Can Methylene Blue reverse Alzheimer’s disease?
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- Опубликовано: 6 сен 2024
- Methylene Blue (MB) can greatly improve the health and function of mitochondria. This is especially true for the neurons in our brain where MB predominantly concentrates. But beyond mitochondrial health, MB has also been shown to break down and prohibit the formation of amyloid beta plaques (the proteins accumulating in Alzheimer's disease) in several humanized Alzheimer's rodent studies. These histological findings are in sync with behavioral and memory improvement in mice and human subjects receiving MB.
#methyleneblue #alzheimer #mitochondrialhealth
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My wife was diagnosed with alzheimer's about a year and a half ago. She is 75 years old with a family history of AD. We started taking methylene blue about a year ago along with the Neuronic red light helmet. I believe that both therapies help but are not a cure. It is still progressing, but her behavior is pleasant but confused, and she is able to sleep through the night. We have tried different doses but are now using about 14 mg (one capsule with 14 drops of a 2% solution). I have not discussed this with my doctor because I know he would not approve. I am preparing for the day I will need to place her in Memory Care, but for now, she can live at home.
Thank you for your comment. I’m very sorry to hear about your wife’s condition. I I like that you are also using a red light helmet, with NIR 850nm and 630nm red light I am assuming?
Medication and supplements, including methylene blue will not always work perfectly. I am sure. It also depends greatly on the type of dementia and how fast it progresses. Not that I am suggesting it, but have you tried doses higher than 14 mg today? Another important fact to hear is her metabolic health. Are you following her HGA1c? A very low carb or even ketogenic diet has shown improvement in some Alzheimer’s patients. The brain can process ketones quite well and it decreases the insulin resistance.
Hal Cranmer had people reverse their dememtia in his nursing homes in Mesa AZ, not a cure, maybe not even helpful, but I thought I'd mention it.
@JonasKuehneMD The Neuronic helmet uses a 1070nm. Here is a link to a study done on the helmet. www.ncbi.nlm.nih.gov/pmc/articles/PMC8219492/ We tried the keto diet for a few months with no change. We did try higher doses of MB 65mg for a couple of weeks but started feeling strange so we backed down. I may try again at 30mg. I do believe it helps but I think we may have too much damage to repair. Time will tell, thanks for your concern.
I believe she might also be suffering from vitamin B deficiency. Especially thiamine (B1).
If you get a B vitamin complex get the methylated form ( methyfolate/ methylcobalamin and not folic acid/cobalamin) because her methylation is most probably impaired.
A mega dose of benfotamine (fat soluble form B1). Would be good.(150-300 mg)
And B1 cofactors magnesium (magnesiumthreonate passes the blood brain barrier).
Zinc (no more than 50 mg) potassium, and choline
80% of the body’s B1 is found in the mitochondria.
God bless
Carnivore diet is also showing astonishing results from what I’m reading from families with Alzheimer’s relatives. Add Methylene Blue and could compound the benefits.
The wonders of a substance that both donates as well as receives electrons in the electron transport chain.
Yes, it’s amazing that this very artificial looking molecule has such a profoundly positive effect on our mitochondria.
I don't know if you are familiar with this study, I somehow missed it until yesterday but I have since greatly reduced my daily dose down to about 0.2mg/kg. "The effects of acute Methylene Blue administration on cerebral blood flow and metabolism in humans and rats" This 2023 study showed very clearly the hormetic nature of MB and why higher doses should be avoided.
Thanks for mentioning this. I've been trying to figure out dosing but it's very confusing. Suggestions seem to be all over the map.
Rushed to hear about this. Newest best idea for the Brain. Gonna continue further research on Methylene Blue as I am interested to order it for preventative measures. I have HSV2 and sick of waiting for better antivirals than current ones and always looking for natural antivirals that might cooperate with Valcylivar in Case my body gets renally fed up with Valcylivar. Another antiviral in my back pocket wouldn't hurt esp one with brain protective qualities as out of control Herpes as you know can attack the brain. Your video could be life and death info for me. All antivirals or mito food interests me. Bonnie
Yes, due to its hormetic nature doses up to 15 mg for most people are sufficient. One thing to keep in mind is that due to its half-life of 5 to 7 hours any reduction in blood flow at higher doses will be temporary, but should still be avoided
@@JonasKuehneMD Should the total daily dose be divided...or taken as a single dose and, if so, would that be in the A.M.?
''WARNING''
"Blue Methylene " BEWARE from it !
WHY ?
It contains : Arsenic, Lead, Mercury, Cadmium .
It is also chloride.
And the most basic thing for me is that it blocks the entire solar light spectrum that mitochondria need to produce water and energy through the natural electron chain.
If you block natural light, you create all these dysfunctions of diseases in our modern world.
See the Lab Analysis :
cztl.bz/cdn/shop/products/HeavyMetals-Analysis-CZTL_1024x1024@2x.jpg?v=1674153769
I wish you had linked the studies that you used in your video so I could read them in their entirety.
I have been taking MB a little over a year in hopes of avoiding Alz which took the life of my mother. I’m 52 years old.
Yes, that was my oversight. Will see if I can still edit it in.
I always start new meds for me at very low doses than recommended
Im naturopathic and I work up to a therapeutic dose. Just me. Loved this lecture. Worth every minute
Thank you so much! I totally agree with you. Start at the lowest dose to see effect. I started around 7 mg on methylene blue and I’m now on 15. Going higher caused increased heart rate and feeling too activated.
I have never felt nor tested any different from dosing with MB, neither acutely nor chronically, in spite of being far from optimal mitochondrially speaking. I'm not on MAOs, my kidneys work normally, etc. Given the heavy metal hazard presented by MB sources, it doesn't seem worth it to me, unless I can address whatever is apparently preventing it from performing its job in the mitochondria. Any suggestions as to why that might be? Are there any chemical, dietary, or genetic factors that prevent MB from working?
Heavy metals are a concern in methylene blue, however, the pharmaceutical version should have minimal amounts here. Some people do not feel a great deal of difference, especially if your mitochondria are healthy.
Please research mega dosing vitamin B1. I believe a chronic B1 deficiency has to do with many disorders.
80% of the body’s B1 is found in the mitochondria.
Love your well thought out videos. So informative. I use MB typically ten drops, but not daily. I suffer from low BP usually 100/60. This helps me keep it stable I think. Also, I believe this has done wonders for my prostatitis. Again, thanks for the great info, doc.
Thank you for your kind words and great comment. I use MB six days a week at about 10 to 15 mg in tablet form. Has significantly improved my focus and concentration.
Just starting this with my mum who’s been deteriorating but has stabled off. I’ve been cycling peptide bioregulators, Nmn/resveratrol and dihexa just recently but trying this methelyn blue for 2 months whilst stoping her statins for a short period of time to see!
She’s had pet scans , mri, and many scans nothing found so next and last step a lumbar spine injection to check brain fluid
Thank you for sharing this. I’m glad she has excellent exams and follow up on her condition. What dose of methylene blue are you currently using?
Please advise. I'm looking everywhere for an answer. Nothing to do with this but would really appreciate a response. I regularly eat canned Icelandic cod livers which come in lots of their own fresh oil. Today I found out that we are being advised NOT to eat the oil thanks to new UK research that it does more harm than good. Your response on this please? With grateful thanks.
There were some red flags when it came to medicinal cod liver oil per this article:
www.sciencedirect.com/science/article/abs/pii/S0045653519309774
This article may also be helpful:
omegavia.com/cod-liver-oil/
@@JonasKuehneMD Thanks for the links.
I am seriously looking at taking Methylene Blue for myself. I have a G6PD variant from my 23andme DNA test and it states not to take Methylene Blue n. I am not sure if this is totally true. As I question what "authorities " say these days . I am researching ...
This is a great point. I would suggest to test your G6PD levels (blood test). If your G6PD enzyme levels fall within reference range, then this will be very reassuring. Having said this, the doses we are talking about here somewhere between five and 15 mg daily are extremely unlikely to trigger methemoglobinemia. Also keep in mind that method in blue is used to treat methemoglobinemia, so in lower doses, it treats it, and in higher doses it can cause it.
Thank you ! @@JonasKuehneMD
@JonasKuehneMD ... Great video! Thank you for the great visuals and analysis. Would you consider doing a video examining the combined effect of MB and Hyperbaric Oxygen Therapy (@ 1.5 to 2.0 ATA)? I plan to start giving MB to my 91 yr old mom whose battling early stages of dementia.
That’s a very interesting topic. I will definitely look into this. You could also add a PEMF mat like Bemer. It will open capillary beds and allow better perfusion. Also important to check HgA1c fasting insulin to make sure there is no metabolic dysfunction. A low-carb diet with with adequate protein and good fats helps as well.
That’s a very interesting topic. I will definitely look into this. You could also add a PEMF mat like Bemer. It will open capillary beds and allow better perfusion. Also important to check HgA1c fasting insulin to make sure there is no metabolic dysfunction. A low-carb diet with with adequate protein and good fats helps as well.
I've been researching hyperbaric oxygen therapy (HBOT). From the literature it seems lower pressures below 2.0 ATA are excellent for brain health, cognitive function, while 2.0 to 2.5 ATA are better for systemic healing and overall anti-aging. One study at 2.0 ATA showed an increase in Telomere length by 37%. HBOT's mechanism of action is fascinating. Also, you probably already know this but Magnesium L-Threonate is the best form of Magnesium capable of crossing blood-brain barrier and studies show a significant benefit to brain health. Watch this video by Dr. Dave Clayton, MD, "This Magnesium Keeps Your Brain Young" (he goes over a study on the elderly that shows a 9 year reduction in brain age).
It has been said that methylene bue can be used internally as a UV blocker. Do you know if used , would it block vitamin D3 production ?
When used externally, methylene blue can act as a UV blocker/sunscreen. When ingested, the amount ending up in the skin should be minimal and not dramatically impact vitamin D production in my opinion.
@@JonasKuehneMDthanks for replying. I was wrong about taking it internally for a UV blocker. Some companies are already adding it to sunscreen.
I'd be careful now. I took it in very small doses while taking St John's Wort and was quite sick with a range of symptoms similar to serotonin syndrome ( shivers, sweats, fever, headache, nausea, diarrhea, stomach cramps which lasted 3 days. Took it again when clear of the St John's Wort and everything ok.
Thank you for your comment. Yes, for some people, the threshold to serotonin syndrome is lower than for others.
The one thing you cannot do is take MB while taking SJW...or SERONTININ Or any SSRIs. When you try stuff...lol online and learn what these drugs interact with. By itself...it's amazing. Try it again....minus SSRis and Valariean Root or St JEort
Im 48. I have an MTHFR gene mutation and slow COMT. Would it be ok to still supplement with MB? Also, if you start supplementing do you just continue to take this or does there come a time when you should stop it? I'm interested in it for prevention of dementia. Thank you.
Methylene blue is a supplement that does not need to be methylated. So I think the MTHFR mutation is not that important here. There are no long-term studies at low doses (up to 15mg daily) that are recommended for dementia. The medication has been around since 1876. I would always suggest to discuss this with your physician first. There are many people now that are taking it regularly and so far with several years of use, there have not been significant side effects as far as I am aware. I think the dose should be somewhere between 10 and 15 mg daily, but this may vary from person to person and is certainly not medical advice. I had feedback from some people that 15 mg was too much for them and they are doing fine on 5 mg.
80% of the action of methylation in the body is to make creatine. I have MTHFR, and would recommend supplementing 2-3 grams creatine monohydrate (a bit more for males) so that you take the workload off methylation and allow that process to focus on other work in your body. Creatine is good for muscle and brain. It can turn ADP into ATP for the recycling of energy.
I take methylene blue, and do find that it helps metabolic function.
Look into a methylated form of B complex
my wife was on prosac for 25 years and Adderall for 5 . she stopped taking both and took methylene blue for 3 months to get off of them .
That is great. A much safer alternative in my opinion.
Interesting. Thank you.
Very welcome
We’re the mice actually given BM or a down stream metabolite. My naturopath said it was actually MB in is regular form.
Is methylene blue something you should take at a low dose continually, or is it better to be on it for a couple of weeks, then off for a month and repeat?
That is a great question and there is no clear answer for that. Methylene blue has been used as a medication since the 1800s. Usually it is in higher doses for a short period of time. Small doses on the order of 5 to 15 mg daily have not been studied for more than a few months. I currently use it six days a week (10-15mg) and take one day off for it to clear completely out. I do not know if this is necessary. Using a daily for a month and then taking a week off is another approach. When we think of its action on plaque formation and improving mitochondrial health, taking a week off should not be harmful to the positive effects as we are talking about slow processes here.
How many hours after oral administration of Methylene Blue have you noticed blue/green urine?
Within about an hour
Is this bad for the gut biome if it’s an antibiotic?
If you take higher amounts orally, then there may be an issue with the gut microbiome. As far as I am aware that happens and doses that exceeds 30 mg daily.
Can I take MB together with Ciales ?
Thank you in advance.
There are no reported interactions between MB and Cialis This is of course not medical advice and you should always check with your primary care doctor before adding any supplement or medication.
Can we use MB 5 mg and rises it up to 15 mg with escitalopram 5 mg? as the dose is little or its absolute contraindication
The concern is a risk of serotonin syndrome. That’s why you should ask your prescribing physician for the escitalopram. In my opinion, the low-dose is between five and 15 mg are very unlikely to cause issues here but this is of course not medical advice.
How do you take methylene blue?
It is most commonly taken as a liquid or tablet by mouth. In the hospital setting, we can also use it intravenously. The oral absorption is very high, close to 90%. For most people anywhere between 5 to 20 mg daily are sufficient.
@@JonasKuehneMD thanks.
ROS: 'Reactive' Oxygen Species
Have HSV virus. Gonna further study antiviral effects of MB as brain protection important in HSV as well neuro mito food
Either it does or doesn't
It does according to rodent studies
Dear Dr. Kuehne, i truly appreciate your information on Methylene blue. I have recurring brain fog after the pfizer vaccine for covid, so I started trying tge USP grade methylene blue, 1 mg in 1 ml water solution, twice a day and I am on the third day today. Strange though i dont have blue or green urine . does it mean my dose is too low? My body weight is 51 kg ,so thought i better start with low dose. Hope to have your opinion. After each dose, my mind clears a bit for 3-5 hours. Therefore i have the 1 mg dose twice a day when am awake. Thanks a lot indeed.
At such a low-dose, I would not expect much change in urine color. This does not mean that it is not working for you. You should always take the minimum dose needed to feel the effect. A lot of people have been doing well with doses between 2 to 5 mg daily. I am currently taking 15 mg daily but I do weigh 80 kg.
thanks a lot, i am titrating up 0.5 mg each day to find my best dose. Thank you Doctor
Where an how do i or can i get this in america??? I cant find it.. seems everyone talking as if i can, wth
Pharmaceutical grade methylene blue is available on Amazon mostly in liquid form. You can also get it as tablets:
www.best365labs.com/?ref=Jonas
Code Jonas10
Meraki blue