VIDEO NOTES: MOVEMENT: 2 MAIN RULES 1. Proteins like to change shape when stuff binds to them 2. Changing shapes can allow proteins to bind or unbind with other things SARCOMERE: •contain 2 active proteins of actin and myosin •Thin actin strands and thick myosin strands •In a z shape, contract brings together •When muscles are resting, actin and myosin do not touch, but want to SLIDING FILAMENT MODEL: STEPS: 1. Actin wants to go to myosin but is trapped by tropomyosin and troponin 2. gaurds can move with ATP and calcium (sarcoplasmic reticulum loaded with calcium pumps) 3. eceptors on muscle cells release AcetylCoa and rush of sodium goes to cell, causing sodium channels to open in muscle cell 4. action potential goes to T-tubule 5. calcium stored inside t-tubule is released 6. troponin binds with calcium, causing the protein to change shape as it pulls trypomysoin away 7. ADP attaches to myosin and myosin goes into stretched position 8. myosin finally binds to actin and myosin releases stored energy and retracts whole muscle 9. ADP and phosphate unbind with myosin and ATP binds with myosin 10. myosin releases from actin 11. myosin then breaks down ATP to ADP and phosphate to get ready for next release of energy 12. calcium pumps grab calcium from tropomyosin back into place ~keeps replaying~ I hope some of these help you! If you are reading this, just know that you are such a beautiful, wonderful, and intelligent human being! I hope you all have a lovely day/night
Watched these videos to study for the MCAT. Crushed the exam and got into my top choice medical school. Now I'm using them to study for med school exams. The story keeps repeating itself! You're the best, Hank!
This stuff absolutely blows my mind. On another note, my professor basically spent two 50 minute class periods on the sliding filament model and I only had to watch this video twice to learn what I needed to know. You guys do great stuff, thank you!
@angelswave88 Dude, all teachers are good guys here. They're trying to make us a little smarter. The Green brothers are absolutely awesome 👍😎. But that doesn't mean we need to demean our college profs 😇
Thank you Hank! I hope you know that your biology and anatomy/physiology videos are educating future nurses (me), doctors, surgeons, exercise scientists, physical therapists, etc. just trying to fumble through the undergrad years of college!
+body parts this is basically pre med made simple. At my school pre med is incorporated into our high school syllabus (for some reason our school system hates us all) since we pick our subjects according to what courses we want to take in Uni (the system makes no sense)
Also, future dancers (me) and professional athletes. 'Cause we're expected to know our bodies in order to prevent the need for nurses, doctors and surgeons, and to make the physical therapists (which are kind of inevitable given that we're high performance athletes) job's easier.
Yup John Green is his brother xD He does humanities videos on this channel while Hank does more science-y videos, plus he's on the channel Vlogbrothers along with Hank!
Favorite part: 9:00 "The whole drama plays itself over and over again, kind of like you'll have to replay this video over and over again to catch all the little steps." I had to laugh as I paused it for the 40+ time to take a note.
He makes all of his videos so colorful! Thank God he's not bland like the average A&P teacher!!! He makes it so much easier to understand verses just copying a bunch of powerpoints!
I am a 34 yo adult who has recently decided to go back to school to study Medical Coding and Billing/Health Services Administration and currently I am studying Medical Terminology. These videos have been so helpful I am am so grateful that you and all of your wonderful people have taken the time to do these videos because it really does help. Not just learning the term and definitions but also the explanation of the terms or at least some of them. Now, how do I get you to be my professor? Because in all honesty, you make it all fun. Thanks again!
I was cоmpletely shocked bу how dramatic thе results wеre after just оne week. My energy levels were noticeablу higher aand I felt like аn absolute beast in the gуm.. => twitter.com/388c910fe281456e0/status/742668391975096320 Muscles рart 1 Musсle Cеlls Crash Course A P 21
Dr.Smarty Pants it's true but crash course gives an encouraging welcome to learning making you want to learn more, and they make it so relatable that it sticks to your head and I don't think you can become an MD without a strong learning attitude and a good retentive memory which I believe crash course gives the best foundation
luckystrke Yeah, people walk around all the time letting out smelly farts. Some people love to whiff them because they like the smell of their own smelly farts.
I am a 20 year old in college taking human physiology and i swear crashcouse never gets old 😂😂 i cannot tell you how much this channels helps with school!!
With background info from my textbook, the analogies you use and the animations really help me learn and understand each of these processes. I really thank you and your team for these videos. Without you, I’d be lost in my classes. I owe you a great deal when I finally become an RN!!!!!
He ideally isn't someone I'd choose to hang out with on a Friday night but I find that as I take A&P, he's the only person I end up hanging out with on a Friday night. If you can get past his dorky sense of humor and ignore some of the extras, you can really get a lot out of this for A&P. I'm completely new to this class and never even thought of going in this direction that I'll be majoring in so this class has been hell, to say the least. But the way he breaks it down is perfect. The animations really are a huge help because they're broken down into kindergarten terms. Highly suggest him. He definitely gains my respect. I don't normally post comments but I figured he doesn't get near as much credit as he should for all the help he's given over the years. Appreciate it!
I love how he mentioned watching it multiple times. I totally paused and rewatched sections, as well as watched it in half speed. Definitely provides a basis for my classes so I can begin to understand!
When chemistry was introduced to my A&P, my heart literally sank I was TERRIFIED. I have a wonderful professor, but I probably kept rereading my textbook chapters like 20 times and it was still not making ANY sense. Legitimately I have never been more grateful to find a channel that is helping me at the very least pass!!
He was right about repeating this video over and over. Just to take notes and understand the whole very complex concept. . I dislike reading just read this whole chapter and understood absolutely nothing...but Learned more in this crash course.
I wish I could give this guy a thousand likes, my house, my glycogen reserves, some of my myosin and all of my ATP. This has got to be one of the best channels on RUclips!!! Thank you so much!
Christie Nel Well....I agree with the sentiment, but really, everyone needs school. This is great content, but it can never be a replacement for a teacher who's actually in the room with you. How about a school where the homework is watching Crash Course!
J. van der Linden i'd say everone needs education, as education leads to growth of the mind and the continued greatness of our species... however school is different to education, if anything its more like an evolutionary cousin. School is merely societies way of measuring your worth by filling your brain with facts, for you to regurgitate during an exam. There are many forms of education for example crash course :D education is needed, school is in need of education. Also crash course as homework would be awesome
Took honors A&P during High School and it was one of my favorite classes ever. The human body is so interesting and the amount of detail to it is just endless.
Literally, you’re my favorite person on the internet. I love listening to you talk, your analogies help this class make so much more sense, you’re funny and for once, science isn’t boring to listen to!!! Thank you Hank Green!
Im 1 year at PT school, and I subscribe to Crash Course and its saving my life. this week I passed my first exam about research in health with 8 (scale 1-10) THANK YOU regards, a future physical therapist
9:09 YUP, called it. I had to skip back about a dozen times to get ALL of the information I needed about the Sliding Filament Model, and the actin and myosin.
well, your teacher is telling the same thing over and over that much, that he/she is doing it automaticly, without thinking whether it is fun or not. His/jers aim is to make you understand in the way you could further show that on test and enter the university w/this knowledge.
My teacher sometimes show videos like this whenever he doesn't feel like lecturing our class himself. I was able to repeat these videos as well. I also use my notes and encyclopedias to help me learn more about anatomy.
I just want to say that this channel is the sole reason I passed my histology exam because my lecturer is useless and my textbook was way complicated. So thank you for breaking it down and helping me visualize YOU ARE MY HERO NEVER STOP WHAT YOU'RE DOING
bro this man made me understand all of this in literally 10 minutes, THANK YOU I WILL CONTINUE MY NOTES and actually understand what I am taking notes of.
Can't thank you enough! You are a brilliant teacher! I've taken a lot of classes online and most of them aren't taught very well. I hope you keep getting donations so you can keep offering these classes for free. You're the best online teacher I've seen. Heck, you could probably create an online course on udemy or somewhere teaching people how to teach an online course. You could probably charge $100 for it... But please keep offering these classes for free. They're a lifesaver for some of us.
Thank you so much for these amazing quality videos. I am currently homeschooling my 12 year old son who is dyslexic, but a gifted visual-spatial learner. He needs to see the "big picture" to help him attach meaning to the smaller details, and your videos do that perfectly. To have a kid who hated school, laughing and being completely engaged in learning is such a gift. *He especially loved the reference to middle schoolers at a dance, as well as Hot Pockets and Assassins Creed ;) Well done!
troponin : girl's mother tropomyosin: girl's father Ca+2: flowers Actin: girl Myosin: boy when the boy buy flowers for girl's mother, she pushed her husband out of the away , and romance begin !
This not only explained everything I wanted/needed to know, it was also super fun to watch and the references to the daily life/love story really do make it easier to understand. Thank you for saving both my grades and my brain from a breakdown.
This is so awesome and interesting, I’ve always wanted to know how our bodies ACTUALLY work and move on the cellular level and you guys teach us with so much detail! Thanks Crash Course
When I booted up this video, I watched it for about two minutes, before this dialogue went through my head: "Wait, how do my muscles contract anyway? It probably has something to do with being activated by synaptic charges, as with all things. But why can my brain make synaptic charges?" It was at this point that I paused the video because I needed a minute, continuing: "What makes a brain able to crate electric charges form its desire. And to that extent what makes me a person, and not just a brain. I mean, I'm like a space probe. My eyes are the camera, my mouth the analysis lab, my digestive system my solar cells and my heart my power distribution system, but spacer probes are controlled by people, what am I controlled by? A brain? Well obviously but I mean, what else. And for that matter how weird is it that I'm technically a brain whose thinking about its body thinking about its brain which is now thinking about its body. When did that happen, like, in an evolutionary sense? When was it possible for something to think about itself like that. Has anything but a human done it?" Followed by about 30 minutes of rambling. Also, if you read all that... wow, you're a trooper. Thank you? I guess?
Vensey Ness After reading this, all I can think of is one of the verse's from Hank's song /The Universe Is Weird/, "The Universe created a tool with which to know itself." So you are a construct made by the Universe (through a rather slow process of star and planet formation, then formation of life and finally billions of years of evolution) which it uses to understand just how weird it is. Admittedly, some artistic license is required to think of the universe as a being with agency and a will.
Vensey Ness and I am thinking about you thinking about your brain thinking about your body... through a comment in other language written in a video on the internet
E Hernandez it's actually a quote from Carl Sagan: "Some part of our being knows this is where we came from. We long to return. And we can. Because the cosmos is also within us. We're made of star-stuff. We are a way for the cosmos to know itself." -Carl Sagan
I watched this years ago in high school, I watched it again in medschool and now preparing for usmle I'm watching it again. Crash course is one of the best resources I've ever seen. 👍💯💯 💯
Read my chapters on sliding filaments for two days and couldn’t understand. Then learned it in 30 mins of watching this video while taking notes and screenshots. AMAZING!
Already had an idea of how myosin heads grab onto the actin molecules, but it totally helps watching the animation and actually seeing it rather than looking at my A&P book! Crash course is always a savior
Hank knowing that we have to play these videos over and over again to get all the details gave me the saddest laugh of my life. Somehow still a lot shorter and to the point than the textbooks everytime tho, thank you!
THAAAANNKKKSS I WAS SO HAPPY WHEN I TYPED IN MECHANISM OF MUSCLE CONTRACTION AND FOUND A CRASH COURSE VIDEO ON IT I WAS LIKE YAAASS IM GONNA GET IT ALL INTO MY HEAD. NOW MAKING THE PRESENTATION IS SO MUCH EASIER
Sliding Filament Model: 1. Brain sends an action potential to the motor neuron until it synapses with a muscle cell in the arm by releasing acetylcholine 2. Receptors on the muscle cells open up and release a rush of sodium into the cells as a graded potential (since they are ligand-gated sodium channels) a. If strong enough, nearby voltage-gated sodium channels open 3. Action potential goes to the sarcolemma’s T-Tubules, and triggers voltage-sensitive proteins linked to calcium channels in the sarcoplasmic reticulum 4, Calcium channels are opened and release a rush of calcium into the cell 5. Calcium binds to troponin and changes shape, then pulls tropomyosin away from actin strands that myosin wants to reach 6. Myosin that contain and converted ATP to ADP move into a stretched position and bind to actin 7. Myosin releases its stored energy and changes shape by pulling on actin strands 8. Sarcomere retracts and causes the muscle to contract 9. Myosin unbinds with ADP and phosphate and changes shape, which causes ATP to bind to the myosin 10. Myosin changes shape and unbinds from actin 11. Myosin converts new ATP into ADP and phosphate to be prepared for the next release of energy 12. Calcium pumps take calcium from tropomyosin to restock sarcoplasmic reticulum 13. Tropomyosin is put back into place
I had to take notes step by step to get the process and now I completely get the concept! It was one ear and out the other in my lecture but now since watching this video for 2 hours, i get it now. I should be prepared for my exam this Wednesday.
Thank you Hank. Your videos are so helpful! You should know many of us (including myself) are going into the medical field, and we could not be more thankful!
SO much of me wants the little noise that happens when the ions bind to receptors/troponin as my message tone. Its so satisfying and also reminds me of how much these videos are going to help me nail my exams!
I swear if I had him as my professor for Bio I wouldn't mind going to class. Thank you for explaining this part of the chapter in a way we can understand it. you are helping me for my bio exam. BLESS YOUR SOUL
2020 and I think this video is out of date, because phosphate detaching from Myosin should cause a power stroke. My question is does a cross bride form before or after ATP binds to Myosin?
let me sleep the Myosin head has an actin binding site and an ATP binding site, so after tropomyosin leaves the actin binding site uncovered, ATP binds to the myosin head and the myosin head hydrolysis ATP into phosphate and ADP, the hydrolization of ATP causes the myosin head to become erect and be able to form a crossbridge with actin. Phosphate detaches from the myosin head causing a power-stroke. Then ADP detaches from the myosin head after the powerstroke and a new ATP attaches to the myosin head initiating the cross-bridge cycle.
The “chemistry” between myosin & actin makes my heart beat (:
VIDEO NOTES:
MOVEMENT: 2 MAIN RULES
1. Proteins like to change shape when stuff binds to them
2. Changing shapes can allow proteins to bind or unbind with other things
SARCOMERE:
•contain 2 active proteins of actin and myosin
•Thin actin strands and thick myosin strands
•In a z shape, contract brings together
•When muscles are resting, actin and myosin do not touch, but want to
SLIDING FILAMENT MODEL: STEPS:
1. Actin wants to go to myosin but is trapped by tropomyosin and troponin
2. gaurds can move with ATP and calcium (sarcoplasmic reticulum loaded with calcium pumps)
3. eceptors on muscle cells release AcetylCoa and rush of sodium goes to cell, causing sodium channels to open in muscle cell
4. action potential goes to T-tubule
5. calcium stored inside t-tubule is released
6. troponin binds with calcium, causing the protein to change shape as it pulls trypomysoin away
7. ADP attaches to myosin and myosin goes into stretched position
8. myosin finally binds to actin and myosin releases stored energy and retracts whole muscle
9. ADP and phosphate unbind with myosin and ATP binds with myosin
10. myosin releases from actin
11. myosin then breaks down ATP to ADP and phosphate to get ready for next release of energy
12. calcium pumps grab calcium from tropomyosin back into place
~keeps replaying~
I hope some of these help you! If you are reading this, just know that you are such a beautiful, wonderful, and intelligent human being! I hope you all have a lovely day/night
thank you so much for this. ive watched this video a few times. some of its sticking and some not. these notes are a gods send!
Doing the lord's work, thank you.
Also for #5, calcium is released from the terminal cisternae of the SR, not the t-tubules.
Saviour.
Thanks brother..made it more clear.
NEVER STOP DOING WHAT YOU ARE DOING. YOU ARE SAVING MY WHOLE EXISTENCE. THANK YOU THANK YOU
+Umesh Lawati fck u
why suck violence, don't act like a *mitch* the word makes me laugh everytime XD KEVIN HART... DAMN YOU
I agree! Great for visual learners! I wish there was a RUclips channel like this but for math!
RUclips cop! We are the LAW! There is
Eventually he will have to stop since physical life is finite and like all of ours his will come to an end.
Watched these videos to study for the MCAT. Crushed the exam and got into my top choice medical school. Now I'm using them to study for med school exams. The story keeps repeating itself! You're the best, Hank!
Very good
Love the fault in our stars reference
Jess245 Fun behind-the-scenes fact: that was Nick's own on-set edit :D
-Nicole
CrashCourse love it and love him! !
CrashCourse When is part two coming out ?
***** Thanks .
PRICHARDxLUST GAMERxGIRLZ Next Monday! Barring anything unforeseen, new A&P episodes go up on Mondays at 3pm Mountain Time :D
-Nicole
That myosin head ain't loyal tho. Switching actin binding sites all the damn time
Baller
Dear Hank,
Thank you for saving me when I have an Anatomy test the next day.
Sincerely,
Everyone Subscribed to CrashCourse
Literally me today!!
Sammmmeee
LOL I even listen to them on my 45 minute ride to class the day of my phys exams!! It really works
amen to this
Me right now buddy ...me right now
What's fascinating to me is just how quickly all this happens
This stuff absolutely blows my mind.
On another note, my professor basically spent two 50 minute class periods on the sliding filament model and I only had to watch this video twice to learn what I needed to know. You guys do great stuff, thank you!
Try a 2 hour and 10 minute long class...
@angelswave88 Dude, all teachers are good guys here. They're trying to make us a little smarter. The Green brothers are absolutely awesome 👍😎. But that doesn't mean we need to demean our college profs 😇
angelswave88 well my high school anatomy teacher spent less than one 45 minute class on this soo
one day I'll owe you my medical degreee
milu ska did u get it yet?
@@MemeRepublic too early to ask my guy 😂😂😂
I'm just gonna comment here for me to get a notification from when she answers the question.
@@TaliAlba33 same
Same
Thank you Hank! I hope you know that your biology and anatomy/physiology videos are educating future nurses (me), doctors, surgeons, exercise scientists, physical therapists, etc. just trying to fumble through the undergrad years of college!
+body parts this is basically pre med made simple. At my school pre med is incorporated into our high school syllabus (for some reason our school system hates us all) since we pick our subjects according to what courses we want to take in Uni (the system makes no sense)
Also, future dancers (me) and professional athletes. 'Cause we're expected to know our bodies in order to prevent the need for nurses, doctors and surgeons, and to make the physical therapists (which are kind of inevitable given that we're high performance athletes) job's easier.
Hopefully a future Marine Biologist or two too :D
PE teachers too!
and vets!
I lost it when he referred to his bro's book like,
"Okay?"
"Okay."
I love how Hank makes a reference to his brother's, John, book. "Okay? Okay".
OMG I DIDN'T KNOW lol
omg john is his brother???
Yup John Green is his brother xD He does humanities videos on this channel while Hank does more science-y videos, plus he's on the channel Vlogbrothers along with Hank!
Ikr, half fangirled. 🤷🏽♀️😍 Then got very serious again, cuz it's biology 😒.
Favorite part: 9:00 "The whole drama plays itself over and over again, kind of like you'll have to replay this video over and over again to catch all the little steps." I had to laugh as I paused it for the 40+ time to take a note.
Do you even -lift- attach and release your actin and myosin, bro? :D
Dennis Chiu wouldn't you have to leave it attached to be able to lift?
Guilherme Pata The act of lifting implies that of lowering. Hence the release.
Repeat 4,500,000 times to become Arnold Schwarzenegger.
good point
Nerd-bros. I love it. :)
Understanding science with a joke... Genius.
When you reference your own brother's bestselling novel
@@kellyendicott4517 Yes lol. The Fault in Our Stars
I was looking for that comment, loved the nod to Hank lol
He makes all of his videos so colorful! Thank God he's not bland like the average A&P teacher!!! He makes it so much easier to understand verses just copying a bunch of powerpoints!
"The mitochondria is the powerhouse of the cell"
-Said every biology book ever
Saliva contains Amylase, an enzyme that digests starch.
Until you get to oxidation phosphorylation
honestly I don't think I've ever heard the term "powerhouse" except when referring to mitochondria.
I am a 34 yo adult who has recently decided to go back to school to study Medical Coding and Billing/Health Services Administration and currently I am studying Medical Terminology. These videos have been so helpful I am am so grateful that you and all of your wonderful people have taken the time to do these videos because it really does help. Not just learning the term and definitions but also the explanation of the terms or at least some of them. Now, how do I get you to be my professor? Because in all honesty, you make it all fun. Thanks again!
I can't beleive I'm smiling while studing
Thank You !
same here !
(*sheds a tear*)
beautiful...
I was cоmpletely shocked bу how dramatic thе results wеre after just оne week. My energy levels were noticeablу higher aand I felt like аn absolute beast in the gуm.. => twitter.com/388c910fe281456e0/status/742668391975096320 Muscles рart 1 Musсle Cеlls Crash Course A P 21
Umer Saleem wot.
i ship it
Our bodies are unbelievable.
unbelievably small
Please don't mention god.
Dr.Smarty Pants it's true but crash course gives an encouraging welcome to learning making you want to learn more, and they make it so relatable that it sticks to your head and I don't think you can become an MD without a strong learning attitude and a good retentive memory which I believe crash course gives the best foundation
luckystrke
Yeah, people walk around all the time letting out smelly farts.
Some people love to whiff them because they like the smell
of their own smelly farts.
I am a 20 year old in college taking human physiology and i swear crashcouse never gets old 😂😂 i cannot tell you how much this channels helps with school!!
With background info from my textbook, the analogies you use and the animations really help me learn and understand each of these processes. I really thank you and your team for these videos. Without you, I’d be lost in my classes. I owe you a great deal when I finally become an RN!!!!!
He ideally isn't someone I'd choose to hang out with on a Friday night but I find that as I take A&P, he's the only person I end up hanging out with on a Friday night. If you can get past his dorky sense of humor and ignore some of the extras, you can really get a lot out of this for A&P. I'm completely new to this class and never even thought of going in this direction that I'll be majoring in so this class has been hell, to say the least. But the way he breaks it down is perfect. The animations really are a huge help because they're broken down into kindergarten terms. Highly suggest him. He definitely gains my respect. I don't normally post comments but I figured he doesn't get near as much credit as he should for all the help he's given over the years. Appreciate it!
Actin and myosin...sounds like "action and motion". Fitting.
You look a bit like Rachel Evan Wood in this small picture
I couldn't do this without you. I might actually pass this exam tomorrow 😅
I love how he mentioned watching it multiple times. I totally paused and rewatched sections, as well as watched it in half speed. Definitely provides a basis for my classes so I can begin to understand!
When chemistry was introduced to my A&P, my heart literally sank I was TERRIFIED. I have a wonderful professor, but I probably kept rereading my textbook chapters like 20 times and it was still not making ANY sense. Legitimately I have never been more grateful to find a channel that is helping me at the very least pass!!
He was right about repeating this video over and over. Just to take notes and understand the whole very complex concept. . I dislike reading just read this whole chapter and understood absolutely nothing...but Learned more in this crash course.
You knew we would rewatch and replay LOL! That made me laugh!
Me too
haha i didn't but i think i will anyway. :P
Literally learned more just in this one video then I have this entire semester in Anatomy.
I wish I could give this guy a thousand likes, my house, my glycogen reserves, some of my myosin and all of my ATP. This has got to be one of the best channels on RUclips!!! Thank you so much!
Who needs school when you have CrashCourse?
Christie Nel Well....I agree with the sentiment, but really, everyone needs school. This is great content, but it can never be a replacement for a teacher who's actually in the room with you.
How about a school where the homework is watching Crash Course!
J. van der Linden i'd say everone needs education, as education leads to growth of the mind and the continued greatness of our species... however school is different to education, if anything its more like an evolutionary cousin. School is merely societies way of measuring your worth by filling your brain with facts, for you to regurgitate during an exam. There are many forms of education for example crash course :D
education is needed, school is in need of education.
Also crash course as homework would be awesome
GUYS......he's joking.......
Christie Nel These videos are really nice!
+Liam Worsley chill nobody cares
I have an anatomy exam on this and some other stuff tomorrow... this just saved me a solid 2 hours of studying. Thanks so much!!
Eating, texting, taking notes. Repeating segments of the video a hundred times. You really know everything, Hank!
HANK, I DON'T NEED TO START HAVING FEELS ABOUT MY MUSCLES EVERY TIME I MOVE.
And when you run a mile....
Took honors A&P during High School and it was one of my favorite classes ever. The human body is so interesting and the amount of detail to it is just endless.
For the love of god! Please keep these videos on RUclips until the end of time! You’re a life saver
Literally, you’re my favorite person on the internet. I love listening to you talk, your analogies help this class make so much more sense, you’re funny and for once, science isn’t boring to listen to!!! Thank you Hank Green!
still better love story than twilight
Muhammad Faisal BAHAHAAHAHA
Well could have been if the guy would have been R Patz
Lmao STOOOOP
I would think itachi would like twilight
haha, never change internet. never change
Hank and John Green. The modern day Bill Nye Show. Love it!
Im 1 year at PT school, and I subscribe to Crash Course and its saving my life. this week I passed my first exam about research in health with 8 (scale 1-10)
THANK YOU
regards,
a future physical therapist
9:09 YUP, called it. I had to skip back about a dozen times to get ALL of the information I needed about the Sliding Filament Model, and the actin and myosin.
The perfect channel for anyone studying A&P!
why cant my teacher be this fun
they dont get paid nearly enough to prepare fun animations and pop-up notes to go with their lecture lol
Bcuz your not trump
well, your teacher is telling the same thing over and over that much, that he/she is doing it automaticly, without thinking whether it is fun or not.
His/jers aim is to make you understand in the way you could further show that on test and enter the university w/this knowledge.
My teacher sometimes show videos like this whenever he doesn't feel like lecturing our class himself. I was able to repeat these videos as well. I also use my notes and encyclopedias to help me learn more about anatomy.
Yes. I still have encyclopedias at my house.
I’m here studying for STEP 1 and I forgot how much I loved you during MCAT studying!! Truly the GOAT
No wonder evolution took hundreds of millions of years to get to multicellular organism. This is fascinating!
But they did have to have the ability to reproduce/duplicate with the very first thing we could call life.
Ray Sharky I just knew relgious nutjobs would appear sooner or later... Well, better go ahead of the useless flamewar...
+Robbie Jeffcott yes they did. reading might actually help on your question
shena mackey There is too much evidence to the contrary.
+1234kalmar not enough
I just want to say that this channel is the sole reason I passed my histology exam because my lecturer is useless and my textbook was way complicated. So thank you for breaking it down and helping me visualize YOU ARE MY HERO NEVER STOP WHAT YOU'RE DOING
myosin. .....guys
actin...........girls
tropomyosin.....father
troponin. ........mother
ATP n Calcium.............(varies)...time, grandparents, heart change, luck....etc
😁😁forgive me...just couldn't resist
scientific ninja 😂😂
scientific ninja thank you!!!!!!!!!!!
ATP + calcium would be 💰 money.
Love this!!
yo this actually makes sense lmao thanks!!!
bro this man made me understand all of this in literally 10 minutes, THANK YOU I WILL CONTINUE MY NOTES and actually understand what I am taking notes of.
The accuracy how he said I was eating and texting and taking notes and Im definetly going to have to rewatch this 🤣
Can't thank you enough! You are a brilliant teacher! I've taken a lot of classes online and most of them aren't taught very well. I hope you keep getting donations so you can keep offering these classes for free. You're the best online teacher I've seen. Heck, you could probably create an online course on udemy or somewhere teaching people how to teach an online course. You could probably charge $100 for it... But please keep offering these classes for free. They're a lifesaver for some of us.
THANK YOU SOOOOO MUCH TO THE WRITERS AND PRODUCERS OF THIS SERIES. Truly a godsend.
Thank you so much for these amazing quality videos. I am currently homeschooling my 12 year old son who is dyslexic, but a gifted visual-spatial learner. He needs to see the "big picture" to help him attach meaning to the smaller details, and your videos do that perfectly. To have a kid who hated school, laughing and being completely engaged in learning is such a gift. *He especially loved the reference to middle schoolers at a dance, as well as Hot Pockets and Assassins Creed ;) Well done!
troponin : girl's mother
tropomyosin: girl's father
Ca+2: flowers
Actin: girl
Myosin: boy
when the boy buy flowers for girl's mother, she pushed her husband out of the away , and romance begin !
i loved watching hank's crash courses in highschool. i now find myself here again helping me through my first semester of college.
Anyone else lookin' at your muscles and thinkin' 'holy shit' :O ?
I'm a German medical Student and love these videos to get an unterstandable and entertaining introduction to my topics!
This not only explained everything I wanted/needed to know, it was also super fun to watch and the references to the daily life/love story really do make it easier to understand. Thank you for saving both my grades and my brain from a breakdown.
These videos are saving my life!! 96% in Human Biology !! Never stop these !!
This is so awesome and interesting, I’ve always wanted to know how our bodies ACTUALLY work and move on the cellular level and you guys teach us with so much detail! Thanks Crash Course
THANK YOU!!!!! The text book was not making any of this clear. Now I actually get what's happening. You are my savior!!!!
When I booted up this video, I watched it for about two minutes, before this dialogue went through my head:
"Wait, how do my muscles contract anyway? It probably has something to do with being activated by synaptic charges, as with all things. But why can my brain make synaptic charges?"
It was at this point that I paused the video because I needed a minute, continuing:
"What makes a brain able to crate electric charges form its desire. And to that extent what makes me a person, and not just a brain. I mean, I'm like a space probe. My eyes are the camera, my mouth the analysis lab, my digestive system my solar cells and my heart my power distribution system, but spacer probes are controlled by people, what am I controlled by? A brain? Well obviously but I mean, what else. And for that matter how weird is it that I'm technically a brain whose thinking about its body thinking about its brain which is now thinking about its body. When did that happen, like, in an evolutionary sense? When was it possible for something to think about itself like that. Has anything but a human done it?"
Followed by about 30 minutes of rambling. Also, if you read all that... wow, you're a trooper. Thank you? I guess?
Vensey Ness After reading this, all I can think of is one of the verse's from Hank's song /The Universe Is Weird/, "The Universe created a tool with which to know itself." So you are a construct made by the Universe (through a rather slow process of star and planet formation, then formation of life and finally billions of years of evolution) which it uses to understand just how weird it is. Admittedly, some artistic license is required to think of the universe as a being with agency and a will.
Vensey Ness and I am thinking about you thinking about your brain thinking about your body... through a comment in other language written in a video on the internet
Vensey Ness na, i just skipped to the end, i aint not no trooper
Vensey Nessit makes so happo to see people think like that.
E Hernandez
it's actually a quote from Carl Sagan:
"Some part of our being knows this is where we came from. We long to return. And we can. Because the cosmos is also within us. We're made of star-stuff. We are a way for the cosmos to know itself."
-Carl Sagan
Crash Course is my hero. I have used them for both US History and Human A&P and they never let me down!
I really enjoy these videos they reinforce my understanding of my lectures. Thank you.
I watched this years ago in high school, I watched it again in medschool and now preparing for usmle I'm watching it again. Crash course is one of the best resources I've ever seen. 👍💯💯 💯
"googles "Chris Evans when he first walks out of that machine in Captain America"*
Me: Yes, I see.
Why can't everyone make science fun like you! THANK YOU!!!
Watch this video again? I'll be watching this whole series again.
Read my chapters on sliding filaments for two days and couldn’t understand. Then learned it in 30 mins of watching this video while taking notes and screenshots. AMAZING!
Just realized that at: 7:05 he references his brother's book "Fault of our stars" which I am currently reading.
I have a test today I didn’t study for bc I had another test that I needed to prioritize and this channel is saving my butt. THANK YOU
Am I the only one here who doesn't have a test on this or anything but just wants to learn?
yes
Absolutely not!
I'm trying to learn anatomy so I can draw better. I gave myself a deadline to animate a cartoon before October, but I have no idea how the body moves.
Rag Ninja
Just look at a skeleton and see where all the muscles are attached and how the joints move...
+greg77389 Thanks
This is by FAR, the best RUclips channel I've come across in yearsss!
It takes guts to learn Anatomy
Already had an idea of how myosin heads grab onto the actin molecules, but it totally helps watching the animation and actually seeing it rather than looking at my A&P book!
Crash course is always a savior
I did re-watch this video, again and again and again. It's just such a great love story.
Pure brilliance. Shakespeare and the sliding filament model. Cross curricular education at its finest!
Whoever came up with muscles is a genius thanks god!
Hank knowing that we have to play these videos over and over again to get all the details gave me the saddest laugh of my life. Somehow still a lot shorter and to the point than the textbooks everytime tho, thank you!
“ they don’t touch but really really want to”
Sounds like my sad love life
Thank god, my lecturer has called in a student to teach us this section and she makes absolutely NO sense. These videos are saving my grade!!
THAAAANNKKKSS I WAS SO HAPPY WHEN I TYPED IN MECHANISM OF MUSCLE CONTRACTION AND FOUND A CRASH COURSE VIDEO ON IT I WAS LIKE YAAASS IM GONNA GET IT ALL INTO MY HEAD. NOW MAKING THE PRESENTATION IS SO MUCH EASIER
Sliding Filament Model:
1. Brain sends an action potential to the motor neuron until it synapses with a muscle cell in the arm by releasing acetylcholine
2. Receptors on the muscle cells open up and release a rush of sodium into the cells as a graded potential (since they are ligand-gated sodium channels)
a. If strong enough, nearby voltage-gated sodium channels open
3. Action potential goes to the sarcolemma’s T-Tubules, and triggers voltage-sensitive proteins linked to calcium channels in the sarcoplasmic reticulum
4, Calcium channels are opened and release a rush of calcium into the cell
5. Calcium binds to troponin and changes shape, then pulls tropomyosin away from actin strands that myosin wants to reach
6. Myosin that contain and converted ATP to ADP move into a stretched position and bind to actin
7. Myosin releases its stored energy and changes shape by pulling on actin strands
8. Sarcomere retracts and causes the muscle to contract
9. Myosin unbinds with ADP and phosphate and changes shape, which causes ATP to bind to the myosin
10. Myosin changes shape and unbinds from actin
11. Myosin converts new ATP into ADP and phosphate to be prepared for the next release of energy
12. Calcium pumps take calcium from tropomyosin to restock sarcoplasmic reticulum
13. Tropomyosin is put back into place
Thank you so much for creating these videos, I wouldn't have passed any of my science courses without Crash Course!
I had to take notes step by step to get the process and now I completely get the concept! It was one ear and out the other in my lecture but now since watching this video for 2 hours, i get it now. I should be prepared for my exam this Wednesday.
Thank you Hank. Your videos are so helpful! You should know many of us (including myself) are going into the medical field, and we could not be more thankful!
love the "okay, okay" fault in our stars reference
This video is better than anything my biology teacher says...
Crashcourse, on behalf of all the academic viewers so passionate about learning and those viewers who procrastinate in school, thank you.
definitely one of your best videos yet guys, great work
SO much of me wants the little noise that happens when the ions bind to receptors/troponin as my message tone. Its so satisfying and also reminds me of how much these videos are going to help me nail my exams!
this needs to be said: I love the little chubby fish on your right.
- and ofc: awesome video
The savior of K103. As an IUPUI Jag, I have to say I appreciate the nod to your brother. 😊
I've played this 3 times and I still feel like I know nothing. Onto Three hundred.
I swear if I had him as my professor for Bio I wouldn't mind going to class. Thank you for explaining this part of the chapter in a way we can understand it. you are helping me for my bio exam. BLESS YOUR SOUL
Who’s still watching these in 2019?
Im watching it in 2022
2020 and I think this video is out of date, because phosphate detaching from Myosin should cause a power stroke. My question is does a cross bride form before or after ATP binds to Myosin?
@@mariosaldana1053 wat
Very sweet, but why is it not translated into Arabic?
let me sleep the Myosin head has an actin binding site and an ATP binding site, so after tropomyosin leaves the actin binding site uncovered, ATP binds to the myosin head and the myosin head hydrolysis ATP into phosphate and ADP, the hydrolization of ATP causes the myosin head to become erect and be able to form a crossbridge with actin. Phosphate detaches from the myosin head causing a power-stroke. Then ADP detaches from the myosin head after the powerstroke and a new ATP attaches to the myosin head initiating the cross-bridge cycle.
I love when my anatomy teacher shows us crash course videos! It helps me understand so much better.