Biostasis and Mitohormetic Fitness in Deep Space
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- Опубликовано: 1 окт 2024
- Can humans survive in suspended animation? Can we stay fit when we can't exercise? Modern technology is creating a method of stimulating mitochondrial fitness through a process called mitohormesis, that could revolutionize the health industry, while doctors are using therapeutic hypothermia, a form of biostasis, to save the lives of trauma patients. Full cryohibernation may be in our near future. Which will come in handy on that long flight to Titan!
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Can't remember if it's Scandinavian or Canadian doctors who said "You're not dead until you're warm and dead".
Both probably! I'm sure it wasn't Hawaiian doctors :-)
I bet you a Canadian doctors. Especially because you can get euthanasia half off there
Better than dying screaming in your bed hooked up to machines I guess... Hopefully I'll go quickly when I freeze myself in liquid helium :-)
Thanks again. I learn something new every week from you and your channel.😮
Glad to hear it and thanks for watching!
In the '70s, I remember an article about " Bassett coils" to help broken bones heal without casts, and much faster than the standard methods. Coils driven by pulses were placed near the break. I don't remember what frequency the coils were driven at, but apparently it worked...
I have heard stories about people living near substations with huge transformers ( and the huge magnetic field around them) having neurological problems...
A lot of " haunted" houses are in areas with strong magnetic fields...
Exceptional video! If some sort of reliable suspended animation is possible, it would definitely solve a lot of issues....
Those are all examples with substantial evidence to support further study. Sadly the power company only pay for conclusions... Like the federal government with cannabis for the last half century.
Would certainly prefer EM treatment to electric contact pads & probes in delicate places.
Very true...
Oh how I luv me some A&P refresher!! Hey Doc, a wheel-house subject and a great workout for my mitochondria. I mean rocket science is why I’m here, but dipping back to my roots is always nice. Plus, the two are symbiotic so it’s a win win. The depressing thing about all the aging talk is I, like Sheldon, will not live long enough to become a singularity. Bummer.
Don't bet on it Dennis! Freeze that noggin and let's see what the 25th century is like :-)
Wouldn't muscles not atrophy in a hyper sleep? Like if they are all but frozen( I know you can't freeze a body as the water expands and ruptures the cell walls), wouldn't your systems stop to the point that your body doesn't breakdown unused muscle? I defer to your superior knowledge in this Doc, I just don't understand why your muscles would break down.
Great video as always, Thanks for everything.
They would slowly loose their tone... This can also work for zero g without hibernation also.
That is super interesting. This is the kind of subject matter, related to space, which you are well suited to present and discuss. Thank you
Thank you and you are most welcome!
Tech millionaire Brian Johnson is also doing studies on how to stop aging or slow it down to less than half of what is normal. This could mean living past two hundred years and imagine the technical breakthroughs that will be discovered over the next 100 years. One problem now with medicine is how corrupt it has become. I also think that hypnosis might trigger the metabolic reactions we need to stop the metabolism from running so fast. Make us believe in a sleep like state that we are in a deep coma or something... with pleasant music and very slow stories on audio tape.
Interesting, I've been watching some of his journey
@@terranspaceacademy I don't like the idea of taking blood from younger people but certain foods lengthen the Telemeres and other foods shorten it. New connections on this are being made every week or two. And on Nootropics, for enhanced brain function. I believe that a kind of sleep can be induced that is like cold in that your body would not atrophy for long periods and you could sleep for days or weeks instead of hours and do it in zero G to mitigate bed sores .
College kids would appreciate the cash for a little plasma if you filter out the Red Bull :-)
I have no doubt this riddle can be solved.
We have to remain optimistic, life is a gift.
It is indeed my friend...
I wonder if we couldn't trick the hypocampus into THINKING it was very cold and triggering a low metastasis, like hybernation in Squirrels?
There should be a chemical "trigger"
One of the videos of which I spoke.
“Scientists Are Learning How to Reverse Aging”
There are many more.
They are indeed...
Good morning everyone
Good morning!
Brilliant that suspended animation ideas are still considered. An other method of reducing metabolism is poisoning with hydrogen sulfide. As far as I understand it this sulfide is an ancient bacterial switch for switching from oxygen metabolism to anaerobic sulfide metabolism, only the switch does not switch on the sulfide metabolism, only switches off oxygen metabolism. Normally this would kill us, but there were some cases where a person was poisoned naturally in a cave or mine and was very cold and presumed dead. When brought out of the cave into sunlight he/she warmed up and started breathing again. It seems this happened not once but several times. Also the subjects were perfectly healthy afterwards.
I remember reading about research with lab animals and some species did fine but some other species had issues. Of course it is not patent-able so nobody will finance this. It would need unpaid volunteers to test how far you can go with this. Also you need to rotate the subject to avoid blood cells collecting at the lower parts.
hydrogen sulfide is a very interesting possibility... I was thinking insulin coma then hydrogen sulfide...
If you've lived long enough you get tired of these wacky claims. Yes, Including ones that say have have pear review. So, I'll take a wait and see stance on this.
Understandable... The Skeptics are most often proven right.
Cool shit. There was a Dean Koontz book I read when I was in the 7th grade that went on at the beginning about someone being brought back from a cold temperature death and described a lot of the free radical issues etc. That was so many years ago and obviously based on reality. I’ve often wondered what our current state of knowledge on the system must be.
It is advancing rapidly now after a thirty year "dead zone" :-) King I know, but he and Koontz collaborated on at least one book. The Talisman I think. I loved Koontz too.
why aren't channels like these more popular than the bulshit AI channels. your channel actually cover facts and possibilities that might be possible in the near to mid future. unlike many other channels that just. tell you information you already know, or keep repeating themselves to make up time. LETS GET YOU TO 100,000 SUBS!
Thank you so much for saying so! It's tough unless you cater to the algorithm. :-)
Thank you very much 😅
Even bio is interesting when you explain it.
You are most welcome!
In the video, you talk about, using suspended animation, hibernation, deep sleep stasis. For interstellar space travel. I think it depends on how far you go. For example, if you want to goto the moon Triton maybe, a mild genetic modification by AI might be enough. If you want to go farther for example, star V2500 Ophiuchi 😎 using hibernation deep sleep for the 100 years journey with AI assist it might work. But, I think deep sleep hibernation can only work for upto 300 years max, because cells, DNA, brain tissue, muscle, bones,etc,etc,etc, will degrade badly after a certain amount of time. And don't forget radiation. But what if you want to go farther. For example, (Gaia BH 1), it's 1500+ light years away. Hibernation won't work. So what do we do, give up ? No, we need a equation based on silicon, silicon, in other words AI. Since all equations in the future will be silicon based. It's a new era, coming soon. Maybe we can do a thought experiment of an AI equation. This is the equation ((cerebrum= corpus callous)^(AI)+ (cerebellum)^(AI)+ (brain stem= medula oblongata)^(AI)+ (Diencephalon= thalamus)^(AI)× (neurons + synapse + engrams))^(Binary Code)×(CPU chip = GPU chip)^(AI)^(Binary Neural Brain = Bi pedal robotics)) = (interstellar space travel to Gaia BH 1). Let me explain, we'll I think the equation is self explanatory. Look at the equation again and add up all the field parameters. You get the solution to space travel. We must upload our essence, our being, our personality, in other words our SOUL to cpu, gpu chip. Our soul must be Binary Code with the help of (AI) in order to travel to Gaia BH 1 and see what's there ? And we can go farther, because now we have an almost infinite lifespan. We can be a go anywhere do anything species. We can go sight see on our 1500+ year trip to Gaia bh 1 and not worry about radiation. Or warp drive quickly and also not worry about thermo radiation, hawking radiation because we are immune. We will finally take our next step in evolution. If we survive ourselves in the upcoming (AI) war.
Those are very interesting concepts. We could try to reproduce a digital simulation of perfect fidelity and morphic parameters to simulate the current mind and allow for learning new experiences. The problem is this would be copy. Only if we replace one neuron/glial cell at a time with an exact digital duplicate could we "transfer" consciousness to another stratum. We discussed this in the Tesla robot lesson. Hopefully the war will be verbal with sarcastic weapons, and not actual, with thermonuclear warheads... :-)
@@terranspaceacademy maybe the next video could be about black holes. Everybody likes a mystery. And has a opinion about black holes.
A fascinating and informative video.
I think we are on track for this research to eventually be useful for interplanetary travel.
For interstellar travel and the time that takes, the decay of radioactive materials in our own bodies may become the limiting factor, we can not slow that process.
The final solution,if achievable, may fall to nanobots capable of repairing DNA etc.
I should also mention, the technology I mention above also has the potential for considerable life extension negating some of the need for freezing you in the first place, IF this tech is possible.
I think we are on the cusp of a revolution in this area of science.
Good morning Captain, i believe it's time to have Elon Musk for a serious talk i hope you can have him explain to us what he mean by " human consciousness
preservation".
Thanks again for the best space channel on the planet Earth.
Thank you so much for your kind words and support! That is an interesting question... The singularity perhaps? Digital upload? That's a copy but not a continuation. Replacing cortex slowly with artificial cortex that perfectly emulates the original? That's a thought and takes us back to the ancient Greek boat problem. If I keep replacing planks on my boat until all have been replaced is it still the same boat?
@@terranspaceacademy yeah all the subjects you suggested would be ideal to ask maybe we can get a not boring interview like he's giving now.
Adipose tissue? Dr. Who strikes again ;)
Never trust the adipose!
Very interesting. Something I’ve been loosely following. It seems recently I believe it was an MIT professor claims he cracked the code for aging. I’ll look in my saved videos and see if it’s there if it is, I’ll let you know about it.
I think I saw it. They can now run mice backward or forward in time.
Yes, and the professor was from Harvard not MIT
Thanks!
Learn how to speed up the metabolism, the mitochondria production rate, learn how to age faster and speed up the brain to a hyper intense level with Glutathione or something similar. Get that information down and then do the exact opposite .
The problem is we know many ways to speed up the clock... The most serious being progeria. Does someone on this planet have ageria?
@@terranspaceacademy Perhaps you have seen the Bruce Willis movie Unbreakable with Sam Jackson. He had brittle bones and believed someone out there must be the opposite, being unbreakable. Some people do age slower, My aunt lived to be 107 and my uncle Archie to 104 if I recall. Non smokers, stayed active. But I am looking for a chemical trigger for the hybernation aspect. What do squirrels use? And those frogs who can freeze solid in the winter and then come back to life on their own in spring? That is a kind of miracle. What planning that took. It could be an enzyme trigger but might need a special subroutine in the DNA program to make it work. Which is why I though hypnosis might help.
Hyperglycemia seems to be a major player in many animals after oxygen levels drop as a kind of natural antifreeze.
An important disease among human metabolic disorders is type 2 diabetes mellitus. This disorder involves multiple physiological defects that result from high blood glucose content and eventually lead to the onset of insulin resistance. The combination of insulin resistance, increased glucose production, and decreased insulin secretion creates a diabetic metabolic environment that leads to a lifetime of management. Appropriate models are critical for the success of research. As such, a unique model providing insight into the mechanisms of reversible insulin resistance is mammalian hibernation. Hibernators, such as ground squirrels and bats, are excellent examples of animals exhibiting reversible insulin resistance, for which a rapid increase in body weight is required prior to entry into dormancy. Hibernator studies have shown differential regulation of specific molecular pathways involved in reversible resistance to insulin. The present review focuses on this growing area of research and the molecular mechanisms that regulate glucose homeostasis, and explores the roles of the Akt signaling pathway during hibernation. Here, we propose a link between hibernation, a well-documented response to periods of environmental stress, and reversible insulin resistance, potentially facilitated by key alterations in the Akt signaling network, PPAR-γ/PGC-1α regulation, and non-coding RNA expression. Coincidentally, many of the same pathways are frequently found to be dysregulated during insulin resistance in human type 2 diabetes. Hence, the molecular networks that may regulate reversible insulin resistance in hibernating mammals represent a novel approach by providing insight into medical treatment of insulin resistance in humans.
www.ncbi.nlm.nih.gov/pmc/articles/PMC3854349/
Please make a video about starship v2, v3 or with raptor3
I have several but we'll need to integrate what Elon just said into the equations :-)
@@terranspaceacademy that goofy v3:)