Melatonin Inhibition and Circadian Rhythms
HTML-код
- Опубликовано: 6 авг 2024
- In This Video we will be discussing about Melatonin inhibition and Circadian rhythms.The Circadian Rhythms are regulated by presence and absence of light, The Retina receives light and propagates it via three different cells viz Rod , Cone and Photosensitive cells to the brain , which then sends signal to different organs for a specific action.The Pineal Gland secretes Melatonin which is also called Sleeping Hormone.
I have delayed sleep phase disorder and it’s extremely disruptive to my life. I’ve tried several methods to alter my circadian clock ( light therapy, diet and exercise changes, melatonin supplements, blue light blockers, black out curtains, humidifier, snake plant and air purifier, etc) and nothing works. I’ve been able to work from home the last 3 yrs and sleep in my own rhythm, which has helped TREMENDOUSLY with not feeling exhausted and sleep deprived all day every day, but in two weeks, it’s back to the office at 8:00am, which means a 6:30 wake up, which means HELL and TORTURE for my body again. There MUST be a way to alter my melatonin production successfully 🙏
u need to listen to your body and have a week of long sleeps and visits to serene places
Have you tried diaphragmatic breathing or holding your deep breath during meditation ?
How r you doing now my friend
Easy, crisp and Cristal clear explanation ❤️
Thanks bro
Thank you so much. I really loved your explanations, was crystal clear. Thanks a lot once again.
Thanks Asma for appreciation..Glad it helps ✌️
God bless you
Easy to follow and good explanation. Thanks
thanks for appreciation
Thankyou so much beautifully explained great diagrams. X
thanks for appreciation...Glad to know that it helps ✌️
If you like ...Try this too.
ruclips.net/video/aipLGZMxQ_k/видео.html
I go to bed late after midnight, but I normally keep a regular schedule. Also sleep for 8 hours, but do you know if that has effect on growth hormone release?
Hello! I wanted to ask is it possible to increase my melatonin receptors M1 & M2 ?
Very helpful!
thanks for appreciation
Smart man
Sometimes we fall asleep for tiredness even in the daytime presence of light. what is the reason behind it ??
Hi,,Debanjan
First of all if the tiredness is Physical one then it is obvious that we are deprived of ATP molecular generation thereby Physical fatigue can be caused by a lack of energy in the muscle, by a decrease of the efficiency of the neuromuscular junction. So in order to get back to the equilibrium we rest , or even take a nap by closing our eyes so that we cut the supply of light going to the retina, thereby initiating dim-light melatonin onset.... ( like we keep sleep mask while travelling).......
While sleeping our body is at rest and consumes much less energy than our active life,.....SO rest/Sleep restores our energy currency and we get back to the work........
thank u sir for the explanation ..
thanks bro, for appreciation...
daytime doesn’t mean you are affected by daytime specially when you are in a room with closed blinds or no windows all day. Electric light can never make up to intensity of natural light and it affects on your retina.
Narcolepsy is excessive sleepiness. It can be caused by low Dopamine. Poor diet contributes to this. Hence the old saying "Breakfast is the most important meal of the day". Eating a well balanced breakfast can resolve excessive sleepiness during the day.
Very nice analysis
Thanks bro...
Hi doc , can you help me why am I not able to sleep when I am doing working out .. even if I am doing the workout in the day time early morning .
Very nice explanation.
If the IPRG cells are photosensitive and response only in the presence or absence of light, how is it that they depolirise even more with short wave-length light?
If you like ...Try this too.
ruclips.net/video/aipLGZMxQ_k/видео.html
Nice explanation sir thanku 😊
Thanks Neha for appreciation.....
Thankyou soo muchh
most wlcm
Thanks for the video, where did you get the bibliography from the video? i´ll be pleased you to give me more info about that
Thanks for appreciation..Glad to know that it helps....
Lodish Molecular Biology.
and NCBI
Phenomenal, perhaps this is why the ancient mystics were practicing in caves.
Nice
is there any medications for cure insomia. i am suffering from it for last 2 years.
please any one help me.
Fantastic.A very short clip but i dont find any hesitancy to say that its quite helpful in learning about pneal gland.DR RIZVI
Sir ,thanks for appreciation
Where is your video related to superchaismaic nucleus cell signalling ? I couldn’t find
I think i have skipped off from my mind.. ( the then i thought i had made that video ) apologies.....
Will be making that video soon
Very nice video! The only thing i don`t understand is, if the SCN is the master clock itsself, why is it still sensitive to melatonin?
Would highly appreaciate an answer!
First of all thanks for appreciation....
Now coming to the question ..
The Melatonin acts as a Messenger to let the SCN know what is going on and for that SCN has MT1 receptors which receive the Hormone and confer the signal.
I hope this makes some sense bcz i am not very specific for this answer😉😉
Hussain Biology Sure. But the strange thing is that the SCN wouldnt need melatonin, since it has the input from the ganglion cells already, thus it knows whether it is day or night without melatonin (other than the rest of the oscillators, which dont have light-input). You know what I mean? Somehow that is answered nowhere on ncbi :/ thats why im hoping you can help me
Thanks Julius for letting me know .
Really i never ponder upon it and now i will also research on that .
You know we are always in a learning phase and i am very thankful to you for getting into it.
Hussain Biology Yes absolutely, and im really thankful for you putting in the effort of creating these videos. And please let me know if you find out something regarding the question!
Surely i will let you know if i find anything or you let me know if you find anything .....Right
shukran aqii
thanks Adna for appreciation
but why we can sleep during day when we are even not closing eye
why i am worried and have anxiety at day time but as sunset it disappers, please tell me, i am suffering from this 😭
Could be the blunt ... but I understood absolutely everything you said. Namaste 👁
But I have a very curious question. What effect on the body would the sunlight have? Looking it directly at it ?
Definitely it will hurt ur eyes ( like light sensitive cells ).
Looking directly will always create an involuntary reflex within you which will take out ur sight directing sun.
Hussain Biology I’ve learned to use my circadian clock ... sun resets it .
@@fatpanda8884 that is great way of regulating ur body
Hussain Biology namaste 🙌🏼💆🏻♂️👁
If you like ...Try this too.
ruclips.net/video/aipLGZMxQ_k/видео.html
love u sir
Thank You Aaqib, for ur love and support
Very useful sir
thanks for appreciation
1:06 three different types of photosensitive cells in Retina of Eye
What if microwaves are present or unseen light in the spectrum.
It has been experimentally shown that the presence of electromagnetic waves disrupts the normal functioning of brain particularly the sleep cycles.But it has not been directly linked to Circadian rhythms.
As per the NCBI article ( link given below ) the presence of EMF has disrupted the Pineal Functioning .
The pineal gland is likely to sense EMFs as light but, as a consequence, may decrease the melatonin production.
Rest you can follow the article in the given link
www.ncbi.nlm.nih.gov/pubmed/23051584
I hope it helps
I appreciate the quick response. Thank you very much.
I was also kind of wondering what types of chemicals that effect the red blood cell could be associated with exothermic reactions. If any.
I would have replied , the time u commented but i was not home that time .
Thanks Charles I appreciate ur support for a small channel ...
@@hussainbiology I checked the abstract of that article. So, how much EMF would disrupt our melatonin secretion? Does using my cellphone at night to talk would disrupt it? or the EMF produced by the electric circuits where I live?
Melatonin hormone decrease level during sleeping time snoring will happen?
If you like ...Try this too.
ruclips.net/video/aipLGZMxQ_k/видео.html
3:03 inhibition of endocrine functions of Pineal Gland
2:30
2:54 light depolarizes IPRG cells in Retina
ok can the circadian rhythm be corrected , especially for persons on the Autism Spectrum?
Avoid artificial lights and maintain constant sleeping time ( 8 hours approx )
U know. Early to rise , early to bed makes a man healthy wealthy and wise.✌️
@@hussainbiology can I use 5-HTP and GABA for a.family member on the spectrum that doesn't sleep at night . But sleeps during the day ?
That is some sort of medical advisory which i can't advice.
Better to consult Doc.😊
@@hussainbiology ok, will consult him on Monday.
What if one doesnt have a pineal gland? How then is he able to sleep? Such is the case for myself. I had a brain tumor on my pineal gland that was removed a year ago, and with that the gland itself was removed. How do you explain how i'm still able to sleep?
If you like ...Try this too.
ruclips.net/video/aipLGZMxQ_k/видео.html
0:50 pathway and interaction
P A Z & A M O R ❤️
0:26 external sources which impact the Circadian Rhythms
thanks for timelines
How to cure?
If you like ...Try this too.
ruclips.net/video/aipLGZMxQ_k/видео.html
Wear computer glass to prevent blue light at night
4:40 Mobile phone Blue light stops release of MELATONIN
U forgot attach links ?
If you like ...Try this too.
ruclips.net/video/aipLGZMxQ_k/видео.html
3:43 CAS
2:09 Circadian clock in Blind persons