New FDA Approved PARP Inhibitor: Talzenna (Talazoparib) & Xtandi |
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- Опубликовано: 16 июл 2023
- The FDA recently approved a new PARP inhibitor, Talzenna (talazoparib) to be used alongside Xtandi (enzalutamide) for homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer. The HRR genetic mutations evaluated in the trial that led to FDA approval were ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, and RAD51C.
In this video, PCRI's Alex and Medical Oncologist Mark Scholz, MD, explains how Talzenna and Xtandi work, surveys side effects and side effect mitigation, and provide context for how this treatment protocol compares to other similar therapies and the situations in which a patient and his doctor may consider Talzenna + Xtandi as a treatment for his case of prostate cancer.
View the FDA approval here -- www.fda.gov/drugs/drug-approv...
0:06 Talazoparib ( was recently FDA-approved alongside Xtandi (enzalutamide) for some men with advanced prostate cancer. Could you provide a background on these two drugs, Talzenna and Xtandi?
3:02 PARP inhibitors are becoming more relevant in the treatment of men with advanced prostate cancer. How do PARP inhibitors work, and what is the patient experience like when they are taking these medications?
4:06 How effective was Talzenna + Xtandi in the treatment of advanced prostate cancer?
4:40 What are the most common side effects of Talzenna + Xtandi?
5:07 Should a patient and their physician be monitoring blood counts (or any other health indicators) while on Talzenna + Xtandi?
7:27 In which patients would Talzenna + Xtandi be considered, and when should it be used?
9:55 How does Talzenna compare to other PARP inhibitors that are used in the prostate cancer space, Olaparib, and Rucaparib?
11:09 If a patient is already on another second-generation anti-androgen (for example, Zytiga, Erleada, or Nubeqa) would they need to switch to Xtandi if they wanted to add Talzenna?
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The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
The information on the Prostate Cancer Research Institute's RUclips channel is provided with the understanding that the Institute is not engaged in rendering medical advice or recommendation. The information provided in these videos should not replace consultations with qualified health care professionals to meet your individual medical needs.
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Thank you Alex and Dr. Scholz for continuing to provide this information - appreciated by so many.
Thanks for this terrific video. I'm Gleeson 6. 60 years. Metastatic. Was PSA 527 in March. Now on combo of Nubeqa and Orgovyx plus Lutetium trail. About to receive 3rd of 6 infusions. PSA now 13 after 4 months. Your videos, from the beginning, have been incredibly helpful and the doctor's calm, humane, fact-based tone has been a great comfort to me. Feeling very good, constantly exercising and eating right,and not suffering many side effects at all (slight fatigue). Again, much gratitude to you both.
Thank you so much for sharing this information.
I am 74 years old.
I am metastatic. My PSA is 0.77 now from 118 when i was diagnosed with cancer a year ago. I am taking Erleada pills and Lupron injections every 3 months. I also have a monthly injection of Xgeva to stregthen the bones.
I changed my diet, I exercise and I am meditating and reducing the level of stress.
I started with a Lupron shot and Bicalutamide pills one a day and my PSA continued to fall. Then my Oncologist prescribed Xtandi for 2 months, it's $9000 with a $3000 copay for a one month supply, however they found someone to pay the copay since I'm retired. I have stage 4 metastatic and my PSA is now down to 0.02. I do feel tired but try and ride a stationary bike, but often dose off watching TV shows. The hot flashes are more intense and more frequent plus head aches than while on the Bicalutamide pills. I'm grateful to still be alive. Good to hear your take on these treatments👍
Another great informative video. Thank you.
The logic of attacking both types (hormone sensitive and hormone independent ) of cancer cells at once (provided side effects are manageable) is very compelling.
Once one realizes the emergence of hormone sensitive and hormone independent cancer cells is not sequential, the logic for a sequential application of effective drugs begins to fall away.
Thank you for your very clear presentation, as usual.
Thank for your help! The information you give us is helpful in SO many ways. I’m 56 with stage 4 metastatic prostate cancer. I was diagnosed in March 2023 my PSA was 67.3. I’ve been on Abiraterone pills and Lupron injections I’ve cut out sugar and Carbs from my diet I also exercise and now my PSA is .34. I have numerous sclerosis all over my skeleton. At this point, any good news is encouraging.
Soy cubano 58 año casi sin tratamiento por falta de recursos en este país como se compra la abiraterone
Thanks Alex and Dr Mark....God bless you for such a great service to prostate cancer patients....I hope you are reaching out to urological oncologists to keep them up-to-date.. since they may miss some treatment developments due to their ever increasing workload of steep climb in this disease..
Thank you!
These videos are highly informative and greatly appreciated!
I know the FDA approved of the talazoparib/enzalutamide combo for those with HRR-gene mutations, but it sounds as though this therapy may also show some benefit for those without those mutations. Do you know of any cases wherein insurance has covered this for those without the mutations?
Hi, please reach out to our Helpline team so they can help you research questions regarding your specific case: pcri.org/helpline
hi - I echo many of the comments below .... thankyou. I would also like to get your opinion on the metabolic theories of cancer mgt and prostate cancer in particular - david upfal
Hi, please reach out to our Helpline team so they can help you regarding your specific case: pcri.org/helpline
The person asking the questions could dress more professionally
She is very professional.