I am a bit worried that these glycan clocks correlate so strongly with hormones, generally not known to be causally involved in aging*, and rather weakly with healthy dietary patterns, a better candidate to actually modulate intrinsic aging. Nevertheless it is good to have these. Now we just need head to head benchmarks and validation of the different clocks on prospective cohorts and longevity trials like e.g. TAME. *see the eternal failure of testosterone and estrogen supplementation to do anything useful when tested in rigorous studies
There was a recent independant study of several different omics clocks (including the glycan clock) within the same cohort of people published in aging (Erin Mcdonald-Dunlop et al, Aging, 2022). Menopause is a key inflection point for aging and diseases in women, where multiple body system experience rapid decline, example metabolism (Kate Bermingham et al, preprints with The Lancet, 2022). 17-a-estradiol introduced late in life extends lifespan in mice by 19% (David E. Harrison et al, Aging Cell, 2022).
Every time I see those monkeys in the CR experiment I am enraged that they were kept isolated in small cages their entire lives. no social interaction. No sun and wind and tress. Brutal and totally unnecessary.
Totally agree that better animal husbandry was called for. However, the studies of primate caloric restriction themselves were important. In fact, I would rank them among the most important studies performed in the history of mankind. We need hard evidence that lifespan extension is possible and plausible in humans and primates are a great model for this.
Thank you for this wonderful sharing. I love the opening music, it makes me happy. Can you please share the name of the song? Thank you.
"Happy Place" by the complete fiction featuring phoebe scott
I too love the music. Thank you for the question. ☺️
@@agingresearch960 thank you so much. It will be in my play list on replay every morning when I do my morning exercises! 😁
I am a bit worried that these glycan clocks correlate so strongly with hormones, generally not known to be causally involved in aging*, and rather weakly with healthy dietary patterns, a better candidate to actually modulate intrinsic aging. Nevertheless it is good to have these. Now we just need head to head benchmarks and validation of the different clocks on prospective cohorts and longevity trials like e.g. TAME.
*see the eternal failure of testosterone and estrogen supplementation to do anything useful when tested in rigorous studies
There was a recent independant study of several different omics clocks (including the glycan clock) within the same cohort of people published in aging (Erin Mcdonald-Dunlop et al, Aging, 2022). Menopause is a key inflection point for aging and diseases in women, where multiple body system experience rapid decline, example metabolism (Kate Bermingham et al, preprints with The Lancet, 2022). 17-a-estradiol introduced late in life extends lifespan in mice by 19% (David E. Harrison et al, Aging Cell, 2022).
Great lecture!
Every time I see those monkeys in the CR experiment I am enraged that they were kept isolated in small cages their entire lives. no social interaction. No sun and wind and tress. Brutal and totally unnecessary.
Totally agree that better animal husbandry was called for. However, the studies of primate caloric restriction themselves were important. In fact, I would rank them among the most important studies performed in the history of mankind. We need hard evidence that lifespan extension is possible and plausible in humans and primates are a great model for this.
Little technical