Thanks Dr. Perlmutter..! Questions on a few items: 1) In study low sodium diet defined as below 6g per day. That is 6,000 mg a day which is huge number..! If we are avoiding processed foods, eating whole food, and maybe only adding modest amount of let's say Himalayan pink salt to our diet, most of us will be way below 6,000 mg of sodium daily..! 2) Study defined low fructose as below 20 g of fructose daily. It would have been helpful if you would put that into perspective. Quick study on high fructose foods identifies banana with about 6 g of fructose. Of course we should minimize fruit juices, processed foods containing high fructose corn syrup, etc., but my understanding is 2-3 pieces of whole fruit a day should keep us way below 20 g fructose daily, as whole fruit often contains fiber, other nutrients, that can act as buffer to modulate blood sugar to keep in acceptable range. The scope of this video may not have included the above two items, but I found myself wanting while watching video due to no context provided on practical ways to adjust our eating habits to stay below 6,000 mg sodium and 20 g fructose daily. Also, it would have been great to give viewers some dot points on other topics to improve mitochondrial function, and mitochondrial production, so viewers could do additional research on supporting optimal mitochondrial function as we age. Thanks again..!
Very helpful. Any ideas on how to calculate how much extra a person who is sweating a lot under the sun in a manual labour job along with heavy resistance training in the evenings might need? Obviously impossible to tell without exact details, just interested to know what you think.
A low sodium diet is only for people that are mainly sedentary. For those of us who exercise and stay active, a higher sodium (sea salt) diet is much more preferred.
@@AlanNguyenMDabsolutely! I get @4-5g daily just in my homemade electrolyte drink as potassium nitrate, hence my nitric oxide also tests high. Life is hard 😅
@@AlanNguyenMDyes, and LAZY DOCTORS just tell people to cut salt, knowing they are already probably not getting enough potassium, with injurious results to their overall health.... most humans are not getting enough potassium, because it does take some education, focus ,and practice to get the daily recommendations through diet alone, but there are no shortcuts!....
Lower Fructose, Lower Sodium + Fasting for Autophagy/Mitophagy. Result = Lower Free Radicals, lower Oxidative Stress, lower Uric Acid. Thanks Dr PerlMutter, you advice is powerful as usual.
My takeaway is; 1. We have evolved to fatten up in the fall and hibernate through the winter. 2. The deeper we dig into things, the more questions we come up with.
Something else people forget is that the foods that grows locally is enough to sustain and create health. Otherwise we wouldn't be here. You don't need avocados if they don't grow where you are. Find another source of good fat. The further north you go the more you need to choose meat.
Not sure that applies universally. Maybe for people that live in cold climates... People who live in the subtropics and to the equator can be outside year round working, exercising, etc... I think cold weather people get lazy in the fall and realize they need to look good for the beach or pool in the early spring. It's psychological for the cold weather folks
Mitochondria are a microscopic life form that resides within all living cells. And we are symbionts with them. Life forms living together for mutual advantage. Without the mitochondria, life could not exist and we would have no knowledge of the Force. They continually speak to us telling us the will of the Force.
This study is incredibly interesting re fructose but I can’t see it tells us anything about sodium. The comparison was low sodium vs low sodium with high fructose. Unless you also compare with medium and/or high sodium combined with low or high fructose only the data on fructose is meaningful.
Yes, that seems glaringly obvious. Surely there's an explanation (by the researchers) regarding this point. I can't imagine what it would be though. Then again, there's a PLETHORA of poorly designed "bunk" research/studies in publication. I wonder what Peter Attia's, author or co author of a publication of some sort called "studying studies", opinion would be should he take an in depth look at it?
You are a true life saver Dr. Pearlmutter. I am always blown away by your depth of knowledge and how simply you explain it to us. May you be blessed in all things good.
Red light therapy, sauna exposure around 180 degrees Fahrenheit, regular exercise, and doing cold therapy like ice baths a few times a week. Low sodium diet goes against most Dr's these days
To several who noted, yes there have been follow-ups showing NaCl is the bigger player in this. Just remember if you cut out or cut way back on Iodized Salt, you must supplement with Iodine....
Thank you very much doctor.🙏 This is the clearest and most useful clip on "polyol pathway" mechanism. Such understanding provides for important direction for elimination diets. It was my good health fortune to have listened in.
Thank you Dr. Perlmutter. At my age 80 this. Helps to better understand why my mitochondrial function isn't balanced enough to create new muscle. And healthier skin Etc. I'll just keep up with my biodynamic agriculture foods and clean diet.
Central nervous system neurons have a lot more than 1,000 mitochondria! The range is between 2,000 and 2,500. Cardiomyocytes also contain about that same number. Highly physiologically active cells found in the kidneys, liver and spleen generally number over 1,000 mitochondria. Although it's been a while, the director of the mitochondrial lab I worked in said that the current (2010) estimate of mitochondria in the ovum is 250,000. However there was speculation that the number may be as high as 1 million. Note that mitochondria compose 10% of human body weight. The number of mitochondria in the human body is roughly 10^17.
I am retired, and I don't buy very many new books now-a-days !, But I bought 'Drop Acid" yesterday ! (It cost $ 31.76 ) Thanks for your sincere efforts to help us all !
Please continue with U tubes. I'm a naturopathic person with HSV and I research mitochondrial support and thymus regeneration. I will watch mito u tubes more than once as I am getting very familiar with specific medical terms. Appreciate you Bonnie
High salt and fructose intake are a marker for a diet high in processed food. However seems to me that fructose is the driver not the salt. See Richard Johnsons' research on fructose.
High salt does the same as fructose, also glutamine in diet. But ofc too low salt is very bad or worse. Salt is also a driver for sure also creates uric acid reaction. But some salt before exercise is very healthy for heart providing more blood volume and so less need for oxygen for heart in hard situation or while digesting and moving with high blood requirement.
I'm confused. It seems that many respected doctors & researchers have - in recent times - indicated that salt is of no concern because the body knows how to deal with excess salt/sodium.
Latest research that I have seen is that people are more likely to have issues with low sodium than high. Salt intake is not an issue if you have good kidney function.
@@michaeltrumper high salt intake works exactly the same way as fructose or rather causes uric acid production check out Richard Johnson talking about it deeply
@@szymonbaranowski8184 True, but in context, it is much bigger risk of people having too low salt intake than loo low fructose. Or to put it another way, there is a requirement for endogenous salt, but none for fructose.
I read your book, "Drop Acid," and I'm skeptical of subclinical hyperuricemia in the absence of excessive carbohydrates. Are you sure the "independent" risk factors of UA are really independent at the subclinical level? I suspect there are cofactors that are not accounted for, as carnivores would all be suffering the consequences, and there have been plenty over the ages. I think fructose (or excessive other carbohydrates), for example-even in high fiber foods-is a likely cofactor, for sodium too. I'm sensing a potential plant-based bias and/or dependence on low-quality epidemiological studies. PS: My suspicion is that people who strictly control carbohydrates may not need to worry about subclinical hyperuricemia, and that in that context, sodium is also not an issue. I can't prove it, but I'd like you to tell me if you know why that's wrong-because we're both after the truth.
You will definitely have high uric acid levels if you eat only meat, but that does not really mean anything in and of itself. It's not the uric acid itself causing issues, though it seems that way. It is your liver (not kidneys) being metabolically deranged that makes your kidneys unable to deacidify the blood enough to keep uric acid crystals from forming. Make sense? Probably not, but it is not a simple subject.
@@LTPottenger thoughtful, thanks........let's hope the doc here deals with the subject of upper gi tract glycan binding lectins and their relationship with acidic food consumption......
So, low sodium = no significant change. Low sodium/ low fructose = significant positive change. Why didn't the study include the effect of low fructose in isolation? Also, am curious on the effects this would have on subjects not overweight-- of normal healthy weight?
Yes but combining things can be significantly different than how things work by themselves. So really both should be studied by them selves in order to get a more clear picture. Salt is highly necessary for many of the functions of the body and you can just cut it out without there being problems.
I kept walking past your book until late last month. Gout hit my ankle again. Coincidentally our health group, we had others gout confirmed by labs. Found your RUclips’s Now our group of 300 owns 30meters and wow… 75% (roughly) have levels over 7. Ordered bulk Quercetin Glycine and Potassium Citrate to start.
Very interesting but what about for those that are not obese? I thought we need salt if we work out a lot, do fasting etc... I do keto ore mostly so sugar intake is very l low.
Many thanks for the information. From another video I was told that the intake of sodium (preferably in the form of sea salt or Himalayan salt, as these are rich in many other minerals) should be counterbalanced by the right amount of potassium (leafy salad, avocados, bananas etc.) and that half a teaspoon per day, especially when transpiration is increased, is a good thing to add.
you need potassium and magnesium regardless of how much sodium you consume. Its just best those 3 to be in synergy for optimal cell energy, hydration and ofc your blood pressure. BTW - potatoes are one of the best potassium sources. They can feed you, be tasty as heck and are low calories if you are looking for that hehe. Carrots also have plenty of potassium. And fresh carrot juice is just heaven.
So mitochondria dna has increase after 8 weeks of low sodium and fructose diet. Did this translate to the participants feeling to have more energy or had any measured weight loss? Just an increase in mitochondrial dna on it's own doesn't appear to be a useful effect otherwise?
QUESTION: How do we know which is the cart and which is the horse? Do people with low mitochondrial function feel energy-starved and need to eat carbs for energy, so that's how they gain weight? Rather than mitochondrial function declining as a result of weight gain?
@@michaelb41 Knowing what the weather is predicted to be has never changed what I do in any particular day. Sure, some people live under threat of tornados and hurricanes, but that is what the public safety system is for. Likewise, these theories have zero impact on how most people liver their lives. I can do without them both.
If my blood test shows low sodium is that the same as reaffirming a low sodium diet? Sodium is a necessary mineral for electrolytes assisting in the electrical aspect of exercise and the heart.
I have gone totally off all sugars including fructose since April 2023 . SOmehow though my A1C has come down drastically, for the first time I found that my uric acid levels are elevated to 6.7 . Im completely confused as to what to do what to have how to control this . Could you please advise
Question: I see people including children on you tube videos recording extreme carnival rides like on a slingshot or Rollercoaster and often times they scream and even pass out...just wonder what is the impact on the brain..could they be doing irreparable damage?
Sodium causes leptin resistance, thus making people hungry. Fructose causes insulin resistance of the liver, thus making toxin processing more difficult. Combinations might synergize to increase advanced glycation end products and inflammatory processes that induce mitochondrial apoptosis in white blood cells?
What’s the source of sodium they removed? Table salt? I imagine everything in moderation even applies to things like Redmond’s Real Salt. But specifically calling out the source could help determine if iodized table salt is causing oxidative stress.
So, how does one go on a low sodium (salt) diet and not threaten the essential level of hydrochloric acid in the stomach? I would suggest using chloride forms of minerals such as magnesium chloride, calcium chloride, zinc Cl, etc where ever possible.
My mitochondria are doing good thanks but I am worried about my cytosomes and my Golgi apparatus. People are just not taking care of these organelles and there is so little information available could you please help?
In the study, did they use fructose in the form of fruits? Would the antioxidants in the fruits reduce the negative effects? On a mostly Vegan diet consisting of potatoes, fruits, veggies and no added salt, my results are: Uric Acid 5.0, HbA1c 4.7% (avg 3 mo BG 86), Chol 185, TG 78.
Why do scientists so often mix multiple variables into studies? Did I miss something? Where is the study of low sodium on mitochondria and low fructose on mitochondria? What sense does it make to introduce another variable? Apparently sodium had minimal effect, but fructose was a significant difference.
Thank You! Always interesting and informative. What the Swedish news used from this study was the sodium angle...and how much salt there is in processed meals...
Knowing what you just said certainly makes this study more understandable. Processed salt in processed foods! Natural salt has 2% trace minerals which is extracted in commercial salt. When harvested from the sea, salt contains 14% moisture. Also, sea salt has not been crushed by heavy machinery, thus causing very sharp splinters of crystal which can irritate the endothelia of blood vessels and capillaries, thus causing systemic inflammation.
The study was from 2013, have there been follow ups to confirm the finding? Also why not have seperate studies on fructose and salt? is there a synergy between them?
To several who noted, yes there have been follow-ups showing NaCl is the bigger player in this. Just remember if you cut out or cut way back on Iodized Salt, you must supplement with Iodine....
What happens to the mitochondria if the person has a neutropenic fever due to chemotherapy? I had breast cancer and after my first dose of chemo, I got neutrpenic fever after my first dose of chemo. I was told that my neutrophils were 0.5 and normal was 13. I recovered, but I was wondering if that is why I had 'brain fog' afterwords the chemotherapy and radiation. That was 10 years ago. I am currently eating a low sodium and most of all, low sugar (carb) diet. I got off of sugar using monk fruit and now I am trying to eat less real fruit with the exception of a few, like kiwis. I am also taking vitamins such as MNM and trans reseratrol. I am noticing that my I have been retaining information better and memory has improved. Please tell me what you think about this.
Dr. Peter Attia address many health issues that you would be interested in. First in my mind is becoming bullet proof to illnesses. Largely that is due to exercise. Attia has many videos on RUclips and podcast. Best wishes in your journey to wellness and greater health.
I've read some studies by Rick Johnson. The polyol reaction seems to be key to uric acid levels which in turn prompts conversion of glucose to fructose (and triggering the 'uricase mutation'). His take on it (interview with Dr. Peter Attia) is that it's relative sodium levels - so dehydration can do this as well. His take on it was (paraphrasing) "if you're going to eat something salty, drink liquids first). It's an interesting area. I hadn't made the connection with mitogenesis and mitophagy but how else would an organism reduce energy consumption? Subscribed, BTW.
Since the body cannot use fructose except in small amounts in the gut, and only through conversion in the liver to fat, what is the body doing converting sugar into fructose? What use is endogenous fructose?
In addition to many other supplements, I am taking 20 mg per day of pyrroloquinoline quinone or PQQ. Are there good substantive studies done on this compound with respect to mitochondrial function and mitochondrial genesis?
I'm wondering just how well the white blood cell mitochondrial density correlates-serves as a proxy for muscle tissues (?). Seeing a 70-fold increase in mitochondrial density sounds like it would mean a fantastic rise in potential muscle cell performance. I know there would still be other muscle performance limiting factors, but at least mitochondrial density should no longer be one.
@DavidPerlmutterMD Would you consider doing a video on how to improve mitochondrial efficiency as well ? Thank you for the amazing content that you create to educate us. Much appreciated ! :)
from my undergraduate studies in kinesiology i can tell you that inside the walls of the mitochondria a cascade of numerous chemical reactions takes place to produce the energy molecule atp (adenosine triphosphate). something like 75% of these reactions involve magnesium, so i make sure my magnesium content is topped up.
It is thought-provoking for me. Please advise. - Uric acid is at 7.9. - LDL is high. - I am 50 years old. - I am very active in sports. I cycled 1100 km last month. - I have no symptoms of high LDL or uric acid. - I have been struggling to lose 5 kg of weight for the past year. - I haven't used added sugar for 6 months. - I eat mostly boiled vegetables with olive oil once a day. - I occasionally eat a small amount of fruit (fructose). - I usually don't add salt to my food. Please advise on what I should do to lower my uric acid levels, as I can feel that I am not metabolically healthy anymore. My physician is not very helpful.
HIIT has been a clear and simple path to increasing my own mitochondria. This stress forces your mitochondria to multiply. Curious if there is any research data on combing both? I have always taken Fish and Flaxseed oil to keep my blood pressure low and scoop up free radicals etc. I am often thought to be 20 years younger then my actual age.
Thanks for providing the interesting finding. However, what could be the potential links between mitochondria and fructose/salts? It seems to me that conducting a study based on already obese individuals don’t make a lot of sense since they need to reduce daily nutrients intake anyway.
If you do a little digging on pubmed you'll find this study was called into question with the sample size too small and the variance of results too large to draw any meaningful conclusions.
I don't understand why our ancestors's bodies would've perceived the intake of fructose as a sign food was scarce and mitochondria should down regulate to save energy. Wouldn't it be the opposite?
20g of fructose - does that mean added fructose? Cos one apple has about that much, depending on a variety, size and ripeness. Are you saying that if I eat two apples I am at a risk of dysfunctional mitochondria? And how much salt is too much? I seem to be one of those who don't respond to salt intake with hypertension. I need to take more salt to keep my fluids in or they get flushed right through. And no, I don't suffer diabetes insipidus.
Thanks Dr. Perlmutter..!
Questions on a few items:
1) In study low sodium diet defined as below 6g per day. That is 6,000 mg a day which is huge number..! If we are avoiding processed foods, eating whole food, and maybe only adding modest amount of let's say Himalayan pink salt to our diet, most of us will be way below 6,000 mg of sodium daily..!
2) Study defined low fructose as below 20 g of fructose daily. It would have been helpful if you would put that into perspective. Quick study on high fructose foods identifies banana with about 6 g of fructose. Of course we should minimize fruit juices, processed foods containing high fructose corn syrup, etc., but my understanding is 2-3 pieces of whole fruit a day should keep us way below 20 g fructose daily, as whole fruit often contains fiber, other nutrients, that can act as buffer to modulate blood sugar to keep in acceptable range.
The scope of this video may not have included the above two items, but I found myself wanting while watching video due to no context provided on practical ways to adjust our eating habits to stay below 6,000 mg sodium and 20 g fructose daily.
Also, it would have been great to give viewers some dot points on other topics to improve mitochondrial function, and mitochondrial production, so viewers could do additional research on supporting optimal mitochondrial function as we age.
Thanks again..!
I think those of us that eat only whole nutrient dense foods can use Real Redmond salt on our food freely and still be way under 6g of sodium per day.
No.
Very helpful. Any ideas on how to calculate how much extra a person who is sweating a lot under the sun in a manual labour job along with heavy resistance training in the evenings might need? Obviously impossible to tell without exact details, just interested to know what you think.
@@bobcooterTry 1 tsp and see how it feels. You may need more than that at times.
Methylene Blue helps your mitochondria, research it.
A low sodium diet is only for people that are mainly sedentary. For those of us who exercise and stay active, a higher sodium (sea salt) diet is much more preferred.
same applies for low carb diets
you need potassium to balance sodium
@@AlanNguyenMDabsolutely! I get @4-5g daily just in my homemade electrolyte drink as potassium nitrate, hence my nitric oxide also tests high. Life is hard 😅
Sources? Thanks
@@AlanNguyenMDyes, and LAZY DOCTORS just tell people to cut salt, knowing they are already probably not getting enough potassium, with injurious results to their overall health.... most humans are not getting enough potassium, because it does take some education, focus ,and practice to get the daily recommendations through diet alone, but there are no shortcuts!....
Lower Fructose, Lower Sodium + Fasting for Autophagy/Mitophagy. Result = Lower Free Radicals, lower Oxidative Stress, lower Uric Acid. Thanks Dr PerlMutter, you advice is powerful as usual.
What is best fasting regiment ? Thanks...
My takeaway is; 1. We have evolved to fatten up in the fall and hibernate through the winter. 2. The deeper we dig into things, the more questions we come up with.
Something else people forget is that the foods that grows locally is enough to sustain and create health. Otherwise we wouldn't be here. You don't need avocados if they don't grow where you are. Find another source of good fat. The further north you go the more you need to choose meat.
Not sure that applies universally. Maybe for people that live in cold climates... People who live in the subtropics and to the equator can be outside year round working, exercising, etc... I think cold weather people get lazy in the fall and realize they need to look good for the beach or pool in the early spring. It's psychological for the cold weather folks
Mitochondria is the powerhouse of the cell…
it's not a mitochondria video until it uses that phrase!
*powerstation
Mitochondria are a microscopic life form that resides within all living cells. And we are symbionts with them. Life forms living together for mutual advantage. Without the mitochondria, life could not exist and we would have no knowledge of the Force. They continually speak to us telling us the will of the Force.
The mighty mitochondria 😁
This study is incredibly interesting re fructose but I can’t see it tells us anything about sodium. The comparison was low sodium vs low sodium with high fructose. Unless you also compare with medium and/or high sodium combined with low or high fructose only the data on fructose is meaningful.
That was to be my comment exactly. Thank you!
Yes, that seems glaringly obvious. Surely there's an explanation (by the researchers) regarding this point. I can't imagine what it would be though. Then again, there's a PLETHORA of poorly designed "bunk" research/studies in publication. I wonder what Peter Attia's, author or co author of a publication of some sort called "studying studies", opinion would be should he take an in depth look at it?
Sodium is an enzyme inhibitor.
@@bryantcofty2709 At this point, I’m cynical enough to think it had to do with funding based on the “low salt = good” message.
We are electric. Need sea salt, Need real salt.
You are a true life saver Dr. Pearlmutter. I am always blown away by your depth of knowledge and how simply you explain it to us. May you be blessed in all things good.
David Perlmutter should win a Nobel Prize. Incredible video.
Great presentation, Dr.Perlmutter! Please present more factors/studies how to improve mitochondrial function-
would be highly appreciated.
Red light therapy, sauna exposure around 180 degrees Fahrenheit, regular exercise, and doing cold therapy like ice baths a few times a week. Low sodium diet goes against most Dr's these days
@@cain6981 Add Vitamin D3, the main catalyst in cell energy production
Excellent and interesting presentation! Thanks for the many ways you help all of us learn. You're a great teacher. 🙏
To several who noted, yes there have been follow-ups showing NaCl is the bigger player in this. Just remember if you cut out or cut way back on Iodized Salt, you must supplement with Iodine....
Thank you very much doctor.🙏 This is the clearest and most useful clip on "polyol pathway" mechanism. Such understanding provides for important direction for elimination diets. It was my good health fortune to have listened in.
Thank you Dr. Perlmutter. At my age 80 this. Helps to better understand why my mitochondrial function isn't balanced enough to create new muscle. And healthier skin
Etc. I'll just keep up with my biodynamic agriculture foods and clean diet.
Central nervous system neurons have a lot more than 1,000 mitochondria! The range is between 2,000 and 2,500. Cardiomyocytes also contain about that same number. Highly physiologically active cells found in the kidneys, liver and spleen generally number over 1,000 mitochondria.
Although it's been a while, the director of the mitochondrial lab I worked in said that the current (2010) estimate of mitochondria in the ovum is 250,000. However there was speculation that the number may be as high as 1 million.
Note that mitochondria compose 10% of human body weight. The number of mitochondria in the human body is roughly 10^17.
Great info, thanks..
. sep.t3- no brnach*
Wow, thats a neat fact.
Most nutrition for mitochondria is NIR .near infrared from sunlight especially morning and evening when the uv index is low ,below 3
hi! there, I am wondering if you care to provide a reliable source for your statement? thx.
Can you explain please.
Doing just that. It’s helping.
Thank you Doctor Perlmutter. Excellent presentation.
Wow! I heard that salt could cause oxidative stress but didn't understand why and it gives the answer, thanks for it.
I am retired, and I don't buy very many new books now-a-days !, But I bought 'Drop Acid" yesterday ! (It cost $ 31.76 ) Thanks for your sincere efforts to help us all !
try your library...they have great stuff
Please continue with U tubes. I'm a naturopathic person with HSV and I research mitochondrial support and thymus regeneration. I will watch mito u tubes more than once as I am getting very familiar with specific medical terms. Appreciate you Bonnie
why did the study fail to look at just Fructose w/o a change in Salt ? did they cherry-pick it out?
High salt and fructose intake are a marker for a diet high in processed food. However seems to me that fructose is the driver not the salt. See Richard Johnsons' research on fructose.
High salt does the same as fructose, also glutamine in diet. But ofc too low salt is very bad or worse. Salt is also a driver for sure also creates uric acid reaction.
But some salt before exercise is very healthy for heart providing more blood volume and so less need for oxygen for heart in hard situation or while digesting and moving with high blood requirement.
I'm confused. It seems that many respected doctors & researchers have - in recent times - indicated that salt is of no concern because the body knows how to deal with excess salt/sodium.
Latest research that I have seen is that people are more likely to have issues with low sodium than high. Salt intake is not an issue if you have good kidney function.
Would have been nice to see another category that were fed just low fructose
@@michaeltrumper high salt intake works exactly the same way as fructose or rather causes uric acid production check out Richard Johnson talking about it deeply
High salt has effects. Body knows how to deal with toxins too should you take toxins? Salt also makes hungry.
@@szymonbaranowski8184 True, but in context, it is much bigger risk of people having too low salt intake than loo low fructose. Or to put it another way, there is a requirement for endogenous salt, but none for fructose.
💖 Thank you for a very helpful and informative video..your delivery of info is really great...
Excellent video. Thank you
Would you PLEASE post the link to this study in the lowbar? Thanks!
very informative ... well presented
Great presentation!
Thank you Doctor! Liked and Subscribed. Just started reading your Grain Brain book... fascinating! Keep up the great work!
I read your book, "Drop Acid," and I'm skeptical of subclinical hyperuricemia in the absence of excessive carbohydrates. Are you sure the "independent" risk factors of UA are really independent at the subclinical level? I suspect there are cofactors that are not accounted for, as carnivores would all be suffering the consequences, and there have been plenty over the ages. I think fructose (or excessive other carbohydrates), for example-even in high fiber foods-is a likely cofactor, for sodium too. I'm sensing a potential plant-based bias and/or dependence on low-quality epidemiological studies.
PS: My suspicion is that people who strictly control carbohydrates may not need to worry about subclinical hyperuricemia, and that in that context, sodium is also not an issue. I can't prove it, but I'd like you to tell me if you know why that's wrong-because we're both after the truth.
You will definitely have high uric acid levels if you eat only meat, but that does not really mean anything in and of itself. It's not the uric acid itself causing issues, though it seems that way. It is your liver (not kidneys) being metabolically deranged that makes your kidneys unable to deacidify the blood enough to keep uric acid crystals from forming. Make sense? Probably not, but it is not a simple subject.
@@LTPottenger thoughtful, thanks........let's hope the doc here deals with the subject of upper gi tract glycan binding lectins and their relationship with acidic food consumption......
Doctor, in the study they isolated low sodium but not low fructose separately, this is incomplete, I would be interested in a further study.
Letting sodium and fructose relative to what? What was the baseline level for the folks who experienced the decreases?
Fascinating.
Thank you
Lovely info. Can you please mention the test name for mitochondrial density. Thanks.
Did they not control for only low-fructose? I saw only the comparison between low-sodium and low-sodium, low-fructose.
How long should it take to drop Uric Acid, say, to 6, from 7, if following the protocol described in your book?
Thanks a lot for the advice
Interested if instead of lowering sodium you raised potassium and magnesium
So, low sodium = no significant change. Low sodium/ low fructose = significant positive change. Why didn't the study include the effect of low fructose in isolation? Also, am curious on the effects this would have on subjects not overweight-- of normal healthy weight?
High sodium is the same as fructose. Literally spikes uric acid the same way
Yes but combining things can be significantly different than how things work by themselves.
So really both should be studied by them selves in order to get a more clear picture.
Salt is highly necessary for many of the functions of the body and you can just cut it out without there being problems.
I agree would love to have seen the low fructose numbers by themselves
Didn't know there was a test for Mitochondrial density, appreciate the info.
Agree. How or what do you order on a regular lab requisition?
Hello , right ?
the company viome tests mitochondria also
They will test you anything, if you pay enough. They will also make you believe it is important.
I kept walking past your book until late last month. Gout hit my ankle again. Coincidentally our health group, we had others gout confirmed by labs. Found your RUclips’s
Now our group of 300 owns 30meters and wow… 75% (roughly) have levels over 7.
Ordered bulk Quercetin Glycine and Potassium Citrate to start.
Contradictory to what many find.
great info.
Very interesting but what about for those that are not obese? I thought we need salt if we work out a lot, do fasting etc... I do keto ore mostly so sugar intake is very l low.
Many thanks for the information.
From another video I was told that the intake of sodium (preferably in the form of sea salt or Himalayan salt, as these are rich in many other minerals) should be counterbalanced by the right amount of potassium (leafy salad, avocados, bananas etc.) and that half a teaspoon per day, especially when transpiration is increased, is a good thing to add.
you need potassium and magnesium regardless of how much sodium you consume. Its just best those 3 to be in synergy for optimal cell energy, hydration and ofc your blood pressure. BTW - potatoes are one of the best potassium sources. They can feed you, be tasty as heck and are low calories if you are looking for that hehe. Carrots also have plenty of potassium. And fresh carrot juice is just heaven.
But is potassium chloride in anyway heat sensitive/damaged?
Animal products contain potassium.
@@danielmason8574 No.
@@veniqer They do, but the most potassium-rich food sources are fruits and vegetables.
So mitochondria dna has increase after 8 weeks of low sodium and fructose diet. Did this translate to the participants feeling to have more energy or had any measured weight loss? Just an increase in mitochondrial dna on it's own doesn't appear to be a useful effect otherwise?
This was powerful info
QUESTION: How do we know which is the cart and which is the horse? Do people with low mitochondrial function feel energy-starved and need to eat carbs for energy, so that's how they gain weight? Rather than mitochondrial function declining as a result of weight gain?
You mention a simple blood draw test to measure mitrocondira in the white blood cells. What is the name of this test? Thank you
Do we know what happened to the energy levels, the blood pressure or cognitive function of the study subjects?
I love these theories about early man that are pure speculation, but are used to explain current medical theories.
It's like being a weatherman.
Good analogy. Imagine being without the weatherman.
@@michaelb41 Knowing what the weather is predicted to be has never changed what I do in any particular day. Sure, some people live under threat of tornados and hurricanes, but that is what the public safety system is for.
Likewise, these theories have zero impact on how most people liver their lives.
I can do without them both.
❤😂
but weathermen are usually wrong
If my blood test shows low sodium is that the same as reaffirming a low sodium diet? Sodium is a necessary mineral for electrolytes assisting in the electrical aspect of exercise and the heart.
I have gone totally off all sugars including fructose since April 2023 . SOmehow though my A1C has come down drastically, for the first time I found that my uric acid levels are elevated to 6.7 . Im completely confused as to what to do what to have how to control this . Could you please advise
what kind of diet is low sodium and low fructose?
You didn't mention potassium values !!!
Question: I see people including children on you tube videos recording extreme carnival rides like on a slingshot or Rollercoaster and often times they scream and even pass out...just wonder what is the impact on the brain..could they be doing irreparable damage?
Sodium causes leptin resistance, thus making people hungry. Fructose causes insulin resistance of the liver, thus making toxin processing more difficult. Combinations might synergize to increase advanced glycation end products and inflammatory processes that induce mitochondrial apoptosis in white blood cells?
Agape 💙 .Dr. David. Ty 4 telling me the truth. I'm on it.
What’s the source of sodium they removed? Table salt? I imagine everything in moderation even applies to things like Redmond’s Real Salt. But specifically calling out the source could help determine if iodized table salt is causing oxidative stress.
So, how does one go on a low sodium (salt) diet and not threaten the essential level of hydrochloric acid in the stomach? I would suggest using chloride forms of minerals such as magnesium chloride, calcium chloride, zinc Cl, etc where ever possible.
My mitochondria are doing good thanks but I am worried about my cytosomes and my Golgi apparatus. People are just not taking care of these organelles and there is so little information available could you please help?
Thanks
I would have found additional interest in seeing the results of a group that was only low fructose.
In the study, did they use fructose in the form of fruits?
Would the antioxidants in the fruits reduce the negative effects?
On a mostly Vegan diet consisting of potatoes, fruits, veggies and no added salt,
my results are: Uric Acid 5.0, HbA1c 4.7% (avg 3 mo BG 86), Chol 185, TG 78.
Hi doc, great presentation. What blood test reveals the mitochondrial count in the white blood cell?
I second this question, what is it ?
Thank you
Why did they not have a low fructose only arm?
thank you
Why do scientists so often mix multiple variables into studies? Did I miss something? Where is the study of low sodium on mitochondria and low fructose on mitochondria? What sense does it make to introduce another variable? Apparently sodium had minimal effect, but fructose was a significant difference.
That's the honest truth. The only thing that likely has any effect is sugar. Salt is negligent.
What does drop acid refer to?
How do I repair mitochondria after ciproflaxen toxicity?
very interesting
Thank You! Always interesting and informative.
What the Swedish news used from this study was the sodium angle...and how much salt there is in processed meals...
Knowing what you just said certainly makes this study more understandable. Processed salt in processed foods! Natural salt has 2% trace minerals which is extracted in commercial salt. When harvested from the sea, salt contains 14% moisture.
Also, sea salt has not been crushed by heavy machinery, thus causing very sharp splinters of crystal which can irritate the endothelia of blood vessels and capillaries, thus causing systemic inflammation.
What was the sample size, did they placebo-control the overweight subjects and were the overweight participants dieting?
The study was from 2013, have there been follow ups to confirm the finding? Also why not have seperate studies on fructose and salt? is there a synergy between them?
To several who noted, yes there have been follow-ups showing NaCl is the bigger player in this. Just remember if you cut out or cut way back on Iodized Salt, you must supplement with Iodine....
@@BluesDoctorIF your thyroid wirks
So how low is low enough sodium. How much sodium should we have per day?
Definitely NOT what I thought when I saw “drop acid”. This is really cool though.
What about the requirement for high sodium intake for low-carb and ketogenic diets
What happens to the mitochondria if the person has a neutropenic fever due to chemotherapy? I had breast cancer and after my first dose of chemo, I got neutrpenic fever after my first dose of chemo. I was told that my neutrophils were 0.5 and normal was 13. I recovered, but I was wondering if that is why I had 'brain fog' afterwords the chemotherapy and radiation. That was 10 years ago. I am currently eating a low sodium and most of all, low sugar (carb) diet. I got off of sugar using monk fruit and now I am trying to eat less real fruit with the exception of a few, like kiwis. I am also taking vitamins such as MNM and trans reseratrol. I am noticing that my I have been retaining information better and memory has improved. Please tell me what you think about this.
Dr. Peter Attia address many health issues that you would be interested in. First in my mind is becoming bullet proof to illnesses. Largely that is due to exercise. Attia has many videos on RUclips and podcast. Best wishes in your journey to wellness and greater health.
I've read some studies by Rick Johnson. The polyol reaction seems to be key to uric acid levels which in turn prompts conversion of glucose to fructose (and triggering the 'uricase mutation'). His take on it (interview with Dr. Peter Attia) is that it's relative sodium levels - so dehydration can do this as well. His take on it was (paraphrasing) "if you're going to eat something salty, drink liquids first).
It's an interesting area. I hadn't made the connection with mitogenesis and mitophagy but how else would an organism reduce energy consumption? Subscribed, BTW.
Since the body cannot use fructose except in small amounts in the gut, and only through conversion in the liver to fat, what is the body doing converting sugar into fructose? What use is endogenous fructose?
In addition to many other supplements, I am taking 20 mg per day of pyrroloquinoline quinone or PQQ. Are there good substantive studies done on this compound with respect to mitochondrial function and mitochondrial genesis?
Pqq works but use it in conjuction with exercise or just walking do ur daily steps
If I read it correctly at 5:20, low sodium was defined as less than 6,000 mg, which is still a lot
I'm wondering just how well the white blood cell mitochondrial density correlates-serves as a proxy for muscle tissues (?). Seeing a 70-fold increase in mitochondrial density sounds like it would mean a fantastic rise in potential muscle cell performance. I know there would still be other muscle performance limiting factors, but at least mitochondrial density should no longer be one.
How does damaged mitochondria stop weight loss?
I had no idea that Willem Dafoe knew so much about mitochondria. 😜
How do I increase midoclorians?
@DavidPerlmutterMD Would you consider doing a video on how to improve mitochondrial efficiency as well ? Thank you for the amazing content that you create to educate us. Much appreciated ! :)
Get morning sunlight on your retina and skin for improved mitochondrial health, and avoid blue light after sunset.
from my undergraduate studies in kinesiology i can tell you that inside the walls of the mitochondria a cascade of numerous chemical reactions takes place to produce the energy molecule atp (adenosine triphosphate). something like 75% of these reactions involve magnesium, so i make sure my magnesium content is topped up.
@@TerriblePerfectionwell said
It is thought-provoking for me. Please advise.
- Uric acid is at 7.9.
- LDL is high.
- I am 50 years old.
- I am very active in sports. I cycled 1100 km last month.
- I have no symptoms of high LDL or uric acid.
- I have been struggling to lose 5 kg of weight for the past year.
- I haven't used added sugar for 6 months.
- I eat mostly boiled vegetables with olive oil once a day.
- I occasionally eat a small amount of fruit (fructose).
- I usually don't add salt to my food.
Please advise on what I should do to lower my uric acid levels, as I can feel that I am not metabolically healthy anymore. My physician is not very helpful.
Its sodium or its fructose affecting mitochondrial function..???
HIIT has been a clear and simple path to increasing my own mitochondria. This stress forces your mitochondria to multiply. Curious if there is any research data on combing both? I have always taken Fish and Flaxseed oil to keep my blood pressure low and scoop up free radicals etc. I am often thought to be 20 years younger then my actual age.
Now we need to know what foods not to eat that are high in fructose
Thanks for providing the interesting finding. However, what could be the potential links between mitochondria and fructose/salts? It seems to me that conducting a study based on already obese individuals don’t make a lot of sense since they need to reduce daily nutrients intake anyway.
If you do a little digging on pubmed you'll find this study was called into question with the sample size too small and the variance of results too large to draw any meaningful conclusions.
I don't understand why our ancestors's bodies would've perceived the intake of fructose as a sign food was scarce and mitochondria should down regulate to save energy. Wouldn't it be the opposite?
Uh, so what can we eat?
What is the best diet to support mitochondria?
What about a group with high sodium and low fructose? It seems to me that this study doesn't tell much about sodium.
But wait, 6 grams of salt/sodium is NOT a low sodium diet.
salt is an enzyme inhibitor, so it can't be that great. need All my enzymes.
20g of fructose - does that mean added fructose? Cos one apple has about that much, depending on a variety, size and ripeness. Are you saying that if I eat two apples I am at a risk of dysfunctional mitochondria? And how much salt is too much? I seem to be one of those who don't respond to salt intake with hypertension. I need to take more salt to keep my fluids in or they get flushed right through. And no, I don't suffer diabetes insipidus.
When they say salt, is it table salt or sea salt bc those are very different things.
Being on a ketogenic diet gives me mighty chondria.
This seems to me another good reason to cut off fructose. Just wonder why it toke 8 weeks before we see big changes in mitochondria.
Is salt such a problem. Could you do a book on salt?