My english ist not so good, so sorry, If my question was already answered im the Video: Does it mean, irp are able to bind in the 3' End and 5' End of the same RNA? So how does the irp know, of they have to bind at the 5' and or at the 3' End? Thanks a lot!
It binds to the 3 prime ends of tranferrin mRNA stabilizing it so that mRNA canbe translated easily to make more transferrin. Tranferrin amounts increase and they transfer irons inside the cell (because we are iron deficient and we want iron inside the cell). It aslo binds to the 5 prime ends of ferritin because of this binding ribosome cannot go on to bindto this mRNA so ferritin is not synthethised, (good because we are iron deficient and we dont want ferritin to take the iron and transport it to somewhere else) Keep in mind ribosomes bind to mRNA at their 5 prime ends and translates them from the 5 prime to 3 prime.
his voice tingles my brain in a good way
this still makes no sense to me but still much better than what the slides taught me!!
GREAT animation too ❤
Thank you
Thank you！
Check out the new video illustrating the role of hepcidin in the regulation of iron homeostasis - ruclips.net/video/Ub5n6q8MMqI/видео.html
Great job
My english ist not so good, so sorry, If my question was already answered im the Video:
Does it mean, irp are able to bind in the 3' End and 5' End of the same RNA? So how does the irp know, of they have to bind at the 5' and or at the 3' End?
Thanks a lot!
It binds to the 3 prime ends of tranferrin mRNA stabilizing it so that mRNA canbe translated easily to make more transferrin. Tranferrin amounts increase and they transfer irons inside the cell (because we are iron deficient and we want iron inside the cell).
It aslo binds to the 5 prime ends of ferritin because of this binding ribosome cannot go on to bindto this mRNA so ferritin is not synthethised, (good because we are iron deficient and we dont want ferritin to take the iron and transport it to somewhere else)
Keep in mind ribosomes bind to mRNA at their 5 prime ends and translates them from the 5 prime to 3 prime.