How to Take Niacin Without Hurting Your Liver | Chris Masterjohn Lite
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- Опубликовано: 8 сен 2024
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I love niacin. I use it for blood flow, pain, sleep, anxiety and and as detoxification stack with infrared light sauna therapy. Its not just for cholesterol. Its a pretty amazing. I take 500mg doses. But i started with 100mg
I really enjoy the flush.
I've just took 500mg for alcohol withdrawal, the scaly skin behind my ears has vanished and I'm now going for a sleep burning hot! I love it cuz it really helps
Is it ok to begin taking 500 right away. I just bought some for anxiety and sleep
I've taken 1,500 mg of Niacin daily for over 30 years as prescribed by my healthcare providers. I get tested every so often, and have never had any problems with my liver enzymes. My understanding is that it becomes dangerous in amounts over 2,000 mg/day.
Usually the slow release type is the kinds showing liver damage. That's what I've read in studies.
I love niacin flush.
@@Soul_Contract Yes, the slow release is the dangerous type of niacin. I love the "burn" too. Especially taking a dose right before I lift weights!
@@big-daddy-o8576 yeah, it really puts the zest in. Do you take it empty stomach or with carbohydrate?
@@Soul_Contract I usually take it with food, but I don't need to. I'm very used to the affects. Been taking it for 30 years.
30 years. That’s impressive.
People take niacin in high doses for relief of panic attacks and anxiety, not just cholesterol.
@@ydl3084 I wish and I've been trying for years but it only kept getting worse
@@ydl3084 You obviously don't know what anxiety, or panic attacks are.
We aren't talking about feeling shy, or nervous. This is a severe and debilitating condition, that is caused by a chemical imbalances. I have it. It is also caused from severe childhood trauma and neglect.
I have it so badly, I used to get hospitalized, because I couldn't sleep for a week straight.
You have no idea what you're talking about.
@@kaylacarpenter272 Agreed on all points. My anxiety is comparatively mild, but I’ve been surprised by the extent to which it responds to fixing hormonal and nutrient deficiencies (ie, physical health problems). I didn’t know that niacin is potentially one of them.
I can say one thing, If you take niacin on empty stomach you get panic attacks and anxiety, thats for sure. Strange....
Hi does it help with anxiety thx
Signs of liver toxicity:
* Elevated liver enzymes
* Jaundice
* Nausea
* Vomiting
* Headache
Doses with higher risk of liver damage:
* >3-9 g nicotinic acid, but potentially as low as 750mg
* >10 g nicotinamide/niacinomide, but potentially as low as 3g
All forms of niacin have potential for liver toxicity, primarily be depleting methyl groups in the liver. You can avoid this by doing the following:
* Match your nicotinic acid or nicotinamide/nicinomide dose 1:1 with TMG (trimethyglycine).
* If taking nicotinic acid, take half the dose as glycine or 1.5x the dose of as collagen/gelatin. This is in a addition to TMG. So for 1,500 mg of nicotinic acid, you combine it with 1,500 mg of TMG and 750 mg of glycine (or 2,250 mg of collagen).
* If taking NMN or NR, use 2:1 ratio of those forms to TMG- that means your TMG dose will be half the NMN or NR dose.
Can we skip the TMG and just use glycine while on niacin?
@@larryc1616No because the TMG is necessary to provide the methyl groups so that you don't become depleted in methyl groups because niacin uses up methyl groups. Make sense?
But there are methyl donor as well?
I take 500 mg to control skin cancer, namely Bowens as recommended by my radiologist. Lowering cholesterol was a bonus. It only works with the flushing type. Flushing does not bother me given how improved my skin cancer is.
It helps with skin cancer?
It's really important that you make sure you're getting a good amount of all of the other B vitamins as well so that you don't cause any imbalances. Nutritional Yeast or Liver are good options.
Yes, I am just starting to integrate more b3 foods in, but what kind of liver? I think this happened in me cause I don't like eating fish at all. I got the nutritional yeast tonight + will eat more turkey + eggs
where are you getting thst informatio?
If you look up oxalate content in nutritional yeast, it'll knock you off your seat.
Nutritional yeast is harmful idc what you say it's associated with a bunch of diseases. Contains high levels of MSG and isn't healthy at all. One of the worst things you can take if you suffer from chronic illnesses.
Niacin does a lot more than just control cholesterol
I have no doubt most people take niacin... but it can also be used to reverse schizophrenia and probably other neurological conditions ... would love to hear your take on using niacin for these purposes... apparently there is a book written in the fifties or 60’s about clinical results.., and I think there might be literature from the late 1800’s using a nutritional approach to help schizophrenics... it seems there is about a fifty percent success rate using niacin/nutritional approach to reversing schizophrenia... sounds like a good approach to try before committing people to psychotropics... my neighbor is schizophrenic... it’s not cool
Correction: I have no doubt most people take niacin for cardio reasons
@Lisa Bohanan can you share the protocol please?
@Lisa Bohanan I hope it works! Can you please share you observations if you see any improvements?
I think a ketogenic diet has been prescribed for epilepsy and schizophrenia patients since the 50’s too?
@@idkijstmadethis4no yes the keto diet might work as new findings suggest schizophrenia is related to an issue with glucose metabolism. But there is also research showing schizophrenia is associated with methylation abnormalities, and more specifically overmethylation. Eating a lot of meat in this case as is often done in keto would be counterintuitive. The safest approach for schizophrenics would be to do keto while limiting meat/eggs and animal products in general and to get most their daily calories from vegetables. While also taking high dose niacinamide and zinc to over time lower methylation and decrease copper levels which has been shown to negatively affect impact the brain and is associated with anxiety and schizophrenia.
I also found out that alcoholism is successfully treated with high doses of Niacin
I just took it and it helps definitely
What is the dosage to take for alcoholism?
Please help me.
Thank you🙏
Best not to drink at all. I come from a dry culture.
What a ridiculous post. We aren't all you.
@@nassermj7671 He mentioned that he/ she was an alcoholic. That is an addiction. I am sure that you are addicted to something at the least "judging," others.
This video literally saved my life! I was dealing with major fatigue day after my workouts for the longest time. Thank you so much!
My naturopathic way to get TMG is to have 100 grams of Spinach(110 mg TMG),
100 grams of Beets(260 mg of TMG),
100 grams of Quinoa(gives 600 mg of TMG),
50 grams of Wheat Bran (160 mg of TMG) which offer around 1000 mgs of TMG to me for what you suggested as I cannot find TMG in India at an affordable price.
Thank you for the amazing Information.
uhhhh youre gonna run into other problems getting TMG from spinach and beets... why not collagen protein instead? wtf?
@@bannanaization why would he tho
Any luck finding affordable tmg in india ? Also what brand niacin do you suggest
@@shejar why would he run into other problems? Oxalates
@@bannanaization I don't think 100grams of each will give him that problem but 100grams of spinach can be a lot I guess.....Also oxalates doesn't effect everybody I think?
Niacin seemed to help a bit with adhd too
I agree 👍
We're not graduate students doctor. Your challenge is to say it in layman's terms so we can all understand. Hope that helps for next time.
Krane maybe you could crack a book yourself? Just saying.
@@JCrow-kz4nw As a matter of fact I did, and took the course. That's how II learned how it's suppose to be done. Allow me to refresh your memory. First rule: consider your audience. Perhaps you also slept through that class?
@@krane15 Yes. But his audience should know this...people into b3 niacin are following.
trust me, it's better that he doesn't dumb it down. You start to realize your average mainstream tv doctor is full of inconsistencies because of how dumbed down it is. You can't dumb down science, or else it is full of bad information.
@@Submersed24 Fortunately, I've learned enough to know that nothing could be further from the true. In fact, its the very best teachers that have the experience and vocabulary to put things in terms simple enough for others to understand.
Its like learning math: you can define an abstract to someone perfectly in scientific terms, but it means nothing to them unless they have something tangible to compare it with.
I’m taking niacin. I started with 1000 mg. I up this by 1000 per month for 6 months. I now take 3,000 mg in the morning and 3,000 at lunch. I have taken this for 15 years. I had a cholesterol of 270. Before niacin, I was taking several different cholesterol medicines. I tried four different brands and they all drove my liver enzymes up. Now my cholesterol is 159 and my liver enzymes are perfect as a matter fact my complete blood work is perfect now but the main reason I started taking niacin clean the cholesterol in my veins, i take 6000 mg a day and I don’t feel any flush when I take it. As a matter fact, it even gives me a little energy and if all you’re looking to do is lower your cholesterol. What niacin did for me? Was it helped lower my blood pressure in conjunction with my blood pressure pills. With the blood pressure pills I was running about 130/90.. once I began the regimen about 18 months afterwards my blood pressure lowered to 110/70 and stayed there since. When I reach 65 they did the x-ray of the center part of my chest. Check the aorta for cholesterol buildup. The doctor was surprised to find that I had none. Of course I never told him how much niacin I was taking. I didn’t wanna freak him out. But I’m just one person and not a study. But I have 15 years worth of history. The other part of niacin is, you’ll be hard-pressed to find any of it has flush with it. Everything they sell now is flush free. They’ve done several study’s on niacin and it help the fatty liver to lower enzymes . This is diametrically opposed to what this guy is saying.. I take responsibility for the care of my body. I read a lot and make the best choices I can based on the amount of knowledge they put out there.. I never go on what one person says I always look for a consensus. I’m now 70. I can run now where I couldn’t 15 years ago. I am very active and have not gave up any of my favorite sports. The above number were at a weight of 208. In the past 3 months i started Ozempic. I’m now down to 160. I feel even better. As we age we have to take control over our body’s while still working with your family doctor. I just did my yearly checkup and my doctor was very impressed with where i am today. I still ride my dirt bikes and crotch rockets. I still bass fish, i scuba dive and now restore old cars. Just because we get old doesn’t mean you have to give up and go to a nursing home. Stay on top of your health and it will take care of you.
Are you saying that you take niacin flush free or flush effect?
@@Harry00020
I’ve taken it for 15 years. I can’t feel flush anymore. I don’t believe it’s flush free. But I’m not sure they make a niacin pill anymore that gives you a flush.
Exelent ! way to go man!
@@mikerash-pc4jc still confusing, which brand is he using,? Is the niacin flush free ,? Did he get these results with the flush free version?
good to hear this info to counter the imbalance caused by high doses
Megadoses of Niacin also help with schizophrenia and bipolar disorders. The question is how to take megadoses on a long-term without damaging the liver. Thanks for this video.
I think 1-2grams a day should be fine. People who do the anti aging protocols (check Dr Brad Stanfield's youtube channel) take around 1mg one to two times a day, with TMG (and other B vitamins and Magnesium).
That's exactly what I was going to mention! It's also effective for depression & addictions.
@@passsacaglia I milligram is a lot different than 1 GRAM.
Take the megadose once a month.
Take niacinamide. Keep it at less than 3g. I wouldn't go over 2g just to be safe. Limit the amount of animal products you eat. The reason niacin works for schizophrenia is because it decreases methylation and absorbs methyl groups from your body. Schizophrenia has been associated with elevated methylation. Therefore limiting meat and animal products should also be a priority for schizophrenics since they contain extremely high amounts of methionine which is the main methyl donor in the body. Niacin lowers these methyl groups so you can tackle this by both taking niacin (niacinamide is much better for this), and also limiting the amount of methyl groups you get from your diet.
This also applies to anyone who has anxiety/paranoia disorders for whom niacin worked to improve symptoms. You're most likely an overmethylator.
Niacin actually helps fatty liver
Would like to hear more as I have fatty liver
I've read studies showing it helps also. Its worth researching. Most toxicity studies are on slow release and you need carbohydrates before taking it to avoid issues too
Currently Started taking 500mg 2 times a day, and based on your advice i also added TMG and Glycine. including NAC. hope these work well together :)
What are u taking it for ?
@@petrichor100 Reduce LDL mainly
@@supernova1976 Did it lower your cholesterol?
@@I-XIV-IV-XXV Haven't tested yet . , Will update as soon as I test .
@@supernova1976 -- Are you experiencing any gastrointestinal side effects?
Most people have iron overload issues due to the copper and iron from water pipes low level poisioning us for generations just like the Romans did! You need magnesium and trace minerals to unlock the copper overload to allow the copper to become bioavailable to then regulate your iron better which is easier than having to donate blood!
wow, this is deep
I’ve been taking 2000 mg of Nicotinic Acid for 3years and my liver is fine. GGT test is normal. Don’t worry about it.
I have been taking 2 500g no flush niacin nearly a year. I'm also taking other supplements, like vit E, vit C, food based multivitamin, coq10 (very low dose 50mg), eggshell for calcium, B-complex., omega 3. Not all together, and not religiously either. Vit C is perhaps the more regular one I take and depending on need( stressors like the covid curently) I may take more some days, some days less (betw 2g up to 7 or 8g, and this is rare). My liver test was fine, last year. I probably have to do another test but I'm pretty sure I feel generally fine. No sleep problems, no fatigue, but just normal tiredness. I don't smoke, take drugs, drink, or eat any processed foods. Mostly veggies, some meat ocassionally. Very ocassional feasting, then fasting for a few meals after that. Moderate exercise.
@@hannah5245 The no flush niacin is the one more known to cause liver problems. You should get regular niacin.
Sam Herbert what are your credentials for saying that? Or have you not read Niacin The Real Story by Abram Hoffer MD, PhD, Andrew W Saul, PhD.
@@hannah5245 I don't have any medical credentials, but I do know how to read and I've read a lot about Hoffer's work. I'm assuming you haven't or you'd know he only used Nicotinic acid and stated the no-flush niacin is harmful.
Sam Herbert i have read the book at least 3 times from cover to cover! My GGT was 19! Other liver profiles came out very good too! And this even after taking more than I am taking now!
i was about to pile on the Niacin until i watched this video. I have diabetes and gout.Im glad i watched.
If you are type 2 and a fatass, i suggest watching 'snakediet's videos. Learning how to fast correctly will reverse type 2 and gout.
I heard that the flushing form of niacin can clear out the pipes as well as Dr. Christopher's cayenne pepper extract, is that true?
I love the niacin flush! I’ll take my 500mg every morning and enjoy that 30 minute ride 😬.
Hi Doctor can you tell me please if Nocotinic Acid 250 to 500 Mg per day will help me with Axiety and erectile dysfunction?
Hope you’ve gotten your d*ck to work again over the past two years lol
add TMG 3:00 and Glycine 4:05 for example: 1000mg nicotinic acid, 500mg TMG, 500mg Glycine or 1,5g collagen/gelatin.
Do you take them at the same time? I am anxious and the times I've taken niacin the flushing was severe and worrisome. I also take grass fed gelatin every day and taking glycine already. I'm wanting to help myself but the flushing makes me upset. Should I push through?
@@puggirl415 I only did the whole niacine thing for a couple of weeks. Each time was horrible and often caused me itchiness all over my body for days. I ve also had ear issues/hyperaccusis/tinitus like issues while doing the niacine. I didn’t do it ever since and I honestly don’t recall how I took what.
@@StephyGrowsWeed I'm going to keep track of all the ways in which the niacin flush can be ameliorated. Eat first, take glycine and start low dose of 50mg working up to 250 over the course of 5 weeks. If that's not slow enough then I probably shouldn't take niacin.
One side effect (?) I have by taking niacin around 750-1000mg is that I get stone cold in body, 12-24 hours after, why is that ? Its not nice.
It can lower blood pressure.
Has the same effect on me
its activating youre circulation and making you hot activating metabolism.
@@danigomez3321Put on your glasses, I wrote I was COLD !!!
It’s because it displayed your blood vessels so you feel cold after. I noticed the feeling went away after taking 1000-2000 mg daily for a couple weeks.
It also helps in alcoholism.
Thank you Chris!!!! You’re the first person I’ve heard that addresses liver toxicity remediation! Excellent video. I’m taking nicotinic acid to reduce lp (a). Did you address extended release NA as being effective in any other videos?
Wow, details really matter!! Thanks
My question is do you have to stay on it even after you have reduced your numbers and increased your HDL? can you then lower the dose or eliminate it? This would be assuming you are on a good healthy diet(whatever that is), exercise, weight is optimal, etc.
I'm good with 100mg and still get Niacin flush.
unbelieve... thanks you a lot. Can i get a answer please?
how much niacin to get the best results for lipids but not to destroy the liver?
He said over 3000 mg you have to watch out for.
Does anyone recommend some reversal of massive overdose? I accidentally ate a shit ton of niacin powder earlier last year. I was making oatmeal for breakfast and wasn’t' paying attention scooping what I thought was stevia (sugar substitute). Ended up eating about 5-6 tablespoons (estimate about 20ish grams of niacin) full because the oatmeal “just wasn’t getting sweet enough”. Huge scare, my whole body did the usual flush but x100 more intense; candy apple red, jaw jittered for an hour, felt freezing, went into an irrational panic attack, crazy shit. I’ve been feeling “dizzy” for about 9 months straight ever since, eye sight went from 20/20 to needing glasses. What kind of damage could I have done? Liver? Anyone have any tips?
Methyl support and glycine seem to make sense since you could have depleted them and never repleted them.
@@chrismasterjohn thank you very much! I’ll order some from Amazon immediately and try to remember to update within a month with updates. God bless!
Daaaag. Surprised you survived that dose. 😱
@@SkedgySky yeah it was a wild ride for sure! I recently tried taking glycine and a "mythel guard plus" from Throne for two weeks first thing in the morning, but noticed very very poor sleep so I since stopped. Hoping that's what he meant by "Methyl support"... If anyone has a clue on what bloodwork i could check or tests for the dizzy feeling I would be real grateful!
@@surfsky2264 you need complete blood work with current vitamin and mineral status
I have a question and need some help. I have a low white blood cell count of 2700. Particularly my Absolute Neutrophils is low at 977 and my Absolute Monocytes is 192, I'm 55 years old. Have to make an appointment with a Hemotologist, but in the meantime, I hear Niacin Vitamin B3 would increase my White Blood cell count and that it is very proficient in doing so. Is this true? Any suggestions would be helpful, thank you,
I have same problem. Would love to know answer.
Thank you for the updated information, and for clarifying the amount of TMG and glycine that should be taken when taking the nicotinic acid form of niacin.
I tried taking NR for a few weeks, and felt horrible. Taking TMG along with it didn't help (though it did help me feel better quickly after I stopped the NR).
I am, though, able to take plain old niacin (nicotinic acid). I don't have any problems with it... I feel fine, none of the symptoms that came up when taking NR. It completely controls my high triglycerides.
To control triglycerides, and raise my HDL levels, I've been taking between 500 and mg of niacin a day, along with 200 mg of niacin-bound chromium and 1000 mg of TMG. I do experience skin flushing with niacin sometimes, but don't mind it.) After watching this video, I'll add 500 mg of glycine to the mix.
According to the video, if you're taking 500 mg of niacin, you should take 500 mg of TMG and 250 mg of glycine.
Whot is Glycine??
Whot is Glyscine ??
Why is it a 1:1 ratio of niacinamide to trimethylglycine if there are 3 methyl groups per glycine?
That was my initial question. What if I want to only take 100 mg of B3 at a time with my 1g of TMG?! Must it be balanced?
Some studies claim that 4PY, which is a metabolite of niacin has been linked to heart attack, stroke, and other cardiac related conditions. Can anything be done to prevent this when using niacin? I would love to see a more in-depth video discussing how to take niacin safely, and any additional supplements that may have a protective effect.
Listen to Nick’s Physionics’ video on this study. He’s a PHD in molecular biology that analyzes studies. You’ll be glad to find out why he still gave the thumbs up on niacin after analyzing the study.
What about taking 500mg Niacin a day? Should I worry about liver damage? or just take it at night?
No worries.
Take at night with a meal , 500 mg
Stick with the term niacin, all those other terms confuse some people who's gonna be taking that high of a dose anyway
Could you please update your info on Niacin? Al the videos by you on it, appear to be 4 -5 yrs old. I understand that many of the studies, that dissed it, compared it against statins, rather than a placebo.
True. Physonics videos goes into depth about that study. After analyzing the studies, bottom line. It was an unfair comparison to use statins plus niacin I the control group. He said when you take those stats out, niacin is favorable.
Thanks for the info Chris. I have this SNP rs7946(T;T), does this affect my choline intake requirements or utilisation in the liver, while taking a 250mg low dose of nicotinic acid.
So what would the implications of taking niacin with a MTHFR mutation?
Interesting question. I just learned about MTHFR. Seems like it would hit livers with that mutation harder?
I still don't understand how the use of TMG helps with niacin induced methyl group reduction...
Wouldn't recycling homocysteine to methionine with TMG just deplete methionine over time?
Presumably, TMG would also increase flux down the trans-sulfuration pathway, thereby depleting methionine even further.
Could someone help clarify this for me?
Niacin also lowers bp
that’s why I am taking it Half a pill in the morning. I can’t handle the flush to intense.
@@tsrealtexan7333I take 500 mg B3 every day and do not get a flush if I take it with food.
Awesome information. You are good at what you do.
Great info! What about Epstein Barr from Mono? Isn't a person DXed with EBV a higher risk for harm to liver?
you really need to post links to citations used for this video.
Hi
I request you to cover the topic of relationship between niacin and thyroid.
Check out iodine deficiency the thyroid. I was absolutely shocked!
He has to be specific by using the long names because there are different kinds of Niacin. I ubderstood everything he said...but I am an SLP.
So should someone take TMG with niacinamide together? Or do they need to be taken? If so, exactly how much?
I described exactly how much in the video. It’s probably good to take them together.
@@chrismasterjohn Thank you!
@@chrismasterjohn could someone drink beet root juice instead of taking TMG supplement? To protect and clean the liver or even Nac or milk thistle? Or does it have to be TMG?
I say, beet root, because TMG is made from beet root.
Niacin’s is good for ED
Why would we want to control our cholesterol? Its governed by millions of years of evolution. Hdl to trigylerides is a better marker for heart disease, and its only damaged cholesterol that is problematic. Try not to damage it maybe. Try not to damage the arteries. Control our diet first. Fix metabolic syndrome. Plenty of LDL hyper responders with ZERO calcium deposits in the arteries. Even people with familial cholesterol problems die at the same rate as everyone else. It kind of throws the whole cholesterol theory out the window, much like the saturated fat theory. The thrombotic theory of arteriosclerosis fits much better. Damagrd arterial walls scab up and plaque up...causing blockages. The causes are vast. The science backs this up more than a mythical cholesterol number, which doesnt actually correlate to heart disease. Inflammation , glycation , chemical insults, pollution, stress , gum infections, leaky gut and LPS infiltration, metabolic syndrome, diabetes, seed oil consumption, suger consumption.. wars cause massive heart disease. ( stress) All these are more revelant to heart disease than the bogeyman of high cholesterol. Your post code correlates more accurately for heart disease than your cholesterol ever will. (It denotes, poverty, stress, food deserts) Cholesterol is the absolute weakest correlator to heart disease of over 40 or more factors. High cholesterol is associated with a LOWER mortality in aged populations. High cholesterol...Ldl, actually removes arterial plaque. If your cholesterol is too low...despite statins , you will still see plaque progression. Explain that? Cholesterol removes LPS from the blood. Cholesterol builds neuronal sheaths and cell membranes and countless hormones. Lower cholesterol ( from statins) causes dementia , alzheimers and type 2 diabetes). Forget about cholesterol. Just try go keep it undamaged. S healthy terrain is more important than a number. Just as many oeople die of heart attacjs with LOW cholesterol than with high. What up with that? Niacin can absolutely be beneficial to the body...but reducing cholesterol is the least of its benefits. More important is probably NAD production but it has multiple other benefits as do ALL the b vitamins. You can take heaps of niacin but if you are deficient in vit b 1 or vit b 12...good luck to you. Cholesterol is a white whale. For a theory to be correct it must be ABSOLUTELY correct, with no paradoxes or embarrassing circumstances where the theory doesnt fit. ( much like the saturated fat myth propounded by Ancel Keyes) It seemed sooo plausible....yet the full data says otherwise. Forget about cholesterol and make sure your arterial walls are healthy and you are not glycating or poisioning them. Focus on the terrain.
Thanks for all your efforts in sharing all the important info., I am a Carriers of hepatitis B, is it 500mg per day of Niacin for me will overdose in my liver? Will Niacin danger to me, if not, how many doses of it can I take every day? thanks for your response.
You should ask your doctor, not random people on the internet
Thank you, that's so interesting. Is high dose niacin (I'm not sure which form) also good for multiple sclerosis? I know they've done studies on this but I just wanted to know what you thought. Is it beneficial? Thanks!
bump
@@mateuszmazurek7991 thank you ;)
Hey, I want to know if it's good for multiple sclerosis. Have you taken it to find out?
@@shelton191 It is beneficial, yes. I bought the niacin (nicotinic acid - the one that causes the flush) and it helps in a small way, nothing significant regarding a symptom fix. But it has so many benefits in general, as in for mood, digestion, etc...that I continue to take it. I took a break for a while so I'll have to build up my tolerance to the flush again. Take with food and some vitamin C to minimize the flushing. Start at a low dose, like 50-100 mgs only, and work your way up to 500 mgs if you want.
@@ldjt61841000mg 3 x a day try get there..
How about ‘betaine’ and ‘choline’? Would it help to supplement with these when taking niacinamide? If yes, in what amounts?
Ugh...whatever you do, don't crush a niacin tab to add to your Stamet's Stack. It feels like I'm gonna die. Thought I'd make a mushroom coffee drink so I powdered everything. BIG MISTAKE. Only 50 mg but my body said nuh-uh sista.
Hello. Will it be safe to take niacinamide 2g a day for 3 months for example it helps me with breathing and anxiety.
1) Do you not suggest real Niacin?
2) What Do you think of Stinging-nettle and Dandelion ingestion in various forms both drunk and eaten, please? Thank s for good video ínfo with warnings.
I am living on a disability pension after being injured in the military. I'm 65 with several coronary artery blockages. I cannot afford $33 per month to subscribe. $33 is more than I budget for fuel for my car. I only wanted the cheat sheet. I understand that you went to school for 4 years to become a doctor, but, ffs...give back to the community without making us pay you a king's ransom. It's not an honourable way to help people. You DO want to help people, don't you? What would Hippocrates do?
Lol i just took 500mg for first time in 18 yrs and got a bit worried by the multitude of acute symptoms. Its been three hours. Lying down...flush is finally subsiding.
You can take Vit C and applesauce with it to reduce flushing. Also , work up to 500 mg to give body time to adjust.
Can u cut a niacins 3 my face burned for 3 hours and it wouldn’t cool down and it scared the heck out of me and made my heart beat so hard!!!!!!
One question I've always had:
Does the betaine in betaine HCl count as betaine/TMG. Obviously you'd have to subtract the weight of the HCl but in my mind once the HCl is seperated your body would absorb it as regular TMG and use it the same.
Is this the case or is there some reason it's different?
Yes. I have how much it counts in the cliff notes. chrismasterjohnphd.com/cliffnotes
I am surprised the video quality is not higher. Thanks for the info though!
What about DMG? Would DMG work as well with nicotinic acid, and what would be the dose? Thanks!
Great videos!
Is 500g Niacin daily ok? Is this considered high dose?
Thank you! Great video.
I take Magnesium Glycinate. Is that glycine?
Yes.
Do you take Tmg and reservatrol with it? Do I need tmg? has it affected yuur blood? Im taking 1000mg niacin from nicotinic acid with 200mg of trans reservatrol and 100mg grape seed extract im scared of naicin giving me brain bleeds
Pork rinds are rich in collagen 👌
INSIGHTFULL!!!!!
Is 100mg daily safe amount? Thanks
Chris
what do you think about the cheaper phosphatidylcholine to add methyl groups?
It isn’t cheaper, you are likely misreading the label to confuse elemental choline with the mass of the phospholipid, but it is in any case far less targeted to methylation.
@@chrismasterjohn Hi Chris I take 500 mg of non flushing form of Niacin. So would that be problematic as I have been taking this for years but my LDL is 99 or 110 but HDL is very low due to diabetes even though I work out a lot. I have a non fatty liver due to metabolic syndrome. Is flushing niacin much better for cholesterol than non flushing ?
Low dose and What if you cycled off every 3-4 weeks...would that be helpful ??
Experimenting with a low dose, 500ngs, to see what effect it would have on my LDL levels
Me too. My ND has me taking 500 mg 2x day now…we will see…
@@Meadows191 fyi ... I read the study ..it severely flawed
Does this also protect against glucose problems that I hear Niacin could possibly cause and is TMG different from Glycine ?
Please do a video on Copper detoxification. Diet & supplements
Zinc decreases copper
@@JaiJatt7 It does so by inhibiting it from being digested, not by depleting existing stores.
@@DDumbrillethanks!!!
You can be copper toxic AND copper deficient at the same time. Magnesium citrate can be bad for copper regulation, but other forms do not. I think it's the citrate that causes the issue though. Beef Liver is very high in good copper. Oxidized copper (like almost every supplement, it is blue in color) is bad and will likely cause toxicity. Copper is important for iron utilization, so copper toxicity or deficiency can cause anemia.
For skin improvement, what’s best, niacin or niacinamide?
Niacinamide @1000mg taken in two doses of 500 a day. In my case. I saw a marked improvement in my particular form (can't remember what it's called) LOL of Eczema which when bad made me look like an extra in a horror film. and stopped me from going anywhere. I've suffered it for over 20 years. I saw a definite improvement which seems to be ongoing IN THREE WEEKS. Good luck
Thank you,
I just take about 200-250 mg of nicotonic acid every other day. Gives the flush. Why would I need more?
Can you site the study that shows niacin causes liver damage?
Della Marie slow release niagen causes liver damage ... that’s it
@@victordasilva5255 Evidence of study pls ?
@Tommy Scott You have the internet,look it up sheeesh. free info from a doctor and you still want him to do more work for you...USE THE GOOGLES
@@Atheist-Pinar You have the internet,look it up sheeesh. free info from a doctor and you still want him to do more work for you...USE THE GOOGLES
You have the internet,look it up sheeesh. free info from a doctor and you still want him to do more work for you...USE THE GOOGLES
Thank you very much!
Excellent vid, Half glycine to nicotinic acid sounds like a easy to take combinationm, so TMG not necessary if we take it with Glycine?
TMG or Trimethylglycine provides methylgroups as well as glycine so it’s not so plausible why you need extra glycine added
It doesn't provide glycine directly, TMG [Betaine/Trimethylglycine] needs to first be converted to DMG [Dimethylglycine] *Which can act as a glycine site agonist with different properties to glycine* through BHMT (zinc dependent enzyme), then to Sarcosine [N-Methylglycine] by DMGDH (FAD dependent enzyme) , then to Glycine through SARDH (THF substrate dependent).
That's a long chain that can have a lot of disruption, and besides that, once it becomes glycine, that glycine is going to be preferentially used down the creatine synthesis pathway rather than recycling back through Serine, Ethanolamine, Choline and back to Betaine. There are many disorders that could cause any of these chains to work poorly, but most importantly the addition of Niacinimide/Niacin increasing the demand for many of these enzymes/chemicals.
@@corahnihlost923 Thanks for your thorough answer. Yet I think that since TMG can be used in relatively large doses most of the problems/disorders associated with the use of TMG can be avoided. I take 2 x (500 mg Niacin + 1000 mg TMG) per day and have pristine liver enzymes and a reduced homocysteine level
@@dankurth4232 My bigger concern with using Niacin over Niacinimide to do with Glycine requirements would be the increase in Glutamate that Niacin induces through it's conversion to NAD+.
Niacin goes through Glutamine-Dependent NAD Synthetase/Glutaminase to fuel de novo NAD+ synthesis.
Glutaminase converts Glutamine into Glutamate by transferring Ammonia into the Synthetase step of NaAD-NAD+.
The extra Glutamate being produced, combined with revving up the metabolism of Glutamine-Glutamate would warrant additional Glycine to balance out at the glycine sites on NMDA receptors. As well as additional Glutamine to ensure a proper balance of NH3 metabolism.
Niacinimide is recycled through NAMPT/NMNAT, which is generally a lot safer of a choice, Oleic Acid is a good way of boosting NAMPT.
@@corahnihlost923 Thanks again. With respect to your concerns it might be a good idea to add a ‚Glutathione Booster‘ (a combination of NAC, Glycine and Glutamine) to the ‚diet‘
And certainly oleic acid is a very good supplement anyway, mostly available in the rather not so mild olive oil
Thanks for the info. I just got your "Cheat Sheet" I am already putting it to use.
I took Niacin, 250 mg on a daily basis for three weeks. I noticed, that I
became really tired and as well I had huge eye bags. Is this a normal
side effect of niacin?
Niacin increases histamine
its detoxifing you.
@@yougotshnaucked no it doesn't actually increase histamine it depletes your body of it and you temporarily yet a histamine release but then it is depleted out of your body and then when you get saturated enough you don't flush anymore I've taken up to 2,000 mg a day without flushing and didn't damage my liver. Some of these doctors just want to get people on drugs and I want proof where's the studies? dr. Abram Hoffer took it til he was 96 years old every day and did not get liver disease or die of a heart attack. He used to use it to control schizophrenia in his patients because people who are histadelic AKA too much histamine can be schizophrenic so it doesn't actually raise your histamine it leaves your body of it so when it's on its way out that's when you get the flushing or high. This goes away.
@@ByGraceIGo you are the MVP.
You might be causing an imbalance with your total b vitamin status , make sure your getting plenty of the other b vitamins they all work together
hi Doc, hypothyroid people do not flush when they take immediate release niacin, what's the reason?
But i do experience flush . I have hypothyroidism
Thanks man this was good.
Fucking awesome. Thank you, been looking for such detailed info for ages.
Hey Chris i took NR one week and felt very bad. So i have metilation problem.So is better maybe just stop taking NR or taking with TMG? What you recommend you ?
I had the same problem. I bought the Jarrow TMG and the side effects stopped.
Marcelo Rivadeneira yes maybe visible side effects stopped but you never know whats happening in your body. Maybe you poisoning your body slowly. Thats why maybe better don’t touch anymore NR
Same problem... felt terrible when taking NR. TMG helped me recover after I stopped taking it, but I still couldn't take NR after that, even along with the TMG.
I was told after trying NR it caused muscle weakness & other concerning side effects in clinical studies.
Niacin releases toxins to detox the body, according to many doctors & experts of detoxing heavy metals and other toxins. I’m familiar w detox symptoms & I’ve definitely gotten them from Niacin, which apparently releases toxins into the bloodstream to help the body remove them. That alone can make someone feel off or even awful,. I’ve definitely experienced multiple times from regular Niacin. NR May have other side effects as well, other forms don’t cause & may cause more harm than good.
Aside from the advice in the video, I think it’s a good idea to use regular Niacin (that causes a flush) and to start at lower doses...to afford stressing the body.
Curious what Chris’s opinion is on this
take niacin pure not nr , thats bad !
I'll take just 100mg and get a major flush and i thought 100mg was a lot but 3g?
If you don’t want the flush, you can take some applesauce with it and Vit C. 3000 mg would be in divided doses.
Please take the time to answer my question.I can't seem to find it myself. Can I take niacin when extended fasting or intermittent fasting ? Thank you so much.
There are vids naicin with ketos so im guessing its okay
should be taken with food. Please read the label. Take the real niacin not the non-flush version.
Pls make a video on your beard. Much thanks
Thanks
What is the difference between the supplements, trimethylglycine or just glycine?
Chemically, three methyl groups. Health wise, you should treat them independently.
I wish ppl when they post "niacin" on here they would say if It is niacinamide or Niacin or is it some other name? I stay so busy I have a hard time not being confused.
very useful information...💪💖✌🏻👍👽
Metal groups are heavy rock bands
@Radiana Prakash hii I wanted to ask did you heard about Walsh tests to find out vitamins deficiency that is mostly cause of mental illness.
Top notch CM
Excellent video 🙏👍
Thank you 🙏
• I use one 750 mg SloNiacin with TMG supplement 😉👌
In my B50 complex there is 50 mg of niacinamide. Is it okay to take it everyday? Is 50 mg niacinamide too much?
No