Why aPTT is used to monitor unfractionated heparin (UFH) not LMWH (low molecular weight heparin)

Why aPTT is used to monitor unfractionated heparin (UFH) not LMWH (low molecular weight heparin)
This question was asked by one of the ‪@TheICUChannel‬ member

[@lokesh20000]

I had this question for so long!. thank you!

[@TheICUChannel]

Glad it was helpful!

[@siddeshwarshinde6730]

Sir,
if possible please take a lecture on antibiotics dosing in sepsis, septic shock with AKI and in patients with CKD +/- hemodialysis , the necessary dose modifications especially nehrotoxic drugs. Thank you.

[@MegaPyrrhus]

That is very nicely explained, Sir. Thank you.

[@adityab10]

Beautifully explained in a simplest possible way sir.. thanks Ankur sir

[@TheICUChannel]

Thank u

[@RameshNagarajanDr]

Very good sir.. thanks

[@GurpreetKaur-ow2mb]

Really good video

[@luckyjaiswal4190]

Your way of explaining quite simple n understanding
Thanku sir for explaining lots of important things

[@TheICUChannel]

Thanks and welcome

[@sameerpatel6820]

​im not clear still my concern is if we block factor 10 meaning we will block thrombin and its ability to enhance the intrinsic pathway so then both drugs should require monitoring OR are we sayin that the extrinsic pathway generates thrombin which then enhances intrinsic pathway so the anticoagulant effect is mild then unfractionated

[@arkaprabhachakraborty5301]

Beautiful explanation. Thank you very much.

[@Sickdude420]

Legendary video.

[@TheICUChannel]

Thank u

[@chinmayakumarsahoo3192]

Sir, plz explain the importance of lactic acid in ABG , and its interpretation.

[@Drtk2021]

Thank you sir for clearing the concept

[@TheICUChannel]

You are most welcome

[@hemantpatel1118]

Sir, factor 13 is fibrin stabilizer and if I remember correct factor VIII is associated with VWF

[@drpankajbhutada2818]

Very nice explanation sir thanks

[@TheICUChannel]

Thanks and welcome

[@dr_karpagaraj]

Thanks for this Simplified concept!

[@TheICUChannel]

thank you, glad to hear it was helpful

[@paridhigupta3639]

Sir , but indirectly x is blocked by lmwh and it also blocks thrombin indirectly ... So why can't we measure aptt for lmwh? Regards

[@TheICUChannel]

I have answered that only … view once again .

[@chandrahaspatidar3273]

Very well explained sir

[@TheICUChannel]

Thanks and welcome

[@drasadmasood572]

Sir you are a legend. Thank you very much. Love from Pakistan

[@hemabhuriya4350]

Nicely explained sir

[@TheICUChannel]

Thanks and welcome

[@YouNeedToKnowsidovative]

Fantastic explanation sir🙏🏻

[@TheICUChannel]

Thanks and welcome

[@cookwithgarimasangwan8196]

Sir plz tell how to monitor/watch appt further , during iv heparinisation levels , when to stop over heaprin

[@3.0minutetipsandtricks.33]

thanks,sir.
love from u.k

[@TheICUChannel]

Thanks and welcome from India.

[@sigmawalin5732]

Wonderful!!

[@sohailsarwar881]

I have crude heparin sodium extracted from sheep intestinal mocusa in hands, I want to know its calculation international units /mg, how to do this test

[@kamildurre3133]

sir then why only pt in case of warfarin why not aptt even warfarin also block factor 2,10and 9 that is factor of comon and itrinsic pathway respectively

[@sahanaveeraraghavan6460]

Please post a video on anticoagulants and it's reversal agents sir

[@pankajpandey4584]

Boss will u please a video on dyselectrolemia and approach and management

[@tomcruise9317]

Also why pt for warfarin as 3,7 9,10 are inhibited 3,7 seen in extrinx path way and 9 seen in intrinsic pathway so both pt,aptt are prolonged .why we use specifically pt for warfarin

[@DR.SP.]

Thank you sir,helpful😊

[@TheICUChannel]

Welcome 😊

[@renishlakhani4279]

What happens to pao2/po2 in anemia sir.
Can you teach us this concept.!?

[@GauravSharma-lx9rb]

Sir factor x block ho jaega to thrombin formation bhi to affect hoga

[@dr.pradhyumnkumarmehrania7057]

Sir, kindly explain why Von willebrand disease leads to increase in both bleeding time and clotting time?

[@TheICUChannel]

noted.

[@heisenbergdalton332]

wow

[@learnwithveer]

Thank u sir🙏🏽

[@TheICUChannel]

Most welcome

[@saranraj186]

Sir, please explain about mixing studies

[@kabiratahmir1279]

Sir please make a video on sedative paralysing agent use in icu
Please.......from Pakistan 🇵🇰 ♥️

[@drkapilpianist2792]

Thank you!!

[@TheICUChannel]

Welcome!

[@rajsingh-kt4qc]

Sir please make video on RRT
Details
Plz sir

[@nehasrivastava5801]

Thank u sir

[@TheICUChannel]

Welcome

[@yogeshwartikle2805]

Thanks sir

[@TheICUChannel]

Welcome

[@m.usmanriaz986]

When we heparinized the patient like in NSTEMI wat level of aptt we should maintained?

[@chineduekwueme1837]

Thank you

[@TheICUChannel]

Welcome!

[@saranraj186]

Sir please explain about mixing studies

[@drimranshah8005]

Sir please also explain heparin warfarin brigde usage

[@danieldykes3147]

It is because warfarin inhibits protein C (a thrombolytic factor), and so can cause a paradoxical hypercoaguable state, until the clotting factors can be adequately inhibited, therefore heparin is used intermittently to "bridge" this problem.

[@reshamgajbhiye5377]

Sir plz tell about lactic acid or lactat in abg

[@keyurshah2924]

Thank you sir , nicely explained 😊

[@TheICUChannel]

Most welcome

[@tomcruise9317]

Sir so we cant monitor lmwh as both pt aptt will be prolonged but if we use uf heparin pt will also be prolonged as commen pathway trombin is inhibited so aptt will be more prolonged that pt is this is what you are saying

[@TheICUChannel]

Read this for more clarity .
www.sciencedirect.com/topics/nursing-and-health-professions/activated-partial-thromboplastin-time#:~:text=However%2C%20APTT%20is%20the%20test,coagulation%20factors%20this%20drug%20targets.

[@gasmno6507]

If that how we can observe LMWH proper dose ?

[@TheICUChannel]

its actually not required or recommended for LMWH

[@drpankajbhutada2818]

Very nice explanation sir thanks