I had a hard time understanding the process of synthesis and metabolism but this guy saved my life. Clear, easy and fun. Best educational video. Please stay in the educational field. Also, gentle people? you're amazing.
my mind is blown. As a student from India I thank you for explaining these concepts so elegantly. Our current education system is corrupted as the intent is not about understanding but memorizing large words due to the pressure of scoring grades. We have so much to learn from how the way you teach
Thank you sir, you have made Pharmacology much more easier and understandable. I watched your videos before an exam and i got 95%!!!!!!!!! You're GREAT
This is so crucial for people with MTHFR / Methylation issues (which are often downplayed as "quackery") because without proper synthesis of choline from phosphatidylcholine, there will always be a lack of choline to support ACh synthesis. I have C677T ++ but also an impaired PEMT gene, and whilst MTHFR led me down a path of "Methylfolate is everything" I came to realise that Choline support is huge - especially in my case. So it would appear for me that taking Alpha GPC would bypass the impaired PEMT gene and better support my ACh synthesis, as choline supplements apparently do not cross the BBB as well and phosphatidylcholine requires synthesis (via PEMT) so that's also a no-go (stuck coins in your gumball machine - or rather, lack of coins to begin with! 🤣) I've only been studying this for 8 months with no medical/scientific background, but have so far "cured" my migraines (not 1 after suffering daily for 20yrs) and am now focusing on ADD/ADHD. Great video.
Excessive accumulation of acetylcholine (ACh) at the neuromuscular junctions and synapses causes symptoms of both muscarinic and nicotinic toxicity. These include cramps, increased salivation, lacrimation, muscular weakness, paralysis, muscular fasciculation, diarrhea, and blurry vision👍
Thanks for your comment ... i am kicking myself that i did not include the mnemonic DUMBBELSS that i usually use to describe symptoms of AChE inhibitor poisoning: Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of muscle and CNS, Lacrimation, Salivation and Sweating.
Several of these symptoms include excess fluid/mucous production therefore I am guessing that a runny nose might also be a symptom. What about sensitivity to light, is that a symptom?
It does not cure the hyperhydrosis because the body eventually creates more SNARE protein complexes so the nerves release ACh again ... maybe 4-6 months. Then another injection would be recommended.
There are drugs that block acetylcholine to stop sweating. But I wonder if this affects on building muscle & performance. I noticed my muscles have gotten weaker since taking an anticholinergic. Is there a point to even trying to build muscle when acetylcholine is blocked?
You are the definition of a high quality teacher. I hope to be able to teach students the way you do. Please never stop making videos you’re a blessing. Currently a resident doctor in the UK and these videos are helping me with my training.🙏🏽🙏🏽🙏🏽
I was on a low dose anti-cholinergic anti-depressant called clomipramine for 4 years. Now I am off it...to what extent has it negatively impacted my memory...will my memory rebound?
Hi, i got a question, by the way excellent videos, Acetyl CoA can go outside the mitochondria directly or it must be converted to citrate first and then can go out of the mitochondria?
I like the word ching😂😂😂😂
That’s my favorite part 😂
SHINGGGGGG!!!
I also 🤣🤣🤣
I had a hard time understanding the process of synthesis and metabolism but this guy saved my life. Clear, easy and fun. Best educational video. Please stay in the educational field. Also, gentle people? you're amazing.
Glad it helped!
my mind is blown. As a student from India I thank you for explaining these concepts so elegantly. Our current education system is corrupted as the intent is not about understanding but memorizing large words due to the pressure of scoring grades. We have so much to learn from how the way you teach
We're all gonna make it brah
Thank you sir, you have made Pharmacology much more easier and understandable. I watched your videos before an exam and i got 95%!!!!!!!!! You're GREAT
What a teacher! the best so far. made it very simple and objective. congrats!
This is so crucial for people with MTHFR / Methylation issues (which are often downplayed as "quackery") because without proper synthesis of choline from phosphatidylcholine, there will always be a lack of choline to support ACh synthesis. I have C677T ++ but also an impaired PEMT gene, and whilst MTHFR led me down a path of "Methylfolate is everything" I came to realise that Choline support is huge - especially in my case. So it would appear for me that taking Alpha GPC would bypass the impaired PEMT gene and better support my ACh synthesis, as choline supplements apparently do not cross the BBB as well and phosphatidylcholine requires synthesis (via PEMT) so that's also a no-go (stuck coins in your gumball machine - or rather, lack of coins to begin with! 🤣) I've only been studying this for 8 months with no medical/scientific background, but have so far "cured" my migraines (not 1 after suffering daily for 20yrs) and am now focusing on ADD/ADHD. Great video.
He's back!!!! We've missed you! Hope you and your loved ones are safe! Will always cheer for your amazing work!
Thank-you :)
The noted anatomist! 😍
Thanks Leo!
Mr Handy Anatomist,your lectures are enjoyable and you make them easy to understand,thanks
Thnkuhhhhj ❤❤❤❤❤ plz aur topic per bhi bnaye ... Its really worked
I mean all respects for Walter white but YOUR THE DANGER 😂🔥
Organophosphates are insecticides, not fertilizers. They have a similar effect on insects to that of nerve gas on humans.
Best video abt cholinergic avlbl on yt 👍👌👌
How I understood this as compared to what I was taught by my prof
Thank you sir
Finally legend is back😁
Excessive accumulation of acetylcholine (ACh) at the neuromuscular junctions and synapses causes symptoms of both muscarinic and nicotinic toxicity. These include cramps, increased salivation, lacrimation, muscular weakness, paralysis, muscular fasciculation, diarrhea, and blurry vision👍
supposedly it would make moving your eyes harder, right?
Thanks for your comment ... i am kicking myself that i did not include the mnemonic DUMBBELSS that i usually use to describe symptoms of AChE inhibitor poisoning: Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of muscle and CNS, Lacrimation, Salivation and Sweating.
What are the symptoms of low ACh
@@jimmythedog2882 look into autonomic dysfunctional illnesses, like POTS.
Several of these symptoms include excess fluid/mucous production therefore I am guessing that a runny nose might also be a symptom. What about sensitivity to light, is that a symptom?
The best parts were every time he said "SHINGGGG"
voice is very similar to Sal Khan, I thought it was him for a sec haha. Thank you Dr. Morton for your videos. Helps a lot.
yes I was adamant that it was Sal from Khan academy!!!!!!!!!!
This simplified this concept so well! I’m glad I found this video. Great job teaching!
Glad it was helpful!
Thank you very much for your meaningfull vidios
Your voice is like Khan Academy hehe
Shiii...ng 😊
Thumbs up my friends 😇😅
Thank you, sir and fuck nervous system
Thank you❤
you are best.may allah gives you more and more
Omg this is simplified, thank you
Sooooooooooooooo GOOOOOD
Thanks doctor
❤❤
Very great
Great presentation! Thank you
Great Emma reference! Thank you for this - I've been struggling to understand for my anatomy class and this has clarified a lot for me. Well done!
Very beautifully explained and demonstrated. Just love it.
- a Veterinary Student from India.
Thank you very much!
Jesus bless you. Thank you!
Does botox completely cure hyperhydrosis
It does not cure the hyperhydrosis because the body eventually creates more SNARE protein complexes so the nerves release ACh again ... maybe 4-6 months. Then another injection would be recommended.
@@TheNotedAnatomist oh men i wish it did but anyway love your explanation keep up the good work.
Thanks allot 😌 dear sir
Where can i learn these things?
Superb presentation! Thank you!
Thank you too!
Am a student from Uganda,I like uo presentation,they are soo touching and easily understandable
This video has made my concept crystal clear. thanks!
love your lectures!
There are drugs that block acetylcholine to stop sweating. But I wonder if this affects on building muscle & performance. I noticed my muscles have gotten weaker since taking an anticholinergic. Is there a point to even trying to build muscle when acetylcholine is blocked?
Thank you so much this was so helpful!
Glad it was helpful!
I love you Man❤️
You are the definition of a high quality teacher. I hope to be able to teach students the way you do. Please never stop making videos you’re a blessing. Currently a resident doctor in the UK and these videos are helping me with my training.🙏🏽🙏🏽🙏🏽
Wow, thank you!
Very well explained cleared all my doubts actually I didn't actually got a chance to have one👏🏻
Thank you so much for this wonderful explanation of such complicated topic!!!
Thank you much. This was so helpful
Glad it was helpful!
❤❤❤
ching😂😂😂
You make really good videos keep it up
I appreciate it!
can you please do pharmacology-based videos glad I found your channel ❤
Shing~~⚔️
Up
are you also The Thought Emporium guy? wtf, your voice is exactly the same as his
Great
Amazing! 👏
a 2 hour lecture is explanied in14 mins thx a lot doc
This helped me so much! Great discussion
oh you just ease me of my stress, thank you so much and God bless you
This one video taught me more than a 2-hour lecture about ACh.
I want the pdf or PowerPoint and thank you so much 😊
I want the pdf or PowerPoint and thank you so much 😊
Why you didnt tell you need B1
Vitamin for synthesis
This helped me so much. Thanks a lot❤❤
Amazing! Fantastic! Incredible! Astonishing! Mighty! Better than most of Marvel's superhero movies!
The clinical correlates are very helpful
I was on a low dose anti-cholinergic anti-depressant called clomipramine for 4 years. Now I am off it...to what extent has it negatively impacted my memory...will my memory rebound?
Thank you sir ....
Most welcome
Excellent lecture 👌
Thanks a lot
Beautiful!!!❤
Thank you! 😊
THANK YOU SO MUCH
You're welcome!
Great explanation!! Super helpful 😃
Please can acetylcholine be extracted from the neuron or nerve fibre of an animal when they are synthesized?
Love your work Sir.
Are you on social media? (FB, Snapchat, Insta)
Kind of ... i have an instagram and FB account but have not done much with them yet. I plan on doing more this month.
@@TheNotedAnatomist kindly share your username(s)
Would love to join you, and follow you there too, would be such an honour.
Hi, i got a question, by the way excellent videos, Acetyl CoA can go outside the mitochondria directly or it must be converted to citrate first and then can go out of the mitochondria?
amazing to say the least
King
...Blush:)
Good
Thanks
Richard.. is that you?
Missed your videos sir.
One of concept based teaching 🎉🎉🎉
Thank you
It's my pleasure
THANK YOU!!!!
thank you
Soo awesome 👌🏻
Your videos are fantastic! Really helping me to consolidate the info for my psychopharmacology course! Thank you!
Thank u so much..❤❤❤❤
💚💚💚
You. Are. The. Best.
Aglae Row
amazing video. THANK YOU
thank you ❤
Ching
Excellent video thank you so much!!
you are going to rock the field of pharmacology too.
Nicely done 👍
Many Thanks 👍
Just what I needed.. Thanks a bunch.
Thank you Dr Morton!
You're most welcome!
Ziiiiiing! Love it!
Yay! Thank you!
Great explanation! Thank you, keep it up!
You are a life saver thank you ❤️
Best ever explained