does the 0.25% Finasteride topical form apply for women also?
It is not approved in women.
Thank you prof. for explanation about Finasteride and dutasteride
My question is ..for how long we can use these medications systemically ?
And can we use Finasteride or dutasteride 3 days/ wk to decrease the chance of side effects without affect kn efficacy..?
Thank uou so much
Thank you. As per available data there are no time limits. Dutasteride 3/week was discussed because of the longer half-life but there are no studies about efficacy of this type of dosing
The chances of side effects are extremely low. Why don’t you just try it everyday and see how that goes?
Maam.. what’s your opinion on bicalutamide for acne and hair loss? I am 41 and female. I was on finasteride 5 mg since 6 years and was doing fine. But last few months I was noticing that my scalp had again started showing. So my doctor switched me to bicalutamide 25 mg daily. But ma’am after 2 months of taking it, I feel my acne is only getting worse. For hair I know that it will take time. What should i do?
I rarely use it but it may be an option
Pani doktor, Może w kolejnym odcinku o leczeniu lzs skory głowy? Mimo dostępnych leków nadal pozostaje utrapieniem wielu pacjentow
Dziękuję bardzo. Wpisane na listę tematów do opracowania. Bedzie tu lub na kanale polskojęzycznym 😊
Pani doktor, czy gdy przy stosowaniu finasterydu efekt jest średni mozna pomyśleć o dutasterydzie?
Taką decyzję podejmuje się zawsze z dermatologiem, który prowadzi leczenie.
nice
Thanks!
Thank you for the video
I'm already on finasteride 1mg a day for 5 months
Can I combine with dusdasterine with finasteride and if yes how much and how often ?
Thank you in advance
No, this is not a usual treatment regimen, because both drugs have a similar mechanism of action
Yo diría que la ginecomastia en hombres que toman finasterida es bastante frecuente. Los estudios dicen una cosa pero la realidad es otra.
Are you a dermatologist or a urologist ? What is your experience?
@@profLidiaRudnicka no doctora, pero tomo finasterida y tengo ginecomastia y a dos amigos mios les sucede igual. 🙂
This is 3 persons. This is in my opinion not sufficient for statistical conclusions in a world where multiple millions of people are taking the drug….
@@profLidiaRudnicka 🥲🥲🥲🥲
Witaj pani Lidia! It that possible to have an appointment with you or with any dermatologist in Klinika Dermatologii i Wenerologii in Warsaw?
And how to call to them?
Yes, just call and make an appointment
Szanowna Pani Profesor. Po pierwsze chce przekazać Pani wyrazy uznania, podziwiam ludzi takich jak Pani-którzy cały czas rozwijają naukę i siebie, są zawsze głodni wiedzy! Mam takie pytanie, czy poleca Pani Profesor jakiego dermatologa w Krakowie-najlepiej takiego szczególnie zainteresowanego chorobami włosów i skory głowy-dokładnie mam AGA. Bardzo mi zależy żeby kierował się EBM. Może zna Pani takiego… będę bardzo wdzięczy za odpowiedz. Pozdrawiam i dziękuje
Ps. To prawda że mezoterapia dutasterydem i osoczem ma swoje oparcie w EBM (w AGA)?
Dziękuję bardzo. Dutasteryd doogniskowy ma pozytywne opinie wielu ekspertów, ale jest w minimalnym stopniu EBM. Przede wszystkim nie jest zarejestrowany jako lek, więc nie przeszedł niezbednych dla leków kontroli. Dlatego nie ma go w tym wideo. W Krakowie jest wielu doskonałych dermatologów i jestem pewna że wszyscy lub prawie wszyscy zajmują się AGA.
hi doc, is the result of hormone DHEAS a definitive result for androgenic alopeacia, my result is normal but I still lose hair from the crown area a lot. P.S. I'm female.
I am not sure that I understand the question. If the question is whether hair loss is reversible, the issue is complex, but it may be reversible
I am a patient of OCD and taking psychotic medicine last 6 years. My main concern is my hair fall started when I was 14. Now I am 30years old. Totally bald. Probably Norwood 7. But the problem is I have losing hair from lower and side portion of the head. Maybe retrograde alopecia. And also losing beard.almost 70% of my beard density has gone and losing my beard line. I saw many dermatologist but nothing works. I just want to know is it treatable?
You definitely need a diagnosis. There are at least few conditions which cause this type of hair loss
@@profLidiaRudnicka I am from india. How could I contact you?
Could you please discuss what types of hair loss are associated with both head and pubic hair loss? I’ve been shedding for a year ( 25 yr old girl) and now my pubic hairs are falling :(
Thank you. This is complex, especially with no details. In a young person the most probable case may be alopecia areata, whereas in a 40+ woman it may be for example lichen planopilaris (Grham Little type). Some skin diseases may be associated with diffuse hair loss....
@@profLidiaRudnicka I would love to become a patient at your practice. What is the best phone or email to reach you?
Where are you prof lidia
Hello I have fibroadenomis in my breast and If I treat my androgenetic alopecia with minoxidil 5% , does have any side effect in my breast?
In my opinion not , but the opinion of the doctor who takes care of your breast condition is most relevant
What does it mean to see a red thread like strand on trichoscopic view. Noticed this on three different clients
Thanks for asking. I would need to see an image...
@@profLidiaRudnicka image has been sent to your Instagram DM ma'
Hey doc , i have alopecia and i used minoxidil and finasteride for one year 8month and the finasteride now is Cut off from the market switched to dutasteride injections every 10 days i going to clinic for injection for 6 sessions
-May question now my plan its good or no ,because i stop the finasteride and make duta sessions and how many time to back my hier its good ?
Thanks doc .
Yes, switching from finasteride to dutasteride is ok.
Pani Profesor proszę o poradę - przyjmuję finasteryd 1mg doustnie a poziom DHT nie dość, że się nie zmniejszył po kilku miesiącach, to jest większy (ok 1500). Dlaczego, co robić?!
Analiza stężenia DHT w surowicy nie jest parametrem skuteczności klinicznej finasterydu
@@profLidiaRudnicka dlaczego, skoro powinien blokowac synteze dht? Jak inaczej sprawdzic skutecznosc? Ps: po roku stosowania ponowilem badanie dht - teraz jest bardzo male, ok 250.
Mam i have androgentic alopcia high testosterone what should i do
I suggest to analyse with the endocrinologist the reason for increased testosteron and whether it requires endocrinologic treatment
Mam I have diffused thining,Doctor gave me dutasteride and it is not working
It depends on treatment time, dose, expectations, and the perception of efficacy. I suggest to consult the doctor about modifying the treatment.
@@profLidiaRudnicka is dutasteride better than finasteride in terms of improving hair? I HAVE Sebbhoric dermatitis too
Mam can i use dutasteride 0.5 mg for hai because i am very sad for my hair loss
Every diagnosis and treatment decision has to be made by your dermatologist. Every situation is different
I saw a video that states the since Dutasteride is over 500 Dalton it doesn't cross into the blood from the scalp if applied topically. But Finasteride is less than 500 Dalton and does cross. Even if both drugs causes and is systemically absorbed, it is still way less (> 10X) absorption than the oral forms correct?
ruclips.net/video/cc1MbFDXE7A/видео.html
Partly yes, but any skin changes (scraches, folliculitis etc) on the scalp, even minor, may alter the penetration
Wow ❤
Very interesting, informative and to the point therapeutic pearls as usual,
Thanks our dear professor
But I have a question
What is your experience regarding
Intralesional dutasteride in AGA in the form of nesotherapy
And topical spironolactone in AGA ( I have previous published study with good and significant results :
Ammar AM, Elshahid AR, Abdel-Dayem HA, Mohamed AA, Elsaie ML. Dermoscopic evaluation of the efficacy of combination of topical spironolactone 5% and minoxidil 5% solutions in the treatment of androgenetic alopecia: A cross sectional-comparative study. J Cosmet Dermatol. 2022 Aug 29. doi: 10.1111/jocd.15328. Epub ahead of print. PMID: 36039391.)
Thanks in advance ❤
Thank you, it is always such a pleasure to have your feedback! Intralesional dutasteride has good opinions and some literature data , but it is not approved as a drug with all consequences, so I prefer to wait for a more validated product. Regarding spironolactone - you are the master, so I can only repeat after you "oth spironolactone as a 5% topical solution and minoxidil as a 5% topical solution might be used safely in a twice-daily dosage to treat AGA". 💕
@@profLidiaRudnicka
It is a great honor for me dear professor and mentor, thanks you for your kind words and the continuous support, god bless you ❤️ ❤️