This Cursed Molecule Will Teach You About Aromaticity | Pagodane & dodecahedrane synthesis chemistry

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  • Опубликовано: 11 дек 2024

Комментарии • 34

  • @totalsynthesis
    @totalsynthesis  Год назад +6

    Check out CELL to get 15% (!!) off on your next glassware with "SYNTHESIS15":
    www.cell-supplies.com/store/
    If you like the regular videos and would love to see more, consider supporting the channel via Patreon (www.patreon.com/totalsynthesis) or RUclips membership

  • @lithiumferrate6960
    @lithiumferrate6960 Год назад +41

    Someone should do total synthesis of this starting only with carbon and hydrogen.

    • @Strobie_one
      @Strobie_one Год назад

      Yea fuggen gday cants. Today were ganna make some Dodecahedrane using the lump of coal Scott Morrison brought into parliament, and some benzine I found in me nans gin cabinet.
      Shit, this script rights it’s self and it’s fkn gold!!!!!!

  • @Grak70
    @Grak70 Год назад +11

    I can’t find a better word to describe this synthesis than “symphonic”. It combines so many different yet basic reactions in masterful harmony.

  • @stepulya9108
    @stepulya9108 Год назад +10

    The old-fashioned synthesis of Pagodane is so fascinating in its simplicity! It is always exciting to see how authors are able to create something outstanding utilizing almost trivial transformations.

  • @atescoshorse8399
    @atescoshorse8399 Год назад +5

    Have just covered most of the reactions used in this total synthesis in my uni course right now. Its amazing to see how powerful pericyclic chemistry is and some of its applied uses. Love the videos

    • @totalsynthesis
      @totalsynthesis  Год назад

      Nice! You are right, pericyclics are insanely useful, especially also for tertiary or quaternary centers

  • @totalsynthesis
    @totalsynthesis  Год назад +9

    Let me know any thoughts on this video and any suggested topics in general - what would you like to see more of?
    ❓basic chemistry stuff or advanced?
    ❓natural products, pharmaceuticals, random nice looking molecules or materials?
    ❓total synthesis, medicinal chemistry or reaction methodologies?

    • @Strobie_one
      @Strobie_one Год назад +1

      Hey man, your videos are absolutely amazing!!!! Please upload a video per day where you just read crazy papers like this. Screw the animations, break the stick and balls out. Everyone loves balls ❤
      Keep up the good work! 😊

    • @kshitijkumar5629
      @kshitijkumar5629 Год назад

      I want total synthsis involving organic chemistry!

    • @totalsynthesis
      @totalsynthesis  Год назад

      @@kshitijkumar5629 Next video will be focused on this! But quite advanced

    • @kshitijkumar5629
      @kshitijkumar5629 Год назад +1

      @@totalsynthesis hey, can you check that MDMA video comment section, i asked some doubts regarding the reactions.

    • @totalsynthesis
      @totalsynthesis  Год назад

      @@kshitijkumar5629 ive just replied

  • @glebanful
    @glebanful Год назад +2

    Wow, what a brilliant story! Thank you for putting in all the effort, it was totally worth it!

  • @joalsoal1645
    @joalsoal1645 Год назад +3

    An odd carbon structure that would be an interesting total synthesis is iceane. It is the building structure for the mineral lonsdalite in the same way that adamantane is for diamond. The mineral is only found in space and has a theoretical moh’s hardness higher than diamond due to its hexagonal diamond lattice compared to the typical cubic diamond lattice. There wasn’t much literature I could find on it however there is a few synthesis papers.

  • @lysergicbrew7908
    @lysergicbrew7908 Год назад +3

    Love your videos, so thankful there is at least a little bit of orgo/synth chem content of this style.

  • @knivesnico8775
    @knivesnico8775 Год назад +1

    This synthesis is so satistying

  • @spanishSpaniard
    @spanishSpaniard Год назад +2

    I know is "normal" in organic synthesis but ring contractions still fascinate me. The electrons of the carbons in the ring jump!

    • @totalsynthesis
      @totalsynthesis  Год назад

      Oh yeah. Stuff like regioselective migrations as seen in Baeyer-Villiger reactions and others are really nice

  • @bigjay875
    @bigjay875 Год назад +2

    Nice!

  • @knivesnico8775
    @knivesnico8775 Год назад +1

    Keep griding friend 😤😤😤

  • @_juraj_
    @_juraj_ Год назад +1

    Can it be somehow nitro-oxydated or manganase oxy-dated to be explosive?

    • @totalsynthesis
      @totalsynthesis  Год назад

      🤣 yeah after closure to pagodane, you might nitrate using the ester groups instead of decarboxylating

    • @_juraj_
      @_juraj_ Год назад

      @@totalsynthesis Is it strong explosive?

    • @totalsynthesis
      @totalsynthesis  Год назад

      @@_juraj_ Without nitros not at all, with nitros maybe but probably nothing crazy

  • @1.4142
    @1.4142 Год назад +1

    Now make super dodecahedrane just like super benzene.

  • @BarbaraGarcia-q2j
    @BarbaraGarcia-q2j 2 месяца назад

    Harris Donna Allen Elizabeth Johnson Elizabeth

  • @hellothere3163
    @hellothere3163 Год назад +2

    Yummy