Covid-19 Update: Epidemiology, Virology, Drugs & Vaccines, and UCSF’s Experience in Navajo Nation
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- Опубликовано: 3 окт 2024
- In this UCSF Medical Grand Rounds presentation (May 7, 2020), UCSF experts provide an update on the epidemiology and virology for COVID-19, prospects for drugs and vaccines, and the role of biopharmaceutical companies. We also hear a brief report from a UCSF physician who is part of a volunteer group of 21 faculty and nurses working in the Navajo Nation. The session is hosted by UCSF Department of Medicine chair Bob Wachter.
Program
Bob Wachter: Introduction
00:02:16 - Sriram Shamasunder, Associate Professor of Medicine, UCSF Division of Hospital Medicine; Director of the HEAL Initiative - Report from the Navajo Nation
00:13:22 - George Rutherford, Professor, Dept. of Epidemiology & Biostatistics; Director of the Prevention and Public Health Group - Epidemiology and the Next Stage
00:25:20 - Q&A
00:32:32 - Joel Ernst, Professor of Medicine and Chief of UCSF Division of Experimental Medicine - Viral Immunity and Vaccines
00:45:45 -Melanie Ott, Senior Investigator, Gladstone Institute of Virology and Immunology and Professor, Dept. of Medicine - Virology of SARS-CoV-2
00:58:55 - Nevan Krogan, Professor, Dept. of Cellular and Molecular Pharmacology; Director of Quantitative Biosciences Institute - SARS-CoV-2 and Drug Discovery
01:13:30 - Panel Discussion including Joel Ernst, Melanie Ott, Nevan Krogan and:
• Donald Ganem, Professor Emeritus of Medicine, Division of Infectious Diseases; Head of Infectious Disease Research at Novartis, 2011-18 - SARS-CoV-2 and the Role of Biopharmaceutical Companies
01:38:23 - Bob Wachter: Closing
See previous Covid-19 Medical Grand Rounds:
• April 30: Update on Covid-19: Clinical & Neurological Manifestations, Contact Tracing, and UCSF’s Experience in NYC
• Covid-19 Update: Clini...
• April 23: Update on Covid-19: The Next Stage of the Pandemic, Virology & Diagnostics • Update on Covid-19: Th...
• April 16: Update on Covid-19: Epidemiology, Treatments, and Health Disparities
• UCSF Update on Covid-1...
• April 9: Update on Covid-19, at UCSF and Around the Country
• Update on Covid-19, fo...
• April 2: Epidemiology, Science, Clinical Aspects, and Therapy for Covid-19, Part 2
• The Epidemiology, Scie...
• March 26: Impact on Covid-19 on Medical Education
• UCSF Educational Leade...
• March 26: UCSF Researchers Tackling Covid-19
• COVID-19 Campus-wide R...
• March 19: Epidemiology, Science, Clinical Aspects, and Therapy for Covid-19, Part 1
• UCSF Experts on the Ep...
Chilling numbers from George. So far this is the only place I've heard that will name where this is spreading. If I got it right, it's primarily essential workers, institutions and laterally in family homes. I feel like there should be more places in that list but no one is publishing that data that I can tell.
Mostly, that data is kept quiet, as in the past, when groups or specific locations were listed, threats of violence and violence occurred against the named location or group.
Caregivers and staff are vulnerable, one misstep or brief violations of protocols result in exposure and illness, as was well evidenced in our youngest, who while working in housekeeping on a COVID floor, she contracted COVID-19.
@@spvillano we meet again :)
@@SyBernot singing, "It's a small net after all, it's a small net after all"... ;)
Please comment on potential utility of oral NAC supplementation for reducing COVID-19 symptoms, oxidative stress, and vascular issues. Multiple papers out there suggest that NAC may be beneficial.
Wish UCSF would bring in some experts on child brain development. I worry about my 10 year being forced to use computer/screens for education and social isolation of our children. I don't worry about adults using computers more, our brains are already developed. But, child being forced to isolate and no peer interactions and only access to the world is via a screen. Frontal lobe research shows kids with too much screen time become future failures at being able to focus. What about damage of kids being treated as inmates in a prison?
Ok.
It's a lot less damage than dying or being needing dialysis or a lung transplant from COVID-19!
Now, do learn the difference most babies learn early on, temporary absence isn't perpetual absence.
Thank you so much for your great public service. The mission local blog actually provides a pretty decent written summary of the grand rounds.
Political comment: I wish society would give people like you 10% of the adulation and resources that they give to entertainers and ball players.
Great infomative talk. Thanks. Much appreciated.
Are there studies planned monitoring the population of patients currently taking hydroxychloroquine for autoimmune disorders or malaria to see if there is modification of COVID-19 disease severity as a result of the medication being present at the early stages of infection?
Great idea! Can you make some calls to get it going?
@@jasonvoss1984 Thank you. I have no credentials or connections to get it going. Most current studies are focused on efficacy of hydroxychloroquine treatment for patients sick enough to be admitted to the hospital. I think a study of possible prophylactic effect might be very useful, especially in countries with endemic malaria.
Yes, I believe such studies have been done. I am pretty sure there was one in China. Not sure about USA. Sorry I don't hve the link at the moment, but it was pre published in one of the journals. The result I think was people on HCQ for lupus almost never get it.
@@hoffman408 Thank you for the information. I try to download pdf's of reports that I see, but they are not always free. I've forgotten the details of several reports I have read, and regretted not being able to look back at them.
My real focus was on the current strategy for chemoprophylaxis of malaria in sub Saharan Africa. They currently use amodiaquine as one medication for preventing malaria. I am not familiar with amodiaquine, I assume it is in the same family as hydroxychloroquine. The strategy would be a modification (either drug substitution, or timing/frequency of administration) for providing some additional benefit of reducing risk of SARS-CoV-2 infection, while at the same time providing prophylaxis for malaria. The advantage is that the medication can be provided in a short time frame for a reasonable cost (with hopefully no increase in risk from the cardiac toxicity).
If the population of patients with autoimune disorders are found to have a lower risk of serious COVID-19, that would suggest the next step, finding the right drug combination and strategy of administration to provide some benefit in countries where malaria is endemic (I doubt the finding would change the strategy for medication of the autoimmune disorder). In countries such as the USA, there is a relatively large population of patients undergoing treatment with hydroxychloroquine for autoimmune disorders. There is also developing data about the true prevalence of SARS-CoV-2 infection. The USA provides opportunities to address the question of whether pretreatment with hydroxychloroguine would provide even a small benefit by reducing the severity of COVID-19. Reducing severity by 5% would have a significant effect on mortality that is likely to develop in sub Saharan Africa.
I am not predicting that results will be positive. I am just suggesting there is much to be gained if studies on drug prophylaxis show some benefit.
If you have pills for prevention of malaria left over from past travels, DON'T TAKE THEM! Medication needs to be managed by licensed health care providers. There are cardiac toxic effects that require testing and monitoring.
Thank you much!
Impressive demonstration of the conversion of disparate sciencing re-search to practical policies gauged to actual circumstances.
Hello from H. S. (BSc.Chelsea, London 1978, BSc. Open Uni (UK) 2019, very interested to hear about drugs targeting human proteins required by SARS cov2 (QBI Coronavirus Research Group). Added to this approach may be a rescue agent given to the patient a short time later to prevent drug toxicity. So let the drug inhibit the virus and a short time later give the patient 'antidote' to the drug. this approach may give the immune system time to kick in to contain the virus and limit toxicity.
Harsh Sharma theconversation.com/we-found-and-tested-47-old-drugs-that-might-treat-the-coronavirus-results-show-promising-leads-and-a-whole-new-way-to-fight-covid-19-136789
Is anyone studying the effect of vitamin D deficiency on severity of COVID?
Here you go - I follow his blog regularly. ruclips.net/video/GCSXNGc7pfs/видео.html
@@TomJones-wi4nh Thank you. Dr Campbell is great. I am more wondering whether there are actual studies conducted on COVID patients to access Vit. D levels to possibly elucidate a mechanism behind the disparities in deaths that is remediable.
The fact that vitamin D is not part of the national discussion is a case of criminal malpractice on the part of our big pharma driven medical establishment.
No!!!!!!!!
@@MyPerennial it's behind a paywall, but enough info in the preview... www.telegraph.co.uk/news/2020/05/03/time-take-seriously-link-vitamin-d-deficiency-serious-covid/
Thanks, a rare voice of reason on RUclips.
This virus is bad, but it may kick in a quantum leap for science.
At about 1:14:45 the guy mentions how much BILL GATES is doing to help out with the logistics of the vaccine production... hmmm... why does that not feel right and altruistic...? Something stinks in Denmark.
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wow.. straight up honesty.. that was refreshing! so nice not to be lied to for once!
A bunch of well paid physicians telling those struggling to feed and shelter themselves that the lockdown must continue is obscene. This isn’t a trade off between life and economy. Economic damage kills just as surely.
One question, has it been confirmed that only viral RNA is being shed and not an attenuated or inactivated virus?
Thank your for sharing these discussions. Very interesting information for one trying to learn about this virus. Good and bad news for us the hosts...
Dr. Ott
Are there mechanisms by which dietary cholesterol may assist viral reproduction?
Excellent and detailed information! Thank you for all you are doing!
Antibody misinformation.
At 1:18:00 your extreme bias against Hydroxychloroquine is painfully obvious. Did you all agree before the camera started rolling that you would avoid mentioning it? Is it ethically dangerous to allow political bias to enter into medical considerations during a pandemic?
Great info! Thanks,!
I have been taking 10,000 iUS FOR SIX YEARS since i turned vegan. Not even a cold since.
Don't think you need to keep taking such a high dose. Get your calcium levels checked too much Vit D can cause calcium levels to go too high. Check urine for oxylates to make sure kidney stones don't occur. I got my levels up to 50ng but that is a bit too high. So skipped a few days. Supplementing isn't the same as sunlight. Vit D is stored in fat cells released slowly into bloodstream.
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Seems like a lot of unnecessary political content and naive medical knowledge. There is no way this will be resolved by mid summer. The comments are dissociated from the graph’s displayed. I stopped viewing a short of the way into this politically biased, self-congratulating behavior.
LOLOLOLOLOL. I like that, it's fun fun