The Role of BRCA1 in Cancer

BRCA1 is an integral protein in the DNA repair pathway. Inherited alterations in the structure of BRCA1 cause interruption of the DNA repair process, which over time, lead to accumulation of more and more DNA damage in cells. This greatly increases the risk for cancer. Women afflicted with these inherited changes in BRCA1 face a lifetime of constant surveillance and medical intervention to fight the possibility of cancer developing. At the Peter MacCallum Cancer Centre, we are at the forefront of research into the myriad mechanisms causing cancer. We also provide the world's best cancer diagnostics, care, medical advice and management and psychological support.

[@sophiecorline7153]

the sound edit makes this process even more intriguing

[@from_my_perspective]

I have been studying molecular dynamics simulation. This video shows very realistic movements and binding motions. Thank you for your amazing visualization.

[@from_my_perspective]

Could you tell me what softwares are used to make this video?? such as Blender?

[@majadivjak4538]

Thank you so much, that means a lot to me!

[@majadivjak4538]

@@from_my_perspective Sure, the software used is Autodesk Maya and the structures are animated with nCloth. Compositing is done in After Effects,

[@miriamart9712]

My child's Homework brought me here. Very interesting information.

[@majadivjak4538]

Glad you found it useful

[@lisa-rouletlawfirm9307]

Wow, thanks for sharing this!!! Exceptional explanation!

[@majadivjak4538]

Thank you!

[@mokshaanyadav107]

Excellent

[@thasiyanamweso1575]

Please make more videos on gene mutation

[@TTBOn00bKiLleR]

so, couldn't brca1 and brca2 be extracted from an individual at birth, since at least one pair would not be mutated, usually, (thus useful for DNA repairs), then decoded, assembled, incapsulated in some lipid nanoparticle or whatever and shot back into the body at specific intervals to preserve the critical mass of such genes in order to be able to fight back mutated cells?

[@jaskay1309]

Tell me you haven't studied biochemistry without telling me you haven't studied biochemistry.

[@fa5110]

@@jaskay1309 tell me u think highly of urself without telling me u think highly of urself. it was a curious suggestion and the tone of ur response was not needed

[@simomis4]

it's not that easy. you can't randomly transfer BRCA genes in the genome (remember that you need only one cell to have BRCA mutated to get cancer) because there are specific regions where BRCA is located. Also, not everything you put on blood gets to all the cells. Think about the epidermis, which is not vascularized, and gets nutrients by diffusion.

[@user-hr4jo2eu2b]

Have a goodnight production volunteer 😊

[@mattycohen832]

The DNA looks so tasty