Dr. Huberman, I just wanted to take a moment to express my deep admiration and appreciation for your exceptional work. Since the day you launched your podcast, I have been an avid listener, eagerly absorbing the valuable insights and wisdom you share. Your ability to articulate complex concepts in a clear and engaging manner is truly remarkable. In fact, I have dedicated a special notebook solely for jotting down the profound ideas, quotes, and thoughts you express during your podcast episodes. Your passion for your work shines through in every episode, and your commitment to sharing knowledge and empowering others is truly commendable. The impact you have had on my personal and professional growth is immeasurable. Thank you once again for your remarkable work. You have truly made a positive impact on my life, and I am grateful for the opportunity to learn from someone as knowledgeable and inspiring as you. Niloufar from Iran
What changed my cognitive to the fullest was the utilization of focused vision (like manually telling yourself to focus on what you see and not wander off) and being in the present moment (to the point of telling yourself that past and present is an illusion). It's like a superpower!
"The eighteenth Century thought itself to be the age of reason; the nineteenth century thought itself to be the age of common sense while the twentieth century can only think of itself as the age of uncommon nonsense." G. K Chesterton
An episode about brain damage would break the internet. Concussions and how they affect people in general, martial artists etc. A topic not spoken enough of.
It might just be a short snippet, but that little bit about estrogen and dopamine is information I’ve been looking for for 15 years! My hormones have been wreaking havoc on my cognitive functioning for a very long time to the point where I am barely functional. I’ve still got a long way to go to get my life back, but this is a major piece of the puzzle! Thank you for having conversations with experts that we don’t the ability to converse with ourselves, and helping us understand the latest research!
After Huberman taught us how to regulate and control our dopamine I have been experimenting on myself. What an eye-opener!! It's also been a longtime coming for me as well! Understanding dopamine would resolve so many issues in this world.
As an adult female of a certain age who wants to retain as much cognitive function as possible this was insightful. I'm keeping my brain active by taking up new tasks, languages, a musical instrument and still doing online games, covering memory, focus and enjoying every minute of these podcasts so thank you for the knowledge you impart.
Here's something important to aid your brain health goal: much more powerful than any of the good techniques you mentioned is something unexpected: exercise of all kinds. I forget which episode Dr H. discussed this but he was very clear: when you're simply using your body, such as walking through a forest, the brain effect is much larger than, say, doing a language puzzle.
Dr.H - I studied Polysomnography, and your content has expanded my knowledge on the brain and how it works. I love your podcast. Youre a blessing to all. May God continue to bless you.
Enormous thanks to Dr. Mark D'Esposito for validating Persistent Post-Concussion Syndrome & its devastating physical & psychological impacts (1:20:50). I'm at 3 yrs post-TBI & he is spot on re attitudes & lack of interventions for this invisible injury (not unlike Long Covid). We need more like Dr Mark in the field.
I had a really bad concussion during college sports And physically I was fine but mentally I was messed up for about a year and a half very cloudy couldn’t think straight, my grades went down because I couldn’t keep focus. Sort of brought a lot of chaos or thought I was just being careless.
Dr. Huberman, Your recent episode on "Optimizing Cognitive Function and Brain Health" deeply inspired me. As someone who sustained a traumatic brain injury (TBI) at the age of five during a mountain accident and is currently navigating college with ADHD, I find immense value in your insights. As a science major, I face significant academic friction, yet your podcast offers practical strategies that resonate with my circumstances. Your dedication to neurobiology and brain health improvement is profoundly motivating, and I am eager to apply your recommendations to manage my TBI and ADHD symptoms better. Thank you for your impactful work, which serves as a beacon of hope for individuals like myself striving to overcome neurological challenges and achieve academic success. Warm regards, Drew
No mention of the "The End of Alzheimer's" books by Dr Dale Bredesen. It is working for me after repeated head traumas over most of my 66yrs. Your dawn/sunrise walks out in the countryside were a gamechanger for me. thank you.
I appreciate the content of that book very much. However, I believe it could benefit from a more accessible writing style, especially for readers with shorter attention spans (like mine). Dr. Huberman’s expertise as a technical communicator is commendable, and I recommend that if he were to bring Bredesen in that he have a summary of the book set in his memory, and to steer the interview to make the all-over-the-map points more digestible to the audience, as I would hate to see people turned off to Bredesen's concepts just because he does go all over the place with it in the book.
Super excited about this episode! As a cancer (chemo) survivor who still struggles 10yrs later with memory issues from it plus lifelong ADHD I love these kinds of episodes! ❤️
ive had memory issues my whole life when i was 8 these guy made me drink this weird chemical from mexico that makes you forget but since i was stilll devolping and i had alot of it my memory was destoroyed.. but i got brain damaged not to long ago and my brain healed and gave me a new dopamine receptor and i had a floo of very intense memories of my life that i never thought of crazy it was a gift in a way ecxept the memories filled me with some regret because my memories i forgot about people i cared about and never pursed more of them i just forgot complety
@@adilsheikh1401 I got ADHD and love giving unsolicited opinions. There is a need to get an Gene test and to see if the Dopamine receptors are at fault prior to taking medicines. There is also genes for acetylcholine, hormones, and norepinephrine (sp?) as well as melatonin receptors that are implicated in symptoms amounting to ADHD. Also some of us have too little Gaba. Another neurotransmitter not mentioned yet in the podcast. People point to dopamine but we also have cortisol levels that rise and stay high with hard fast workouts. Not conducive to remaining calm during the day. Lest you do like Goggins and tire out the agitation. Run for 5 hours? Testing for neurotransmitters in Alt Health claim to be accurate. Yet in conventional medicine there is no such thing. "Neurotransmitter test? No such thing." They say we are wasting money taking these tests. It's a matter of getting to the right naturopath or open minded Doctor. Some even use the Braverman Test. I heard this episode 2 days ago and I could have sworn there was more info in this re ADHD. I don't forget the info. Just where I got it from. Something about how the Dopamine has a lot of ebb and flow almost like our behaviors have a mind of their own.
In my opinion as someone with ADHD. It's lacking in explaining the neurotransmitters and how they affect memory outside of the same old Dopa . Like it's being steered away from Gaba, Cortisol, which both affect anxiousness which messes up my Working Memory. Etc. I agree with genetics testing. Melatonin receptors are lower in ADHD yet sleep was mentioned for better memory it did not explore the brain with less receptors for melatonin to start with. Also, Cortisol levels, as many with ADHD do have issues dispersing it. Keep in mind this is not a specialist in ADHD and Neurology. Yet I wish more specialists did pick up a copy of Edward O Wilson and read Consilience. Too narrow of a speciality does impare ones peripheral vision and thus create drugs that don't address the true issue. 🤔
My diet, specifically cutting out sugar and processed foods have the biggest impact on my ability to have sustained focus and concentration. The minute I go back to a junk food diet I'm back to ocd, adhd like symptoms.
Thank you Dr. Huberman and Dr. D' Esposito, for offering this particular compilation of brain mechanisms. There was a wide variety of helpful pointers.
I definitely have symptoms of adhd and as I work from home I struggle with procrastination and focus. Since last year I've taken up spinning/running in the mornings and find it so much easier to jump into work when I get back on the mornings when I've exercised ❤
Strong work with this one, and truly all of them. Just a thought- would you ever consider an episode on longevity/ wellness for people in high stress and 24-hours-a-day working environments? Personally, I am a paramedic and a mountain guide, but, I imagine many of your listeners are military, nurses, police, emergency physicians, etc. Any lifestyles that it is hard to optimize the pillars of mental and physical health. I see many colleagues suffer and compensate poorly which in turn affects patient outcomes, empathy, etc. I believe such an episode could benefit not only frontline workers and our ability to sustain a career that we love, but it would also have massive trickle down effects to patients, families, healthcare systems, justice systems, and society as a whole. Rock on
First thing on Tuesday morning (Mongolian timezone), I directly go to Huberman Lab podcast with a lot of excitement. Thank you so much for making our lives much better!
Dr. Huberman, please accept my sincere appreciation of your continuous efforts regarding this podcast. I would never be able to approach the nonstop-evolving negative complexity of my life circumstances without the language base I primarily build with your unintentional involvement. English vocabulary by itself creates enormous barrier for post-graduates being marginalized by emigration. The use of it - is another level of an issue which explodes by frontal lobes impairment caused by spousal mistreatment and psychological abuse. If not for your consistency I would have no example of normality. No pattern of speech to measure my adequacy by on certain topics. Thank you. Please, be and do ..as you are 😊
I'm 5 years post injury, fainted and fell onto the back of my head. I look pretty normal until I'm not. can go from speaking normal to not finding words or getting them out, balance can get wonky if too tired or in a busy and loud environment. Thank you for talking about PPCS! It's not understood by most docs, and that goes for most neurologist s. Brain training has helped me relearn simple math, spelling and improve memory. You could devote an entire episode on mTBI, such as how age, number of previous TBIs, being female, hx of migraines all affect the rate of recovery. Thank you so much for all your good work.
Dear Dr. Huberman, I have an immense respect for what you're doing. Could you please make a video on facial twitches, frequent blinking, making convulsive throat sounds, especially in children. What causes these when no ADHD, or Epilepsia or Tourette are diagnosed. How they can be cured both medically or, even better, with some behavioral routines. Is there a link between them and social media, devices and TV time? IS there an age when these twitches are particularly frequent? Maybe some supplements can be useful?
I moved from Kansas City (17 years there) to Barcelona 2.5 years ago and learning a new culture, language, friendships, and a city layout was like a nonstop firework show in my brain for months. I would encourage anyone to start a foreign language - not just on an app like Duolingo but watching tv in the language, trying it with a friend, or even getting a coach. My brain was working its best and converted into my business and other areas of my life. Ps I went from listening to zero of your stuff to now a top 2 show for me. You replaced two other podcasters! As a premium member, keep up the great work sir. -Jon Appino
As someone who is deeply interested in brain science and executive function in particular, I want to say how valuable this episode was to me. I will be revisiting it. Thanks to both Dr Hubermann and Dr D'Esposito!! 🎉
My mother just underwent a Brain Tumor removal for a Metastasized Lung Cancer that was in her right Frontal Lobe Cortex. Good timing, finding the information very interesting. The Neurology Team described the area as her personality center generically so learning all the nuances of what the Frontal Lobes do has been enlightening. Shes doing well now, I got her into a Clinical Trial with some of the latest technology, and shes doing quite well overall. Thank you Andrew & Mark for making information like this available to public so we can all grow a little wiser.
It is simply inexpressible how one could improve their lives because of the knowledge shared absolutely free here. Just want to say thank you! Please, continue doing what you do! Since started listening to Andrew about a year ago, I have successfully implemented several positive habits, including cold plunge, gym and some sleep tricks ! This podcast has helped me to make up my own protocols outines, which I can say truly improve the quality of life! Tiny title piece of request, would be marvellous to see some overview about daily protocols outines\supplements one can do (you personally do?) , as kind of template for newcomers. For instance, I have found that adding cardio and plunge before breakfast plus start working after eating, gives me tremendous performance boost, lasting till at least 3-4 pm and simplifies other routines\schedules during the day. How do you start the day and what benefits might be noticed from it?
Such an informative conversation with Dr. D'Esposito! And, I agree that Michael Merzenich deserves the Nobel for his innovation in the field of brain plasticity-based therapeutics!
I wrote a paper about female concussions in college and we can have worse concussions because we hold more water in certain parts of our cycle that could cause more inflammation and women also tend to have longer, thinner necks than men, potentially causing more whiplash.
Hi, Andrew. Firstly, thank you for your amazing work. Your podcast has become one of three podcasts that I listen to every week. Secondly, I wanted to make two episode requests: 1) An episode/series on diet/nutrition that dives into the various diets (omnivore, vegetarian, vegan), what people should consider if they fall into each of those categories (e.g. vegans need to supplement with Vitamin B12) as well as a deep dive into hotly debated foods such as eggs, dairy and red meat; and 2) An episode (or even a video) on what a typical day looks like for you, including what you eat, what you supplement with and your routines/rituals. Thank you
I appreciate the ongoing education we get from your podcasts. Thank you for your efforts on our behalf. Not only do you present and clarify information to us well, your interviewing skills are also a talent that we benefit from. I am hoping some day you will interview Benjamin Bikman, Phd.
I read a couple of D'Espositos review papers & was pretty impressed by the work. Nice to see that he's such a pleasant & knowledgeable person in person as well!
What causes a neurological blockage of the Stimulants for those with ADD/ADHD? apparently up to 20% of these people have this blockage. I have searched far and wide for many years and Zero. Thanks
Dr. Huberman, I appreciated the brief discussion on TBI and what occurs in the brain as a result of TBI. As a psychology doctoral resident practicing exclusively in neuropsychology, one thing I've noticed (at least in my geographical area) is the lack of communication and collaboration between psychology and neurology/neurobiology, etc. I would love to see a future episode on TBI/mTBI - in psychology, the literature I've read and the supervision I've received has largely said that an mTBI in a healthy child/adult does not and cannot cause any long-term cognitive problems, and any reported cognitive problems that occur 3-6 months or longer after an mTBI are somatic in nature. I would love to dig deeper into this and hear from experts in neurobiology/physiology whether these claims are supported or not, and it would be great to hear more about TBI/mTBI generally from the biological lens rather than from the psychological. These lectures greatly contribute to my overall understanding of health and wellness, and I'm excited to be able to use the information both personally and professionally. Thank you so much for doing these lectures for us!
Much appreciated the discussion about TBI; and as one delve deeper into the realm of paediatric TBI it becomes evident that the recovery process is considerably more complex than initially perceived. The phenomenon of the pruning brain attempting to regain functionality adds an extra layer of intricacy to the already complicated landscape of childhood TBIs.
After working shortly at a nursing home and visiting some very big Alzheimer's villages, I got it in my head that the movie 2001 from the mid 60's was the beginning of the, don't think I'm totally insane, the beginning of the Alzheimer's plan to get rid of older people along with their wisdom in a seemingly natural way. Alzheimer's does turn people into helpless newborn's, again. Also, thank you for all the time that you both put into this very informative, easy to understand conversation. It's maybe more relevant to humanities future than is imaginable.
Sir hello from India , I ve found your videos podcasts very very helpful. Sir I have already wasted my 8 years on unproductive unprofessional things. But due to your podcasts , I'm able to change my life. Thank you sir. And one thing I like about you Americans that you spend so much time on research and analysis. And you guys are very professional , practical people. Thank you and have a nice day
I've said this before, you need to loop in Dr Paul Conti. Trauma changes the brain and I think we are missing a key aspect of decision making skills. How I interpret reality is completely different than I did before I discovered your podcast and Dr Conti. As Dr. Conti stated 95% of our behavior sit in our subconscious which is what drives our decision making. Each week I think you've done the best podcast and the next week it is more fascinating than last week. Thank you for all you do!
Dr. Huberman, I sooo wish you would talk about damage to cognitive function from chemotherapy. There is still - even after it became an accepted medical diagnosis -- no solution to these "side effects" that can be disabling and last a lifetime!
I am very thankful for this video. I have a son who has severe brain cells loss due to patalogical pregnancy and no body ever explained to me how his brain works and what should we work on to help his brain improve. That video is treasure to me. Thank you❤
Thanks for this! I always appreciate neurology-based episodes. That said, I'd love to see an episode of how TBIs can affect vision and the treatments to fix the resulting issues (asking for a friend) and/or one on functional disorders, such as Functional Neurological and Functional Cognitive disorders. Thank you!
This was an excellent podcast with Dr. D'Esposito. He was brilliant and his kindness came through the conversation and made listening very enjoyable. Some guests have an aggressive or angry tone voice or do not speak clearly and makes listening difficult. I have shared this podcast with my friends and colleagues. Thank you so much for ALL the wonderful podcasts you provide, A.H.!
Please make a video about Hyperbaric Oxygen Therapy! I really want a concise, quality video about the subject, because I can't find it on YT right now.
I'm deeply appreciative of the knowledge and insights you've shared through your work. It has been a beacon of positivity, guiding me away from a tumultuous sea of anxiety, fear, and countless sleepless nights. Your podcasts have been a transformative force in my life. I would be keen to hear your thoughts on managing allergies, as they are causing sleep deprivation and the subsequent haze of drowsiness from antihistamines. Despite having food allergies, my bloodwork does not indicate any intolerances. However, upon experimenting with supplements discussed by you in one of the pods, I've begun to suspect that my allergies might stem from poor gut health. I'm now on a quest to understand this better and would greatly value any in-depth insights you could offer on this matter.
Taking my daughter to Brain Balance really helped her greatly overcome struggles of autism and sensory processing delays. I love and have learned so much about neuroplasticity from authors Normon Doidge and David Eagleman. Love Brain HQ! How about discussing PoNS translingual neuromodulation
My symptoms after my TBI (from fainting forward) did not present themselves in the initial 2.5 years but are now happening occasionally. Just like how it was described at around 30:35 of this video, I am now experiencing occasional mind blanks like walking to my kitchen but was uncertain as to why I had gone there. I haven't lost my capacity to brew a coffee/tea or cook my meals but did not know why I had gone to my kitchen.
Dear Dr. Huberman. I follow you from Brazil for about three years now. I'm not a doctor, I'm someone interested in learning the most I can to mantain my health as I age (I'm now 71). About you and Dr. D'Esposito talking about the lack of a test to the brain health, I wondered: the reaction time isn't somehow related to brain health?
Love these intelligent and digestible conversations. I can tell you guys know your stuff because of how you're able to simplify communication and explain the connections. I love the brain talks
I have been a subscriber for over a year and love your diligence and the thorough information you provide. A topic that is becoming increasingly relevant in our society is that of EDCs. I would love to see you do a full episode on Phthalates/BPAs and other Endocrine Disrupting Chemicals. I enjoyed Dr. Shanna Swan’s work on the subject matter and think many people would benefit from you giving it your time and attention!
Thank you Dr Desposito and Dr Huberman! Great episode. I was delighted that mindfulness was mentioned. Can we please get a podcast about mindfulness ? ❤️
Hello ! First of all I would like to thank you for your dedication to making science accessible and for the tremendous impact your work has on those eager to expand their understanding of the world. Secondly I would love to hear Jessie Inchauspé on your podcast. She is a biochemist at the origin of the glucose revolution. Also known as glucose goddess on the social network. I look forward to continuing to learn from your podcasts!
I can't get enough of this. I read a book with a similar topic, and I couldn't get enough of it. "Unlocking the Brain's Full Potential" by Alexander Sterling
I love to hear what the Huberman Lab would came up with if they did an episode on focal dystonia and related conditions ("the twists" for gymnasts or "the yips" for golfers etc.) ... a lot of musicians including myself would be super curious about best practices following a diagnosis because a lot of us are flying blind here. Love the show, love the guy, keep being awesome.
Thank you Andrew for the great content as usual, and thank you Mark for coming on the show. In future episodes, I would love to hear more about what your average person can do to improve working memory. The scientific dialogue is interesting, but for most people, it will be in one ear out the other. Practical actions that anyone can take, however, connected to easy to understand objectives, those tend to stick.
🎯 Key Takeaways for quick navigation: 00:14 *🧠 Understanding Executive Function and Memory* - Executive function and memory are vital for daily functioning. - Dr. Mark D'Esposito discusses neural circuits controlling executive function and memory. 02:21 *🍽️ Optimizing Cognitive Function* - Strategies to optimize executive function and memory are explored. - Research findings on behavioral and pharmacologic approaches are shared. 03:31 *💡 Sponsors' Product Promotions* - Promotion of Maui Nui Venison as a nutrient-dense protein source. - Promotion of JuV red light therapy devices for various health benefits. 06:27 *🧑🏫 Introduction to Dr. Mark D'Esposito* - Andrew Huberman introduces Dr. Mark D'Esposito. - Acknowledgment of Dr. D'Esposito's expertise in neurology and neuroscience. 07:09 *🧠 Basics of Frontal Lobe Function* - Discussion on the roles of the frontal lobes and prefrontal cortex. - Emphasis on executive function, cognitive control, and goal-directed behavior. 15:09 *🤔 Understanding Brain Rules and Algorithms* - Exploration of how the brain stores and applies rules. - Examples of hierarchical rule storage and application in decision-making. 20:16 *🧠 Training Prefrontal Cortical Abilities* - Speculation on the neuroplasticity of prefrontal cortical abilities. - Consideration of strategies for training executive functions, especially in children. 20:43 *🎯 The importance of maintaining long-term goals* - Maintaining long-term goals is more beneficial than short-term goals. - Prefrontal cortex plays a crucial role in maintaining and applying long-term goals. 21:51 *🧠 Generalization of learning in the prefrontal cortex* - Learning in the prefrontal cortex can generalize to various contexts. - Cognitive therapy aims to improve memory and executive function abilities. 25:47 *🌊 Understanding "lyic friction" and the frontal cortex* - The concept of "lyic friction" illustrates mental resistance to distractions. - The frontal cortex interacts with other brain areas to regulate focus and attention. 29:01 *🌿 Frontal cortex's connections and functions* - The frontal cortex connects with various brain regions, indicating its importance. - It controls not only cognitive functions but also physiological processes like heart rate. 36:10 *🎭 The interplay between the frontal cortex and emotions* - The frontal cortex plays a role in regulating emotional responses. - Damage to specific frontal areas can lead to social and emotional impairments. 39:08 *📱 The impact of technology on brain algorithms* - Smartphone usage shapes brain algorithms related to task switching and engagement. - The algorithms learned from smartphone usage may not generalize to other domains. 41:13 *📱 Technology's Impact on Decision Making* - Technology reliance questions its contribution to optimizing frontal lobe function. - Concerns raised about technology's influence on decision-making processes. 44:40 *🧠 Understanding Working Memory* - Working memory defined as the ability to hold and manipulate information temporarily. - Importance of working memory highlighted as foundational for various cognitive processes. 47:53 *💡 Dopamine's Role in Working Memory* - Dopamine's role in modulating working memory function elucidated. - Different neural circuits for movement and working memory explained in relation to dopamine. 54:26 *💊 Exploring Bromocriptine and Dopamine Modulation* - Discussion on bromocriptine as a dopamine agonist and its impact on working memory. - Potential effects of dopamine modulation on cognitive enhancement considered. 01:01:46 *🧠 Pharmacological Potential for Cognitive Enhancement* - The pharmaceutical industry has not focused on developing drugs to enhance cognition, despite clear data and existing safe drugs. - Current neurology research tends to prioritize disease treatment over cognitive enhancement. 01:04:21 *🧬 Multimodal Approach to Enhancing Cognitive Function* - Boosting neurotransmitters like dopamine, norepinephrine, and serotonin can improve working memory. - Drugs such as Wellbutrin and guanfacine, known to boost norepinephrine, show potential for enhancing cognitive function. 01:09:12 *🧪 Challenges in Measuring Neurotransmitter Levels* - Accurately measuring neurotransmitter levels in the brain is complex and often requires neuroimaging techniques. - Neurotransmitter systems like dopamine operate in a delicate balance between brain regions, making measurements more challenging. 01:12:51 *💊 Pharmacological Optimization and Concerns* - Bromocriptine, despite being well-tolerated, has subtle effects on reaction time and cognition. - Optimizing brain function through pharmacology requires a balanced approach, considering individual differences in neurochemistry. 01:21:09 *🧠 Understanding Persistent Post-Concussion Syndrome* - Persistent post-concussion syndrome can occur in a significant percentage of people even a year after the initial injury. - Symptoms may include mental fog, light sensitivity, dizziness, and other vague yet impactful cognitive issues. 01:22:20 *🧠 Explaining Concussion and Brain Injury* - Concussion involves tearing and stretching of axons in the brain, even without loss of consciousness. - The severity and duration of symptoms correlate with the extent of axonal damage. 01:25:42 *🧠 Impact of Sleep on Brain Function and Recovery* - Sleep disruption is a common symptom following brain injury and can exacerbate cognitive deficits. - Even a poor night's sleep can significantly impair prefrontal cortical function. 01:28:43 *🧠 Rehabilitation and Interventions for Brain Injury* - Traditional recommendations for rest post-concussion are shifting towards gradual return to activity. - Brain training games, like those from BrainHQ, offer accessible interventions for cognitive rehabilitation. 01:32:10 *🧠 Maintaining and Optimizing Brain Function* - Continuous engagement in cognitive activities, such as reading and learning new skills, can help maintain and strengthen brain function. - Lack of structured approaches to brain health assessment and promotion hinders progress in the field. 01:41:09 *📚 The importance of various lifestyle factors for brain health* - Reading non-fiction books and increasing knowledge. - Engaging in social interactions. 01:42:59 *🧠 Understanding the impact of technology and social media on cognition* - Social media lacks the cognitive richness found in traditional activities like reading books. - Engaging in activities that require goal-setting, multitasking, and focus, like playing chess or participating in improv, can benefit cognition. 01:47:36 *🧠 Insights into Alzheimer's disease* - Lack of a straightforward genetic link to Alzheimer's. - Current understanding of Alzheimer's pathology involving plaques and tangles in the brain. 01:51:57 *🧠 Challenges and approaches in treating Alzheimer's* - Symptomatic therapy focuses on managing day-to-day issues and behaviors. - Socialization and reminiscence therapy can be beneficial for patients. 01:56:44 *🧠 Exploring potential cognitive enhancers like nicotine* - Nicotine's impact on the cholinergic system and potential benefits in Alzheimer's treatment. - Lack of conclusive evidence for nicotine's efficacy in preventing neurodegenerative disorders. 02:01:15 *🧠 Estrogen's Impact on Cognitive Function* - Estrogen levels are important for cognition and vascular function. - Both men and women have testosterone and estrogen, with men needing adequate estrogen levels for cognitive and vascular health. 02:02:48 *🏃♂️ Aerobic Exercise and Cognitive Function* - Aerobic exercise has been found to improve executive function and working memory. - Studies suggest aerobic exercise can be as effective as cognitive therapy in improving cognitive function. 02:04:40 *🧘♂️ Mindfulness and Cognitive Enhancement* - Mindfulness training, when added to cognitive therapy, enhances executive function. - Mindfulness serves as a focus exercise, aiding in concentration and attention management. 02:11:09 *🧠 Understanding Brain Networks and Well-being* - Recent neuroscience research focuses on brain network activity rather than isolated brain regions. - The brain's modularity, or network organization, predicts individual well-being and response to interventions. 02:21:06 *🧠 Brain Modularity and Physiology* - Exploring the possibility of developing a modularity metric for cognitive function in real time. - Investigating proxies for modularity using physiological data like heart rate variability and oxygen levels. 02:23:10 *🔄 Brain Connectivity and Psychedelics* - Discussing the impact of psychedelics, specifically psilocybin, on brain connectivity. 02:25:30 *🧠 Integrative Therapies for Brain Health* - Exploring the combination of drug therapies, cognitive training, and transcranial magnetic stimulation for brain health. 02:26:54 *🤣 A Neurologist's Role and Appreciation* - Reflecting on the evolution of neurology and the role of neurologists in addressing brain health issues. Made with HARPA AI
I am recovering from a TBI and about three years in discovered that I had significant eye issues including double vision from Convergence Insufficiency. My chiropractor, not my eye, primary, psychiatrist or neurologist finally referred me to an eye specialist. This made all the difference and I am about halfway through vision therapy. Two questions related to this very helpful podcast (many thanks to Docs Huberman and D'Esposito) 1) Why aren't eyes always checked for Convergence/saccades/pursuits checked after every concussion and TBI incident? 2) Can eye movements such as these be used as a reference stat for brain function per this podcast topic?
Can you do an episode on Tinnitus as there are no significant studies on efficient treatments The realm of this condition stretches over far more than just ear health since mental health, psychosomatic symptoms and physical conditions are all part of it. Would be so helpful for us ❤🙏
Yes I got tinnitus last month and since then I am hearing constant high pitched sound. I have one very imp exam in two months. I believe it's was because of using headphones all day. I hope they will make some helpful video about it.
Hi Andrew, Can you do an episode on the science of social skills? Why some people don't have the ability to hold a conversation, read the room and why some people have charisma, lots of friends etc
Thank you so much for expanding public knowledge on brain health. I experienced a TBI in Nov 2018 and have been a prolonged recovery journey since then. Before the injury, I was an avid book reader and athlete. After it, I lost the ability to both run/dance, drive and read due to extreme nausea, fatigue and visual issues. Your podcast is one of the things that has kept me hopeful and motivated to stick with weekly neuroopthamology PT sessions. It’s taken over 5 years, but I can do 30 minutes of gentle yoga again, walk for 30 minutes , read in large print for 30-40 minutes and drive for short distances. I determined to return to my full capabilities again. Thank you again for all that you do-having free access to cutting edge research and science has been life saving for me.🙏🏽🙏🏽🙏🏽
Hello Dr Huberman, I’ve gained so much knowledge from your efforts in this podcast- thank you. If you would consider having me on I’d really enjoy the conversation. I was hit by a truck while training for an Ironman in 2009 and became a paraplegic. Since then I finished Ironman Kona in 2012, went to Alpine skiing world champs in 2017, and have represented the US archery team since 2017. I am the current Paralympic champion, world champion, and national champion for recurve archery. Lots of things we could unpack on how to overcome challenges. Keep up the great work. Kevin Mather.
in this podcast, there was a brief discussion about the pharmaceutical industry’s priorities. While they focus on addressing health conditions, they seem less inclined to explore the potential of the same drugs for enhancing cognitive performance. The underlying reason appears to be the financial model: pharmaceutical companies can bill insurance providers for drugs used to treat diseases, but there is no mechanism to bill for the same drugs when used to enhance cognitive function. In essence, the industry’s emphasis on treating illnesses may overshadow the exploration of cognitive enhancement, which lacks a direct financial incentive. This dynamic highlights the delicate balance between health improvement and economic considerations in the pharmaceutical landscape.
Excellent topic and guest. It could be helpful to have a neuropsychologist come on the podcast for topics such as this given that we receive specialized education and training in brain-behavioral relationships, with a particular emphasis on cognitive and emotional functioning. We also are trained in both assessment and treatment (cognitive rehabilitation, therapy), as well as functional neuroanatomy, hence there may be an opportunity to have both a more nuanced and comprehensive discussion about various cognitive disorders and their behavioral manifestations. We often work closely with neurologists and other providers to assist with differential diagnosis, monitoring cognition over time, and provide treatment recommendations. I know for a fact that your podcast immensely enhances my practice as well as many other neuropsychologists I know, so THANK YOU!
It would be great if you could do a full episode on Parkinson’s disease, since you’ve touched on it in many episodes. My mother suffers from it and it’s devastating to see the full range of symptoms and side effects.
Would love to see Dr. D'Esposito back to talk about frontotemporal dementia (FTD), especially with the diagnoses of Bruce Willis & Wendy Williams coming out and most people (luckily) knowing nothing of the disease and the ways it differs from Alzheimer's.
Dr. Huberman, thank you for your hard work! My son is on the autism spectrum and loves waking up to your nsdr 10 minute recording every morning. It would also be nice to listen to an expert and find out what the resources are for high functioning autistic young adults so that they can prosper and become a part of society and contribute to it. We, parents struggle with this everyday…(Hope you read this) thank you :)
I was interested in Dr D'Esposito's mention of covid "brain fog" and would have liked to have heard this explored more - what is going on with covid and the brain. Thanks for the discussion.
Idea: ask, "In your opinion, what is the most fascinating aspect of the brain?" and then ask questions based off the conversation instead of having a set list. This would be like link surfing on wikipedia - one topic dives into more specific topics, back to the original topic, back down another rabbit hole, etc.
An episode about autism on a physiological and neurological level would be appreciated, especially about the impact on the sympathetic and parasympathetic nervous systems. As an adult who was diagnosed with autism and ADHD last year at 29, I find it hard to find scientific resources that are helpful. Love your podcast and can not recommend it enough to others.
hey andrew, i would love an episode on rheumatoid arthritis! i've been diagnosed for 21 years now and it's been a rollercoaster of a ride. living in a small town, my options for rheumatologists and PT are hard to come by so i'd love to hear the science behind it and how i can limit symptoms!
An episode on EMDR, considering it’s a front line highly effective trauma treatment would be excellent and well received. Dr Sarah Schubert who has co authored the recent Oxford text book would be a fantastic option.
Dr. D'Esposito's is again an excellent informative podcast. My question is on the dyslexic brain. Is how does it relate to the average brain in relation to the topics covered such as modularity, concentration, and so on. Please consider a podcast on dyslexia, the neurological differences (pros and cons), and how to address them. Thank you again for your fantastic podcast.
Dr Huberman. I hope you know these podcasts are not under appreciated. You are a certified legend. These kinds of podcasts are the best thing on the internet by leaps and bounds, especially for people like me who are not book worms and cannot for the life of me absorb information from the written word unless I have an extreme interest in a certain subject. You and a few others have broadened my knowledge considerably and impacted my general quality of life substantially. I do not drink that much anymore but I’d buy you a beer if I met you that’s for certain 👍
IMPORTANT TIP for all who have brain health goals: much more powerful than any of the good techniques like learning a language, reading, etc. is something unexpected: exercise of all kinds. I forget which episode Dr H. discussed this but he was very clear: when you're simply using your body, such as walking through a forest, the brain effect is much larger than, say, doing a language puzzle. Weird, huh?
Ouch, some painful conditions mentioned there, hope anyone struggling with memory loss are getting help. With so much to remember my head throbs, notes notes more notes, just remember to update any changes and watch they don't get moved or altered. Cheers both Dr. S.
I met bromcriptin only in purulent surgery to inhibit lactation by mastitis, and i can say patients were not inspired of this treatment because of side effects. You know, i am also very engaged into idea to improve neuroplasticity easy and safe. Now i think it is possible to do without psychedelics, only with use of mental exercises. Sure i want firstly check all possibilities we have, and particularly is it mix of different practice from "west" and "east" neuroscience, but i think it is really something important. My english is not enough good to discuss it yet, but i work on it. Thank you for great job! And sorry for mistakes:)
Dr. Huberman, I just wanted to take a moment to express my deep admiration and appreciation for your exceptional work. Since the day you launched your podcast, I have been an avid listener, eagerly absorbing the valuable insights and wisdom you share. Your ability to articulate complex concepts in a clear and engaging manner is truly remarkable. In fact, I have dedicated a special notebook solely for jotting down the profound ideas, quotes, and thoughts you express during your podcast episodes. Your passion for your work shines through in every episode, and your commitment to sharing knowledge and empowering others is truly commendable. The impact you have had on my personal and professional growth is immeasurable. Thank you once again for your remarkable work. You have truly made a positive impact on my life, and I am grateful for the opportunity to learn from someone as knowledgeable and inspiring as you.
Niloufar from Iran
I think this person speaks for more than themselves 🎉
I thought I was the only one that has a special notebook for Hubberman episodes. This podcast is a definite game changer
Mashala chghd hal dashti english benevisi khaharam😂😂
😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊
An episode about skin health would be great
Agreed
👍
Indeed!
yes sir
+1
What changed my cognitive to the fullest was the utilization of focused vision (like manually telling yourself to focus on what you see and not wander off) and being in the present moment (to the point of telling yourself that past and present is an illusion). It's like a superpower!
If that's the case cats should be the most cognitively advanced creatures on the planet.
Sounds like the work of Eckhart Tolle
@@dimaknopf Aren't they? They don't give a damn, man, haha!
"The eighteenth Century thought itself to be the age of reason; the nineteenth century thought itself to be the age of common sense while the twentieth century can only think of itself as the age of uncommon nonsense."
G. K Chesterton
😂
An episode about brain damage would break the internet. Concussions and how they affect people in general, martial artists etc. A topic not spoken enough of.
It might just be a short snippet, but that little bit about estrogen and dopamine is information I’ve been looking for for 15 years! My hormones have been wreaking havoc on my cognitive functioning for a very long time to the point where I am barely functional. I’ve still got a long way to go to get my life back, but this is a major piece of the puzzle!
Thank you for having conversations with experts that we don’t the ability to converse with ourselves, and helping us understand the latest research!
After Huberman taught us how to regulate and control our dopamine I have been experimenting on myself. What an eye-opener!! It's also been a longtime coming for me as well! Understanding dopamine would resolve so many issues in this world.
As an adult female of a certain age who wants to retain as much cognitive function as possible this was insightful. I'm keeping my brain active by taking up new tasks, languages, a musical instrument and still doing online games, covering memory, focus and enjoying every minute of these podcasts so thank you for the knowledge you impart.
Here's something important to aid your brain health goal: much more powerful than any of the good techniques you mentioned is something unexpected: exercise of all kinds. I forget which episode Dr H. discussed this but he was very clear: when you're simply using your body, such as walking through a forest, the brain effect is much larger than, say, doing a language puzzle.
Thanks for your personal adaptive mental balance andto
I am trying to learn biochemistry. I am 65 and pleasantly retired
Dr.H - I studied Polysomnography, and your content has expanded my knowledge on the brain and how it works. I love your podcast. Youre a blessing to all. May God continue to bless you.
Fasting for ladies before menopause. Thanks!
Enormous thanks to Dr. Mark D'Esposito for validating Persistent Post-Concussion Syndrome & its devastating physical & psychological impacts (1:20:50). I'm at 3 yrs post-TBI & he is spot on re attitudes & lack of interventions for this invisible injury (not unlike Long Covid). We need more like Dr Mark in the field.
I had a really bad concussion during college sports And physically I was fine but mentally I was messed up for about a year and a half very cloudy couldn’t think straight, my grades went down because I couldn’t keep focus. Sort of brought a lot of chaos or thought I was just being careless.
Dr. D'Esposito is so pleasant and humble. I appreciate this discussion greatly!
Dr. Huberman,
Your recent episode on "Optimizing Cognitive Function and Brain Health" deeply inspired me. As someone who sustained a traumatic brain injury (TBI) at the age of five during a mountain accident and is currently navigating college with ADHD, I find immense value in your insights.
As a science major, I face significant academic friction, yet your podcast offers practical strategies that resonate with my circumstances. Your dedication to neurobiology and brain health improvement is profoundly motivating, and I am eager to apply your recommendations to manage my TBI and ADHD symptoms better.
Thank you for your impactful work, which serves as a beacon of hope for individuals like myself striving to overcome neurological challenges and achieve academic success.
Warm regards,
Drew
What are your takeaways?
& wish you all the best!
Thank you for making these podcasts available for those who simply want to learn. Your uploads are greatly appreciated Dr. Huberman.
Yes
No mention of the "The End of Alzheimer's" books by Dr Dale Bredesen. It is working for me after repeated head traumas over most of my 66yrs. Your dawn/sunrise walks out in the countryside were a gamechanger for me. thank you.
I appreciate the content of that book very much. However, I believe it could benefit from a more accessible writing style, especially for readers with shorter attention spans (like mine). Dr. Huberman’s expertise as a technical communicator is commendable, and I recommend that if he were to bring Bredesen in that he have a summary of the book set in his memory, and to steer the interview to make the all-over-the-map points more digestible to the audience, as I would hate to see people turned off to Bredesen's concepts just because he does go all over the place with it in the book.
Super excited about this episode! As a cancer (chemo) survivor who still struggles 10yrs later with memory issues from it plus lifelong ADHD I love these kinds of episodes! ❤️
ive had memory issues my whole life when i was 8 these guy made me drink this weird chemical from mexico that makes you forget but since i was stilll devolping and i had alot of it my memory was destoroyed.. but i got brain damaged not to long ago and my brain healed and gave me a new dopamine receptor and i had a floo of very intense memories of my life that i never thought of crazy it was a gift in a way ecxept the memories filled me with some regret because my memories i forgot about people i cared about and never pursed more of them i just forgot complety
Great. What were some key points you got from an ADHD point of view?
@@adilsheikh1401 I got ADHD and love giving unsolicited opinions. There is a need to get an Gene test and to see if the Dopamine receptors are at fault prior to taking medicines. There is also genes for acetylcholine, hormones, and norepinephrine (sp?) as well as melatonin receptors that are implicated in symptoms amounting to ADHD. Also some of us have too little Gaba. Another neurotransmitter not mentioned yet in the podcast. People point to dopamine but we also have cortisol levels that rise and stay high with hard fast workouts. Not conducive to remaining calm during the day. Lest you do like Goggins and tire out the agitation. Run for 5 hours? Testing for neurotransmitters in Alt Health claim to be accurate. Yet in conventional medicine there is no such thing. "Neurotransmitter test? No such thing." They say we are wasting money taking these tests. It's a matter of getting to the right naturopath or open minded Doctor. Some even use the Braverman Test. I heard this episode 2 days ago and I could have sworn there was more info in this re ADHD. I don't forget the info. Just where I got it from. Something about how the Dopamine has a lot of ebb and flow almost like our behaviors have a mind of their own.
In my opinion as someone with ADHD. It's lacking in explaining the neurotransmitters and how they affect memory outside of the same old Dopa . Like it's being steered away from Gaba, Cortisol, which both affect anxiousness which messes up my Working Memory. Etc. I agree with genetics testing. Melatonin receptors are lower in ADHD yet sleep was mentioned for better memory it did not explore the brain with less receptors for melatonin to start with. Also, Cortisol levels, as many with ADHD do have issues dispersing it. Keep in mind this is not a specialist in ADHD and Neurology. Yet I wish more specialists did pick up a copy of Edward O Wilson and read Consilience. Too narrow of a speciality does impare ones peripheral vision and thus create drugs that don't address the true issue. 🤔
@cmauro7912 Wow thanks for your insight. You mentioned a book. Is that good for people with ADHD?
My diet, specifically cutting out sugar and processed foods have the biggest impact on my ability to have sustained focus and concentration. The minute I go back to a junk food diet I'm back to ocd, adhd like symptoms.
Thank you for a useful comment.
Thank you Dr. Huberman and Dr. D' Esposito, for offering this particular compilation of brain mechanisms. There was a wide variety of helpful pointers.
I definitely have symptoms of adhd and as I work from home I struggle with procrastination and focus. Since last year I've taken up spinning/running in the mornings and find it so much easier to jump into work when I get back on the mornings when I've exercised ❤
Thank you for a useful comment.
Strong work with this one, and truly all of them. Just a thought- would you ever consider an episode on longevity/ wellness for people in high stress and 24-hours-a-day working environments? Personally, I am a paramedic and a mountain guide, but, I imagine many of your listeners are military, nurses, police, emergency physicians, etc. Any lifestyles that it is hard to optimize the pillars of mental and physical health. I see many colleagues suffer and compensate poorly which in turn affects patient outcomes, empathy, etc. I believe such an episode could benefit not only frontline workers and our ability to sustain a career that we love, but it would also have massive trickle down effects to patients, families, healthcare systems, justice systems, and society as a whole.
Rock on
First thing on Tuesday morning (Mongolian timezone), I directly go to Huberman Lab podcast with a lot of excitement. Thank you so much for making our lives much better!
Dr. Huberman, please accept my sincere appreciation of your continuous efforts regarding this podcast.
I would never be able to approach the nonstop-evolving negative complexity of my life circumstances without the language base I primarily build with your unintentional involvement. English vocabulary by itself creates enormous barrier for post-graduates being marginalized by emigration.
The use of it - is another level of an issue which explodes by frontal lobes impairment caused by spousal mistreatment and psychological abuse.
If not for your consistency I would have no example of normality. No pattern of speech to measure my adequacy by on certain topics.
Thank you.
Please, be and do ..as you are 😊
I'm 5 years post injury, fainted and fell onto the back of my head. I look pretty normal until I'm not. can go from speaking normal to not finding words or getting them out, balance can get wonky if too tired or in a busy and loud environment. Thank you for talking about PPCS! It's not understood by most docs, and that goes for most neurologist s. Brain training has helped me relearn simple math, spelling and improve memory. You could devote an entire episode on mTBI, such as how age, number of previous TBIs, being female, hx of migraines all affect the rate of recovery. Thank you so much for all your good work.
Dear Dr. Huberman, I have an immense respect for what you're doing. Could you please make a video on facial twitches, frequent blinking, making convulsive throat sounds, especially in children. What causes these when no ADHD, or Epilepsia or Tourette are diagnosed. How they can be cured both medically or, even better, with some behavioral routines. Is there a link between them and social media, devices and TV time? IS there an age when these twitches are particularly frequent? Maybe some supplements can be useful?
Thank you for bringing Dr. Despacito to the podcast! Very excited
D'Esposito. 😂 Despacito means slow in Spanish.
@@mariee.5912 I know, I was joking! But still a great episode.
@@armablue7914 I figured. 😆
I moved from Kansas City (17 years there) to Barcelona 2.5 years ago and learning a new culture, language, friendships, and a city layout was like a nonstop firework show in my brain for months.
I would encourage anyone to start a foreign language - not just on an app like Duolingo but watching tv in the language, trying it with a friend, or even getting a coach.
My brain was working its best and converted into my business and other areas of my life.
Ps I went from listening to zero of your stuff to now a top 2 show for me. You replaced two other podcasters! As a premium member, keep up the great work sir. -Jon Appino
We dont care about you
As someone who is deeply interested in brain science and executive function in particular, I want to say how valuable this episode was to me. I will be revisiting it. Thanks to both Dr Hubermann and Dr D'Esposito!! 🎉
My mother just underwent a Brain Tumor removal for a Metastasized Lung Cancer that was in her right Frontal Lobe Cortex. Good timing, finding the information very interesting. The Neurology Team described the area as her personality center generically so learning all the nuances of what the Frontal Lobes do has been enlightening. Shes doing well now, I got her into a Clinical Trial with some of the latest technology, and shes doing quite well overall. Thank you Andrew & Mark for making information like this available to public so we can all grow a little wiser.
It is simply inexpressible how one could improve their lives because of the knowledge shared absolutely free here. Just want to say thank you! Please, continue doing what you do!
Since started listening to Andrew about a year ago, I have successfully implemented several positive habits, including cold plunge, gym and some sleep tricks ! This podcast has helped me to make up my own protocols
outines, which I can say truly improve the quality of life!
Tiny title piece of request, would be marvellous to see some overview about daily protocols
outines\supplements one can do (you personally do?) , as kind of template for newcomers.
For instance, I have found that adding cardio and plunge before breakfast plus start working after eating, gives me tremendous performance boost, lasting till at least 3-4 pm and simplifies other routines\schedules during the day.
How do you start the day and what benefits might be noticed from it?
Such an informative conversation with Dr. D'Esposito! And, I agree that Michael Merzenich deserves the Nobel for his innovation in the field of brain plasticity-based therapeutics!
I’m a listener from Germany and I really love your Podcast. Thank you so much!
I wrote a paper about female concussions in college and we can have worse concussions because we hold more water in certain parts of our cycle that could cause more inflammation and women also tend to have longer, thinner necks than men, potentially causing more whiplash.
My brain got healthier just seeing the notification of this episode 🔥
Nice!!😎😊
Hi, Andrew. Firstly, thank you for your amazing work. Your podcast has become one of three podcasts that I listen to every week.
Secondly, I wanted to make two episode requests:
1) An episode/series on diet/nutrition that dives into the various diets (omnivore, vegetarian, vegan), what people should consider if they fall into each of those categories (e.g. vegans need to supplement with Vitamin B12) as well as a deep dive into hotly debated foods such as eggs, dairy and red meat; and
2) An episode (or even a video) on what a typical day looks like for you, including what you eat, what you supplement with and your routines/rituals.
Thank you
I think both of these have been done already
Thank you Dr. Huberman, team, sponsors and supporters.☀ Thank you Dr. Mark D'Esposito.
I appreciate the ongoing education we get from your podcasts. Thank you for your efforts on our behalf. Not only do you present and clarify information to us well, your interviewing skills are also a talent that we benefit from. I am hoping some day you will interview Benjamin Bikman, Phd.
Thank you very much for your work, Andrew Huberman!
I read a couple of D'Espositos review papers & was pretty impressed by the work. Nice to see that he's such a pleasant & knowledgeable person in person as well!
Thanks!
Best part of Mondays
What causes a neurological blockage of the Stimulants for those with ADD/ADHD? apparently up to 20% of these people have this blockage. I have searched far and wide for many years and Zero. Thanks
Dr. Huberman, I appreciated the brief discussion on TBI and what occurs in the brain as a result of TBI. As a psychology doctoral resident practicing exclusively in neuropsychology, one thing I've noticed (at least in my geographical area) is the lack of communication and collaboration between psychology and neurology/neurobiology, etc. I would love to see a future episode on TBI/mTBI - in psychology, the literature I've read and the supervision I've received has largely said that an mTBI in a healthy child/adult does not and cannot cause any long-term cognitive problems, and any reported cognitive problems that occur 3-6 months or longer after an mTBI are somatic in nature. I would love to dig deeper into this and hear from experts in neurobiology/physiology whether these claims are supported or not, and it would be great to hear more about TBI/mTBI generally from the biological lens rather than from the psychological. These lectures greatly contribute to my overall understanding of health and wellness, and I'm excited to be able to use the information both personally and professionally. Thank you so much for doing these lectures for us!
Always a great day when Andrew uploads
Much appreciated the discussion about TBI; and as one delve deeper into the realm of paediatric TBI it becomes evident that the recovery process is considerably more complex than initially perceived. The phenomenon of the pruning brain attempting to regain functionality adds an extra layer of intricacy to the already complicated landscape of childhood TBIs.
It's amazing TBI which can be caused with just severe shakes can cause death or disability.
After working shortly at a nursing home and visiting some very big Alzheimer's villages, I got it in my head that the movie 2001 from the mid 60's was the beginning of the, don't think I'm totally insane, the beginning of the Alzheimer's plan to get rid of older people along with their wisdom in a seemingly natural way. Alzheimer's does turn people into helpless newborn's, again. Also, thank you for all the time that you both put into this very informative, easy to understand conversation. It's maybe more relevant to humanities future than is imaginable.
Sir hello from India , I ve found your videos podcasts very very helpful. Sir I have already wasted my 8 years on unproductive unprofessional things. But due to your podcasts , I'm able to change my life. Thank you sir. And one thing I like about you Americans that you spend so much time on research and analysis. And you guys are very professional , practical people. Thank you and have a nice day
I've said this before, you need to loop in Dr Paul Conti. Trauma changes the brain and I think we are missing a key aspect of decision making skills. How I interpret reality is completely different than I did before I discovered your podcast and Dr Conti. As Dr. Conti stated 95% of our behavior sit in our subconscious which is what drives our decision making. Each week I think you've done the best podcast and the next week it is more fascinating than last week. Thank you for all you do!
Dr. Huberman, I sooo wish you would talk about damage to cognitive function from chemotherapy. There is still - even after it became an accepted medical diagnosis -- no solution to these "side effects" that can be disabling and last a lifetime!
I am very thankful for this video. I have a son who has severe brain cells loss due to patalogical pregnancy and no body ever explained to me how his brain works and what should we work on to help his brain improve. That video is treasure to me. Thank you❤
Thanks for this! I always appreciate neurology-based episodes. That said, I'd love to see an episode of how TBIs can affect vision and the treatments to fix the resulting issues (asking for a friend) and/or one on functional disorders, such as Functional Neurological and Functional Cognitive disorders. Thank you!
Thank you so much for finally covering traumatic brain injury.
Hubermondays💪🏽💜🧠.
My Mondays have been FOREVER changed 🧠
I found your podcasts a month ago. Putting as much as I can into action has been a real life changer. Thanks
Thank you sir for spreading knowledge!
Love from India! 🇮🇳
This was an excellent podcast with Dr. D'Esposito. He was brilliant and his kindness came through the conversation and made listening very enjoyable. Some guests have an aggressive or angry tone voice or do not speak clearly and makes listening difficult. I have shared this podcast with my friends and colleagues. Thank you so much for ALL the wonderful podcasts you provide, A.H.!
Please make a video about Hyperbaric Oxygen Therapy!
I really want a concise, quality video about the subject, because I can't find it on YT right now.
I'm deeply appreciative of the knowledge and insights you've shared through your work. It has been a beacon of positivity, guiding me away from a tumultuous sea of anxiety, fear, and countless sleepless nights. Your podcasts have been a transformative force in my life. I would be keen to hear your thoughts on managing allergies, as they are causing sleep deprivation and the subsequent haze of drowsiness from antihistamines. Despite having food allergies, my bloodwork does not indicate any intolerances. However, upon experimenting with supplements discussed by you in one of the pods, I've begun to suspect that my allergies might stem from poor gut health. I'm now on a quest to understand this better and would greatly value any in-depth insights you could offer on this matter.
Taking my daughter to Brain Balance really helped her greatly overcome struggles of autism and sensory processing delays. I love and have learned so much about neuroplasticity from authors Normon Doidge and David Eagleman. Love Brain HQ! How about discussing PoNS translingual neuromodulation
My symptoms after my TBI (from fainting forward) did not present themselves in the initial 2.5 years but are now happening occasionally. Just like how it was described at around 30:35 of this video, I am now experiencing occasional mind blanks like walking to my kitchen but was uncertain as to why I had gone there. I haven't lost my capacity to brew a coffee/tea or cook my meals but did not know why I had gone to my kitchen.
Morning 🌞✅, work out ✅ coffee ☕ listening to another amazing podcast between two incredible minds ✅ thank you, have a beautiful day 😊😊
Dear Dr. Huberman. I follow you from Brazil for about three years now. I'm not a doctor, I'm someone interested in learning the most I can to mantain my health as I age (I'm now 71). About you and Dr. D'Esposito talking about the lack of a test to the brain health, I wondered: the reaction time isn't somehow related to brain health?
Love these intelligent and digestible conversations. I can tell you guys know your stuff because of how you're able to simplify communication and explain the connections. I love the brain talks
I have been a subscriber for over a year and love your diligence and the thorough information you provide. A topic that is becoming increasingly relevant in our society is that of EDCs. I would love to see you do a full episode on Phthalates/BPAs and other Endocrine Disrupting Chemicals. I enjoyed Dr. Shanna Swan’s work on the subject matter and think many people would benefit from you giving it your time and attention!
Thank you Dr Desposito and Dr Huberman! Great episode. I was delighted that mindfulness was mentioned. Can we please get a podcast about mindfulness ? ❤️
Hello ! First of all I would like to thank you for your dedication to making science accessible and for the tremendous impact your work has on those eager to expand their understanding of the world. Secondly I would love to hear Jessie Inchauspé on your podcast. She is a biochemist at the origin of the glucose revolution. Also known as glucose goddess on the social network. I look forward to continuing to learn from your podcasts!
I can't get enough of this. I read a book with a similar topic, and I couldn't get enough of it. "Unlocking the Brain's Full Potential" by Alexander Sterling
I love to hear what the Huberman Lab would came up with if they did an episode on focal dystonia and related conditions ("the twists" for gymnasts or "the yips" for golfers etc.) ... a lot of musicians including myself would be super curious about best practices following a diagnosis because a lot of us are flying blind here.
Love the show, love the guy, keep being awesome.
Thank you Andrew for the great content as usual, and thank you Mark for coming on the show. In future episodes, I would love to hear more about what your average person can do to improve working memory. The scientific dialogue is interesting, but for most people, it will be in one ear out the other. Practical actions that anyone can take, however, connected to easy to understand objectives, those tend to stick.
Thank you my friend, for helping us to understand ourselves as well as the world around us a little better.
🎯 Key Takeaways for quick navigation:
00:14 *🧠 Understanding Executive Function and Memory*
- Executive function and memory are vital for daily functioning.
- Dr. Mark D'Esposito discusses neural circuits controlling executive function and memory.
02:21 *🍽️ Optimizing Cognitive Function*
- Strategies to optimize executive function and memory are explored.
- Research findings on behavioral and pharmacologic approaches are shared.
03:31 *💡 Sponsors' Product Promotions*
- Promotion of Maui Nui Venison as a nutrient-dense protein source.
- Promotion of JuV red light therapy devices for various health benefits.
06:27 *🧑🏫 Introduction to Dr. Mark D'Esposito*
- Andrew Huberman introduces Dr. Mark D'Esposito.
- Acknowledgment of Dr. D'Esposito's expertise in neurology and neuroscience.
07:09 *🧠 Basics of Frontal Lobe Function*
- Discussion on the roles of the frontal lobes and prefrontal cortex.
- Emphasis on executive function, cognitive control, and goal-directed behavior.
15:09 *🤔 Understanding Brain Rules and Algorithms*
- Exploration of how the brain stores and applies rules.
- Examples of hierarchical rule storage and application in decision-making.
20:16 *🧠 Training Prefrontal Cortical Abilities*
- Speculation on the neuroplasticity of prefrontal cortical abilities.
- Consideration of strategies for training executive functions, especially in children.
20:43 *🎯 The importance of maintaining long-term goals*
- Maintaining long-term goals is more beneficial than short-term goals.
- Prefrontal cortex plays a crucial role in maintaining and applying long-term goals.
21:51 *🧠 Generalization of learning in the prefrontal cortex*
- Learning in the prefrontal cortex can generalize to various contexts.
- Cognitive therapy aims to improve memory and executive function abilities.
25:47 *🌊 Understanding "lyic friction" and the frontal cortex*
- The concept of "lyic friction" illustrates mental resistance to distractions.
- The frontal cortex interacts with other brain areas to regulate focus and attention.
29:01 *🌿 Frontal cortex's connections and functions*
- The frontal cortex connects with various brain regions, indicating its importance.
- It controls not only cognitive functions but also physiological processes like heart rate.
36:10 *🎭 The interplay between the frontal cortex and emotions*
- The frontal cortex plays a role in regulating emotional responses.
- Damage to specific frontal areas can lead to social and emotional impairments.
39:08 *📱 The impact of technology on brain algorithms*
- Smartphone usage shapes brain algorithms related to task switching and engagement.
- The algorithms learned from smartphone usage may not generalize to other domains.
41:13 *📱 Technology's Impact on Decision Making*
- Technology reliance questions its contribution to optimizing frontal lobe function.
- Concerns raised about technology's influence on decision-making processes.
44:40 *🧠 Understanding Working Memory*
- Working memory defined as the ability to hold and manipulate information temporarily.
- Importance of working memory highlighted as foundational for various cognitive processes.
47:53 *💡 Dopamine's Role in Working Memory*
- Dopamine's role in modulating working memory function elucidated.
- Different neural circuits for movement and working memory explained in relation to dopamine.
54:26 *💊 Exploring Bromocriptine and Dopamine Modulation*
- Discussion on bromocriptine as a dopamine agonist and its impact on working memory.
- Potential effects of dopamine modulation on cognitive enhancement considered.
01:01:46 *🧠 Pharmacological Potential for Cognitive Enhancement*
- The pharmaceutical industry has not focused on developing drugs to enhance cognition, despite clear data and existing safe drugs.
- Current neurology research tends to prioritize disease treatment over cognitive enhancement.
01:04:21 *🧬 Multimodal Approach to Enhancing Cognitive Function*
- Boosting neurotransmitters like dopamine, norepinephrine, and serotonin can improve working memory.
- Drugs such as Wellbutrin and guanfacine, known to boost norepinephrine, show potential for enhancing cognitive function.
01:09:12 *🧪 Challenges in Measuring Neurotransmitter Levels*
- Accurately measuring neurotransmitter levels in the brain is complex and often requires neuroimaging techniques.
- Neurotransmitter systems like dopamine operate in a delicate balance between brain regions, making measurements more challenging.
01:12:51 *💊 Pharmacological Optimization and Concerns*
- Bromocriptine, despite being well-tolerated, has subtle effects on reaction time and cognition.
- Optimizing brain function through pharmacology requires a balanced approach, considering individual differences in neurochemistry.
01:21:09 *🧠 Understanding Persistent Post-Concussion Syndrome*
- Persistent post-concussion syndrome can occur in a significant percentage of people even a year after the initial injury.
- Symptoms may include mental fog, light sensitivity, dizziness, and other vague yet impactful cognitive issues.
01:22:20 *🧠 Explaining Concussion and Brain Injury*
- Concussion involves tearing and stretching of axons in the brain, even without loss of consciousness.
- The severity and duration of symptoms correlate with the extent of axonal damage.
01:25:42 *🧠 Impact of Sleep on Brain Function and Recovery*
- Sleep disruption is a common symptom following brain injury and can exacerbate cognitive deficits.
- Even a poor night's sleep can significantly impair prefrontal cortical function.
01:28:43 *🧠 Rehabilitation and Interventions for Brain Injury*
- Traditional recommendations for rest post-concussion are shifting towards gradual return to activity.
- Brain training games, like those from BrainHQ, offer accessible interventions for cognitive rehabilitation.
01:32:10 *🧠 Maintaining and Optimizing Brain Function*
- Continuous engagement in cognitive activities, such as reading and learning new skills, can help maintain and strengthen brain function.
- Lack of structured approaches to brain health assessment and promotion hinders progress in the field.
01:41:09 *📚 The importance of various lifestyle factors for brain health*
- Reading non-fiction books and increasing knowledge.
- Engaging in social interactions.
01:42:59 *🧠 Understanding the impact of technology and social media on cognition*
- Social media lacks the cognitive richness found in traditional activities like reading books.
- Engaging in activities that require goal-setting, multitasking, and focus, like playing chess or participating in improv, can benefit cognition.
01:47:36 *🧠 Insights into Alzheimer's disease*
- Lack of a straightforward genetic link to Alzheimer's.
- Current understanding of Alzheimer's pathology involving plaques and tangles in the brain.
01:51:57 *🧠 Challenges and approaches in treating Alzheimer's*
- Symptomatic therapy focuses on managing day-to-day issues and behaviors.
- Socialization and reminiscence therapy can be beneficial for patients.
01:56:44 *🧠 Exploring potential cognitive enhancers like nicotine*
- Nicotine's impact on the cholinergic system and potential benefits in Alzheimer's treatment.
- Lack of conclusive evidence for nicotine's efficacy in preventing neurodegenerative disorders.
02:01:15 *🧠 Estrogen's Impact on Cognitive Function*
- Estrogen levels are important for cognition and vascular function.
- Both men and women have testosterone and estrogen, with men needing adequate estrogen levels for cognitive and vascular health.
02:02:48 *🏃♂️ Aerobic Exercise and Cognitive Function*
- Aerobic exercise has been found to improve executive function and working memory.
- Studies suggest aerobic exercise can be as effective as cognitive therapy in improving cognitive function.
02:04:40 *🧘♂️ Mindfulness and Cognitive Enhancement*
- Mindfulness training, when added to cognitive therapy, enhances executive function.
- Mindfulness serves as a focus exercise, aiding in concentration and attention management.
02:11:09 *🧠 Understanding Brain Networks and Well-being*
- Recent neuroscience research focuses on brain network activity rather than isolated brain regions.
- The brain's modularity, or network organization, predicts individual well-being and response to interventions.
02:21:06 *🧠 Brain Modularity and Physiology*
- Exploring the possibility of developing a modularity metric for cognitive function in real time.
- Investigating proxies for modularity using physiological data like heart rate variability and oxygen levels.
02:23:10 *🔄 Brain Connectivity and Psychedelics*
- Discussing the impact of psychedelics, specifically psilocybin, on brain connectivity.
02:25:30 *🧠 Integrative Therapies for Brain Health*
- Exploring the combination of drug therapies, cognitive training, and transcranial magnetic stimulation for brain health.
02:26:54 *🤣 A Neurologist's Role and Appreciation*
- Reflecting on the evolution of neurology and the role of neurologists in addressing brain health issues.
Made with HARPA AI
The first song that popped up into my mind is Despacito 😅
Thank you Andrew for making the world a better place ❤
Oh I'm glad I'm not the only one singing despacito 😂
jajajajqja😅
omg same! hahahahaha
I am recovering from a TBI and about three years in discovered that I had significant eye issues including double vision from Convergence Insufficiency. My chiropractor, not my eye, primary, psychiatrist or neurologist finally referred me to an eye specialist. This made all the difference and I am about halfway through vision therapy. Two questions related to this very helpful podcast (many thanks to Docs Huberman and D'Esposito) 1) Why aren't eyes always checked for Convergence/saccades/pursuits checked after every concussion and TBI incident? 2) Can eye movements such as these be used as a reference stat for brain function per this podcast topic?
Shout out to duel-n-back training. Free and well studied.
Can you do an episode on Tinnitus as there are no significant studies on efficient treatments
The realm of this condition stretches over far more than just ear health since mental health, psychosomatic symptoms and physical conditions are all part of it.
Would be so helpful for us ❤🙏
Yes I got tinnitus last month and since then I am hearing constant high pitched sound. I have one very imp exam in two months.
I believe it's was because of using headphones all day.
I hope they will make some helpful video about it.
Hi Andrew,
Can you do an episode on the science of social skills? Why some people don't have the ability to hold a conversation, read the room and why some people have charisma, lots of friends etc
Thank you so much for expanding public knowledge on brain health. I experienced a TBI in Nov 2018 and have been a prolonged recovery journey since then. Before the injury, I was an avid book reader and athlete. After it, I lost the ability to both run/dance, drive and read due to extreme nausea, fatigue and visual issues. Your podcast is one of the things that has kept me hopeful and motivated to stick with weekly neuroopthamology PT sessions. It’s taken over 5 years, but I can do 30 minutes of gentle yoga again, walk for 30 minutes , read in large print for 30-40 minutes and drive for short distances. I determined to return to my full capabilities again. Thank you again for all that you do-having free access to cutting edge research and science has been life saving for me.🙏🏽🙏🏽🙏🏽
Hello Dr Huberman, I’ve gained so much knowledge from your efforts in this podcast- thank you. If you would consider having me on I’d really enjoy the conversation. I was hit by a truck while training for an Ironman in 2009 and became a paraplegic. Since then I finished Ironman Kona in 2012, went to Alpine skiing world champs in 2017, and have represented the US archery team since 2017. I am the current Paralympic champion, world champion, and national champion for recurve archery. Lots of things we could unpack on how to overcome challenges. Keep up the great work. Kevin Mather.
in this podcast, there was a brief discussion about the pharmaceutical industry’s priorities. While they focus on addressing health conditions, they seem less inclined to explore the potential of the same drugs for enhancing cognitive performance. The underlying reason appears to be the financial model: pharmaceutical companies can bill insurance providers for drugs used to treat diseases, but there is no mechanism to bill for the same drugs when used to enhance cognitive function.
In essence, the industry’s emphasis on treating illnesses may overshadow the exploration of cognitive enhancement, which lacks a direct financial incentive. This dynamic highlights the delicate balance between health improvement and economic considerations in the pharmaceutical landscape.
An episode on overgrowth of Candida would be amazing. ❤
Excellent topic and guest. It could be helpful to have a neuropsychologist come on the podcast for topics such as this given that we receive specialized education and training in brain-behavioral relationships, with a particular emphasis on cognitive and emotional functioning. We also are trained in both assessment and treatment (cognitive rehabilitation, therapy), as well as functional neuroanatomy, hence there may be an opportunity to have both a more nuanced and comprehensive discussion about various cognitive disorders and their behavioral manifestations. We often work closely with neurologists and other providers to assist with differential diagnosis, monitoring cognition over time, and provide treatment recommendations. I know for a fact that your podcast immensely enhances my practice as well as many other neuropsychologists I know, so THANK YOU!
Interesting medical conversation, Thanks to both of you for sharing and making us to understand 🙏🙏
It would be great if you could do a full episode on Parkinson’s disease, since you’ve touched on it in many episodes. My mother suffers from it and it’s devastating to see the full range of symptoms and side effects.
As a tbi victim i really appreciate this and the other work you do man!
Great episode BTW.
Would love to see Dr. D'Esposito back to talk about frontotemporal dementia (FTD), especially with the diagnoses of Bruce Willis & Wendy Williams coming out and most people (luckily) knowing nothing of the disease and the ways it differs from Alzheimer's.
Dr. Huberman, thank you for your hard work! My son is on the autism spectrum and loves waking up to your nsdr 10 minute recording every morning. It would also be nice to listen to an expert and find out what the resources are for high functioning autistic young adults so that they can prosper and become a part of society and contribute to it. We, parents struggle with this everyday…(Hope you read this) thank you :)
Thank you so much. Would love to see a discussion specific on how to keep your immune system strong!
Ew.😮😃😀😶🌫️
I was interested in Dr D'Esposito's mention of covid "brain fog" and would have liked to have heard this explored more - what is going on with covid and the brain. Thanks for the discussion.
Ye to. COVID brain fog episode.
I'm really looking forward to this episode halfway through thank you 🙏
Idea: ask, "In your opinion, what is the most fascinating aspect of the brain?" and then ask questions based off the conversation instead of having a set list. This would be like link surfing on wikipedia - one topic dives into more specific topics, back to the original topic, back down another rabbit hole, etc.
An episode about autism on a physiological and neurological level would be appreciated, especially about the impact on the sympathetic and parasympathetic nervous systems. As an adult who was diagnosed with autism and ADHD last year at 29, I find it hard to find scientific resources that are helpful. Love your podcast and can not recommend it enough to others.
Would love an episode with Aida Habtezion MD on ulcerative colitis, specifically in teens , and best treatments for UC
Dopamine Nation is an incredible book. I am two-thirds through reading, and hopefully, I will finish tonight 🌙
hey andrew, i would love an episode on rheumatoid arthritis! i've been diagnosed for 21 years now and it's been a rollercoaster of a ride. living in a small town, my options for rheumatologists and PT are hard to come by so i'd love to hear the science behind it and how i can limit symptoms!
Wow. FINALLY COMT activity is mentioned! It affects not only dopamine levels. Also chatecholamins, estrogen, histamine, glutamate!
As a Muslim I love listening to Dr Huberman, your insights are so inclined with Quran it's scary.
An episode on EMDR, considering it’s a front line highly effective trauma treatment would be excellent and well received. Dr Sarah Schubert who has co authored the recent Oxford text book would be a fantastic option.
Dr. D'Esposito's is again an excellent informative podcast. My question is on the dyslexic brain. Is how does it relate to the average brain in relation to the topics covered such as modularity, concentration, and so on. Please consider a podcast on dyslexia, the neurological differences (pros and cons), and how to address them. Thank you again for your fantastic podcast.
Dr Huberman. I hope you know these podcasts are not under appreciated. You are a certified legend. These kinds of podcasts are the best thing on the internet by leaps and bounds, especially for people like me who are not book worms and cannot for the life of me absorb information from the written word unless I have an extreme interest in a certain subject. You and a few others have broadened my knowledge considerably and impacted my general quality of life substantially. I do not drink that much anymore but I’d buy you a beer if I met you that’s for certain 👍
IMPORTANT TIP for all who have brain health goals: much more powerful than any of the good techniques like learning a language, reading, etc. is something unexpected: exercise of all kinds. I forget which episode Dr H. discussed this but he was very clear: when you're simply using your body, such as walking through a forest, the brain effect is much larger than, say, doing a language puzzle. Weird, huh?
Ouch, some painful conditions mentioned there, hope anyone struggling with memory loss are getting help. With so much to remember my head throbs, notes notes more notes, just remember to update any changes and watch they don't get moved or altered. Cheers both Dr. S.
I met bromcriptin only in purulent surgery to inhibit lactation by mastitis, and i can say patients were not inspired of this treatment because of side effects. You know, i am also very engaged into idea to improve neuroplasticity easy and safe. Now i think it is possible to do without psychedelics, only with use of mental exercises. Sure i want firstly check all possibilities we have, and particularly is it mix of different practice from "west" and "east" neuroscience, but i think it is really something important. My english is not enough good to discuss it yet, but i work on it. Thank you for great job! And sorry for mistakes:)
Please do an episode on the most frightening experience the human consciousness can go through : DEPERSONALIZATION/DEREALIZATION DISORDER