Isotype switching | class switching recombination | Antibody class switching | antibody diversity
HTML-код
- Опубликовано: 2 авг 2020
- Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG.
Amazing man, that´s a perfect review of a theme that takes a long time to understand!
Please check out my entire immunology playlist and share my channel link with your friends
A tip : watch movies at flixzone. I've been using it for watching a lot of movies these days.
@Briar James Yup, have been watching on flixzone} for since december myself :D
@Briar James Yup, been watching on Flixzone} for since december myself =)
This is the best explanation I could ever found .. thank you
Please share my channel link with your friends and help me to reach big audience
Truly an incredible explanation Arpan! I was finding it so difficult until I saw your video.. Thank you very much and take care!
Please share my channel link with your friends and help me to reach big audience.
Amazing ! Thanks to you i've understand in time for my exam this notion ! It is very well explained thank you !
Please share my channel link with your friends and help me to reach big audience
I have immunology exam tomorrow. This is so helpful and lucid to understand. Thank you 😊
Share my immunology playlist with your friends and help me to reach big audience.
Glad to know that my connect is useful
Amazingly explained in detail 🙂 very easy language gud teaching helps me to better undertood I really liked this video plz keep doing👍
Please share my channel link with your friends and help me to reach big audience
@@animatedbiologywitharpan sure definitely 👍
Your videos are just amazing🙌😀 Difficult topics explained in such an easy way. Sometimes it becomes difficult to visualise all the text we have read in books but ur videos made it easy for me Thank you❤️ Great job, keep up the good work👍
Please share my channel link with your friends and juniors.
Thank you very much. Now the concept is more clear
Please share my channel link with your friends and help me to reach big audiance
Cool work man , clear and clean keep up
In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for us.
Thank you, sir Arpan. I am a medical student who tries to understand immunogenetics and your channel is the best thing I could hope for
Please share my channel link with your medschool friends and help me to reach big audiance.
@@animatedbiologywitharpan if the subset of t helpers(viz th1,th2,th17 etc )decides the Ig to be released, by the thier specific cytokines released to the B cell(antigen presenting),then how could we say,
In primary infection,Ig M will be more and in 2ndry infection IgG will be more in serum?
ie,if Th1 is the helper subset formed,would it only cause for IgG producing effector B cell synthesis,so from the first occurance of that infection,IgG may be the main Ig in serum.Is this possible sir?
Salute to your art sir.... Your are great and intellegent teacher... I always search for your videos if I need any topic
glad to hear from you....thanks a lot for the complement
thank you so much, I'm a french med student, it was a very difficult topic to me
but you explained it in an easy way. :)
Please share my channel link with your medschool friends . If you want any topic on which you want an explanation please put it in comments
This was perfectly clear! Thank you very much. :D
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
This video is amazing. Thank you so much!!
Please share my channel link with your friends and help me to reach big audience . Don't forget to check out all my playlists. Wide collection of immunology videos are there.
Great video!!
THANK YOU FOR THIS AMAZING VIDEO
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
Thank you. I was searching our University library, and nothing was so concise as this.
Please share my channel link with your friends and help me to reach big audience
Even after working really hard I can't reach s lot of viewers
@@animatedbiologywitharpan certainly 👌
Amazing!
I shared the link with my friends in the faculty although we speak Arabic but the explanation deserves
Glad to hear that it was helpful for you....comments like yours motivated me to do more
Excellent i just understand each and every detail clearlt
ruclips.net/channel/UC4IpyopsGWSjaPACNTZLuqg please subscribe to my second channel as well
Thank you for the great explanation 😢
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
This is soooooooo good.
Please share my channel link with your friends and help me to reach big audience
Tomorrow in my immunology exam...
The videos of ARPAN DADA... are so easy and lucid to understand that it boosts my confidence level.. 😅
Thank you DADA for ur lovely animated video's.
All the best for your exam
3 more days for me. I also enjoy the content alot! Greetings from germany
Please share my channel link with your friends and help me to reach big audiance. I have an entire immunology playlist
I Tutor organic chem. For next Semester Preperation i will mention you 🙏
@@kevinbenjaminbassler9530 that would be very kind of you. Thanks in advance
Amazing explanation!!
In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for us.
Awesome explanation
Please share my channel link with your friends
koszonom szépen from Hungary
Please share my channel link with your friends and help me to reach big audience
Thank you so much, very informative
Please share my channel link with your friends
Very well explained !!❤️
Please share my channel link with your friends and help me to reach big audience
@@animatedbiologywitharpan Sure❤️
Thank you!
Please support our channel by using super thanks. Your 2$ donation would give us motivation to do more. Super thanks option is present below any of my videos, a heart sign with $ in it.
Excellent !
Please share my channel link with your friends and help me to reach big audience
Very nice and basic explanation
My channel has very low visibility currently, please share my channel link with your friends and help me to reach big audience
Amazing !!!!!!
THANK YOU SOME MUCHE YOU HAVE AMAZING EXPLAINE
Please share my channel link with your friends and help me to reach big audience
explained in details !!
Please share my channel link with your friends and help me to reach big audience
Woooooooow nice explanation
Please share my channel link with your friends and help me to reach big audience
Incredible!
please share my chanel link. Here is the link for the entire immunonology playlist: ruclips.net/video/MQzE_WcXkGI/видео.html
Nice explanation..👍
shubham kr rai please share my channel link with your friends and colleagues
Amazing video👍🏻
Please share my channel link with your friends and help me reach out to big audience
@@animatedbiologywitharpan of course! Keep up the great work👍🏻
Amazing man!!!
Please share my channel link with your friends and help me to reach big audience
you're amazing! ty!
Thanks Julia for your comment. Please share my channel link with your friends and help me to reach big audience. Also check out my entire immunology playlist.
Wow amazing you explain in detail,what do you prefer to prepare for content
Kuby immunology
hi, class switching can also occur before germinal center formation
damit man, you content is lit👊👍
Please share my channel link with your friends and help me to reach big audience
@@animatedbiologywitharpan sure man👍.
thank you for amazing explanation. you mentioned B cell isotype switching is antigen dependent and requires mhc 2 cd40 co stimulation so can we say its also t cell dependent ? is this the case where polysaccharide and conjugated vaccines differ ? polysaccahride vaccines activate b cells indepent from t cells so no somatic hypermutation and generation of high affinity antibodies and ig G thats what i understand
T cell stimulates strong b cell activation which is a prerequisite for isotype switching. Moreover, T cells provide essential cytokine signals, such as IL-4 and IL-21, which direct B cells to undergo isotype switching, resulting in the production of antibodies with different effector functions. This T cell-dependent process enhances the adaptability and effectiveness of the immune response.
Thanks a lot.
Please share my channel link with your friends and help me to reach big audiance
Please support our channel by using super thanks. Your 2$ donation would give us motivation to do more. Super thanks option is present below any of my videos, a heart sign with $ in it.
Wonderfully explained sir 🙏🙏🙏🙏🙏
Please share my channel link with your friends and help me to reach big audience
@@animatedbiologywitharpan sure sir 🙏🙏.
So there is a question. After the AID enzyme comes into action, what really recruits the repair enzyme? And why not any other repair enzyme with high fidelity?
If you will go in more and more detailing you will get a pH, ions presence, and many many other factors 😑
Thank you sir ❤
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
thank you
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
Thank you so much! Btw which program did you use to film your display?
Obs studio
Much appreciated ❤️❤️❤️
Please share my channel link with your friends and help me to reach big audience
Thank u so much
Please share among friends and help me to reach big audience
Thank you sir for the video❤i have a question please: so if i understood, isotype switching happens to the Ab produced not the BCR and one B cell either makes igM or IgD or IgE or IgA or IgG right ?
ya soluble anyibodies are generated and constant regions are changed
you are amazing
Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
When the naive B cell encounters a pathogen, is this with the help of the dendritic cell traveling to the lymphoid with parts of the pathogen covering it? Or does the pathogen make its way to the lymph, and the B cell directly recognizes it and takes a piece from it?
Dendritic cells take the antigen and move towards the lymph node
As far as I know both no affinity and high affinity get destroyed by negetive selection and only T cell with low affinity survives through positive selection
I have a question regarding the naive B cell . So it can produce IgM and IgD without encountering a pathogen ? But why does they use IgM and IgD levels to see if the patient has immunity to a specific disease?
Very good question....let me tell you that with all infection it's not true that there would be class switching as a result only IgM could be produced.Now b cell has IgM by default but its membrane bound ,after infection secreted IgM is synthesized which is specific to the antigen coming from a bacteria let's say.
Please share my channel link with your friends and help me to reach big audience
Why is isotope switching occur ? It only changes the conserved heavy chains which don’t bind to pathogens only to the own B cells, so why do we need different types of conserved regions if they don’t select for pathogens ?
Since the variable region does not change, class switching does not affect antigen specificity. Instead, the antibody retains affinity for the same antigens, but can interact with different effector molecules. Example : IgM interacts with complement better than others...IgG is better in terms of crossing placenta etc.
Hello is interferon y secretion is required for all the antibody isotypes or is it only for igg
IFN-gamma inhibits the secretion of IgG3, IgG2b, IgG1, and IgE, and enhances the secretion of IgG2a.
Well done bro.
Please subscribe to my other channel ruclips.net/channel/UC4IpyopsGWSjaPACNTZLuqg
Please share among friends and help me to reach big audience
Can you make a video on carrier options after msc from any life science stream in future?
ruclips.net/channel/UC4IpyopsGWSjaPACNTZLuqg my second channel would deal with all of these topics
@@animatedbiologywitharpan OK but please make a video on those 3 phases of Tifr interview.BTW video was very helpful for my upcoming gat b exam and all thank you.
Sir,May you please tell me if pathfinder is sufficient for csir NET JRF LIFESCIENCE Immunology portion along with some RUclips vedios.
When CSIR NET is concerned I would suggest Kuby immunology
Do different cytokines all lead to STAT activation?
Yes they do
Thank you for your video! Can hyper IgM syndrome generate IgD?
Nope its not possible in my opinion
Please share my channel link with your friends and help me to reach big aidiance
@@animatedbiologywitharpan Sure! Thank you for your efforts!
Arpan the GOAT
I don't understand any context of your comment.
@@animatedbiologywitharpan don't worry, it means you're the Greatest Of All Time 🐐 for making Immunology make sense 😎
Ok now I understand....
Quite funny...please share my channel link with your friends
Good lecture but B cells mature in bone marrow only and not in lymph node, I believe
No, maturation doesn't take place in bone marrow, it's always in the lymph node
I have a doubt. The region where NK-kb and Stat1 bind , in that region is the AID recruited? I can't understand this part. Plz help me
NF-κB and STAT1 regulate B cell class switching: NF-κB activates AID for DNA recombination, crucial in antibody class change. STAT1 responds to interferons, promoting IgG2a and IgG3 production in infections. Both transcription factors coordinate immune responses, ensuring effective antibody diversification against pathogens.
@@animatedbiologywitharpan ok thank you
❤️
Please share my channel link with your friends and help me to reach big audience
🙏❤️❤️❤️❤️
So class switching is simply T dependent activation ?
Class switching happens in B cells but not in T cells. if there is no strong T cell dependent B cell activation then class switching would not happen
@@animatedbiologywitharpan wow that was a quick response ,thank you so much for clarifying it
Can you please provide a reference for this video?
Kuby immunology 7th edition
Please share my channel link with your friends and help me to reach big audience
Allah yihmeek.
Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
Great video but the sound was not too good.
Thanks for your comment. Please share my channel link with your friends and help me to reach big audience. I will improve the sound quality next time
Can you please improve the audio quality? Its horrible
Thanks for this suggestion....I will try to improve the quality in subsequent videos.
Thank you sir ❤
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.