RNAi: Gene Regulation via miRNAs & siRNAs

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[@MrLjpadk11]

Somebody that speaks CLEAR, Phonetically DISTINCT English. What a pleasant surprise!!!!

[@MissBeautyE4]

NOTE this is wrong what he says in the video. siRNA is NOT miRNA!!!! I used this video as a source for a paper I wrote and my teacher said that this is 100% wrong. Just a warning to you all.

[@mariababaeva5114]

Thank you, I spend 2 hours reading an article on this. But only after watching your video I grasped the concept.

[@yamileediaz]

I love your voice, it made it easier to understand. Thank you!

[@abdulhadisaqib945]

Thank you so much sir for such a clear conceptual explanation

[@senayberaki9988]

A very well done description, much appreciated

[@fidosa8382]

Very nice explanation, you cleared my confusion right up !

[@mohammedal-hammadi5085]

It's pretty clear and great explanation, thank you so much really

[@froglegs4910]

Very good lecture !

[@sumangoswami4524]

Excellent ,thanks

[@shajidislam2222]

It was excellent and well explained. I really enjoyed. Could you please upload some videos regarding the involvement of non-coding RNA in epigenetic modifications. Thanks

[@Chemicals32]

wikipedia says that miRNA differs from siRNA , in which siRNA will always pair with its target mRNA and cleave it whereas miRNA will scan for complementarity and bind with imperfect base pairing thus repressing translation. is this correct?

[@mominamalik1304]

excellent

[@chanteswonderland1630]

I thought that miRNA and siRNA are from different sources, siRNA can't be part of miRNA, just similar pathway at the end @@!

[@thefbi9903]

Yeah, as far as I‘m concerned he‘s completly wrong.

[@akemumoren4133]

and mirna is not fully complementary while sirna is. Additionally, sirna does not use drosha but only dicer cleaving corresponding sequences every 20nt approx in the PAZ region. In mirna, we can have argonaute cleaving in plants but most mammals use partial base pairing. although sirna can come from sense and antisense dsrna of s gene, they are mostly exogenous and mirna are from introns or actual genes. They both interact with argonaute though, so are both rnais.

[@jasonquinones2362]

This is a great figure! I'm a molecular biology professor and would like to use it for my lecture on RNAi. Where did you adopt or modify this from? Can you please provide the citation? Thanks!

[@skoufoss]

The metal ion is Magnesium?

[@swapnanildas9668]

Sir, thn mi RNA ds & si RNA is ss & mi RNA is present in nucleus & si RNA in cytosol -- that's d difference right??

[@alhaeri1]

bad intro good video