honestly the best videos that teach such concepts to great details I have found on youtube!! Thank you, you are the reason for my good score in immunology.
I love the animations and content and I've shared your videos with my friends. But I have one advice: please increase the volume of the videos. Thank you so much! 🇵🇰
Thank you sir for that overview of WHY this somatic hypermutation must happen in the first place. I guess you can think about it like two defenses chaing their strategies (their DNA or their biological makeup ) to have an advantage over the other side because they (the host antibodies or the antigen (bacteria, viruses)) keep changing to adapt to their environment.
Indeed this is important. Thanks for pointing out . At the 4.00-4.30 timestamp of the video it is mentioned that T cell dependent activation is kind of prerequisite for somatic hypermutation. But I agree, it should be stated clearly that it's a process to create highly specific antibodies.
thanks for the video, I have a question though: in 4:11, you showed the interaction of B cell / Th in the paracortex region, are you sure this is where it happens? because as far as I know, B cells don't enter the paracortex region, they stay in the outer cortex and they move to its edge and stay there waiting for passing-by Th cells to recognize their MHC-II. To sum up, I think all of this occurs on the edge where the Th in the paracortex facing the B cell in the cortex exchanging signals.
The T cells are in the parafollicular/paracortical region. B cell can go to parafollicular region but they cant go inside the mantle zone of follicle (until activated by any antigen , either self or foreign) and can't go inside germinal centre of follicle (unless gets activated by foreign pathogen and gets permission from t cell) If you want cd markers then - cd 5 and cd23 . If you still haven't understood anything you can ask again
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After watching the video, I must say the way of explaining is outstanding. I have a doubt: in somatic hypermutation, mutations occur at the genetic level with the assistance of AID mainly. Still, the entire process is being considered a somatic process. why so?
Good point. They name this kind of mutations somatic mutation because these are not inherited. Germline mutations are changes to your DNA that you inherit from the egg and sperm cells during conception. Somatic mutations are changes to your DNA that happen after conception to cells other than the egg and sperm.
Hi bro... beautifully explained...i luv ur content...I want to learn how to make these kind of videos, diagrams? I am using adobe illustrator (cracked version)..but i don't know how to use it....do u create each and every diagram by modifying the basic shapes?
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honestly the best videos that teach such concepts to great details I have found on youtube!! Thank you, you are the reason for my good score in immunology.
Please share my channel link with your friends and help me to reach big audience
I love the animations and the content. Great as a study aid!
I would be really grateful if you share your experience with your friends
I love the animations and content and I've shared your videos with my friends. But I have one advice: please increase the volume of the videos.
Thank you so much! 🇵🇰
Thanks for this wonderful explanation of somatic hypermutation which confused me for a very long time. Well done!
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Thank you for awesome video and explanations! Very good drawn and prepared
Thank you....please share among your friends and help me to reach big audience
THANK YOU SO MUCH FOR WHAT YOU ARE DOING! Big Immune Exam in Few weeks
Watch my entire immunology playlist and it would be useful for you....also share with friends
Very beautifully explained. Thanks!
Very clear explanation. Please do more videos like this!!!
Please share my channel link with your friends and help me to reach big audience
Thank you sir for that overview of WHY this somatic hypermutation must happen in the first place. I guess you can think about it like two defenses chaing their strategies (their DNA or their biological makeup ) to have an advantage over the other side because they (the host antibodies or the antigen (bacteria, viruses)) keep changing to adapt to their environment.
See now you understand the topic so well...not only you have the info but also you have understood the concepts.
Please share my channel link with your friends and help me to reach big audience....feel free to connect via social media
Too good explanation.. my saviour.. thank u
Please share among friends and help me to reach big audience
Correction- Somatic hypermutation is for generation of antibody specificity which is antigen dependent.
Indeed this is important. Thanks for pointing out . At the 4.00-4.30 timestamp of the video it is mentioned that T cell dependent activation is kind of prerequisite for somatic hypermutation. But I agree, it should be stated clearly that it's a process to create highly specific antibodies.
thanks for the video, I have a question though: in 4:11, you showed the interaction of B cell / Th in the paracortex region, are you sure this is where it happens? because as far as I know, B cells don't enter the paracortex region, they stay in the outer cortex and they move to its edge and stay there waiting for passing-by Th cells to recognize their MHC-II. To sum up, I think all of this occurs on the edge where the Th in the paracortex facing the B cell in the cortex exchanging signals.
The T cells are in the parafollicular/paracortical region. B cell can go to parafollicular region but they cant go inside the mantle zone of follicle (until activated by any antigen , either self or foreign) and can't go inside germinal centre of follicle (unless gets activated by foreign pathogen and gets permission from t cell)
If you want cd markers then - cd 5 and cd23 .
If you still haven't understood anything you can ask again
Thank you very much
Your channel is very useful 👍
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GREAT analysis sir
Please share among friends and help me to reach big audience
Is there class switching video available on your channel?
Samarth Kumar it’s coming soon
Your videos are really helpful .keep up the work ,also would you try to make videos on TIFR 2020 biology exam solutions ?
Anything exam related would be published in my other channel
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Awesome video, thank you
You can support the channel by clicking on the super like icon below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for me
After watching the video, I must say the way of explaining is outstanding. I have a doubt: in somatic hypermutation, mutations occur at the genetic level with the assistance of AID mainly. Still, the entire process is being considered a somatic process. why so?
Good point. They name this kind of mutations somatic mutation because these are not inherited. Germline mutations are changes to your DNA that you inherit from the egg and sperm cells during conception. Somatic mutations are changes to your DNA that happen after conception to cells other than the egg and sperm.
@@animatedbiologywitharpan agreed.
please share my videos with friends@@anishchauhan2723
Very well explained!
Please share among friends
This is helpful.. thank you so much.
Please share my channel link with your friends and help me to reach big audience
Hi bro... beautifully explained...i luv ur content...I want to learn how to make these kind of videos, diagrams? I am using adobe illustrator (cracked version)..but i don't know how to use it....do u create each and every diagram by modifying the basic shapes?
Yup it’s all about using the fundamental geometric shapes.....I also hand draw in my iPad
Soon in my patron page I will show how to make this kind of graphics using power point only......be my patreon
www.patreon.com/arpan_parichha
I will also share that using what tools i make these graphics.....my set up ,different styles etc all at $5 per month ( 350 rs only )
@@animatedbiologywitharpan
thanks brother
i love how this indien explain immunology
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Do one plasma cell produce different classes of antibodies?
Nope
Thanks a lot!
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THANKS a lot !
In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for us.
Why prokeryotic replication diagram there 7:50
I always get confused between affinity maturation somatic hypermuation and class switching
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Very helpful, thanks
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@@animatedbiologywitharpan already subscribed! 🌝
Sir what was the reference book for this content
Kuby immunology 7th ed
Sir please make video on junctional and insertional diversification. There are no vidoes on you tube on you tube
ok I will try to mae a video on that soon
@@animatedbiologywitharpan thnqqq sir
Awesome👏👏👏 sir
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8:09 rate, affinity
Can u share this presentation?
I mean it’s not available for free
Ok no problem
activate window :D
ha ha ha.....did it
please share with your friends .....it would help the channel to grow
Definitely. Love the graphical presentation you put thought out the video. 👍
I have another channel as well .....subscribe it as well ruclips.net/channel/UC4IpyopsGWSjaPACNTZLuqg thanks for the support
8:09 rate, affinity