Ristocetin Tests | Hematology
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- Опубликовано: 27 авг 2024
- Ristocetin Tests: Ristocetin cofactor essay and Ristocetin-induced platelet aggregometry (RIPA) | Hematology
Measuring platelet aggregation (Platelet Function Tests).
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Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).
Bleeding 🩸 time (BT) is another test for platelet function.
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I know one more distinction between RIPA & Ristocetin cofactor assay.
RIPA uses patient's platelet rich plasma (tests at the same time vWF and native platelets function) while Ristocetin cofactor assay uses the patient's platelet poor plasma (with vWF but no native platelets) and adds ristocetin and exogenous formalin-fixed platelets which can passively agglutinate. Formalin does not allow the extrinsic platelets to secrete the vWF of their α-granules, and thus only the activity of the patient's intrinsic vWF is tested.
In Bernard-Soulier: RIPA is hypoactive, while the ristocetin cofactor assay is normal (because the problem is in native thrombocytes, not in vWF).
In Type 2B vWD: RIPA is hyperactive, because native thrombocytes are already fixed with vWF & small amount of ristocetin causes rapid reaction. While the Ristocetin cofactor assay is hypoactive, because when you take platelet poor plasma all the vWF is lost with thrombocytes.
Thanks for the explanation
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Absolute legend! Thanks, man
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Im so grateful for your explanations, you are ultimately helping patients throughout the planet! God bless!
Thank you so much 😊
" Why don't they explain like this in medical school?" - couldn't agree more~thanks to you atleast! #SAVIOR! :)
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I am honored!
Platelet aggregation test starts at 7:37
RIPA at 9:53
Thank you 🙏
This is making my life easier.
And my reading is now making Sense
Awesome 👏
BT is also obsolete, and rarely used anymore. Thank you for the mention of Med Techs! :)
You’re welcome 😊
Big fan. I made a channel with STEP1,2 practice videos because of you. I also love educating.
omg STEP0 you the bomb dood
I’m a new lab scientist trying to get my head around the tests. your comment at 6:35 made me laugh. Thank you for the detailed explanation
You said " God bless lab scientists who has to deal with all these crab "
😀😀😀. Thank you
My pleasure 😇
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Thank you so much 😊
And I learned it while doing your gorgeous 50 hematology cases, they made me work hard)))
Юлия Шеина I am so happy to hear that...You're awesome 👏
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Best teacher, thanks a lot
My pleasure 😇
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ur amazing
thank you
Thank you 🙏
Excellent explanation! Thanks a lot
My pleasure 😇
So gooooooooooood! U save my life
What is RicoF test and Vwf:Ag test. If you know plz tell me
Thank you Sir 😊
You’re very welcome!
Excellent thank you doctor
How can we understand if it's von willebrand disease or bernard soulier using RIPA?
Is this a type of caccer? Plz reply me
Thanks a lot!!
My pleasure 😇
Amazing!
Thank you so much 😊
why ristocetin cof is decreased and ripa increased in same disease i.e type 2 b vwd.
Is this a type of cancer? Plz reply me
I have VW
Ohh 😮
I am sorry to hear that!
How is your health?
Is this a type of cancer? Plz reply me
Is this a type of cancer? Plz reply me