Double Testosterone AND Keep Fertility?
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- Опубликовано: 6 сен 2024
- Enclomiphene Citrate can increase testosterone while improving spermatogenesis. This video explains the risks of testosterone replacement therapy on fertility and explains why Enclomiphene Citrate is a viable equivalent to TRT and the preferable choice for men who want to avoid testicular atrophy and infertility. 
#enclomiphene #fertility #trt
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I have been taking enclomiphene 25mg daily for 6 months with no sides and doubled my levels. It really does work
Thank you for your comment. Great results!
Your fertilitys good too?
@@scal7122 lol well No but ✂️ after I was done with my son and daughter.
Whether it works is not the issue, rather, its not an solution that works indefinitely.
I’m starting that same dose today. Living with my test as low as 47 I’ve felt terrible. Ready to get back to normal.
Enclomiphene has a short half-life. Some people take it every 3 days (not daily or EOD) so it has time to clear the hormone receptors. This is to reduce side effects.
Thank you for your comment. I have come across a lot of people taking it in this way. I will research this a bit more, but it was difficult to find data on this kind of scheduling.
What side effects?
@@VernCrisler I think just that enclomiphene will lose effectiveness if it is taken every day because the receptors never get a break. If this happens, it may be possible to resensitize the receptors by taking a sufficiently long break. A longer break gives more time for enclom to clear the receptors, so a 2-day break will give more clearance than a 1 day break.
@@JonasKuehneMD Can't you just do that dosing schedule and then take your blood work, do it that way for 2 months, then do it everyday for 2 months, maybe take a 2 month break in between and compare the blood work?
There is no such thing like "clear hormon receptor, you can't clean or clear anything in your body and eventually you don't have different results dosing Eod Ed or E3D just adjust the dose. 6.25 ed 12.5 Eod ecc..
1 month and have experienced good benefits. Definitely has made me stronger.
Side effects?
Did you get a prescription for it?
I’m on day 5. So far so good. Got a script for 3 months
I’ve been running 6.5mg ED for the last 6 months or so, due to low test levels (didn’t want to go on trt due to fertility issues). I will be getting myself tested again to see what impact it’s had on my test levels. I have not experienced ANY negative side effects to date. Once tested, I’ll update you with test levels to see if there’s been any improvement.
Thank you! I am currently taking 6.25 mg daily testing this out as well. So far, it has significantly increased testosterone (by 70%) without any adverse effect.
So what happened?
25mg or 50mg every 3 days?
We need an update!
Hello do you have any news? How is it going? Did you do blood work? Any sides? How is estradiol? Can you also tell your age and your bodyfat %? It could be helpful to have a baseline
My specialist said that we are unable to get ENCLOMIPHENE in Canada - but he also agreed, he would like to prescribe it instead of CLOMID (ocular disturbances).
There are online pharmacies with physicians prescribing Enclomiphene in the US. I am wondering if they are also working with Canada. Clomid contains Zuclomiphene as well and therefore behaves differently.
I believe you can buy it in Canada from Strate Labs.
I am starting 25mg today. My test back in April bottomed out as low as 47. The effects of long covid has tossed these hormones out of whack. Ever since I had covid 2 years ago I’ve just been going downhill. I found a handful of clinical trials that are being done and have been done to research the effect of long covid on male testosterone and the reproductive system. The studies just answered my question of why at 38 years old, being in fantastic shape, CrossFit athlete did I have such a 180 and have constantly been falling down a cliff.
I would allow one to two months before testing again. I usually run total T, free T, FSH, LH, estradiol, SHBG, IGF-1
@@JonasKuehneMD thank you, I already have the blood work orders from my doc to check all of this. Then we’ll see if adjustments to the dose need to be made.
Would like to know how you get on.
Background is similar to mine. At 37, hit with covid and went from regularly competing in football, weight and cardio training, and former amateur boxer to absolutely ruined seemingly overnight. Have bloodwork in years prior with high test, and, although I have no post-covid bloodwork, it's obviously nuked it. Considering an enclomiphene run at about 6.25-12.5mg. Best of luck, mate.
@@joeryan82 I did 25mg as the price for me was the same as smaller doses. And if it’s too much I was always reduce. But after about 2 weeks I’m noticing better daytime function and I’m able to wake up better. Even getting some spontaneous woody’s again.
Been taking it now for one week. As a pct from pro hormones and I feel great. 12.5 mg a day now. Libido went up as well as endurance and energy levels
Great! Are you going to follow your total and free testosterone labs?
@@JonasKuehneMD I am two weeks after use
@@lorenzoherrera1966 please come back to update when you can
Where did you get Enclo?
Good luck - prohormones are at times worse than steroids and once you stop E Clomid you will most likely crash. Cialis is probably a better option.
I just ordered some online. I did some blood work a while ago and it said my test was in the "normal" range. I definitely have signs of low T though, such as depression, low energy, poor libido. After looking around online my free test is about half of what is considered "optimal" for my age so I thought I'd give this a try.
Great, it seems to be easy to get online via a telehealth physician. What those are you starting on? Would be interested to see your T levels after about three months, if you are comfortable to share them.
Where did you order online?
@@MDE_never_dies strate labs
Update?
Update?
I'm on enclomiphene going on 3 weeks so far 25 mg daily. After six weeks I will go in for blood work and see how much my testosterone has improved.
Thank you for sharing this. How did you select this dose? It would be great to see the change in total and free testosterone over this period.
@JonasKuehneMD The doctor selected the dose. I see you talking about using a quarter of that as much every three days and it scares me. I'm not sure why some people are taking so little and i'm taking as much as i'm taking.
I’ve been on 25mg for a week and already feel increased energy. I’m interested to see your total T numbers from your blood test. They have me getting a blood test after only 3 weeks on
just read this: The FDA stated that, based on recent scientific developments, the design of enclomiphene Phase 3 studies was no longer adequate to demonstrate clinical benefit and recommended that Repros conduct an additional Phase 3 study or studies to support approval in the target population.
Thank you for the tip. I will look into this.
I look forward to hearing updates from your lab work.
Thank you. Will do labs soon and post an update.
Clomid increased my test to 1198 from 291. However I start to get blurry vision after 90 day. Subsequently stopped taking Clomid. Test is now 461. I suffered hair loss coming off the Clomid. Is enclomiphine a safe alternative? Looking to avoid the listed issues!
enclomiphene is definitely superior to clomid for men's purposes. zuclomiphene has a super long half-life and is actually an agonist (activator) of the estrogen receptor, which could be a big part of the issues with the eyes (as they have a lot of estrogen receptors)
If your testosterone is now stable around ~461, then your testes might be healthier than they were before and you may no longer need to take anything. 461 is a decent level that I'd be happy to have. Jeff Nippard is around there.
Enclomiphene does not contain zuclomiphene, which is the second ingredient in clomid. It should therefore not cause ocular problems, however, this needs to be discussed with your primary care physician.
It's effective. I've used it with 25mg of anavar for a year and didn't have any suppression. my free test increase, but my shbg did decrease, which i attribute to the oxandrolone
Great feedback! how much Anvar were you using?
@@JonasKuehneMD 25mg a day. 12.5mg of enclo daily. on workout days(2 days a week), i would also use 10mg of halotestin preworkout sublingually.
Did you have any liver or kidney problems.
@@soorajwrir4433 lever values are under 50. kidney gfr and creatinine are in the healthy range
I’m on 6.5mg enco mon weds fri. Personally it was a rough start for me until my body adapted. Got majorly sick first dose day..fever and sickness for a week. After that I got slightly high estrogen counts on labs with emotional symptoms. It did improve my total testosterone by 35%. 3 months in my body has adapted and I love the product. Way more energy.
That’s great to hear. Interesting that you had fever and illness for a week after the first dose. Did you have to take anything to down regulate estrogen?
@@JonasKuehneMD my estrogen doubled to just outside of the reference range. Personally started taking omega 3 & Zink to help combat.
They prescribed me a low dose of Anasteozole 0.15mg. No side effects.
Hey, ive been told by people that used it that it can lead to low igf-1 and hgh lvl's is this true and does this only occur by prolonged use or just overal?
There was a study that showed that MB can lower HGH by roughly 50% in some individuals and it was not dose related.
I have to follow this and look at other publications.
Use ghrp-6 to increase igf 1
I am 67 and have been on TRT intermittently for a cycle of 4-5 months in the past.. The last time was the summer after covid becausemy strength in weight training went down considerablly after a 5 month lockdown due to our governeor in MI. I even did free weight dumbell training at home put upon return to the gym my strength was noticelby diminished. After about 4 months on T everything was almost back to normal but not quite. I discontinued about then because my PSA about doubled from 1.3 to 2.6. It did go back down in about 3 months. I did feel much better on TRT. My T levels are about 309 last march 2024. After some research I decided to ask about enclomiphene and was placed on 25mg/qd. The dr was skeptical it would work at my age, as was I also. Now after 5 weeks my T levels are 570. I feel different though on this, a bit moodier and I noticed my sex drive went down for about 1 month. I at first attributed it some minor surgery, cataracts, but more likely the enclomiphene. Its coming back now. Also have not noticed a difference in my weight training as of yet even though its a bit early. Will also have a PSA check in a while to see if its elevated on enclomiphene.
Thank you for your detailed comment. The increase in testosterone from enclomiphene looks good on paper. But as you mentioned, it feels different than replacing testosterone. Would like to see if the PSA stayed low or was affected by this as well.
@@JonasKuehneMD Also wanted to thank you for the informative video. Very helpful. I will update my PSA when its tested again. I am wondering if the mild mood change and diminished sex drive was due to the enclomiphene binding the estrogen receptors, I do know that you need some estorgen for sex drive also. My estradiol was 33 vs 27 last time it was tested. Also shbg went from 40.7 to 45.2 and free t 10 vs 5.3 prior to enclomiphene.
makes me sweat like its raising my body temperature super high, specially when training, perfuse sweating. Apart from that, havnt noticed any other negatives. week 2 of 4.
Thank you for your feedback. I am currently taking 6.25 mg daily over the past 4 weeks and have not noticed changes in body temperature
I get this too. Been on enclo for 2 months now. I think the raised body temp is contributed to having increased test, which increases metabolism, which in turn will increase body temp during exercise. I think its a sign that the enclo is working. your body is more effective at burning fat for fuel and turning it into muscle.
That's because you're monkeying with your hormones. Once you stabilize it will subside.
I run Enclomiphene at 5 mg/day as a test base for Ligandrol. I also run it as a PCT. So far, no problems, but I'm not sure if it's healthy to run it long term. Interested in hearing about your results over time...
I have been on 6.25 for the past three months with a 30+ percent increase in total testosterone. Am switching to 12.5 mg and will do an update soon. No side effects either.
@@JonasKuehneMD Excellent! Would love to hear any news about its effect on free test or SHBG levels.
@JonasKuehneMD do you run it everyday or EOD?
I’ve been taking 12mg Enclomiphene every 2 days, and 400iu of HCG between for only 2 weeks. My nads have definitely gotten fuller, and my sex drive is crazy high 😁.
That sounds great. I am currently using 12.5 mg daily up from 6.25 mg and have definitely noticed more strength and drive in the gym.
I have a primary issue when I stopped TRT my test plummeted from 700 to 350 then when I got back on TRT i started to get paranoid. Then I started Enclom and my test went from 350 to 580. However my estrogen went up 15 points but now I take anastrozole every 10 days. Even though I have a primary issue I still feel good on enclom 2 times a week 25 mg
Thank you for sharing this. It is interesting that you are estrogen in relationship to testosterone was too high. Also I’m interested how you decided on taking the enclomiphene at 25 mg two times a week. I have read that for some people taking every other day at a slightly higher dose was superior to taking a lower dose daily.
@@JonasKuehneMD pleasure to share my friend. If I take Enclom everyday my estrogen will eventually rise than the normal norm that being said it does increase my test by almost 250 points also I have high free test in the low 100 range. The Enclom I feel is in my system longer than we think. Most doctors and clinics want me on TRT but I’m content with the Enclom for the time being.
Will enclmiphene cause negative feedback and shutdown further up the messaging chain, by causing estrogen receptor upregulation or something bad?
I cannot find anything in the literature. Keep in mind that it has not been used for longer periods in any studies. I would say go with the lowest dose needed and take breaks periodically.
It’ll cause blood clots this guy is a moron
I have found That my estrogen level the day I tested has been the same every time I've tested. But my estrogen was never too high. It was pretty normal.
@@JonasKuehneMD when is update coming?
What age range do you define as "young" to start TRT in your medical opinion?
Under 40
thank you for that video!
my question would be, if i want to use enclo just for bodybuiling purposes, would
you recomend it? and if yes, for how long, and what i need to do after getting off enclo?
Not medical advice, of course, but enclomiphene can increase testosterone significantly, sometimes doubling it. I think this would significantly improve your gains at the gym. There are no good long-term studies even at the low-dose is required. Most people do fine on 6.25 mg. Others take 12.5 mg daily. Some people have experimented with taking it every other day. As a rough guideline, I would take a month off every three months or so at least. Again this is not medical advice though.
There is a guy here on RUclips that took enclomiphene sulphate for an extended period of time. It started off great both in the testosterone gains and gains in the gym. After a period of time, he was losing his gains and couldn’t understand why. Turns out that extended enclomiphene citrate use will totally crash your levels of growth hormone in the long term which then carries its own issues.
@@glennUK82 that's why u should take mk677 with it.
@@glennUK82 Can you support your statement with any good evidence ?
You mention taking enclomiphene for six months: aren't there risks associated with chronic low estrogen?
It blocks the receptor registering estrogen in the brain, but does not in fact block estrogen production.
I do worry about how this impacts estrogen receptors as someone with low E2 in addition to low T. I believe both of my receptors are down regulated and I do not want to run the risk of either becoming worse. I have a ton of low estrogen sides to go along with my low T sides. Any suggestions? Boron helps about 4 weeks after taking, but it doesn’t last more than 2-3 months before having to cycle off and restart the process
Enclomiphene mostly blocks estrogen receptors in the brain, triggering the release of FSH and LH. This in turn will stimulate the testes to make more testosterone. Estrogen production will follow the testosterone increase in appropriate levels.
What blood tests should I be requesting from the lab while on enclomephene and how often? I typically ask for a testosterone total and free test which also features SHBG.
You could add an FSH, LH, and estrogen to that.
Hey! new to this channel. I suffer from secondary hypogonadism along with low T - also, Almost sterile sperm count (morphology 4%) . enclomiphene is not available in my country so my doctor prescribed me HCG injections (200iu ever 3 days)
what are the main differences between enclo and hcg (pregnyl) and should I consider even making an effort to get enclomiphene?
HCG can also be used to boost testosterone levels. It works slightly different than Enclomiphene. Sometimes people use both in combination. If hCG increases your tea, counts and sperm count sufficiently then I would just stick with that. If you see that even at optimal, do you still have issues, then I would explore with your doctor if Enclomiphene can be ordered.
@@JonasKuehneMD thank you so much!!!
Isnt the lowering of igf1 counter productive for puposes of muscle gains ?
Yes, it can be. Not everyone experiences a lower IGF-1 with enclo. Mine stayed normal at 6.25 mg enclomiphene. Will recheck soon
I hear people saying it decrease growth hormone and increase estrogen? I am thinking about using this but was concern about those two concerns. Do you know if that’s true? I do take finasteride but I do wonder if that work with this testosterone boosting medication?
In one study, it was shown that there is a decrease in HGH when taking enclomiphene, and this was independent of dose. It does not directly increase estrogen, but as testosterone increases, estrogen will increase proportionally. That in my opinion is less concerning.
@@JonasKuehneMD thank you
Should i take clomiphene years after test/ deca cycle , i didnt take pct back then
If it has been years, then you will probably have reached your new or old baseline again. if you’re T and free T are low, you can discuss enclomiphene citrate with your PCP. It does not contain the estrogen agonist zuclomiphene.
Whats a good dosing protocol with enclomiphene?
For a lot of people the lowest dose of 6.25 mg daily or even every other day seems to work quite well. Another dosing option is 12.5 mg every other day. It’s best to work this out with blood tests after you get your prescription from your physician.
I started clomid a month ago, and I just started having vision issues in the past few days. I didn't know that was a side effect. I'm contacting my doctor tomorrow to see if I can switch to enclomiphene.
What specific changes have you noticed? Enclomiphene should be better tolerated here.
I've basically always had perfect vision, and starting the last few days it's been difficult to read small text on screens, like I'm sleep deprived or something. If I close and rub my eyes for a few seconds, it helps temporarily. Otherwise I've noticed no real effects one month into Clomiphene. Hopefully I'm able to switch to Enclomiphene, and it reverses the vision side effect.
Enclomiphene has a lot of the same vision issues clomid does
Yes .... Yes it does ...
Well that's disheartening. I'm just terrified of suppression and don't want to sterilize myself just to be able to burn fat off again. I shouldn't have to lose the ability to read small text on my phone/monitors for that.
So will enclomiphene serve the same purpose as HCG in regards to preventing testicular atrophy?
Similar. HCG acts as an analog to LH, thereby stimulating the testes to produce testosterone.
Enclomiphene works on the hypothalamus/pituitary to secret LH and FSH.
@@JonasKuehneMD so in reality the enclomiphene should actually prevent the atrophy
I got tested recently very low i dont want trt at least not yet.....and i hear about bad side effects with chlomid this seems like an option i would want to take
I have been taken 6.25 mg daily for the last three months and it did increase my total testosterone by about 30%. I will try the 12.5 mg and see if that results in a greater jump. Personally, no side effects or issues with it.
@JonasKuehneMD how long before you felt the affects
What are your thoughts on blood clotting risk and lowered igf
The blood clotting risk would be present with clomid , since it contains the estrogen agonist zuclomiphene. Enclomiphene may slightly lower igf but I don’t think it a big issue
When I take enclomiphene even when my T is on a normal level, does it cause any problems later? And when do the effects show up? After a week or two? What happens when I stop taking enclomiphene after a couple of month? Does my T level go down to its normal like before enclo or does it go down even more? What do you think about the dose 12.5 mg every other day? I would be very thankfull if you could answer some of my questions.
Enclomiphene increases tea by increasing secretion of FSH and LH. When you stop taking it, levels of tea should return to normal baseline, but not below. If you take it after you had been on TRT, it can help to restart the production of testosterone in your testicles. Levels should increase within about two weeks. I have only seen anecdotal data of people taking it every other day. Usually it is prescribed to be taken daily.
How are you guys getting your enclom?… so many places only prescribe Clomid … what the heck
You can try First Care Specialty Pharmacy .
ive been on trt for 13 years and i feel like blah, no sex drive. Im wanting to try this. What has been your experience?
Going off T will cause a period of extremely low T that many people cannot tolerate. Enclomiphene can stimulate your own T production but it will take a bit of time. I have used 6.25 mg and had a 60% increase in total T. I have increased to 12.5 mg now and will do labs in a few weeks. Enclomiphene will probably not be as profound as TRT, but in my opinion a more natural approach.
If your current dose is not working for you, you could also try to increase your dose, and maybe split your weekly dose into 3 injections (mo, we, fr).
Is hair loss a side effect?
Yes, it is a possible side effect.
If im taking clomid and hcg should i stop one or continute? Its for fertility. Clomid 25mg daily and hcg 800ius 3x a week. Thank you
Is this a bad
@@scal7122 Dont think clomid is supposed is supposed to be taken every day,iy contains zuclomifene,which increases estrogen and has a much longer half life than the enclomephene thats in it
But wouldn't also increase the Estrogen (E2/E) due to aromatase? The big horse in the room is what about those who have already a high E2/E3 level due to aromatase and with Enclomi would increase it even further.
From Washington University of health sciences:
“Moreover, unlike aromatase inhibitors, enclomiphene citrate does not inhibit the aromatase enzyme responsible for converting testosterone into estrogen. This property allows enclomiphene citrate to maintain appropriate estrogen levels, contributing to better overall hormonal balance.”
You always will need some estrogen, especially when your testosterone levels increase. Theoretically with Enclomiphene the levels will be balanced.
@@JonasKuehneMDI meant more like example: Now you are at mid range Free Testosterone and total Testorstrone levels. But SHBG 110nmol/l and Estrogen is on the scale at the reference max. 150 pmol/l .. if this further increases it will have negative impact as well..like gyno and fat deposition water retention etc.. so this is what i am looking at ..thanks for your answer Jonas MD ;-)
Can i just take enclo for a pct and thats it , just want to increase and get my test levels back to normal. Im a little skeptical about droping estrogen cause it could lead to other problems but judging by what im reading it isnt thats bad
Enclomiphene does not decrease estrogen, but blocks the estrogen receptor in the brain, tricking the brain to think that levels are low. This results increased secretion of LH and FSH, thereby stimulating the testes to increase testosterone production. Estrogen will then rise in appropriate levels with rising testosterone.
Do you have an update on this video?
Yes, I will post fairly soon as I have been using enclomiphene low-dose for three months at this point.
Where can you get a good enclomiphene where I can choose how many mg I want?
First Care Specialty Pharmacy is a good address. You need a script from a physician
@@JonasKuehneMDgetting the script is the PIA part
When you use enclo do you notice improvement in energy and muscle recovery?
Takes a while, but yeah.
As it increases total T and free T, yes.
Do you still plan to do an update video on Enclomiphene?
Yes, I have been using 6.25 daily for about three months and had labs a week ago. I may increase to 12.5 mg for another two months. I will do a video with an update, addressing total testosterone, free testosterone, estradiol, and IGF-1.
@@JonasKuehneMD alright, thank you!!!
Do you answer questions on here or just do vids ?
Both
on EC. TT to 300ng up from 150ng. E2 19.5, SHBG 43 - been tying top get SHBG down with boron etc and have not been able to reduce. if i can get my shbg down i thing total T will easily increase to 400's. so EC has been great from not invoking polycythemia, but i am not getting the total and free T levels that are in sync with the levels reported in outcome studies.
That is great progress. Yes, it would be nice to decrease the SHBG slightly more to allow more free T. What dose of enclomiphene citrate are you currently using, and in what frequency?
@@JonasKuehneMD 12.5mg
Jonas thank you for the video. My only concern with Enclo that I have heard some people bring up is that it halves your HGH production while on it. Can you look into this and report back? Would love to get a concrete answer one way or the other. If it does indeed half your HGH I may look to supplement with exogenous HGH while taking enclo.
This study showed that enclomiphene decreased IGF-1 which is a marker for HGH by roughly 50%. Interestingly, this was not dose dependent. They could not measure direct HGH so I’m not sure if it translates into a 50% decrease in HGH, which I would doubt.
aacrjournals.org/cancerres/article/73/8_Supplement/1326/586892/Abstract-1326-Oral-enclomiphene-citrate-lowers-IGF
@@JonasKuehneMD thanks. do you think the increase in T is more beneficial than the undetermined reduction in HGH?
@@JonasKuehneMD also does taking exogenous HGH reduce your natural production like with TRT?
@@JonasKuehneMD it effected by sleep and I started getting sweats in the bed and it used to stink. I only tried 12.5mg enclomophene/week. Stopped it and everything went back to normal. I started taking bee pollen to help to maintain testicular size and it does help.
what about using testosterone cypionate with Enclomiphene Citrate?
You could, as it would increase FSH and LH, decreasing the severity of testicular atrophy. Some people take testosterone together with HCG for similar reasons.
i have lh 8.0 at 450 NG/DL is this meaning i have primary ?
While an LH of 8.0 is on the high side, a test level of 450 ng/dl is within normal range.
The question is if Enclomiphene can help to increase you total T. I would discuss this with your primary care, physician or endocrinologist.
I’ve been hearing to take Enclomiphene with hcg is that something to consider? Or would it not have any benefit?
Both will raise FSH and LH, resulting in increased testosterone. Enclomiphene is the better option in my opinion. I do not think that both should be taken simultaneously.
@@JonasKuehneMDyou’re an MD and you think HCG will raise LH & FSH 😳
It's not necessary with Enclomiphene but some guys are not going risk it
No other precautions supplements need to be accounted for while taking enclomaphene ? and it does not need a PCT?
And should I stack this with anything to maximize muscle growth and leanness
It can be a PCT for people coming off testosterone. You need to get it prescribed from your primary care doctor, but generally there are very few contraindications here.
Would taking this ontop of trt help restore spermogenesis?
Yes, it is sometimes used for that purpose. Other medications that are used here are hCG.
@@JonasKuehneMD it will not. I’ve scoured dozens and dozens of bloodwork from guys that are taking the combination, and there is no evidence that taking a SERM with TRT maintains fertility the way HCG does. If you’ve got some examples from your own use, I would love to see them. This is kind of been my hot button issue since most clinics lost access to cheap hCG.
You should check your desmosterol levels on Clomid. They go up about 20 fold. Its artherogenic potential is huge. Almost no one mentions this. This is the reason some new HDL improving agents probably failed in testing hence increasing CVD.
The literature shows that prolonged use of climate can increase desmosterol by 10%.
It is not clear whether this also happens with enclomiphene:
“Clomifene is an inhibitor of the conversion of desmosterol into cholesterol by the enzyme 24-dehydrocholesterol reductase.[41][42] Concerns about possible induction of desmosterolosis and associated symptoms such as cataracts and ichthyosis with extended exposure precluded the use of clomifene in the treatment of breast cancer.[41][42] Continuous use of clomifene has been found to increase desmosterol levels by 10% and continuous high doses of clomifene (200 mg/day) have been reported to produce visual disturbances.”
Long term use?
No great data on long-term use and suggestions on when and for how long to take breaks. Anecdotal data shows that people have been quite successful using it every other day for three months at 6.25 or 12.5 mg and then took one month off.
I ran Enclo for 3 months it definitely boosted my T but if I have low estrogen should I not be taking it or will it also help with low estrogen?
It will increase both testosterone and estrogen.
@@JonasKuehneMD 💪
Let's not forget that this drug blocks estradiol at the receptor, and not just at the hypothalamus so prolonged use will lead to negative effects eventually.
Trust me I did clomid for 2 years, loved it for 18 months then 6months of hell, been on testosterone 8 years now and I would never consider enclomephine now, tempory would be the best I would suggest for anyone.
lm sure it's cytotoxic too so long term would not be healthy
Several people have commented that they take it every other day to allow the receptor to become unoccupied for a while. Enclomiphene does not contain zuclomiphene, so no direct estrogen agonist. This is a big difference from clomid.
Can you elaborate on this and how it works with the receptor and how it can cause problems? I believe my estrogen receptors are already damaged from taking another drug long term; I have low T and E but so many symptoms of low Estrogen. Would this be a risk to try? Clomid safer due to the zuclomiphene?
Does HCG and enclo help with primary hypogodiam?
In my opinion, it would not help with primary hypogonadism, as it requires normal testicular function to increase testosterone levels.
@@JonasKuehneMD If I have primary, then why Eid end raise my T levels? T numbers were 900-1200 but I didnt feel any better
I'm 54 and I think my test levels are ok....boners every morning and afternoon and have no typical low t symptoms however I'd like to boost for training purposes. Is there any reason not to try if your natural T levels are ok? i'd likely start out low dosing and cycling until I find the sweet spot. every other day, 2 weeks on one off to start.....any info on this method? Thanks
If your levels are currently OK, you may not have significant benefits from enclomiphene. Studies have shown that it does increase total testosterone in some cases by 100%, however, it may decrease IGF one, therefore lowering your human growth hormone.
What about trying peptides before TRT?
I am familiar with peptides that increase HGH. I’m not sure if peptides can stimulate the production of testosterone sufficiently.
@@JonasKuehneMDKisspeptin?
@@ioGLNXIgf-1, BPC157
Have you seen how long term enclomiphene use can crash GH?
Enclomiphene can decrease HGH up to 50%, and this was not dependent.
I read that taking enclomiphine every other day is better because in that case estrodial can fill its purpuse.
If we take enclomiphine every day wouldn't it block the estrogen receptors completely?
It is partially blocking. It also depends greatly on the dose used. I did read that many people use it every other day at 12.5 mg or daily at 6.25 mg. I’m not sure which method works better, but if you’re following this with your primary care doctor and can do labs routinely you can try both approaches.
@@JonasKuehneMD Thanks, will try EOD first at 12.5
Was super exited about enclomiphine but started feeling off on it. Got emotional and super tired/depressed, I’m thinking my estrogen is through the roof
@@arcx5065I bet they gave you Clomid (eg. mostly Zuclomiphene)... not Enclomiphene.
@@arcx5065what was your protocol?
I I have been on TRT for three years and just recently about a month ago started on Enclomiphene 12.5 mg a day and then bumped it up to 25 mg a day, I slowly weaned myself off of testosterone over a month and have recently started taking HCG as well, 50 IU a week split into 10 IU over a five day period. So far I feel pretty great. “ These who were prescribed for hypogonadism”
Since Enclomiphene stops the production of estrogen and has a 10 hour half-life would you recommend just taking it five days a week and taking off the weekends to allow natural estrogen production to continue?
Thank you for your comment. This looks like a good strategy. Enclomiphene not the production of estrogen, but blocks the receptor in the brain sensing the estrogen level.
“Enclomiphene works by binding to estrogen receptors in the pituitary gland.1 This action stops the negative feedback that the receptor normally creates and stimulates the production of the hormone GnRH, or gonadotropin. In turn, this hormone stimulates the production of another hormone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH).”
This will increase both the production of testosterone and estrogen. While some people are taking enclomiphene every other day, I do not think that this strategy is needed.
@@JonasKuehneMD OK so thank you so much for your response, there is always a lot to unravel and I want to know the exact science of what I’m taking down to the smallest detail. So you’re saying is if I were to take my 25 mg of Enclomiphene every day, seven days a week, it would not stop the production of estrogen, correct?
So far the mixture of Enclomiphene and HCG seems to be a good combination for natural testosterone and estrogen production.
I would like to do the same. Which clinic do you work with?
Any update ? Are you still off trt ?
@@tonehernandez8598HCG was terrible so stopped that, gave ma weight gain and severe fatigue. I’m taking the Enclomiphene 25mp every other day and slowly getting off the testosterone. I’m also taking CJC1295/ Ipamorelin and it’s amazing.
how long do you run a cycle of trt ?
As mentioned, in the video, I do not use testosterone.
im not on anything and can't get it up at all. Im 50 and feel like my testicles are half the size. Can i try this , at least to start. Everything always comes back normal at the dr
Enclomiphene citrate is by prescription, so you have to ask your primary care doctor to prescribe it for you. It can significantly increase testosterone levels, sometimes even double them.
Uh. I don't need to double. Double can be too high. Your getting this from others. Not yourself and your clients though
Does enclomiphene makes side effects in eye health?
This is a side effect, more commonly associated with clomid which contains zuclomiphene. So far, I have not seen any reports that this happens with enclomiphene.
@@JonasKuehneMD thanks 💪🙏🇵🇹
My endocrinologist didn't even discuss enclomiphine with me and put me straight onto TRT which has significantly boosted my levels. I had low FSH/LH and no pituitary issues but very low T. Is it worth me exploring enclomiphine as an alternative option or perhaps in addition to TRT on a lower dosage? 47 with 2 kids, unlikely to have more.
Enclomiphene will not give you results as dramatically as trt, but will increase FSH/LH and thereby total testosterone. It will prevent testicular atrophy and will allow you to take breaks from the medication once in a while without dramatic drops in testosterone.
My doctor wants to put me enclomiphene and clomid. Also, dhea. My estrogen was low. I wonder if thats why he wants to add the clomid, since you stated it antagagonizes it. My t was 400.
I’m wondering why he would use enclomiphene and clomid. The only difference between the two is that clomid contains enclomiphene and zuclomiphene. When testosterone production increases, estrogen levels should also increase in correlation. If your physician feels that more estrogen is needed, then why not use clomid only?
He wants your money. I would only use enclo
@@stunnaman9 The Stark Law prevents physicians from receiving any compensation from prescriptions (though some docs own the pharmacies attached to their practice, which is unethical). He's prescribing both likely because....
Where does one get Enclomiphene?
You need a prescription, but there are online pharmacies that have telemedicine physicians.
@@JonasKuehneMD Thank you Doctor
Decrease in HGH + my sleep has been horrible. I'll have to stop taking it.
A decrease in HGH has been documented and interestingly is not dose dependent. Was this an incidental finding on your labs? Has your total testosterone and free testosterone improved? Of course sleep is extremely important.
@@JonasKuehneMD Unfortunately I have not gotten my blood work done yet. I have tried enclomiphine on a separate occasion and my sleep was once again horrible. That is very interesting it is not dose dependent. My voice has gotten quite a bit deeper, which might indicate my LH has increased. As for FSH, I’m uncertain. Getting my blood work done tomorrow, will update you.
I was going to consider MK 677 maybe 1 to 2 mg. However, I’ve taken this before as well. Had such an insane increase in prolactin that I developed a thumb size amount of gynecomastia. Was doing research on cabergolin but I don’t think I’ll want to take it after seeing the side effects. I have to wait 3 months to see an endocrinologist. Do you have any tips for lowering gyno from prolactin that I’m certain is from a prolactin increase given the lactation that wouldn’t require a dopamine antagonist like cabergolin? I’ve been supplementing the usual vitamin B6 not sure if P5P is a step up but I think that is my only next option.
If I can find a way to keep the prolactin at a normal or lower level then I would love to update you consistently on my bloodwork using mk-677 with enclomiphine. I do think this can help with sleep and a continued use of enclomiphine. Of course SHBG is another thing to look at.
Anything on how to increase free T ?
Increasing total T will also increase the fraction of free T. If your SHBG is too high, then boron supplementation may help to decrease it.
I am 36 and My test is 25.60nmol and oestrogene 49 🤔🤔
That is 730ng/dL, so good in my opinion.
What are your testosterone levels?
355 ng/dl total, 50 pg/ml free.
@@JonasKuehneMD thanks for the info. Do you think it's like that due to lots of exercise or possibly diet?
@@JonasKuehneMD That's very low. Mine is around 600 and my doc would not prescribe TRT. I just wanna try it for a few months to see what it's like to have very high test.
@@ytsux9259you don’t need it
@@ytsux9259 That's not low at all. Total T doesn't matter. His free T is above range, and Free T is the actual one that matters.
Hallo
Most experts right now say the effect of testosterone is dwarfing the small effects of enclomiphene and thus , not worth the ratio $$$$/benefits . Better finding HCG or get the vet version .
Enclomiphene seems to work better than HCG to increase total T.
@@JonasKuehneMD can you use HCG + enclomiphene?
False, false. you should investigate more enclomiphane has more estrogenic side effects than clomid, on paper you can get deceived by what is supposed to do on paper but when you actually take it, you will have more estrogenic side effects than clomid.
Go on...
Enclomiphene lacks the estrogen agonist zuclomiphene and does not directly increase estrogen. It increases FSH and LH and thereby predominantly testosterone. As testosterone increases, estrogen will also increase due to a feedback loop. This increase in estrogen should be physiologically balanced.
How can you find enclomiphene? I don't think they sell it in the United States anymore
Yes, it is not available at regular pharmacies, but there are online compounding pharmacies that offer it with e-script from their physicians. One of those is Maximus tribe, even though it’s a bit too pricey in my opinion
I use Enclomiphene as my PCT and bought mine from Swisschems
@@MoeSharrif thank you very much!
@@JonasKuehneMD really appreciate it!
Can you please suggest a legit company to buy enclomiphene for people leaving outside the states
Don't think tribe serves anybody else. How to tell if the product isnot fake or could it be dangerous?
As doctor, your income should be high enough to buy glasses, not slipping down your nose all the time...
…it’s not…
@@JonasKuehneMD Watch the video carefullly: You adjusted the glasses several times. If you buy glasses from a god optican, thats not necessary.
Good and relative point there. Im so glad you shared the advice.