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Maja Divjak
Добавлен 13 фев 2014
CAR-T Cells: Engineered Cancer Killers
The Peter MacCallum Cancer Centre is a unique Australian institution consisting of a world-leading cancer research program integrated within a world-leading cancer hospital.
Based on 25 years of research, we are the first site in Australia fully licensed to manufacture Chimeric Antigen Receptor (CAR)-T cells for treatment of blood cancers such as leukaemias and lymphomas. The process involves engineering a patient’s own T cells to express Chimeric Antigen Receptors, or CARs on the cell surface.
When the CAR-T cells are re-infused into the patient, they multiply rapidly and the CARs enable them to specifically seek and destroy cancer cells throughout the body. For some patients this has prov...
Based on 25 years of research, we are the first site in Australia fully licensed to manufacture Chimeric Antigen Receptor (CAR)-T cells for treatment of blood cancers such as leukaemias and lymphomas. The process involves engineering a patient’s own T cells to express Chimeric Antigen Receptors, or CARs on the cell surface.
When the CAR-T cells are re-infused into the patient, they multiply rapidly and the CARs enable them to specifically seek and destroy cancer cells throughout the body. For some patients this has prov...
Просмотров: 2 555
Видео
Intro to Chimeric Antigen Receptors- Trailer for CAR-T Cells: Engineered Cancer Killers'
Просмотров 4162 года назад
This animation is an introductory trailer for our soon to be released 3D animation, 'CAR-T Cells: Engineered Cancer Killers'. This production is a scientifically accurate explanation of this revolutionary new cancer treatment. The trailer gives a brief explanation of the structure of chimeric antigen receptors or 'CARs' and how these work to kill cancer cells. © Peter MacCallum Cancer Centre an...
What Goes Wrong in Cancer?
Просмотров 4,1 тыс.3 года назад
The Peter MacCallum Cancer Centre is a Melbourne institution and world leader in cancer research, treatment and diagnostics. It is Australia's only hospital solely dedicated to the overarching theme of cancer. Our award-winning Peter Mac biomedical animation reveals the invisible molecular world within our cells and how this finely tuned world can occasionally become disrupted, leading to cance...
The Role of p53 in Cancer
Просмотров 100 тыс.4 года назад
p53 is a sentinel protein recruited rapidly in response to DNA damage. p53 slides along the DNA until it finds a critical site, to which it binds. p53 then sends the message, to halt cell division until DNA is repaired, or If damage is too severe, the cell is destroyed. p53 is therefore known as the ‘guardian of the genome.’ A tiny change in p53 results in a structure that is unable to securely...
DNA Damage and Repair
Просмотров 61 тыс.4 года назад
DNA provides the blueprint to create proteins, which are the building blocks of our body. Remarkably, we are subject to vast amounts of DNA damage everyday due to environmental agents and even the byproducts of metabolism. This DNA damage can occur in a variety of different forms. Most of the time our cells do a very good job of dealing with DNA damage and have complex processes in place to rep...
The Role of KRas in Cancer
Просмотров 2,6 тыс.4 года назад
KRas is a protein that controls how often a cell divides. To do this it needs to be switched on before it can turn on cell division pathways. When no longer needed, it is then turned off. A tiny alteration in KRas leads to a protein that is always switched on. This means that the cell division pathways are also constantly switched on. In this situation, cells are more likely to multiply outside...
The Role of BRCA1 in Cancer
Просмотров 17 тыс.4 года назад
BRCA1 is an integral protein in the DNA repair pathway. Inherited alterations in the structure of BRCA1 cause interruption of the DNA repair process, which over time, lead to accumulation of more and more DNA damage in cells. This greatly increases the risk for cancer. Women afflicted with these inherited changes in BRCA1 face a lifetime of constant surveillance and medical intervention to figh...
Student Animation of Cell Division and Cell Death
Просмотров 5324 года назад
This animation was created by students of Shepparton ACE and Shelford Girls' Grammar, Melbourne and is the result of an interactive workshop led by Dr Maja Divjak at the Arts Learning Festival 2019. artslearningfestival.com.au/. Using the same 3D software used in Hollywood cinema productions, students learnt to animate the processes of cell division and cell death. Biology meets art, meets digi...
Clostridium tetani and Tetanus
Просмотров 6 тыс.7 лет назад
Note: This production has been uploaded again to improve quality. Original views totalled 259. Please view at 720p Movement of our voluntary muscles is controlled by our central nervous system. This animation describes the process of infection with Clostridium tetani and how the toxin it releases interrupts nervous control of our muscles, leading to tetanus. This loss of muscle control causes t...
The Specialised Function of the Ciliated Epithelium
Просмотров 23 тыс.8 лет назад
Please view at 720p. This animation describes the normal function of the ciliated airway epithelium. Foreign bodies we inhale, such as dust, pollen and microbes become trapped in mucous, which is brushed up and out of the airways by the waving cilia. This animation was created for the Gene Technology Access Centre, Melbourne, Australia www.gtac.edu.au
Bordetella Pertussis and Whooping Cough
Просмотров 21 тыс.8 лет назад
Please view at 720p. This animation describes the process of infection of the airways by Bordetella Pertussis, a bacterium which causes whooping cough. It specifically details how the bacterium damages ciliated airway cells, impairing normal respiratory function, leading to the severe coughing fits characteristic of whooping cough. Vaccination is vital to protect against this highly contagious ...
What a great video! It’s not that often I find out something new these days there is quite a lot of recycling. But this was new to me! Thank you.
I just visited my friend in hospital day 36 at UCLA, who has the P53 mutation and Diffuse Large B-Cell Lymphoma (DLBCL). Seeing her strength firsthand, despite her white blood cell count being at 0.9, has been incredibly inspiring. It's true what they say: the best teacher is learning from a patient. My friend is the most resilient person I know, and their journey is a powerful reminder of the strength and courage in the face of adversity.
Thank you so much for your insights it's very good of you too show people this knowledge😊
Please make more videos on gene mutation
how do you make these animations doctor? I want to learn how do it
Hi there, I use Maya software, but Blender is free and easier to learn. Take a look at this course here: blender.scidart.com/
thanks so much@@majadivjak4538
🙏🏻
Sou brasileira e tô aqui😅😢
Surely just drinking bleach would solve it? Or bringing a very bright light inside the body?
thank you for those great, clear and informative animations!
i was having a hard time understanding how did the toxin cause spasm. i'm glad I saw this video. books make things so complicated and this animation really helped me understand everything. thank you for this video
does it really make all that noise?
No, there is no sound at the molecular level. The sound effects are to punctuate the action and direct the viewer's attention; it is purely artistic license. 😊
I love the little fixing and clicking noises.
me too. they're so asmr☺
Super
Is it possible to construct P53 proteins with some sort of protection from getting controlled by the cancer cell, if yes they need to be created in a way that the immune system doesn't recognize them as an virus or bacterium
Is the sound real?
Have a goodnight production volunteer 😊
These are all the beautiful and unbelievable creations of ALLAH.
Who didn't believe in god he shoud watch any mechanism of body physiology
Fantastic video!!
That rattle! I will never imagine DNA without that sound again.
Quick two part question. How does the introduction of the spike protein impact the ability of p53 to bind to and repair or destroy damaged DNA strands? And does this have an impact on pathosis' like breast cancer?
mRNA spike protein binds p53 and other cancer suppressor genes. It is very clear and very frightening that these vaccines have several elements to cause a perfect storm in cancer development in those patients lucky enough to have avoided heart attacks, clots, strokes, autoimmune diseases and other common adverse reactions to the Covid vaccines. To advise booster vaccines, as is the current case, is no more and no less than medical incompetence; to continue to do so with the above information is medical negligence which can carry a custodial sentence. No ifs or buts any longer. All mRNA vaccines must be halted and banned now." Angus Dalgleish
That was great
Any chance we get "behind the scenes" for your awesome awesome animations?
Hi Martin, Thank you for your kind words! I'll be giving a talk at the Australian Centre for the Moving Image (ACMI) on Oct 25, if you care to join. See here: www.acmi.net.au/education/school-program-and-resources/the-intersection-of-art-and-science-using-3d-animation-to-tell-the-stories-of-biology/
@@majadivjak4538 That is amating Maja! Your animations (and animations from Drew Barry) really inspired me to do my own projects like protein visualizers / molecular dynamics sim etc ... You two guys are my bioviz heroes! Also thanks for the link to conference, I am going to attend! Keep up fantastic and aesthetic work, care, M.
Allah is great
Thanks
Instruct the cell that a new P53 is needed
Inject photolayse into the bone and cleave the TT uvc bond with different wavelength of light?
Wow what an amazing animation
I'm sorry but this video is really creepy to the point that i actually cried while watching, that was terrifying
mmmm, nerd rope
My 5 year old has been for the last year or so interested in cells and knows more about than I do which is kinda sad
Amazing amazing
How do people discover this?
This is really cool. Does this type of immunotherapy have side effects?
Yes, it can do. Please see page 22 of this PDF that we give to patients www.petermac.org/component/edocman/car-t-cell-therapy-a-guide-for-patients-carers-and-families/viewdocument/218?Itemid=0
I don't know what your thought process was for the sound that you put on this video. But you should delete every sound file that you have because that is awful. Hands down one of the worst sound I've ever heard
Great are the ways of God!
Future
DNA ku, clonning DNA beku
Wow, thanks for sharing this!!! Exceptional explanation!
Thank you!
Excellent explanation, thank you!!!
Fantastic illustrations and mind blowing science. I never imagined the DNA repair process was that complex. Thank you so much for making that video!!!! Much appreciated.
The 21st century and scientists cannot figure out how to fix this gene so that the body can kill cancer cells itself. I have this gene and I have cancer and I want to be healthy
I agree with you, so many good souls suffer from this disease, yet all over the world governments pouring money on war and going Mars instead put the money cure this bloody disease, I'm upset for that reason.
Fasting is the solution to the body promote self healing. Even at DNA level. It promotes autofagy, and can reverse any chronic disease, includind cancer. Unfortunately, the medications industry don't invest in researches about fasting, for financial reasons.
Exactly my thoughts ..
My mom has this
Everyone has the p53. It is a gene that regulates cell proliferation. This means when a cell decides what to do with its energy potential, divide or die are the options. P53 regulates this, it is a gene which is part of your DNA. It’s how your DNA knows how to function, gene is like “key” or tool for your DNA. Deregulation of this cell can change the rate at which cells are created. When functioning properly in (remember when all this gene, put some have mutations) a human body it fights cancer, and viruses. It regulated any biological process related to the cell’s ability to reproduce. As cell may choose “Apotosis” and die, because it is corrupted. A cell would understand that it’s necessary to program its own death, due to it becoming a corrupted “file” in the body. Modulating this gene is difficult because it’s not so much amount turning it “up” or “down” it’s about getting it to regulate itself consistently where cell regulation is concerned. Hope this helps, best of luck.
Wow
the quality of this production is insane. you deserve much recognition
How awesome! Are there other videos like this on all sorts of biological processes? I def hit the bell on this channel. PS, ever since the first animation like these that ever saw, about DNA copying, I still wonder how it's possible for these mere molecules or small collections of amino acids can be 'moving', or sending signals and apparently behaving independently, like the p53 protein made of just 396 amino acids. How are any of these molecules, floating around in cytoplasm, moving around or sensing anything? With no strings, no motors, it all looks like some mental force field doing everything.
wow!
Great presentation! How things are unfolding at the price front, I can just hope when in vivo gene therapy becomes available Novartis won't locck it up just to keep selling the inferior treatment.
🧬
I seen this best video so far thanks lot
Extremely well explained. I did my minor on this subject. Also your vid sound like the inside of Starcraft Zerg hive, which makes it extra cool!