Mechanisms of DNA Damage and Repair

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  • Опубликовано: 15 янв 2025

Комментарии • 274

  • @maria1239876
    @maria1239876 3 года назад +271

    I like the preschool vibes i get from the background while I'm learning stuff in my junior year of college :D it makes me feel all warm and fuzzy.

    • @naturegirl1999
      @naturegirl1999 3 года назад +11

      Imagine how smart preschoolers would be by watching this

    • @noblevenom2858
      @noblevenom2858 Год назад

      @@naturegirl1999nah preschoolers are pretty dumb. They can’t do shit

    • @dr.bibaswan
      @dr.bibaswan 8 месяцев назад +4

      Correct.
      We are all little kids deep inside.
      Our official age may be 20 - 30 but we love the vibes of age 2-3 😇

  • @ComandaKronikk
    @ComandaKronikk 6 лет назад +135

    Dude thanks for getting directly to the point and not fluffing about like so many other youtube videos. U just feed me facts that I CRAVE!!! Professor Dave 4 prime minister 2019

    • @Youssef-zo3ls
      @Youssef-zo3ls 6 лет назад +2

      Paris Coroneos exactly! He gets directly to the point

  • @personalacc4352
    @personalacc4352 7 лет назад +295

    "Now that we are sufficiently terrified of genetic mutations" 😂

  • @BishoujoMegami
    @BishoujoMegami 3 года назад +131

    Professor Dave, I'm still using your videos at Uni😂 They are so helpful. My genetics lectures are really confusing so far but this is helping consolidate my understanding. Genetics was always my week point in biology🙏🏾

    • @alaazein7147
      @alaazein7147 3 года назад +4

      Me too

    • @geetugupta7244
      @geetugupta7244 2 года назад +2

      I don't even have to take biology next year, but I'm forced to learn it this year ...stupid school rules...😭😭

    • @hamzazaqut1315
      @hamzazaqut1315 Год назад +4

      It seems spelling is your “week” point too.

    • @BishoujoMegami
      @BishoujoMegami Год назад

      @hamzazaqut1315 omg, you need to quit your day job and become a stand up comic... you'd be a millionaire...

    • @Eagles883
      @Eagles883 7 месяцев назад

      @@hamzazaqut1315you’re harsh, I was thinking to myself “I’m not going to correct it.”

  • @EpicSelenium34
    @EpicSelenium34 7 лет назад +14

    Thank you professor...another fabulous video. I like how you go deep down into the molecular structures of the mutant amino acids and the pyrimidine dimers (and other such things) instead of just glossing over them. Getting to the chemistry at the heart of what we observe makes the learning experience so much more intuitive!

  • @MrLaTEchno
    @MrLaTEchno 5 лет назад +5

    For a layman like me this series is fairly easy to follow and understand.
    I am therefore very grateful and hope to be able to use your work here on Y-T a lot.
    Greetzzz from Holland [sorry for my bad grammar]

  • @mirarizqah
    @mirarizqah 8 лет назад +29

    This video is great. easy to understand and have a very clear explanation! I love it

  • @VinodGupta-hj8hu
    @VinodGupta-hj8hu 10 месяцев назад

    thank you, Professor Dave your explanations make me learn more. Thank you for producing this videos.

  • @napojusticeramothokoane5536
    @napojusticeramothokoane5536 4 года назад +9

    Thank you Prof. um thinking, I may as well stop paying my school fees and start paying R5.00 per month for joining your channel, this feels great

  • @samlynn7681
    @samlynn7681 Год назад

    Thank you so much! I couldn't understand mismatch or NER for the life of me for the entire semester. I really needed this explanation for my exam tomorrow!!

  • @ravikumarkommareddy3723
    @ravikumarkommareddy3723 7 лет назад +8

    Easy to understand and informative. Thank you very much. Great job

  • @iluvbeef11
    @iluvbeef11 6 лет назад +11

    hey professor dave. great video! your graphics really illustrate concepts that I've been struggling to grasp since high school. this is honestly the best explanation of mutations I've ever seen. I do have one thing I wanna clarify tho. so in the frame shift mutations, it was one whole base pair that you had deleted. let's say you showed an insertion. would it be an insertion of a whole base pair? or could you have an insertion of a nucleotide on one strand but not on the other strand opposite to that added nucleotide? let me know if my question is confusing lol I'd be happy to rephrase it as best as I can

    • @ProfessorDaveExplains
      @ProfessorDaveExplains  6 лет назад +4

      ooh that's a good question! you know i'm not too sure, i'll have to look into that

    • @iluvbeef11
      @iluvbeef11 6 лет назад +4

      @@ProfessorDaveExplains awesome, lemme know when ya know! and thanks again for the great vids

  • @furkaan346
    @furkaan346 5 лет назад +47

    Dave, I suggest you first present a summarized outline using a flowchart classifying different mutations and its subtypes. This way it'll be easier to grasp and make notes at the same time. I suggest you apply it to other videos too

  • @yikotao
    @yikotao 8 лет назад +74

    He knows all about science stuff and he is professor dave explains. This song is like gangnam style. I only watched several videos and start singing when I was cooking my dinner!

    • @tomservo5007
      @tomservo5007 6 лет назад +11

      cooking and singing will increase dna mutations. good luck.

    • @jwh5505
      @jwh5505 5 лет назад

      just keep on cooking

    • @thebigtricky9156
      @thebigtricky9156 4 года назад

      Overtly, I find it annoying, but each to their own.

  • @clent444
    @clent444 3 месяца назад +1

    your videos are so clear and easy to understand. Thank you so much 🙏 😊

  • @MyMorghy
    @MyMorghy 6 лет назад +5

    Thank you so much Professor Dave I have an exam of Genetics this Tuesday and you have explained me about half of the themes of the exam in 11 minutes. Fantastic

  • @nesrineemira6381
    @nesrineemira6381 4 года назад +1

    sir u are a life saver..and that intro sends ...

  • @alwaysambitious
    @alwaysambitious 7 лет назад +3

    I love how clearly you talk! great Videos

  • @renkei7596
    @renkei7596 4 года назад +7

    Love your videos to sum up what i learned in biochem :) But could you do a video about molecular cloning and PCR?

  • @Surgtari
    @Surgtari 8 лет назад +47

    thank you jesu.. I mean prof. Dave this was beyond mind blowing

  • @e.c.2215
    @e.c.2215 5 лет назад +7

    Thank you for all your tutorials! From Chemistry to Bio they all have the exact content that I need.

  • @reemsjourney9070
    @reemsjourney9070 4 года назад +3

    Thank you prof Dave, you made me survive my journey in premed 🙏❤️

  • @fathimashahabudeen3477
    @fathimashahabudeen3477 4 года назад +1

    This video is great now u are my professor.. it’s easy to understand yr videos so simple and made with dedication and love 💕

  • @DanyalLaghari7
    @DanyalLaghari7 Год назад

    your videos are still being used after 7 years. Thanks

  • @henrynyirongo8761
    @henrynyirongo8761 4 года назад

    Professor Dave is one of the very few that take time to respond to the various comments😊

  • @iseegoodandbad6758
    @iseegoodandbad6758 2 года назад +1

    I love Dave so much!! The best teacher so far!!

  • @innate-videos
    @innate-videos 4 года назад +1

    Another great vid and, as always, total clarity. Thank you.

  • @christopherreed2694
    @christopherreed2694 2 года назад

    Thank you Dave for taking 🙏 the time it is appreciated much 👍

  • @lezanibrahim8327
    @lezanibrahim8327 2 года назад +1

    You saved my life by this video ,thank you

  • @breadbread8759
    @breadbread8759 3 года назад +1

    This video was tooo good! so perfect!! Thank you!!

  • @OneWithTheOcean
    @OneWithTheOcean 8 лет назад +10

    Very informative, Thank you!

    • @jwh5505
      @jwh5505 5 лет назад

      if this video is that informative to you, i recommend you not to take ap biology

  • @henrydennis2199
    @henrydennis2199 2 года назад

    @ 5:39
    Dave: Now that we are sufficiently terrified of genetic mutation....
    Me: guuuuuuyyyy!!!😂😂

  • @econguyph
    @econguyph 5 лет назад +1

    *you helped me in biochem class thank you professor I think thank you isn't enough so grateful ❤️*

  • @nileflower9181
    @nileflower9181 4 года назад +1

    you're information is very useful

  • @annestricker6917
    @annestricker6917 2 года назад

    Thanks! Great presentation, much appreciated!

  • @raqimafarhad7745
    @raqimafarhad7745 Год назад

    Very clear and concise 👍

  • @TheAnnie121
    @TheAnnie121 4 года назад +5

    ....am I the only one who ALWAYS sings the intro, even though this channel has been accompanying me since my Senior year? :D

  • @Godessa9shrek
    @Godessa9shrek 2 года назад

    "Now that we are sufficiently terrified of genetic mutations...", lol...a laugh I needed while late night studying. Thanks!

  • @GurpreetSingh-jr8kk
    @GurpreetSingh-jr8kk 8 лет назад +12

    U r fabulous professor ..... u teach better than my teachers in my tutions.... Lots of love from INDIA

  • @belgacem_mehdi
    @belgacem_mehdi 9 месяцев назад +1

    A question :
    2:27 you said if the mutation happen outside the gene it does not cause any thing
    But we know that there many gene that are regulated and activated and deactivated by portions of DNA outside the gene ( epigenic )

    • @fikadugutema556
      @fikadugutema556 6 дней назад

      Thank you Professor. Epigenetic is an external modification to the DNA that turns certain genes "ON" or "OF" without change in the sequence of DNA. That means some times It's an important scenario that should occur in our body during the early cellular differentiation. For instance, in the liver cell there is a gene coding for certain amino acid and in RBC too coding for another amino acids based on their own requirements. In the liver cell, the part of the gene coding for the amino acid required by RBC is turned off by the means of epigenetics. The same true for the gene in RBC. So Epigenic can be both good and bad.

  • @arovana82
    @arovana82 6 лет назад +2

    Very good explanation! Thank you!

  • @omaimah7366
    @omaimah7366 5 лет назад +1

    thanks.. you explain it so clearly

  • @joedart1465
    @joedart1465 4 года назад

    Nice job Dave.

  • @geraldwise335
    @geraldwise335 2 года назад

    wow amazing proff Dave

  • @roxannemacasinag761
    @roxannemacasinag761 4 года назад

    Thank you Prof! My Go To Guy! I’ve been passing my subjs, partly bc of u! And correctly answering activity sheets because of u! THANK U SO MUCH!

  • @4everanjan
    @4everanjan Год назад

    Fantastic !!! really helpful

  • @jeannensantos4296
    @jeannensantos4296 3 года назад

    brilliant. everything I needed in one video clearly explained

  • @dannyfreeman2302
    @dannyfreeman2302 Год назад

    so great this is awesome information thank you dave

  • @sciencenerd7639
    @sciencenerd7639 2 года назад

    very good information, thanks so much

  • @witty_me
    @witty_me 7 лет назад

    Thanks, Professor, for explaining it.

  • @fredcalledbygod
    @fredcalledbygod 2 года назад

    Very good teacher👌🏿👍🏿

  • @TutunChanda
    @TutunChanda 6 лет назад

    Awesome video proffessor

  • @camilasousa5853
    @camilasousa5853 3 года назад

    Thank you so much!! I was really looking for a class like this

  • @johnbates3567
    @johnbates3567 7 лет назад +1

    This is excellent Dave, thank you!

  • @themillennialpa
    @themillennialpa 4 года назад

    I love you PROFESSOR DAVE!!!

  • @jacobguenette273
    @jacobguenette273 4 года назад

    Dude I understand everything so well now. Thanks!

  • @bumblebee434
    @bumblebee434 3 года назад

    Thank you sir ❤️

  • @citysbandaid
    @citysbandaid 7 лет назад +5

    Dave thanks so much for the videos ! Your lectures are complete and easy to understand. :)

  • @joshmemarrynagdey1639
    @joshmemarrynagdey1639 2 года назад

    It's very nice helpful. Thank you

  • @maryamsediqi3625
    @maryamsediqi3625 3 года назад

    Many thanks, was great explanation.

  • @MrMagic-bl3ew
    @MrMagic-bl3ew 5 лет назад +6

    lol aced my genetics final by watching these videos... didn't go a single day to class loooool

    • @klutz3955
      @klutz3955 5 лет назад +1

      College or high school?

  • @abdullahhelal5413
    @abdullahhelal5413 5 лет назад +1

    Dave sir you r great!

  • @nikokallio8650
    @nikokallio8650 Год назад

    It´s very calming that he talks like for baby to me, after being on lectures where you have 20 seconds time for one dia while professor is speaking,,, to read and understand one dia takes 2 minutes and to listen and understand professor takes another 2 minutes which end up you learning nothing and just skip the lectures and try to find what the hell are we supposed to learn and then find how to learn it.

  • @mymonamkeess6516
    @mymonamkeess6516 6 лет назад +2

    Thanks for the wonderful explain ♡
    I loved the song at beginning ^_^

  • @TupeDavid
    @TupeDavid 5 лет назад

    This video is great. easy to understand and have a very informative.

  • @purkinje4248
    @purkinje4248 Год назад

    As a medical student, I appreciate you, sir. You're amazing. God sent u to teach us medical contents

  • @floppy8568
    @floppy8568 10 месяцев назад

    Deletion or insertion reminds me of a situation of a program
    I'm thinking of codons as instructions here
    when an opcode is read as an operand and vice versa
    In computers this gets fixed quickly since instructions aren't stored in a constant amount of bytes, could be one with "NOP" (0x00), could be 2 or even three.
    but genetic code is stored in a constant amount of nucleotides: 3, so this never gets fixed.
    Nonsense mutations gotten from that i like to think as 0xFF in the operand being read as the halt instruction

  • @yusuphajallow5646
    @yusuphajallow5646 5 лет назад +5

    thank you Professor its well explained indeed

  • @ipanemasalinas
    @ipanemasalinas 2 года назад

    ily dave 💖

  • @abidemitoluwaniosho5571
    @abidemitoluwaniosho5571 6 лет назад

    THANKS MAN, THIS WAS Helpful

  • @abdullahhelal5413
    @abdullahhelal5413 5 лет назад

    Informative video.

  • @radhikabiraj5243
    @radhikabiraj5243 4 года назад

    U r amazing sir.....lots of love from india.....ur videos boost my knowledge🤗🙏🙏

  • @maavaishno2198
    @maavaishno2198 4 года назад

    AWESOME EXPLANATION

  • @mapuliclavery9883
    @mapuliclavery9883 6 лет назад

    Very nice professor

  • @sarahward5974
    @sarahward5974 4 года назад

    Really great thank you!

  • @skynabendera7854
    @skynabendera7854 2 года назад

    Super helpful

  • @holden2966
    @holden2966 6 лет назад

    Thanks Dave

  • @RandomNooby
    @RandomNooby 4 года назад

    One of the greatest mysteries of modern science, is how does Dave have such a derpy haircut and yet manage to ooze cool from every fiber of his being?

    • @thebigtricky9156
      @thebigtricky9156 4 года назад

      Most likely his knowledge of his area of expertise and indeed the subject of the content, I think he uses that to stimulate people's interest and become and thus become charismatic.

  • @raoulfulgos8536
    @raoulfulgos8536 6 лет назад

    Nice job, would love a homologous and nonhomologous recombination video if you have it in you

  • @maschinenraum
    @maschinenraum 6 лет назад

    sunscreen is only good for preventing a serious sun burn. but beside that i do not use sun screen because it reduces the vitamin d level in the body. and with a high vitamin d level there is maybe more DNA repair going on.

  • @AR-rf9hc
    @AR-rf9hc 6 лет назад

    Thank you professor

  • @windyanissarecita
    @windyanissarecita 6 лет назад +3

    omg very helpful.. im a big fan

  • @mohammedjobarafadlallah6144
    @mohammedjobarafadlallah6144 4 года назад +3

    شرح ظريف وممتع بالتوفيق وللامام دومااا

  • @ThePhoenixstar88
    @ThePhoenixstar88 2 года назад

    He always makes me smile if he pops up while I’m scrolling by lol ☺️

  • @basmah7837
    @basmah7837 4 года назад

    Thank you so much you are a life saver😟💕💕💕

  • @Lalita_Chevaliere_108
    @Lalita_Chevaliere_108 7 лет назад +2

    Thank you, Professor! Does this mean that if you avoid sunlight, you will be healthier? Say if you just go in the morning sun for a few minutes, and then stay inside all the time? Or do we need sunlight so much that we can't avoid it, though it comes at a price?

    • @ProfessorDaveExplains
      @ProfessorDaveExplains  7 лет назад +1

      well you need some! but excessive exposure increases the risk of skin cancer certainly. sunscreen!

    • @Lalita_Chevaliere_108
      @Lalita_Chevaliere_108 7 лет назад

      Thank you! I'll remember that ;)

    • @jasonl4237
      @jasonl4237 3 года назад

      @@ProfessorDaveExplains What sunscreen type/spf should I choose? Do I need to apply sunscreen to all skin areas (face, neck, hands, arms, legs) exposed to sunlight or only the face? How long should I stay in the sun each day to be healthy? Thanks.

  • @zollingerellison1998
    @zollingerellison1998 7 лет назад +4

    thank you,professor👍

  • @sumanthsumanth6475
    @sumanthsumanth6475 8 месяцев назад

    😊 music superb sir

  • @hibird805
    @hibird805 2 года назад +2

    5:40 😂 i am

  • @prembhattarai7365
    @prembhattarai7365 2 года назад

    you're genius. thanks for saving my life

  • @whisperingsage
    @whisperingsage 5 лет назад

    One big cause of gene damage is minerals and vitamin deficiencies. Too bad he left that one out. Weston Price did work in showing vitamin A deficiencies cause lack of eye development in pigs and puppies, there are pictures of this in his free online book, Nutrition and Physical Degeneration. He also showed where soil mineral deficiencies caused double faced calves and partial absorption of a twin which showed as calves with extra limbs. He even showed where calcium and Magnesium deficient soils caused proud upright horns of an ox to gradually fall when he was moved to an area of poor soil. These are things that are preventable, by supplementation, and soil supplementation. So it's sad that more isn't done in this area as it's an easy and usually cheap fix. Dolomite has calcium and magnesium, much needed by the soil for good crop production (ideal soil needs 68% calcium and 12-20% magnesium) and limestone has calcium and 60 trace minerals (found in the soils of the centenarian cultures) (soilminerals dot com). A"simple" magnesium deficiency can cause multiple illnesses and maladies including death. William Albrecht was the father of soil minerals. He discovered this and helped this farm resolve their high mortality rate.
    Also missing was a discussion of fetal alcohol and tylenol, and smoking and any number of drugs taken in pregnancy. There is enormous chance of damage in pregnancy when ingesting these things. So easy to prevent.

  • @ProfessorFrydman
    @ProfessorFrydman 6 месяцев назад

    Hi Professor Dave! I'm an atheist from Brazil and I wonder how could such a complex mechanism exists without an inteligent mind to project this. I know the answer is very complex. Do you have any content about the origins of this part of biochemistry? It's well related to the origins of life, right?
    I just love your videos, thanks a lot for them!

  • @duolchol3262
    @duolchol3262 5 лет назад

    the greater teacher ever

  • @divyatiwari4990
    @divyatiwari4990 5 лет назад +1

    Sir please start lecture on animal physiology subject.

  • @PitzziMr
    @PitzziMr 5 лет назад

    man, you are awesome.

  • @taif.m1303
    @taif.m1303 7 лет назад

    thank you !

  • @docmaker-italy
    @docmaker-italy 6 лет назад +1

    Bravissimo, molto belli i tuoi video, thumbs up!

  • @AyushPramanik
    @AyushPramanik 6 лет назад +1

    Could you gimme the details regarding the repairing enzymes?
    I mean, not all of them.
    But the main ones.

  • @mooncrystalrose
    @mooncrystalrose 4 года назад

    Interesting!!

  • @Worldwide_info22
    @Worldwide_info22 14 дней назад

    your video starting is just so funnyy.... atleast bring asmile
    😂