1 AMENDMENT: Audio in this Video: Before the comments arrive, I’ll go ahead and acknowledge the audio is a bit off on this video. I’ve been transitioning audio recording systems and ran into issues, so I had to use AI to fix the bad audio (couldn’t re-record, tight deadline). Either that ^ or I never truly existed and I’m simply a fully AI creation by a machine learning SkyNet set to reprogram you to understand science. AMENDMENT: @3:09, I said “CD41” instead of CD38 - whoopsie
I actually realized you were using Ai quite a while ago in your other videos. its very obvious if youre wearing earphones. Does not sound pleasant but i understand since it saves you time
Isn't problem with ageing is that immune system becomes more agressive and drifts more towards autoimmunity? So when you say improved immunity, does that mean a little toned down immunity?
Nic - you have a rare gift for taking complex topics and making them comprehensible for your viewers. Thank you for the valuable information you provide.
I'm in my late 50s and zero creaks, aches or pains, young whipper snapper; just to hedge your generalizations. My yoga teacher is much older than me and any woman of any age would love to have a body like hers: super strong, rippling muscles even on her back with amazing flexibility and balance. I like the phrase "youthing" for the results of practices or therapies that increase vitality and reduce attributes we want to avoid. Thanks for the great content.
Old guy 74 with football high school college past. 51 years of skydiving and 20 years of martial arts. I would give 10 years of life expectancy for 5 years pain free. Still working out 5 days a week, lean and muscular but mornings are hell.
64F (almost 65) was doing great until last March when I slipped and fell on slippery floor at the swimming pool. Physio helped but I am still in a lot of pain. No apparent structural damage but the muscles don't seem to want to let go of a no-longer-necessary effort to protect my spine. So ... Just saying that even if you do everything right, stuff happens. And I think that it's a little harder to recover from that stuff the older you get. I'm working on it from all angles and I really hope to be back to a pain-free back someday, but it's been 5 months now, so I'm not so sure.
We are a very long way from uncovering the secrets of longevity and genuinely slowly aging. Every you tuber that l have watched over the last five years have aged somewhat. At best, whatever that is attempted will only have a temporary effect. When the body finally becomes adapted to the materials used , everything will rever to its actual state. Sometimes with penalty points!
Among the best sights for someone to learn honestly and simply. The doctor PhD has the charisma of teaching. He makes real good to the you tube community
Yeah i was thinking this could be a great preventative treatment for ppl staying in the hospital to prevent infections regardless of age. That could save so many lives
....i'm 56 and in better health than when I was 30....start living healthy now my friend....30 years will go quicker than you think....it may be too late then.
I hope you will address the new GLP-1 peptides on anti aging AND midiocondria . Seems like these peptides (fairly usual it seems), have benefits MUCH beyond glucose and adipose reduction. Can’t WAIT until you do a deep dive 🙏🙌💕
You know I am fascinated how this could also play a role in things like ME/CFS, long covid, post viral syndromes. I wouldn't be surprised if this kind of imbalance exists in a lot of those people, that is worth a study in itself.
@Physionic Thanks for another professional drill-down on a fascinating topic 🙏 I am curious to your view of Dr. Christian Drapeau's work on mobilizing CD34+CD133+ and CD34+CD133- stem cells.
nice research! another step on the long complex road towards understanding how any why we age, and what we can do about it... definitely a complex puzzle though.
Eu comes from Greek and it means good. It is found in words such as euphoria, eukaryotic, and Eurythmics. Youth comes from German, like in the name Karl Jung, and means young.
Thank you for covering such an interesting and uncommon topic. This video led me to your channel. Now i am curious - was it mentioned in the study whether changing the immune profile to anti inflammatory could be a way for treating autoimmune conditions?
Im curious to know which diet you follow for your health. You are more knowledgeable than most here, so im very curious to know your lifestyle. pls reply Nic
Because we didn't *decide* the pronunciations; "eu" is a Greek root for "good", and "you" is from Old English (actual _Old English_ ), from _Proto-Germanic_ . I love how English's mixed pedigree makes for such weirdness, but its tendency to keep everything makes for such fertile grounds for wordplay and ability to avoid repetition. With that in mind, I think you were looking for "rejuvenate", which literally means to make young. Ironically, the words for this form of youth are so old that the Proto-Germanic, Latin, and even Proto Indo European are similar. Blame Greek I guess.
Oh no no no, you'd surprised in fact absolutely shocked to know the actual meaning of the English words if you get yourself this book: 'Word Magic: The Powers and Occult Definitions of Words' (second edition)
I'm not sure if it's my misunderstanding or not, but you seem to be talking mainly about increases in proportions. That doesn't necessarily indicate an increase. Indeed, if there's multiple types and we target one specific type for elimination, therefore reducing its risk amount, it goes without saying that the proportions of the other types will increase, relative to the total, but that doesn't mean their number increased. Could you please clarify that point?! 🤔😅 (I wish I had learned how to read this graphs 😏.)
Hey Nick, i wondered if you ever reached out to some of the researchers of those studies, to get some extra data like in this case the comparison of young and old mice. Maybe the data exists, but didnt make it into the published study. I know that my girlfriend has like 3 times the data than what she used in her masters thesis (micro biology) and she would be allowed to share the data, or at least give a statement. I dont know if you ever asked any of the researchers, or if you even want to talk about unpublished data, but this thought just crossed my mind.
1. Awesome username, Slayer (great band, saw them live). 2. Yea, it's a great idea, but keep in mind I have to manage a lot as one person, so I can't afford the time to hunt down those little details on every study, because I have to be analyzing many other studies on the side so I can keep releasing content. Plus, if they had it, I'm sure they would have reported it, because they did on some of their other assays. You're right, though - surely that have much more data (I know I did, too). I just don't have the time to contact every researcher and interview them or go over their additional data - I'm limited to what's published. Great idea, though. :)
I like your videos which are getting better and better. What I don’t like is that sluggish-picture-background. You should might perhaps eventually really pimp it up.
Very fascinating. I would like to know more. What about CD38? I noticed that was in red, but you didn't mention it. Since we know that Apigenin reduces CD38, can this be a modality for helping to rebalancing the immune system?
After recovering from Covlid ， about 4 weeks ， I literally feel younger ， physical activities gets much better results, also looks younger! I haven't had such serious flu related sickness for 50 years， I am 66, actually I can't remember last flu was，almost never get flu. May be this the reason , virus actually help me as well.
Fascinating stuff. I seem to recall that fasting is supposed to lead to a younger immune system as well. I wonder how that compares to this technique and now the methodologies tor analyzing the impact of such therapies are being established it will be interesting to see how the whole story develops.
Not wanting to be the negative dude, but at age 56 and after about 2 yrs. on Collagen, Taurine, multi vit, good solid amount of 1.5-1.8 gms per Kg of protein, some excersize, a phisically demanding job and good sleep i am no better than before all this. I wonder if any effect has ocurred at all!! So im skeptic with all of this but clearly this is different. Hope it actually comes true, i feel like i need some time to get back and not end up in some elderly home.
"some excersize" (sic). Your diet and sleep sound great. You might want to step up the time you are devoting to exercise. Cardio and resistance training can make a huge difference in how one feels. I'm 71and work out hard 6 days a week and feel great.
No fasting and calories restriction? The only proven anti aging method, targeting almost every hallmarks of aging. Also lower your protein intake to half of that otherwise get it from egg white or lean fish and other seafood. Animal protein itself is associated with very high mortality rate and cancer. We believed it’s mainly BCAAs’ fault and BCAAs intake restriction in mice have indeed made them lived a lot longer. Interestingly, we also consistently observed higher mortality rates among people with low body fat. (and ofc high body fat, it’s u-shaped)
@@Ziprextl vegans and vegetarians dont live any longer than normal people get a grip. Calorie restriction is specifically for people who has eating disorders or addictions. Eating normally without any restriction while incorporating some fasting is already great longevity
Question: What happens to the immune system if you fast aggressively? Now this is difficult for people to do, but it is easy for mice to do, because you simply starve them. Does the immune system return to a more euthfull state? Second Question: To induce autophagy in humans, without all the hunger, how about the use of Ozempic or other appetite suppressant, but in people who are not necessarily overweight. Intentionally create an underweight condition, where the person is 15% below optimal body weight for a period of time, maybe six months. Now what happens to the immune system? Does it return to a more euthfull state?
It’s unrelated but you mentioned the joints popping as an age thing but mine popped a lot more when I was a kid. It didn’t hurt but a person in the same room as me might hear it. It does it a lot less now at 52 and have never had any joint problems but I have read it’s not something to worry about and that it’s genetic and is more about gas release than bone pops. But would love to know more.
So, I have CMV, and majority of population doesn't even know about it because the viral infection is mostly asymptomatic in healthy adults and once this virus is inside human body, it's there for life. The virus lies inside the infected cells in a dormant state but reactivation can occur causing mono like symptoms in healthy adults BUT for folks with a compromised immune system (like in cancer, HIV, organ transplant, or any such serious illness), this virus can wreak havoc leading to multiple organ failure. I've talked to multiple people who have this virus and they were in their 40s, 50s, and 60s, and they were completely healthy. If I go by what you've mentioned in this video about myeloid cells increasing with age and lymphoid cells decreasing with age then it means I have the high probability of dying because of Cytomegalovirus (CMV), which I don't think is true but would love to know your opinion on it.
I love this therapy technique idea, but I wonder, what are the chances the average American will be able to afford it with our insane health insurance system? I see more and more videos with famous athletes talking about how well stem cell therapy helped them overcome serious mobility impairing injuries. But they're rich and I don't see how the rest of us can afford such a treatment, especially given the outsized tendency of our insurers to deny everything they can.
It's about common sense like all laws, simple or complex: a healthy population is a productive and profitable population. So it's in a country's best interest to keep people healthy for longer. It's in a population's best interest to lobby/vote for govt incentives to favor availability and affordability of such medical treatments.
Can you discuss whether taking Fatty 15 plus Rapamycin together or separately corrects the imbalance between the lymphatic and myeloid cells that you discussed in this video?
Very good video once again 😘 Have you watched Neil Degrasse’s Masterclass (of the eponym series)? I wonder if you’d have some thoughts about it as it is about epistemiology and the teachings about how to think scientifically. Maybe you’d like to do a video about it? 😉
The body increases CD38 levels to create inflation in NAD+ to prevent the proliferation of super fit cells which hijack NAD to outcompete normal cells. I wouldn't lower CD38 levels without fixing immunity first. Modulating NQO1 is the best approach.
I really hesitate to ask this question since it is either too obvious or I missed the answer. What are the antibodies that are being used? I’m too old to buy green bananas but would love to get a few more SCUBA dives in before becoming shark scat.
Doesn’t reducing the number of myeloid cells rebalance the myeloid/lymphoid ratio, but also reduce in the total immune cells? How is that helpful? Does reducing morphing into myeloid cells increase morphing into lymphoid cells ?
Could this replace things like IVIG treatments for neuropathy and other diseases. I used to wonder if they’d find a way to get a week of IVIG infusion down to a shot. That would be progress, because that week, and its aftermath, were terribly hard.
Interesting but if we've got to wait for something clinically available, many of us will be dead. Need something we can do ourselves. Will fasting accomplish this? I've got an autoimmune disease.
@@Physionic Thanks :) But, YT is doubling down on censorship, with zero intellectual precision or philosophical leeway. It's just senseless destruction of communication. And don't forget, these are the people at the forefront of current human information sharing, and behind tomorrows omnipresent AGI. We must demand better. Anyway, makes me not want to reverse my age :(
![These Genes extend your Lifespan [6 Studies]](http://i.ytimg.com/vi/amSL4TdDiSQ/mqdefault.jpg)
![These Genes extend your Lifespan [6 Studies]](/img/tr.png)
![[#2024MAMA] ROSÉ (로제), Bruno Mars - APT. | Mnet 241122 방송](http://i.ytimg.com/vi/dgGqD28J6aQ/mqdefault.jpg)
1 AMENDMENT:
Audio in this Video:
Before the comments arrive, I’ll go ahead and acknowledge the audio is a bit off on this video. I’ve been transitioning audio recording systems and ran into issues, so I had to use AI to fix the bad audio (couldn’t re-record, tight deadline).
Either that ^ or I never truly existed and I’m simply a fully AI creation by a machine learning SkyNet set to reprogram you to understand science.
AMENDMENT: @3:09, I said “CD41” instead of CD38 - whoopsie
Skynet is now called Proximus 😉
I actually realized you were using Ai quite a while ago in your other videos. its very obvious if youre wearing earphones. Does not sound pleasant but i understand since it saves you time
Definitely a cloned voice
Isn't problem with ageing is that immune system becomes more agressive and drifts more towards autoimmunity? So when you say improved immunity, does that mean a little toned down immunity?
I think the word you are looking for instead of "youthenize" is: rejuvenate.
Youthenize is a perfectly cromulent word.
Your work embiggens us all, sir.
Bigly!
Truly revitalizing.
whether we have a noble heart or not, whether we are the smallest among us or not...
You go Crabapple
I went to Nepal when I was 21. I was a youth in Asia. I survived it.
Nic - you have a rare gift for taking complex topics and making them comprehensible for your viewers. Thank you for the valuable information you provide.
Thanks :)
What's this dudee's I.Q.? He seems very real. The brain freaks I've met get uptight real fast dealing with normal ppl.
Glad to hear my plan to live to 200 years is becoming more feasible every day
Soon some of the immortal mice will escape the lab and take over the world.
Planet of the Mice
Pinky and the Brain
Hitchhiker's Guide ;)
@@Physionic Isn't it already? There are more mice than men.
Then immortal AI mice 🤣
I'm in my late 50s and zero creaks, aches or pains, young whipper snapper; just to hedge your generalizations. My yoga teacher is much older than me and any woman of any age would love to have a body like hers: super strong, rippling muscles even on her back with amazing flexibility and balance. I like the phrase "youthing" for the results of practices or therapies that increase vitality and reduce attributes we want to avoid. Thanks for the great content.
Old guy 74 with football high school college past. 51 years of skydiving and 20 years of martial arts. I would give 10 years of life expectancy for 5 years pain free. Still working out 5 days a week, lean and muscular but mornings are hell.
It's great that you're feeling good. I hope it keeps up. I felt pretty good in my 50's too. Late 60's is harder.
@@flyfree78644Hopefully you’ll get both
@flyfree78644 I was thinking women tend not to have worked or punished their bodies like we have. So unbalanced comparisons...
64F (almost 65) was doing great until last March when I slipped and fell on slippery floor at the swimming pool. Physio helped but I am still in a lot of pain. No apparent structural damage but the muscles don't seem to want to let go of a no-longer-necessary effort to protect my spine. So ... Just saying that even if you do everything right, stuff happens. And I think that it's a little harder to recover from that stuff the older you get. I'm working on it from all angles and I really hope to be back to a pain-free back someday, but it's been 5 months now, so I'm not so sure.
Rejuvenating is probably a better way to phrase it in the future :P
We are a very long way from uncovering the secrets of longevity and genuinely slowly aging. Every you tuber that l have watched over the last five years have aged somewhat. At best, whatever that is attempted will only have a temporary effect. When the body finally becomes adapted to the materials used , everything will rever to its actual state. Sometimes with penalty points!
Youthification is obviously the right word!
Fantastic research - and fantastic explanation. Thank you.
Now to sort out the thymus aging ...
This channel is exactly what I was yearning for and never got - until now, that is.
Thanks
Thanks!
Among the best sights for someone to learn honestly and simply. The doctor PhD has the charisma of teaching. He makes real good to the you tube community
Maybe now we are getting somewhere! I always believed the immune system would play a big role in anti aging.
May be they will do a study to see how this affects ppl with autoimmune issues. Nice outro music and great work as always Dr.
Indeed. I think treatment for autoimmune disorders would be the first to benefit from this.
Yeah i was thinking this could be a great preventative treatment for ppl staying in the hospital to prevent infections regardless of age. That could save so many lives
I dont think non medical people can follow you. Are you lecturing the public or medical people?
I choked on my coffee when you spoke about getting old..... Get back to me in 30 years Nic
....i'm 56 and in better health than when I was 30....start living healthy now my friend....30 years will go quicker than you think....it may be too late then.
Wow you've gotten big. Almost 200k subs now. Nice work man!
That is revolutionary! I'm already hyped to get a therapy like this, and hope it will become available in the next few decades.
I hope this turns out to be a viable, safe therapy. 🦋
If it sounds too good to be true, it probably is. TY for exposing this aspect of immunology on the innate and adaptive immune system research.
I hope you will address the new GLP-1 peptides on anti aging AND midiocondria . Seems like these peptides (fairly usual it seems), have benefits MUCH beyond glucose and adipose reduction. Can’t WAIT until you do a deep dive 🙏🙌💕
Can we get one to reverse hair loss?
That would be nice! ^_^ Bald to dreadlocks lets gooooo
This sounds amazing for Crohn's Disease and other chronic inflammation diseases. I can't wait til this is available.
Great Video as usual! Such an interesting field of research
It is a fascinating area - much more to cover
My FIL who has since passed from the treatment of multiple myeloma. Fingers crossed these studies will help humans
Etymology lover here.
Eu (good/pleasant) + Thanatos (deity of non violent death).
“Euthanasia” quite literally means, “pleasant death”.
You know I am fascinated how this could also play a role in things like ME/CFS, long covid, post viral syndromes. I wouldn't be surprised if this kind of imbalance exists in a lot of those people, that is worth a study in itself.
@Physionic Thanks for another professional drill-down on a fascinating topic 🙏 I am curious to your view of Dr. Christian Drapeau's work on mobilizing CD34+CD133+ and CD34+CD133- stem cells.
Sounds fabulous! Thanks for the immune system ant-aging research
The “eu” in euthanize can also be pronounced as “oy”… veh to put the pun in punish.
Makes me wonder how this treatment might be able to fight against Immune Deficiency disorders.
Don't we use "rejuvenate" instead of "youthenasia" 😅? Great video again.
True… :)
@@Physionicreyouthenate
nice research! another step on the long complex road towards understanding how any why we age, and what we can do about it... definitely a complex puzzle though.
Thanks for the video. Esp. as you are clearly suffering from the plague. You're a trooper.
Great video! While I like most of the topics you cover, being 67, I particularly like the recent tilt toward analyzing aging-related research.
I love this channel.
Thanks!
Like and comment.
This dude is going to break through to RUclips fame soon.
That's kind of you - slow and stready... :)
for sure
Awesome report!!!
Looks promising. In a century this should be standard of care.
I think in a decade
Eu comes from Greek and it means good. It is found in words such as euphoria, eukaryotic, and Eurythmics. Youth comes from German, like in the name Karl Jung, and means young.
Just read this Word Magic: The Powers and Occult Definitions of Words (Second Edition)
Kindle Edition
Thank you for covering such an interesting and uncommon topic. This video led me to your channel. Now i am curious - was it mentioned in the study whether changing the immune profile to anti inflammatory could be a way for treating autoimmune conditions?
Doesn't high dose melatonin rejuvenate the Thymus? Wouldn't a healthier thymus do this?
Thank you for putting up that new painting in the background. 🙏 Much better than that black thing on your wall.
And what about creaky joints, and some tendons that are painful? Seriously affecting my lift routine, ugh.
I'm wondering if we get a similar result/treatment with autophagy? hmmm... Thank you for this... very awesome!!
Im curious to know which diet you follow for your health. You are more knowledgeable than most here, so im very curious to know your lifestyle. pls reply Nic
This will be smothered in the crib.
Because we didn't *decide* the pronunciations; "eu" is a Greek root for "good", and "you" is from Old English (actual _Old English_ ), from _Proto-Germanic_ . I love how English's mixed pedigree makes for such weirdness, but its tendency to keep everything makes for such fertile grounds for wordplay and ability to avoid repetition.
With that in mind, I think you were looking for "rejuvenate", which literally means to make young. Ironically, the words for this form of youth are so old that the Proto-Germanic, Latin, and even Proto Indo European are similar. Blame Greek I guess.
Oh no no no, you'd surprised in fact absolutely shocked to know the actual meaning of the English words if you get yourself this book: 'Word Magic: The Powers and Occult Definitions of Words' (second edition)
This is wild! Sign me up! 💉💪🧬🔬👩🔬
Thanks so much for translating the complexities of this study!
Where can I get some of this tho?👀
So much for saving Social Security . . .
I'm not sure if it's my misunderstanding or not, but you seem to be talking mainly about increases in proportions. That doesn't necessarily indicate an increase. Indeed, if there's multiple types and we target one specific type for elimination, therefore reducing its risk amount, it goes without saying that the proportions of the other types will increase, relative to the total, but that doesn't mean their number increased. Could you please clarify that point?! 🤔😅 (I wish I had learned how to read this graphs 😏.)
In Italy we have a word 'ringiovanire' that means make/became younger.
Would you comment on the rejuvenation of the thymus gland by Dr. Greg Fahy and how does this relate to the process that you are describing.
Have video on it
Do you have a Physionic "Mechanistic" t-shirt yet? I like the pursuit of "how it works", otherwise how do we know we actually understand? I'd buy one.
Hey Nick, i wondered if you ever reached out to some of the researchers of those studies, to get some extra data like in this case the comparison of young and old mice.
Maybe the data exists, but didnt make it into the published study. I know that my girlfriend has like 3 times the data than what she used in her masters thesis (micro biology) and she would be allowed to share the data, or at least give a statement.
I dont know if you ever asked any of the researchers, or if you even want to talk about unpublished data, but this thought just crossed my mind.
1. Awesome username, Slayer (great band, saw them live).
2. Yea, it's a great idea, but keep in mind I have to manage a lot as one person, so I can't afford the time to hunt down those little details on every study, because I have to be analyzing many other studies on the side so I can keep releasing content. Plus, if they had it, I'm sure they would have reported it, because they did on some of their other assays. You're right, though - surely that have much more data (I know I did, too). I just don't have the time to contact every researcher and interview them or go over their additional data - I'm limited to what's published. Great idea, though. :)
Youthen has been in usage most of my life.
I like your videos which are getting better and better. What I don’t like is that sluggish-picture-background. You should might perhaps eventually really pimp it up.
It's a great page turner, and the author wasn't roo far off with her idea...
Probably not good if you've had a thymectomy.
This should be combined with the thymus rejuvination protocol (growth hormone etc.)
Fantastic developments. Perhaps the bold sci-fi trope @ rejuvenation treatments is coming into view? At 70 I hope they get it done soon!😊
yay, new vid
Interesting, I wonder how this would affect the folks who already have cancer, particularly the blood/immune cancers?
great vid
Very fascinating. I would like to know more.
What about CD38? I noticed that was in red, but you didn't mention it. Since we know that Apigenin reduces CD38, can this be a modality for helping to rebalancing the immune system?
I misspoke when I said CD41 :) See amendment
Are there going to be any conventional treatments produced from this study ?
After recovering from Covlid ， about 4 weeks ， I literally feel younger ， physical activities gets much better results, also looks younger!
I haven't had such serious flu related sickness for 50 years， I am 66, actually I can't remember last flu was，almost never get flu.
May be this the reason , virus actually help me as well.
Interesting that cd38 is the same enzyme involved in function or dysfunction of mitochondria
Excellent!
Fascinating stuff. I seem to recall that fasting is supposed to lead to a younger immune system as well. I wonder how that compares to this technique and now the methodologies tor analyzing the impact of such therapies are being established it will be interesting to see how the whole story develops.
Not wanting to be the negative dude, but at age 56 and after about 2 yrs. on Collagen, Taurine, multi vit, good solid amount of 1.5-1.8 gms per Kg of protein, some excersize, a phisically demanding job and good sleep i am no better than before all this. I wonder if any effect has ocurred at all!! So im skeptic with all of this but clearly this is different. Hope it actually comes true, i feel like i need some time to get back and not end up in some elderly home.
"some excersize" (sic). Your diet and sleep sound great. You might want to step up the time you are devoting to exercise. Cardio and resistance training can make a huge difference in how one feels. I'm 71and work out hard 6 days a week and feel great.
Whole plant diet. It's lower inflammation. Also take 6mg rapamycin once weekly. I'm 53 and feel amazing. Dating women 15 to 20 years younger!
Same😂
No fasting and calories restriction? The only proven anti aging method, targeting almost every hallmarks of aging.
Also lower your protein intake to half of that otherwise get it from egg white or lean fish and other seafood. Animal protein itself is associated with very high mortality rate and cancer. We believed it’s mainly BCAAs’ fault and BCAAs intake restriction in mice have indeed made them lived a lot longer. Interestingly, we also consistently observed higher mortality rates among people with low body fat. (and ofc high body fat, it’s u-shaped)
@@Ziprextl vegans and vegetarians dont live any longer than normal people get a grip. Calorie restriction is specifically for people who has eating disorders or addictions. Eating normally without any restriction while incorporating some fasting is already great longevity
Could this be used to treat CLL?
Sir my shoulder is firecrackinggg hellllp
Question: What happens to the immune system if you fast aggressively? Now this is difficult for people to do, but it is easy for mice to do, because you simply starve them.
Does the immune system return to a more euthfull state?
Second Question: To induce autophagy in humans, without all the hunger, how about the use of Ozempic or other appetite suppressant, but in people who are not necessarily overweight. Intentionally create an underweight condition, where the person is 15% below optimal body weight for a period of time, maybe six months.
Now what happens to the immune system? Does it return to a more euthfull state?
@Physionic This looks like it might benefit people with chronic eosinophilic conditions like EoE or atopic eosinophilic dematitis.
It’s unrelated but you mentioned the joints popping as an age thing but mine popped a lot more when I was a kid. It didn’t hurt but a person in the same room as me might hear it. It does it a lot less now at 52 and have never had any joint problems but I have read it’s not something to worry about and that it’s genetic and is more about gas release than bone pops. But would love to know more.
In this case, "a remarkable breakthrough" is not an overstatement.
Shove the V where the Sun don't Shine !
So, I have CMV, and majority of population doesn't even know about it because the viral infection is mostly asymptomatic in healthy adults and once this virus is inside human body, it's there for life.
The virus lies inside the infected cells in a dormant state but reactivation can occur causing mono like symptoms in healthy adults BUT for folks with a compromised immune system (like in cancer, HIV, organ transplant, or any such serious illness), this virus can wreak havoc leading to multiple organ failure.
I've talked to multiple people who have this virus and they were in their 40s, 50s, and 60s, and they were completely healthy.
If I go by what you've mentioned in this video about myeloid cells increasing with age and lymphoid cells decreasing with age then it means I have the high probability of dying because of Cytomegalovirus (CMV), which I don't think is true but would love to know your opinion on it.
Reminds me of the 'youth in Asia' Ali G sketch about euthanasia, you're not the only one who finds it confusing 😂
I love this therapy technique idea, but I wonder, what are the chances the average American will be able to afford it with our insane health insurance system? I see more and more videos with famous athletes talking about how well stem cell therapy helped them overcome serious mobility impairing injuries. But they're rich and I don't see how the rest of us can afford such a treatment, especially given the outsized tendency of our insurers to deny everything they can.
It's about common sense like all laws, simple or complex: a healthy population is a productive and profitable population. So it's in a country's best interest to keep people healthy for longer. It's in a population's best interest to lobby/vote for govt incentives to favor availability and affordability of such medical treatments.
@@Shaft0 just u wait Shaft0, just u wait.
That's incredible
Antibodies attacking your immune cells. What could go wrong?
Can you discuss whether taking Fatty 15 plus Rapamycin together or separately corrects the imbalance between the lymphatic and myeloid cells that you discussed in this video?
Though I am sure I missed it in the comments but I haven't seen anyone mention the update on your wall.
Very good video once again 😘 Have you watched Neil Degrasse’s Masterclass (of the eponym series)?
I wonder if you’d have some thoughts about it as it is about epistemiology and the teachings about how to think scientifically.
Maybe you’d like to do a video about it? 😉
It is possible to use the same approach to treat humans? Any expected studies on humans?
The body increases CD38 levels to create inflation in NAD+ to prevent the proliferation of super fit cells which hijack NAD to outcompete normal cells.
I wouldn't lower CD38 levels without fixing immunity first. Modulating NQO1 is the best approach.
Hi, how can I participate in Age Reversing Antibody Therapy?
I really hesitate to ask this question since it is either too obvious or I missed the answer. What are the antibodies that are being used? I’m too old to buy green bananas but would love to get a few more SCUBA dives in before becoming shark scat.
Did this immune boosting increase or better the clearing out of senescenct cells?
Doesn’t reducing the number of myeloid cells rebalance the myeloid/lymphoid ratio, but also reduce in the total immune cells? How is that helpful? Does reducing morphing into myeloid cells increase morphing into lymphoid cells ?
Looking forward to antibody therapy.
Youthify works!
Where's the link to the study? 🙏
It’s there
Ah didn't see the dois because they were not blue hyperlinks 😅
Would a simple "rejuvenate" suffice for the problematic "youth-enize"?
Great video.
Definitely :)
Could this replace things like IVIG treatments for neuropathy and other diseases. I used to wonder if they’d find a way to get a week of IVIG infusion down to a shot. That would be progress, because that week, and its aftermath, were terribly hard.
Damn, that's really encouraging!
Interesting but if we've got to wait for something clinically available, many of us will be dead. Need something we can do ourselves. Will fasting accomplish this? I've got an autoimmune disease.
the research on fasting is encouraging. "pottenger's human" on utube covers the topic well with all the receipts.
YT won't let me make a joke with the Youth- and Euth- words.
I really don't like this platform :(
Weird. I actually saw your post for a minute and then it disappeared. Anyway, you’ve had some good ones on the last few videos, I enjoy them.
@@Physionic Thanks :)
But, YT is doubling down on censorship, with zero intellectual precision or philosophical leeway. It's just senseless destruction of communication.
And don't forget, these are the people at the forefront of current human information sharing, and behind tomorrows omnipresent AGI. We must demand better.
Anyway, makes me not want to reverse my age :(
So where do I get this shot?