This is so far the best short video on PARPinhibitors, Would you please make an elaborate video on this topic by explaining the whole PARLyation reactions?
Dear Jukta, I wish I could answer you that question to help you. However, I am not a medical doctor, they know way better which medicine is suited in your case. What I can do is sending you this article about Rucaparib, that may answer a lot of questions to you: www.ema.europa.eu/en/medicines/human/EPAR/rubraca I wish you all the best, Jukta!
From what I know about PARPi, they actually inhibit the 2nd option in case of HRD (homologous repair deficiency), as to making the cell die of too many mutations. In case of HRD, the cell would normally rely on PARP repair, which repairs the DNA but with flaws. So as to avoid the flaws in the repair mechanism, PARPi is given as treatment.
This is the best explanation of PARP inhibitors I've seen. Thanks for making this video!
Simple great explanation! Thank you!
This is so far the best short video on PARPinhibitors, Would you please make an elaborate video on this topic by explaining the whole PARLyation reactions?
Great explanation!
Why parp inhibitors inhibit only cancer cell
Plz sir ,, reply me..... Can I take Rucaparib within 6 months of last chemotherapy??,, Plz sir reply me.... Plz plz
Dear Jukta, I wish I could answer you that question to help you. However, I am not a medical doctor, they know way better which medicine is suited in your case.
What I can do is sending you this article about Rucaparib, that may answer a lot of questions to you: www.ema.europa.eu/en/medicines/human/EPAR/rubraca
I wish you all the best, Jukta!
Was studierst du eigentlich? Und falls du kein Student mehr bist, was machst du jetzt?
Habe gerade den Master in Molekularen Biowissenschaften abgeschlossen
From what I know about PARPi, they actually inhibit the 2nd option in case of HRD (homologous repair deficiency), as to making the cell die of too many mutations. In case of HRD, the cell would normally rely on PARP repair, which repairs the DNA but with flaws. So as to avoid the flaws in the repair mechanism, PARPi is given as treatment.