Causes of Schizophrenia. Glutamate and the Glutamate Hypothesis
HTML-код
- Опубликовано: 17 май 2024
- Causes of Schizophrenia. Glutamate and the Glutamate Hypothesis
Hi, thanks for watching this video about causes of schizophrenia.
Excessive production of the neurotransmitter dopamine, or increased sensitivity of the brain to endogenous dopamine signals, is the most widely-know and widely-cited theory to explain the cause of symptoms, and to guide treatment. However, the dopamine theory does not explain all aspects of the schizophrenia syndrome. And dopamine signal-modifying medications are not helpful for all people with the syndrome. Based on these observations, we can be certain that other factors are important.
This presentation will introduce the neurotransmitter glutamate. Glutamate is one of the ‘amino acid neurotransmitters’ and glutamate is used as a communication signal by more cells in the brain than any other neurotransmitter. This presentation will also introduce the ‘glutamate hypothesis’ which states that many symptoms of schizophrenia may ultimately be traced to a sluggish glutamate receptor. The glutamate hypothesis also suggests medication treatments that don’t rely on the more-common mechanism of blocking dopamine receptors.
🎌 ABOUT OUR CHANNEL 🎌
Our channel is about psychiatric disorders. We cover lots of cool stuff such as causes of symptoms, the treatments.
Check out our channel here:
➡️ / askapsychiatrist
Don’t forget to subscribe!
I also have a Podcast “Ask A Psychiatrist” that is available on Google, Apple or Spotify.
Click here ⬇️ for more information about the podcast:
askapsychiatrist.info
CHECK OUT OUR OTHER VIDEOS
➡️ • Is there a lithium res...
➡️ • Is there a lithium res...
➡️ • Medications for Schizo...
💌 LET'S STAY IN TOUCH 💌
unsponsoredpsychiatry@gmail.com
🈁visit our website for our service:
erikmessamore.com/
The lecture is part of Northeast Ohio University's education(+)consultation service, SZconsult. Powerpoint file for this lecture is available at szconsult.org/
#askapsychiatrist #schizophrenia #glutamate
Related Searches:
what does glutamate do in schizophrenia
what is a leading hypothesis of schizophrenia
schizophrenia treatment
![Chance The Rapper, DJ Premier - Together (2024) | [Official Music Video]](http://i.ytimg.com/vi/ZVwTX6WP-MM/mqdefault.jpg)
Thank you so much for this presentation; excellent description of the glutamate hypothesis in schizophrenia, invaluable in helping with my revision and interview prep.
Research shows: "Augmentation of sarcosine, a natural inhibitor of the glycine transporter type I, normalizes glutamatergic neurotransmission, having a beneficial impact on primary negative symptoms in schizophrenia and may also influence immune system and interleukin 6 (IL-6) levels. Finding a relationship between initial IL-6 serum concentrations or its changes and severity of symptoms as a result of sarcosine addition to stable antipsychotic treatment. Fifty-eight individuals with schizophrenia with predominantly negative symptoms completed a 6-month randomized, double-blind placebo-controlled prospective study. Patients received 2 g of sarcosine (n = 29) or placebo (n = 30) daily per os. We measured IL-6 levels and severity of symptoms at the beginning, after 6 weeks and 6 months. As the main clinical tools, we used the Positive and Negative Syndrome Scale (PANSS) and Calgary depression scale for schizophrenia (CDSS). Augmentation with sarcosine had no effect on IL-6 serum levels in all time points. We noted significant improvements in negative symptoms, general psychopathology, and total PANSS score in the sarcosine group. We found a correlation of initial serum IL-6 with the severity of positive symptoms and a negative association between IL-6 levels reduction and positive symptoms reduction. Sarcosine does not significantly affect IL-6 concentrations but IL-6 may be involved in mechanisms related to the presence of positive symptoms. Copyright © 2018 John Wiley & Sons, Ltd.
" www.science.gov/topicpages/g/glutamatergic+compounds+sarcosine
Can you summarize it for me so that I understand?
is it supposed to have served the negative symptoms yes or no?
Can you summarize it for me so that I understand?
is it supposed to have served the negative symptoms yes or no?
This is brilliant , thank you!
Excellent!
This was excellent! Thankyou.
Could u pls provide me with the references?
Educative
I have theorized that both glutamate and dopamine play a role in schizophrenia but dopamine is comparable to a mere toppled domino because it is important to creating the overall symptoms that define schizophrenia but it’s not the cause, also Glutamate and dopamine are linked and levels of each influence the other this explains why anti psychotic drugs are effective at mainly treating the “Positive Symptoms” and Glutamate Antagonists are only effective at treating the “negative symptoms,” but what if we used both??🤯🤯
Also where’s the FDA they need to get a look at this
How do you know if you have shizophrenia?. I had psychosis 6 times. The negative symptons I have are because of the medictaion.
@@jeanpaultongeren125 yes antipsychotic medications shrink grey matter and cause side effects, do to the reoccurring of symptoms I would look into getting a diagnosis… however if you do want to help negative symptoms I recommend talking to your doctor about lowering the antipsychotics dosage and then pairing it with 200mg panax ginseng and 500mg NAC and 250mcg of selenium to regulate glutamate and reduce negative symptoms.
If you become manic from panax ginseng you have bipolar, if it helps you likely have schizophrenia.
If it does both you may have schizoaffective disorder.
Which is both diseases.
Once again talk to your doctor first before trying anything but the studies for panax ginseng are promising. It’s treats both negative and positive symptoms.
@@agentbertmacklin9880 Thanks
thank you. how much glycine?
using this to put me to sleep
I'm trying to recover from solvent induced psychosis, it's very similar to pcp induced psychosis, no anti psychotics including clozapine have ever worked, it's very difficult to understand this stuff while suffering from psychosis but I'm doing my best, Iv only recently learned there's been long term alterations to nmda activity caused by Touline, I was doing high doses of Glycine and am currently using the glycine re-up take inhibitor Sarcosine, that covers Glycine but what do I do to regulate glutamate activity?, Iv read there's an nmda antagonist medication memante ( not spelled correctly ), it's prescribed for Alzheimer's but I'm hoping I can get an off label script, Iv seen a study that used it to treat psychosis in schizophrenia, will that medication normalize nmda activity?
Iv also seen a study on boosting bdnf to normalize nmda activity so Iv taken 12 gram's of Dihexa and about to start the synthetic version of cerebrolysin called p21.
Can anyone comment on my situation?
I would not recommend memantine or any other antagonists as it is believed that NMDA signaling is already low. There are currently no potentiators available for clinical use. D-cycloserine showed modest benefits in some patients, but discuss this with your psychiatrist first.
There are anti phospholipase a2 natural inhibitors..
That reduces glutamate activity ..
The former is associated with brain inflammation ..
Use the relevent research keywords
Also read up on phosholipase amd astrocytes .
A good research is below with contact email of researcher .
Its about covid but expkains chemistry of pla2 and gives natural options and alopathic options
Utube : achiless heel phospholipase a2
And dont take the vaccine ..it increases pla2
Have you heard of 4dma-78dhf ?
What if it is dopamine auto antibodies? So the new title of the disease would be anti dopamine (1-5) receptor encephalitis?
That would likely be a form of parkinsons.
Anti-NMDAR autoantibodies can sometimes cause a severe form of schizophrenia.