Your Microbiome Holds The Key To Curing Parkinson’s | Sarkis Mazmanian, PhD x Rich Roll
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- Опубликовано: 2 июн 2024
- Rich sits down with Caltech microbiome research scientist & microbiology professor Dr. Sarkis Mazmanian to talk about how gut microbes influence neurological health, behavior, and conditions like Parkinson’s, autism, and depression. To read more about Dr. Mazmanian and peruse the full show notes, go here👉🏾bit.ly/richroll831
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TIMESTAMPS
00:00:00 Intro
00:01:29 Introduction To Microbiome Research
00:04:23 Defining The Microbiome
00:06:11 Acceptance Of The Microbiome
00:07:53 Caltech As A Research Environment
00:09:04 The Gut-Brain Axis
00:13:52 Co-Evolution Of Microbiota And Humans
00:18:25 The Hygiene Hypothesis
00:20:45 Factors Affecting Microbiome Health
00:21:35 Building The Microbiome
00:22:26 Prenatal And Early Life Microbiome
00:24:39 Flexibility Of Adult Microbiome
00:26:27 Microbiome And Potential For Disease Transmission
00:29:49 Sponsor Break
00:30:55 Genetics And Microbiome Interaction
00:32:42 Environmental Triggers And Microbiome
00:35:55 Parkinson's And Gut Microbiome
00:41:55 Autism And The Microbiome
00:45:42 The Gut-Brain Axis And 4EPS
00:47:58 Oligodendrocyte Biology And Myelination
00:49:42 Parkinson's And Alpha-Synuclein Aggregation
00:52:55 Inhibition Of Bacterial Protein As Therapy
00:54:09 The Vagus Nerve And Parkinson's
00:57:01 Challenges In Translating Findings From Rodents To Humans
01:01:31 Sponsor Break
01:02:37 FDA's Perspective On Microbiome-Based Therapeutics
01:05:14 Direct Testing In Humans
01:06:27 The Effect Size Of Drugs
01:07:35 Research Landscape Of Neurological Disorders
01:08:36 Microbiome And Depression
01:11:06 Bi-Directional Communication Between Gut And Brain
01:13:29 Future Interventions For Microbiome-Based Therapies
01:15:56 Challenges And Potential Of Fecal Transplants
01:19:05 Complexity Of Microbiome Data
01:21:35 Dream Experiment For Studying Microbiome Impact
01:26:29 Influence Of Gut Microbiome On Food Cravings
01:29:12 The Microbiome And Sugar Cravings
01:30:17 Microbiome's Potential Impact On Addiction
01:32:10 Impact Of Diet On Microbiome And Cravings
01:35:50 The Microbiome's Influence On Sentience
01:38:57 Lifestyle Factors And Microbiome Health
01:40:30 The Role Of Fiber And Plant-Based Diets
01:43:48 Challenges Of Microbiome Testing And Interpretation
01:46:27 Future Of Microbiome Research And Healthcare
01:48:16 Big Pharma's Stance On Microbiome Research
01:50:04 Big Pharma's Business Model
01:51:54 Intellectual Property And Genetic Modification
01:53:10 Challenges Of Genetically Modified Microbes
01:54:54 Axial's Clinical Approach
01:58:37 Parkinson's Intervention Development
02:01:34 Microbiology Renaissance
02:02:42 Educational Resources And Skepticism
02:04:12 Closing Remarks And Credits
* * * * *
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It was an honor to host Dr. Mazmazian-truly one of the world’s leading scientists on the cutting edge of what the microbiome can teach us about well-being and disease. He is also a superb communicator, translating complex ideas into understandable concepts and actionable takeaways. I love this conversation and appreciate the incredible value Dr. M delivers in this exchange. Take notes and if this video was helpful please subscribe-it’s easy, free, and very helpful to us. Thank you!
It wasn’t easy to listen to such casual and normalized talk about experimentation on animals without any acknowledgement of how ethically problematic it is. However, I appreciate you calling out the scientific limitations, and only wish it prompted a reply that took into consideration the growing toolbox of human-centric nonanimal technologies.
Great interview!
I really appreciate this interview. Especially the discussion on oligodendrocytes and myelin production. I have been living well with Multiple Sclerosis for 18 years. I went vegetarian in 2006 and whole food plant based in 2017. The gut microbiome research fascinates me and I believe part of why I am doing so well is by having a healthy gut.
Good for you!!
@@kathiebishop1 thanks!
Have you seen the work of Dr Exley? He found MS highly associated with aluminum in the brain. He found an even stronger association with Alzheimers. Aluminum also poisons and disturbs the mucous lining of the gut known as mucin. Fluoride increases the absorption of Al and may be the key to fluoride's toxicity. His book is called "Imagine You Are An Aluminum Atom".
The FDA does a terrible job watching out for society’s safety. And does a great job of restricting access to drugs that may actually work or help.
Rich listens with such intensity that it enables him to ask such great questions. While listening I kept saying out loud, GOOD QUESTION! Rich may be the best interviewer I've ever listened to.
Yes!!😊
There is some interesting research about how walking in a rich forested area impacts our microbiome.:)
The Dr. is a complete and utter joy to listen to and learn from. Also, hallelujah! A prominent figure in the field of research is finally speaking out about the importance of shifting from animal testing to human testing (at least in certain circumstances). It's about time.
Humans have eaten meat at least for 2.5 million years. Thanks to that and even more since the discovery of cooked meat the brain increased its volume to double and we became homo sapiens sapiens. But now some geniuses tell us (with fake or no evidence) that meat is harmful to health.
There is information in every minute, much of it new to me. The discussion is worth the entire two hours.
It is not information, it's speculation.
Thanks Rich, you’re a great interviewer 🙏🏼
Thank you so much Rich & guest Dr Mazmanian, this is the kind of info - knowlegde we all need to know and thank to you, you bring it to everyone who wants to heal, learn, see further than 'what we see on too many other places', the lenght is great for hearing the whole story and makes it understandable for all, bless you, from Belgium. (when people do not have the patience (?) to listen what can help, that's their choice.
The state of the microbiome is a reflection of the sate that community in general has gotten to in the world. The take-away is that as long as we are operating in an anti-relational, hierarchal, dominating 'worldview' we will suffer needlessly and destroy the very diverse and beautiful communities we depend on for solutions, evolutions, adaptations, nourishment, care, etc. This is a call to de-capitalize and reunite in relationships that are actually about consent, care, transparency, diversity, localized efficacy, decolonized timelines and structures, redistribution of resources and experiences. The reason many different people can't, wont, don't want to or are unable/uninterested (for many legitimate reasons) in listening to a 2 hr meandering conversation is because of the very burdensome and unsustainable/unmanageable way of living that has globalized itself; an anti-relational worldview. Just like we were punished early on for listening to our intuition and trying to honour our felt intelligences, by this oppressive structure of colonial-capitalism, so to have the organisms that make up the communities within us been abused by the same 'logics' and tactics and realities of that system. It's time to come back together in deep authentic community, which requires many skills and perspectives that we are desperately lacking. Somatic abolitionism is one of the key ways back to health. Rich, you should have on Resmaa!!! Personal transformation and accountability, and deep belief in an alternative way are prerequisites to sustainability. Black and Indigenous wisdom has been offering ways back into balance for as long as the current dominant movement has been reeking havoc.
Before they died at 30 years old, jay. A cavity and 6 feet under.
Enjoyed this conversation very much. Rich, in case you see this, my personal theory on good / bad eating resulting in my microbiome calling out for or craving the same good / bad food totally mirrors yours. You asked the question (a bit sheepishly) right as I was thinking about it again and I was super grateful (and actually a bit surprised it was not confirmed!)
Absolutely fascinating! Thank you Rich!
After 2 decades of chocolate addiction, I managed to (mostly) get off it, by replacing the milk chocolate with dark chocolate (min 70% cocoa). I can now have a tablespoon of cocoa powder in a smoothy without it triggering me buying a chocolate bar in the supermarket. I do feel that this is (in part) because I starved the microbes that craved the sugar-fat-cocoa mix.
Be careful , OXALATE! ❤. Eyes mind heart and soul wide open. NO FEAR !
@richroll I am really looking forward to watching this. And I would really love to know about it’s applications in trauma and PTSD as someone with both. Thank you for all you do. 💖
There is definitely a microbiome axis to trauma. I think this is discussed in 'This is your brain on food'. Personally I found that while therapy helped, I improved my mood significantly (after) when I started regularly eating (home) fermented vegetables. It felt quite miraculous. I could drink a glass of bouillon with a tablespoon of fermentation-juice and feel happy (almost giddy) for the whole morning. The effect is gone now, probably because I'm overall more happy. I do still consume fermented products daily (mostly hot sauce), but at the time it felt quite essential to my happiness.
I do think I healed my trauma caused microbiome disturbance with food. I did combine this with a whole food plant based diet, which is in itself great for the microbiome.
I would not wait to try this sort of thing out, the evidence that fermented foods help the microbiome is already pretty significant. Check out the work by the Sonnenbergs for that - there are plenty of podcasts on RUclips with them.
The trauma axis is less discussed, but as this is a healthy trajectory anyhow, the worst that can happen is that you get more healthy and just a bit more happy.
@@k.h.6991 Thanks so much for your reply. This is so helpful. I started the whole food plant based diet last Sunday and I have already noticed a difference. Therapy has been helpful but it’s not enough and I have done the medication route in the past and the side effects are something I don’t want. I truly believe that the trauma led to the inflammatory conditions I have dealt with in my joints and a recent POTS diagnosis last year. Reading about plant based whole food and learning more after listening to one of Rich’s compilation interviews led me to T. Colin Campbell and the other’s Rich has interviewed and it just intuitively feels right that this way of eating can help and heal. Based on how I am feeling after only a week I’m in. I will definitely look at the resources you shared and look into fermented foods. Thank you again
Wow!!!! Exciting conversation between 2 fascinating people
So helpful, useful, informative and ongoing. To be continued!
Really . How ?
Wow. this was enlightening ...thank you
Dr. Sarkis insights into the microbiome's impact on health are truly eye-opening. Understanding its role in conditions like Parkinson's disease not only expands our knowledge but also opens up new avenues for more effective treatments. 🧠🔬
Incredible, right?
Also, someone please let Michael J Fox know about this, if he doesn’t already know. This could be huge for that community.
That’s the first thing I was thinking about it 👍✌️
What Mazmanian rightly says is that once you get the Parkinson's diagnosis, the damage to the nerves is already considerable. He does not suggest that this knowledge can cure Parkinson's.
Michael has the money to have the best the best working on him.
Thank you very much, as this conversation leaves me even more hopeful.
For the past number of years (five plus), I became quite "unwell". I've been on a journey of seeing specialists in an attempt to resolve the cause of my illness and new list of symptoms that have become serious enough to be effecting my life, my work, relationships as it has been debilitating, keeping me from my prior good health, very active, creative and beautiful lifestyle. Apparently a "mystery" to many physicians as I have agreed to a litany of lab tests, scans, etc as I've been desperately hoping for insights, answers and diagnosis in order for me to understand and be able to apply approaches to healing so I may get back to my healthy, vibrant lifestyle. My illness has remained completely mysterious with no definite results and or approaches.
I have been listening to countless podcasts, reading, ect. In hopes to at least apply my prior knowledge of nutrition and wellness. The past two years I've been "feeling" that it must be something related to my micro biome.
I thank you very much gentleman with much appreciation, for forward thinking, the research and the conversation of scientific possibilities.
Tara
Lyme ?
Have same from. Long covid w cormododorues, lyne, mold, celiac, gut dxsbiosis, skin issues, must test gut GI map 1st,is your sibo methane or hydrogen? Can't just pop a pill, probiotic, see Byron's herbalist, Australia, prices healmgut, also Dr Paul Anderson, Seattle, gut brain health.. is a long process, step by step🙏💕.. this was spot on
This queezy feeling throughout this important conversation due to all this animal testing parlance without any regard to the other qualities that link is. We have similar vagus nerves, what about a desire not to be caged, mutated and tested on. Isn't that why this is done to rodents anyway? It would be cruel to do to people, so we just change it to whom we regard as less worthy of human consideration. Sucks.
Agree.
And this information is obvious and has already been shown for years.
All that testing and killing, just to document the possibilities of a theory’s outcome
💯 agree🙁🐁
So this is all you got from that ?
Not the fact that drugs tested on rodents in 90% don’t work in humans… and perhaps that’s why humans have irreversible side effects.. sometimes?.
I feel bad for humans.
Let me see ..🤔 I feel bad for rodents to live in the sterile areas with purified air and water. Eating good food and have excellent service. Not only that… they are treated if they get sick and the best is that drugs works on them most of the time. They being taken care of if they get sick.
They are expensive too …lol
Would you like the brilliant scientists of the world discover solutions for illness or not?
I am against animal testing, as well. I just want to point out that at 1:05:15, the doctor suggests that it might be more effective to go directly to testing on humans, rather than rodents, in certain circumstances. It is heartening that this assertion is being made by someone who is in a powerful position to possibly effect the way research is conducted in our country, as he is highly respected in his field.
My understanding so far is that genetics are a result of not just environmental change but also the physical manifestation of mental/emotional, and yikes! even spiritual will.
There is a pretty good argument out there for the nonexistence of self will but does it really look at more than flat data?
Over the last 20+ years I've been on a journey of changing my genetic expression, and the most effective supplement has been relationships and shifting my orientation spiritually.
Looking at my thoughts and knowing that they are the root cause of everything that is eventually encountered.
My daughter and I have a different relationship with each other and I have finally come to see that I have value just as I am and that my small life is limitless.
Autoimmune diseases are symptoms of greater disfunction in the self, community and relationships across the board.
Les’ Go!
Might be interesting to develop a “Prompt” (question) for AI (ie ChatGPT or others) on what it thinks is a better nutritional direction for human health, for longevity and quality. Just a thought. would pursue it myself but not quite sure on best way to phrase “the question"
Very interesting! Humans should be educated more in this field. My husband who is 55 years old since his was 28 years old have been dealing with IBS symptoms and have seen numerous doctors in this field with no solution to this date !! Now is just getting worse 🙁🙁
Also sadly at 54 years old he was diagnosed with CLL which is cancer in the blood and bone marrow. I wish all the doctors with work together to help humans with their health. It’s just very frustrating and sad 🙁
Fire his doc. ❤😢 . Tell him to grow some balls and take controll of his OWN health . PLEASE ❤. Eyes mind heart and soul wide open. NO FEAR! PS . Tll him to STOP all alcohol! ❤
Iron in our food, since the early 50'S. Folate! WAKE UP ! All by design $$$$$ . 😢Good luck to whoever listens to this podcast . This is NOT the answer (?). 😢sad. Eyes mind heart and soul wide open. NO FEAR ! ❤ Sad for Rich , he's being swallowed up by the matrix. ma - TRIX . $$$$$$. 😢 sad. He should talk to Joe R. ❤
Im worried about Rich, with all the green juice blend consumption I'm seeing now a days ! OXALATE is a SLOW killer POSION. Ten, twenty years out . I now know of people who have been jucing for many years and are now ill. 😢 sad. Over jucing can cause LEAKY GUT! Please be careful. Time is begging to tell . ❤Don't die. See you in 2500. Eyes mind heart and soul wide open. NO FEAR !
Not sure Autism’s a disease but still an interesting topic❤
Yes - the topic was more about the relationship between the microbiome and the nature of some forms of neurodivergence
Okay why even add autism is or isn’t a disease like that adds nothing to the discussion
Ahh I see! Ty man
@@richroll perhaps it would be better to change the order of the title in that case. Eg other diseases and autism.
I'd ask what those gut bacteria and what molecule signal accumulation of amyloid are. In addition, what kind of environmental factors associated with this kind of bacteria? like processed food?
I was trying to find the effects of artificial sweeteners. Did anyone find a time this was discussed? I’m addicted to diet sodas and I’ve heard mixed signals about their negative effects. Thank you for spending your time to consider my question.
Why are there haters on the gut microbiome science wtf
Rich, it would be so cool if you could interview Robert Kennedy Jr, he really cares about these things
Extra ordinaire ! Hello from France 🇫🇷 fox
58:56 It's even worse than that. As I understand it, lab mice have elongated telomeres which leads to them being able to rejuvinate more robustly, which hides things which are potentially harmful to humans.
Even more worser, experimenters can choose which lab animals to use to show certain effects. Mice show more effect and less harm, primates show less effect (not sure about harm). So, depending if you want to show an effect or the lack of an effect, you can design your experiments accordingly.
And the most worstest, you don't have to publish unfavorable findings.
Hey Rich , it ain't about how much money you accumulate! Its about how much HEALTH you have not wealth you have . 😢❤
What is this drug, and are there trials? I would LOVE this for my mother. Please please advise
It's microbe not drugs , drug kill the good health
The spice, the spice melonge
I would love to contact this Dr! My Mum has PSP (when Parkinson’s medication doesn’t work they diagnose this) and has basically been given a death sentence - nothing will make it better, nothing can help apparently. The only thing we can do is to make her comfortable as she continues to deteriorate ❤ if there is ANY way I can help her get better - please contact me!
@ ticasey - YT won’t allow me to reply to you 🤔….
My answer is- change her microbes in the guts- just like this doctor said.
Feed her a whole food plant based diet. This may slow the progression of the disease.
@@k.h.6991 So absurd
Look at the u tube videos on vitamin B1 for parkinsons. ...
Junk , flawed experiments... ❤😢. Eyes mind heart and soul wide open. NO FEAR !
Well, I wanna get a fecal transplant.
Me too!
In a double blind randomized controlled trial, rimmers were found to have healthier gut microbes than non-rimmers. Just kidding, I pulled that out of my ...
😂
So my understanding is if you try to change the micro biome, Incan briefly. But once you stop with interventions, it goes back to how it was.
Eating a wide range of plant foods, modest amounts of other stuff, minimal amounts of ultra processed food, sleep well, regular exercise...is not intervention. It's how you manifest intelligence.
Activia 7:28
Hey Rich , MTHFR . Wake TFUP. ❤. All due respect . ❤. Wheres Julie ? ❤
Would anyone be kind enough to give me the take away of this interview? Are there actions we can take. Does it boil down to a diversity of Whole Foods?
Genuine question: You have no time to watch/listen to it?
Would it help if the summary was sent to you via email? Maybe other episodes too
I agree. Two hours is too long. A summarized version would be fantastic. ❤
TL;DL? Listen in batches, speed up in places that do not interest you, but the entire discussion is useful.
@mco119jj sadly we've become a TikTok generation. A generation of sound bites 😔.
As with all discussions of human health, there is no "take away".
Where’s the natural solutions here😊😊
192 👍
Drug with no side effects hum
Lol recovering lawyer
It says microbes as medicine didn’t say drugs😊😊
The matrix $$$$ is taking you out 😢❤ !
Flea
My father died of Parkinson’s. He drank regularly. I wonder if alcohol destroys your micro biome. Logically yes.
Yes, it does. It is also neurotoxic when abused. Dose makes the poison.
There is already data that the spike protein damages the biome
ok came here for the clickbait title. I am autistic. I DO NOT want to be 'cured'.
It is my autism that allowed me to 'talk' to my gut biome and learn that when I went on holiday in france a new strain of Smithii joined my biome tenants and directly caused PI-IBS that had given me a lump for 20 years.
double dose of vegan bile followed 24 hours later by a triple strength regime of acid loving probiotics... lump gone as if never existed.
Yes I agree the bile is the key can you talk a little more about the procedure
@@karenedwards3721 Bile in my context would probably have done very little to Smithii as it prefers an alkelai environment, but I actually think the function of the bile in my situation was to act as a surfacent and agitator.
It purged my intestines of things that had gotten stuck. there were actual black lumps in the stool afterwards. just once, and it looked old.
In any other situation, black stool may have been terrifying and hint at deep bleeding, but I just knew it was not that and didnt feel trouble.
The whole thing makes me think that i got a bit of food stuck in a place where we would call leaky gut and my IBS lump was nothing more than a protective cramp, possibly even trying to prevent the food from penetrating deeper.
then I followed it with a large overdose of probiotics. with the dual intention of replacing the good after the bile and making sure that I had so many acid loving bacteria in a short time that they could not help but alter the PH of my colon towards more acid.
That is essentially it.
the only part I am not detailing is that within the same 24 hours of my treatment, I also had some recreational substances.
they may have played a part, but unlikely.
He try’s to make microbiome so mystical and not something you can control and correct.
Brilliant guy. Woody Allen can play him in the documentary about his path to the Nobel Prize.
Very interesting information. I can't help noticing, though, that the huge number of vaccines infants are subjected to wasn't mentioned when listing what has possonly affected human mictobiome. It can't possibly have been omitted accidentally - not between two such intelligent people - which leads me to believe it was intentional. I mean...you wouldn't want to get cancelled for telling the truth, would you?
Why aren’t you talking about correcting micrbiome instead of drugs. Just awful and so old school. You guys are part of the problem.
🩵
JUNK !
marginal evidence, overstating the size effect of an improved microbiome
Microbiome is the new hype, way overrated.
Almost every mental health issue can be traced back to an unhealthy microbiome. Bad take
Underrated!
You’re so naive people already been curing disease on the underground with fmt’s
The contribution of food to health is, in general, still way UNDER-estimated. Food is a major factor in a healthy microbiome, so it is probably also underestimated.