I can't wait to be just like you when I grow up! :) - a molecular biology undergrad who has been dreaming about doing cancer research since I was like 10
Saying "I found it conforting, I promise" about reading a lot of books about cancer after being diagnosed with it is such a Hank Green Thing TM. Very on brand.
My brother probably has osteosarcoma (he's 9 yrs old) and it's been a scary week. Learning more about the scary shit helps calm my anxiety so thank you for this extra-long video! 🙏❤
Here's hoping for a swift diagnosis and treatment as well as nothing but the best for him and your family. The RUclipsr and TikToker Alex1Leg has had osteosarcoma and his videos could also be of some comfort.
@@ivandjurdjevic7463 Yes, he had cancer and he treated it and likely he still has it. Unfortunately cancer is not something dirty, you can't just say treat it then it's forever gone. There are countless failures of treating cancers, there are countless examples of cancer got treated then come back. There is a paradigm shift ongoing likely takes decades at learning what cancer really is and how to properly treat it.
I remember reading about how PET scans work maybe 5 years ago and my mind was blown. You're pumped full of an isotope that decays into a pair of positrons (actual antimatter!) that shoot out exactly 180° from each other. When the machine detects two positron impacts exactly opposite from one another it knows that was from an isotope decay instead of just random noise, and with incredibly precise time signatures it can map the particle impacts back to an origin point within the body. In that way it can "see" where the injected isotope has concentrated in 3D space. That's nuts.
Well, it's actually only one positron, which, when it encounters an electron, annihilates with the electron (matter-antimatter annihilation) and that produces two photons back-to-back. And it's them that get detected by the PET machine. What stroke me most, years after learning about the PET scan itself, is the WHY this works. Why do tumours take up that much glucose for us to detect them in a PET scan? Yes, they need a lot of energy, but that's not even explaining the order of magnitude. What can, is the Warburg Effect (Nobel Prize 1931): tumor cells cannot use the regular mechanism to generate ATP from fuels, but totally has to rely on fermentation, which is inferior with respect to energy production. And it cannot use fats for this, only glucose and glutamine. In essence, what unites all tumours/cancers is, that their mitochondria are broken. Absolutely fascinating! What I'm still waiting for is, that oncologists stop feeding patients lots of sugary crap, because that's what cancer feeds on - almost exclusively.
@@tiegerzahn717except that, as Hank said in the video, you can't just avoid sugar and starve out the cancer. If anything, if you could starve any cells of glucose it would be the healthy ones because the cancer would hog it. Oncologists still shouldn't give out or encourage too much sugary stuff but in the end it doesn't make that big of a difference and comfort is in short supply for cancer patients so I don't see why they can't indulge sometimes. The only link between cancer and sugar intake I can find is that sugar intake can cause you to be overweight, which is a risk factor. So just don't make the cancer patients gain weight from all the sugar and you didn't really do any harm.
@@archerelms perhaps you have a look at the work of Dr Thomas Seyfried. He gets extraordinarily good results, considering he is working with glioblastoma patients. Therapeutic carbohydrate restriction, for example via fasting, is already part of SOC. In some cases this is already sufficient to send patients into remission, but he's also using pulsed glutamine uptake inhibitors, which gives stunning results. Biggest problem: patents for these have long expired, so there's no money to be made.
Ya and to produce this medical crap they torture animals with toxic chemicals and disease. I'd much rather have disease in the world than to have mad science experiments in the world.
I am an oncology nurse who gives these medications every day and will definitely be stealing some of these explanations! You are so gifted in explaining such complex topics. I’ve been watching your videos for many years now, from college to nursing school, now years into my career as a chemo nurse and still learning with you. Sending love from DC!
The medical field is about torturing animals with toxic chemicals and disease 😡😔. Curing disease isn't worth mad Science experiments that's worse than disease. Stop curing disease!
Clicked immediately. My mother passed from cancer in the 90s and I hope and pray every day other kids don't have to experience the fear I had back then.
Something worse than cancer : mad Science experiments torturing animals with toxic chemicals and disease. Cancer research is WORSE than cancer itself. Mad Science experiments are far worse than any disease.
I am getting my pancreas removed mostly because I have a very high risk of cancer due to damage from chronic pancreatitis, which I’ve had since 14 due to a genetic condition. I’m super nervous but I want you guys to know that SciShow is always the best thing to watch to calm me down and distract me :)
Best of luck to you! Pancreatic cancer is one of the least treatable bc of its location behind the stomach, its delicacy as an organ, and its tendency to grow a large blood supply, all making cancer surgery difficult at best. And, as with many cancers, it doesn't always have a lot of early symptoms, so chemo isn't always successful. I think you're doing the right thing, my friend.
It's far better to have diabetes type 1 than pancreatic cancer, and speculating with the odds isn't even worth the risk. You'll live a long life man, be sure about that.
having been cured of 3 different types of cancers (so far) and with two siblings who died of cancer, I am eager to learn all I can about it, I found this to be the best video you've done. You have such a great team and I appreciate all of you.
Please look up Thomas Seyfried of the Boston school of medicine his twenty years of research might be life saving for you he can prove to you things that you'll never learn from the American medical association
That's sad but what's sadder is cancer research it's mad Science experiments giving animals cancer and testing toxic chemicals on them. That's far worse than cancer itself. I don't blame cancer patients for accepting treatment but I blame all doctors and scientists they're all sickos. Alternative to animal testing is cancer. It's better for cancer not to be cured sorry.
Thank you Hank for speaking up about Cancer. People fear what they don’t know so hopefully by educating people it will take away some of the mystery and fear of cancer
Cancer research is worse than cancer they give animals cancer and chemo times ten. That's mad science experiments it's far worse than cancer itself. They should stop curing cancer. I'm sorry for anyone with cancer but mad Science experiments are far worse.
I have the BRCA -2 gene and had ovarian cancer 5 years ago. As well as many family members who have died from cancer (mostly the same kind). Thank you for taking the mystery and the fear out. The cancer genetic doctor I go to has encouraged me that we are indeed learning more and more recently about cancer. I really appreciate you sharing what is new on the horizon.
My closest friend passed away due to cancer on 6th of March. I just find the free time to watch this video. Watching this will be like paying homage. I couldn't stay with him when he needed me the most. I feel sorry for this. I should be with him every second and go with him until the last breath.
We can't always be where we feel like we should be. We aren't perfect beings with perfect timing, or any other perfect ability. I know that from experience. My own closest friend back when I was about 12 years old onward passed away at 28 from ovarian cancer, one of the most difficult cancers to identify before it's so far advanced that it's just a death sentence. I was working nights, and had 2 kids who I needed to spend time with, at the time. That meant I couldn't visit her so often like I wanted to do. Not only that, it meant I couldn't I call to talk to her like I wanted, because I was awake mostly when she (and nearly all the rest of the world, too) was sleeping, and when she might be awake, she could've been taking treatments or otherwise doing something to help her health. So I waited for calls from her. Then she and her S.O. moved away - she told me to be near an oncology specialist that wanted to try a new treatment on her. That meant visits were right out, so I waited for her calls. Which basically stopped. Turns out she knew she was about to go, and didn't want to hurt me by forcing me to go through that. And her SO, who didn't like me, never bothered to tell me until it was too late to say goodbye. So don't beat yourself up because you weren't where you thought you should be.
Before I start, I want to clarify that none of my words are meant to replace or minimize anything that you feel. Grieve and understand there's no right or wrong way and you never stop, you just learn with the pain. Now...please remember you WERE there for your friend even if not at the last moment, you were their friend and you added to the quality of their life. You might even have been in the reel of their life that flashed before their eyes before they died. Take time to feel and grieve but remember to direct your thoughts during the sad and painful times to the joy and beautiful moments you had with them. Live for them. Tell their story. Do the things that mattered to them. Do the activities you did with your friend do with your loved ones and their loved ones and tell them about how you did it with your friend. Blend their memory with your life. You can mourn missing their death or you can keep them alive in yours. I hope you can forgive yourself. I'm sure your friend did. If you want to be haunted, live but make them a beautiful ghost. You're their immortality now.
Hank, your vieos helped me walk through my cancer and its treatment and aftereffects of the same. You, and the messages you carry, are truly necessary. Not wanting to swell your head, but the world is a better place because you are in it.
You're a professional animal torturer. Curing disease isn't worth torturing animals sicko that's the same as torturing them for fun. Stop curing disease dr.mengele.
Dude I'm so happy you're on teh rebound and back up on your feet. You look great sir, and the fact that you just dipped out for a short period of time relatively.. but just dove back in as soon as you could....applause worthy...
Hey! My grandma was in the clinical trials for parp inhibitors! She ended up having the breast cancer come back a total of 19 times and eventually succumbed to it, but she fought it all the way out
19 times? That’s crazy. I’m sorry she went through that but also so thankful for women like her who have come before me - her participation in clinical trials has helped so many of us! Your grandmother is a hero! You should be proud ❤
My son is fighting a cancer and u hank have helped me understand more about how cancer is attacked with medicine thank you I hope u r doing well keep up the fight with the knowledge you pass through ur work
In 2004, I had T2 possibly T3 bladder cancer. I only had 2 surgeries, 1st one was so remove the necrotic tumors inside the bladder infused with medication to slow the tumors growth [usually done with a T1 tumor]. The 2nd surgery lasted 10 hours & removed everything non essential. I have been cancer free since without chemo or radiation. The side effects (neuropathy, the sciatic nerve died in the back of my knee) was worth saving my life. I have had many friends & family die from cancer. I get survivor’s guilt if they lose their cancer battle. ❤
My mom's mom, and her mom before her, both got cancer. My great grandmother was was diagnosed with advanced colon cancer at 92, I met her once when I was a baby, she died 2 months later, my grandmother, so mom's mom, had and beat breast cancer not once, not twice, but three times, and is now 95, and still in remission . Nothing yet from my mom's doctor, and other than chronic pain through a back injury, she is doing ok. I'm very proud of my mama. She is queen badass of the world.
One of the most informative (and hopeful) videos on cancer that I've ever seen. Oncology is such a complicated field and is incredibly dense for the lay person to understand. This video had excellent breadth, and sufficient depth. Well done Hank and team.
42:18 I worked in the medical lab of a pediatric hospital and woof yes we do have a cancer season. Thanksgiving through New Years is ‘new leuk’ season, where we notice a spike of new leukemia diagnoses. We hypothesize it’s because the symptoms of cancer can set on gradually, so parents might not notice their kids’ decline. But around the holidays, family comes around and notice that the child is sickly, leading to a doctor visit and the cancer being diagnosed.
I found out my dad has cancer literally yesterday, and having followed these videos for the last year honestly has helped me process these feelings maybe just a bit easier. Thanks, guys.
After being diagnosed myself a couple of years ago, i did the same. Its both comforting and terrifyng. Good news, the terrifying feeling goes away the more you understand.
I found a book a few years back that was a 60’s textbook on cancer treatments. It was really interesting seeing how many cancer treatments have evolved, how new some cancer treatments were comparatively, and how old others were! Side note: It also had pictures, which I wasnt prepared for and that caused me some about of distress when I saw a cancerous eyeball being operated on 🙃
Haven't had to deal with cancer until now, lucky me. And then suddenly, someone you love is diagnosed, and there I am knowing absolutely NOTHING about cancer treatment, except for the fact that "chemo sucks", but not having a clue whether it also HELPS. Thanks in advance for helping me deal with my beloved stepdad's cancer diagnosis. He's been there for me for as long as I've known him. Now I feel the strong desire to know exactly what he'll be facing, cuz I really won't be able to be there for him if all I know is horror stories. Also, being there for my mom will be easier if I know what cancer treatment is all about.
I'd argue that the youtube comment section is by far more cancerous than a lot of the most popular subreddits. But the cancer award definitely goes to the Facebook comment section. Just peeking in there makes you lose IQ points.
Really amazing video Hank! One minor comment, at 06:31 while talking about mAb trastuzumab/Herceptin, you actually showed the diagram and MoA for the ADC trastuzumab deruxtecan/Enhertu. While both Herceptin and Enhertu certainly target HER2 (the antibody is the same), the mechanism for ADCs is a little different than mAbs in that Enhertu deposits a super cytotoxic chemo-like payload to HER2-expressing cancer cells, while Herceptin simply blocks HER2 signaling to slow cancer growth (as you described). Specifically, the yellow star in the diagram at 06:31 depicts the ADC's payload (which is deruxtecan/"Dxd" here, a topo 1 inhibitor similar to the doxorubicin topo 2 inhibitor chemo that you mentioned you took to treat your lymphoma), and the payload/ADC gets endocytosed where it directly interferes with DNA synthesis in the cell and kills the cancer (like a targeted form of chemo).
Hodgkin's was actually what I battled back in high school myself, Hank! It really does suck, especially when you have to deal with insurance not understanding you half the time. 😅
I started chemo treatment in January 1996 for Hodgkin Lymphoma, I was 23 at the time and in stage 2 going to stage 3. In may 1996 I was cancer free and luckily it never came back. Cancer runs in my family on both sides and it’s not one kind. I still have health problems because of the chemotherapy but I’m still alive and that’s what matters.
SciShow may be the first channel I subscribed to. Even if not, it is one of the first channels which I subscribed to and that has been making RUclips better ever since a few months after I joined it, because I seem to have joined before it existed, which surprised me.
My GF went through treatment for TNBC over a decade ago. Still with us. The chemo and radiation was not kind to her, long-term. Significant neuropathy in her feet, and she has two small aneurysms in her brain that docs are fairly sure were produced by her treatment. But, she's still with us. I have a friend who underwent treatment for mantle-cell lymphoma about 8 years ago. The treatment was one of those "you're very sick. The probability of you dying from your illness is 100%. The probability of you dying from the treatment? Somewhat less". He survived the treatment. But it was decidedly touch-and-go.
The health benefits of sunlight are not limited to vitamin d. There is also an effect on how the green compounds in leafy greens function in the body. Sunlight in combination with leafy greens actually gives a higher antioxidant effect.
Perfect timing! My surgery to find out if i have ovarian cancer (and remove my basketball sized ovarian cyst) is next week Hopefully I won't need the info in this video
Only Hank would take a cancer diagnosis and say "wow, I could make so much content and learn so many people a thing or two about this BS!" And that's why we love him. Glad the cancer didn't get you Hank, you're my favorite youtube science guy.❤
Somehow in the back of my mind I cannot help but "feel" that learning about cancer makes me more prone to get cancer. I have noticed that seeing pictures of cancer tumors makes my body ache in very specific tumor-specific areas. Reading about cancer symptoms,,, well, you get the idea.
My doc suspected lung cancer as I was a prior smoker and had only vague symptoms (mostly fatigue). They did a chest CT scan and saw a couple very small but questionable areas, and then did a chest and abdominal PET scan, where, whoopsie! It turned out to be ovarian cancer, and a fairly large tumor at that (11cm).
I NEED TO KNOW HOW YOUR HAIR GREW BACK CURLY AFTER CHEMO TREATMENT! but congratulations, i dont know if i could live in a world without your amazing science based humorous narration
I'm so glad you're back! I've watched your Sci shows and your crash course vids. You have taught me lots and reignited my passion to learn when I was a young man. Thanks to you I still have the passion. Once again, I am glad to see you back and thank you for being an educational teacher and doing having it out all for free
My dad has been battling with spindle cell soft tissue sarcoma since may. He just had the 12 lb tumor removed from his thigh in January and has been dealing with an infection from the surgery and will be getting two more rounds of chemotherapy at least as soon as he's done with the antibiotic. At removal the tumor was 95% dead and there have been no signs of it spreading anywhere else. This is cancer number for him and has definitely been the absolute most difficult one to deal with and cost him the most. He did lose the muscles in the back of his thigh and he is a hiker so he's going to have to really work to get back to hiking again
4:52 fun fact: chronic eosinophilic leukemia caused by FIP1L1-PDGFRA fusion can also be treated with imatinib. My dad has this cancer (he was diagnosed over a decade ago) and was put on imatinib to see if it would work. Lo and behold he’s been basically cancer free for several years now with increasingly lower doses.
I had cancer last year too. Unfortunately, they weren't able to figure out which kind it was... t was most definitely highly aggressive and malignant, and metastasized from somewhere else in my body. Due to my very wonky system, it just never showed up on ANY scan, up to and including a PET scan; .so far, im the only person in the whole world who's missing 2 out of the 4 proteins in my DNA that make up my autoimmune system. It sucks being a medical mystery and a medical zebra! I just want to experience what "normal" feels like... my doctors aren't allowed to find anything new unless it's completely fixable!!
Thank you so much for this video, it is really helpful in so many ways. I was also diagnosed with Hodgkins lymphoma last year and after 6 cycles of chemo, BEACOPP in my case, i am in remission🎉. I have also read a few books on this topic, but i think it would be great if you could also add in the video description, the ones you read too. For me, at least, it would be very interesting. Great job on the video and i wish you good health!
Currently waiting on test results (actually the doctor’s appointment to interpret said results cause I don’t really understand what my flow cytometry results actually mean) to find out if I have cancer or an autoimmune disease, so naturally I’ve been diving deep into the science of cancer to learn as much as possible and be prepared for my appointment next week. I hope it’s not cancer, even though I doubt an autoimmune disease would realistically be a whole lot better, but it’s very reassuring to see how much science understands now and learning all of the new ways to fight cancer now. When I was a kid cancer destroyed my grandpa’s quality of life but didn’t kill him, and I’d always thought that I likely wouldn’t bother with chemo if I got cancer. I wasn’t expecting to be facing a real possibility of having cancer in my 20s though 0.0 Thank you for this video, it’s nice to know I’m not alone in finding knowledge about an illness empowering, and reassuring.
Watching videos about cancer is definitely harder since my cousin passed away last Saturday because of it... Or like, she didn't die because of the cancer but the treatment (cancer came back in the end most likely but they found out one day before they let her die...)
Oh, an extensive case study about the dynamics between cancer researcher and pop-science outlets. Let's see how often certain types of cancer were on the brink of being eradicated throughout this video.
I have a Ph.D. in Cancer Biology. You guys did a great job at explaining all of this. I can tell that it was a lot of hard and thorough work.
I can't wait to be just like you when I grow up! :)
- a molecular biology undergrad who has been dreaming about doing cancer research since I was like 10
Wow! That’s amazing. I just did a thesis on Terrorism. It’s not exciting and rather depressing.
@@Kitties3evaWell that is very exciting and aspirational!
@@FoodNerdsmaybe not exciting and definitely depressing but yours is a much needed brain in our current world. What are you thinking for future work?
@@rissabiagi1570 Hi I’m not sure. Do you need people who studied terrorism?
Saying "I found it conforting, I promise" about reading a lot of books about cancer after being diagnosed with it is such a Hank Green Thing TM. Very on brand.
Ikr what a nerd. Love this guy
My brother probably has osteosarcoma (he's 9 yrs old) and it's been a scary week. Learning more about the scary shit helps calm my anxiety so thank you for this extra-long video! 🙏❤
Here's hoping for a swift diagnosis and treatment as well as nothing but the best for him and your family. The RUclipsr and TikToker Alex1Leg has had osteosarcoma and his videos could also be of some comfort.
if it helps i have leukemia and made a friend with osteosarcoma and he made it through treatment quicker than he thought ❤️
My thoughts are with you and you family ❤️
I hope you find peace throughout this experience
We are living in a time of knowledge, technology & breakthroughs. There are many stories of young people overcoming cancer. Best wishes.
Glad to see you recovering, Hank!
Recovered?
Don’t worry, Hank is not recovering. You don’t cure a metabolic disease without metabolic therapy. It will come back sooner or later.
@@LittleRadicalThinker I thought he had cancer and he treated it, no?
@@ivandjurdjevic7463 Yes, he had cancer and he treated it and likely he still has it. Unfortunately cancer is not something dirty, you can't just say treat it then it's forever gone. There are countless failures of treating cancers, there are countless examples of cancer got treated then come back. There is a paradigm shift ongoing likely takes decades at learning what cancer really is and how to properly treat it.
@@LittleRadicalThinker sometimes cancer NEVER comes back dont be so negattive
I remember reading about how PET scans work maybe 5 years ago and my mind was blown. You're pumped full of an isotope that decays into a pair of positrons (actual antimatter!) that shoot out exactly 180° from each other. When the machine detects two positron impacts exactly opposite from one another it knows that was from an isotope decay instead of just random noise, and with incredibly precise time signatures it can map the particle impacts back to an origin point within the body. In that way it can "see" where the injected isotope has concentrated in 3D space. That's nuts.
Well, it's actually only one positron, which, when it encounters an electron, annihilates with the electron (matter-antimatter annihilation) and that produces two photons back-to-back. And it's them that get detected by the PET machine.
What stroke me most, years after learning about the PET scan itself, is the WHY this works. Why do tumours take up that much glucose for us to detect them in a PET scan? Yes, they need a lot of energy, but that's not even explaining the order of magnitude. What can, is the Warburg Effect (Nobel Prize 1931): tumor cells cannot use the regular mechanism to generate ATP from fuels, but totally has to rely on fermentation, which is inferior with respect to energy production. And it cannot use fats for this, only glucose and glutamine. In essence, what unites all tumours/cancers is, that their mitochondria are broken.
Absolutely fascinating!
What I'm still waiting for is, that oncologists stop feeding patients lots of sugary crap, because that's what cancer feeds on - almost exclusively.
@@tiegerzahn717except that, as Hank said in the video, you can't just avoid sugar and starve out the cancer. If anything, if you could starve any cells of glucose it would be the healthy ones because the cancer would hog it.
Oncologists still shouldn't give out or encourage too much sugary stuff but in the end it doesn't make that big of a difference and comfort is in short supply for cancer patients so I don't see why they can't indulge sometimes. The only link between cancer and sugar intake I can find is that sugar intake can cause you to be overweight, which is a risk factor. So just don't make the cancer patients gain weight from all the sugar and you didn't really do any harm.
@@archerelms perhaps you have a look at the work of Dr Thomas Seyfried. He gets extraordinarily good results, considering he is working with glioblastoma patients. Therapeutic carbohydrate restriction, for example via fasting, is already part of SOC. In some cases this is already sufficient to send patients into remission, but he's also using pulsed glutamine uptake inhibitors, which gives stunning results.
Biggest problem: patents for these have long expired, so there's no money to be made.
Ya and to produce this medical crap they torture animals with toxic chemicals and disease. I'd much rather have disease in the world than to have mad science experiments in the world.
The radiation from PET scans is through the roof. Not one word in all this about medical-induced cancer.
I am an oncology nurse who gives these medications every day and will definitely be stealing some of these explanations! You are so gifted in explaining such complex topics. I’ve been watching your videos for many years now, from college to nursing school, now years into my career as a chemo nurse and still learning with you. Sending love from DC!
The medical field is about torturing animals with toxic chemicals and disease 😡😔. Curing disease isn't worth mad Science experiments that's worse than disease. Stop curing disease!
Clicked immediately. My mother passed from cancer in the 90s and I hope and pray every day other kids don't have to experience the fear I had back then.
Damn sorry
Something worse than cancer : mad Science experiments torturing animals with toxic chemicals and disease. Cancer research is WORSE than cancer itself. Mad Science experiments are far worse than any disease.
I am getting my pancreas removed mostly because I have a very high risk of cancer due to damage from chronic pancreatitis, which I’ve had since 14 due to a genetic condition. I’m super nervous but I want you guys to know that SciShow is always the best thing to watch to calm me down and distract me :)
Best of luck to you! Pancreatic cancer is one of the least treatable bc of its location behind the stomach, its delicacy as an organ, and its tendency to grow a large blood supply, all making cancer surgery difficult at best. And, as with many cancers, it doesn't always have a lot of early symptoms, so chemo isn't always successful. I think you're doing the right thing, my friend.
It's far better to have diabetes type 1 than pancreatic cancer, and speculating with the odds isn't even worth the risk. You'll live a long life man, be sure about that.
I hope that you get to have many spoons after the surgery ❤
having been cured of 3 different types of cancers (so far) and with two siblings who died of cancer, I am eager to learn all I can about it, I found this to be the best video you've done. You have such a great team and I appreciate all of you.
Please look up Thomas Seyfried of the Boston school of medicine his twenty years of research might be life saving for you he can prove to you things that you'll never learn from the American medical association
You may want to look into WFPB eating. It will reduce your risk of getting cancer. Not to zero, but still.
That's sad but what's sadder is cancer research it's mad Science experiments giving animals cancer and testing toxic chemicals on them. That's far worse than cancer itself. I don't blame cancer patients for accepting treatment but I blame all doctors and scientists they're all sickos. Alternative to animal testing is cancer. It's better for cancer not to be cured sorry.
Thank you Hank for speaking up about Cancer. People fear what they don’t know so hopefully by educating people it will take away some of the mystery and fear of cancer
Cancer research is worse than cancer they give animals cancer and chemo times ten. That's mad science experiments it's far worse than cancer itself. They should stop curing cancer. I'm sorry for anyone with cancer but mad Science experiments are far worse.
I have the BRCA -2 gene and had ovarian cancer 5 years ago. As well as many family members who have died from cancer (mostly the same kind). Thank you for taking the mystery and the fear out. The cancer genetic doctor I go to has encouraged me that we are indeed learning more and more recently about cancer. I really appreciate you sharing what is new on the horizon.
Cancer genetic doctor?? If anyone wanted to go see one, what specialty would they Google etc to find one in there area.
My closest friend passed away due to cancer on 6th of March. I just find the free time to watch this video. Watching this will be like paying homage. I couldn't stay with him when he needed me the most. I feel sorry for this. I should be with him every second and go with him until the last breath.
We can't always be where we feel like we should be. We aren't perfect beings with perfect timing, or any other perfect ability. I know that from experience.
My own closest friend back when I was about 12 years old onward passed away at 28 from ovarian cancer, one of the most difficult cancers to identify before it's so far advanced that it's just a death sentence. I was working nights, and had 2 kids who I needed to spend time with, at the time. That meant I couldn't visit her so often like I wanted to do.
Not only that, it meant I couldn't I call to talk to her like I wanted, because I was awake mostly when she (and nearly all the rest of the world, too) was sleeping, and when she might be awake, she could've been taking treatments or otherwise doing something to help her health. So I waited for calls from her.
Then she and her S.O. moved away - she told me to be near an oncology specialist that wanted to try a new treatment on her. That meant visits were right out, so I waited for her calls. Which basically stopped. Turns out she knew she was about to go, and didn't want to hurt me by forcing me to go through that. And her SO, who didn't like me, never bothered to tell me until it was too late to say goodbye.
So don't beat yourself up because you weren't where you thought you should be.
Before I start, I want to clarify that none of my words are meant to replace or minimize anything that you feel. Grieve and understand there's no right or wrong way and you never stop, you just learn with the pain.
Now...please remember you WERE there for your friend even if not at the last moment, you were their friend and you added to the quality of their life. You might even have been in the reel of their life that flashed before their eyes before they died.
Take time to feel and grieve but remember to direct your thoughts during the sad and painful times to the joy and beautiful moments you had with them.
Live for them. Tell their story. Do the things that mattered to them. Do the activities you did with your friend do with your loved ones and their loved ones and tell them about how you did it with your friend.
Blend their memory with your life. You can mourn missing their death or you can keep them alive in yours.
I hope you can forgive yourself. I'm sure your friend did.
If you want to be haunted, live but make them a beautiful ghost.
You're their immortality now.
Hank, your vieos helped me walk through my cancer and its treatment and aftereffects of the same. You, and the messages you carry, are truly necessary. Not wanting to swell your head, but the world is a better place because you are in it.
Honestly, as someone who's both autistic and disabled: I get it. Sometimes Knowing about the scary thing going on with you is comforting!
my mom died from pancreatic cancer in 2017, 3 years after diagnosis. it is somewhat comforting to learn more about it.
My lab does research into the microbiome and it's effects on adjuvant immunotherapies in certain cancer lines. I've kept your plight in my heart. 💜
Wow! That sounds exciting!
Nice! My thesis is on the interaction between betten PPIs and ICIs which is thought to be mediated by the microbiome.
@@medman4309what have you found so far? i have GERD so i'm curious
You're a professional animal torturer. Curing disease isn't worth torturing animals sicko that's the same as torturing them for fun. Stop curing disease dr.mengele.
Your thesis is on torturing animals with toxic chemicals and disease. Curing disease isn't worth torture, stop curing it.
My aunt just died of cancer just over 48 hours ago and I feel like learning about what killed her might help
sorry for your loss. Take care, may she rest in peace 🕊
Dude I'm so happy you're on teh rebound and back up on your feet. You look great sir, and the fact that you just dipped out for a short period of time relatively.. but just dove back in as soon as you could....applause worthy...
Hey! My grandma was in the clinical trials for parp inhibitors! She ended up having the breast cancer come back a total of 19 times and eventually succumbed to it, but she fought it all the way out
19 times? That’s crazy. I’m sorry she went through that but also so thankful for women like her who have come before me - her participation in clinical trials has helped so many of us! Your grandmother is a hero! You should be proud ❤
My son is fighting a cancer and u hank have helped me understand more about how cancer is attacked with medicine thank you I hope u r doing well keep up the fight with the knowledge you pass through ur work
Got diagnosed with stage 3 testicular cancer in 2022 and it sparked a crazy facination in me too. Im super grateful for modern medicine.
In 2004, I had T2 possibly T3 bladder cancer. I only had 2 surgeries, 1st one was so remove the necrotic tumors inside the bladder infused with medication to slow the tumors growth [usually done with a T1 tumor]. The 2nd surgery lasted 10 hours & removed everything non essential. I have been cancer free since without chemo or radiation. The side effects (neuropathy, the sciatic nerve died in the back of my knee) was worth saving my life. I have had many friends & family die from cancer. I get survivor’s guilt if they lose their cancer battle. ❤
My niece, who is only 16, was just diagnosed with a extremely rare heart cancer. I've never even heard of heart cancer
Thank you for the wonderful explanation. I lost my wife to lung cancer in 2016. This video will be helpful to many people.❤
I just lost my Uncle to lung cancer. And his funeral is this week Saturday.. this vid would let me understand some of the stuff he went through
Glad you are in remission. Continued prayers.
Im so grateful you are still here, my friend 💜
My mom's mom, and her mom before her, both got cancer. My great grandmother was was diagnosed with advanced colon cancer at 92, I met her once when I was a baby, she died 2 months later, my grandmother, so mom's mom, had and beat breast cancer not once, not twice, but three times, and is now 95, and still in remission . Nothing yet from my mom's doctor, and other than chronic pain through a back injury, she is doing ok. I'm very proud of my mama. She is queen badass of the world.
Thanks, Hank. I’m watching this from the hospital and awaiting my PET scan!!
Good luck and well wishes! 🍀
One of the most informative (and hopeful) videos on cancer that I've ever seen. Oncology is such a complicated field and is incredibly dense for the lay person to understand. This video had excellent breadth, and sufficient depth. Well done Hank and team.
42:18 I worked in the medical lab of a pediatric hospital and woof yes we do have a cancer season.
Thanksgiving through New Years is ‘new leuk’ season, where we notice a spike of new leukemia diagnoses. We hypothesize it’s because the symptoms of cancer can set on gradually, so parents might not notice their kids’ decline. But around the holidays, family comes around and notice that the child is sickly, leading to a doctor visit and the cancer being diagnosed.
Wow. That is fascinating!
Had a family member recently diagnosed with cancer. The research in the last few daces provide hope
AN HOUR??? Hell yea!!!
I found out my dad has cancer literally yesterday, and having followed these videos for the last year honestly has helped me process these feelings maybe just a bit easier. Thanks, guys.
Sending good thoughts! Hope your dad is doing well.
After being diagnosed myself a couple of years ago, i did the same. Its both comforting and terrifyng. Good news, the terrifying feeling goes away the more you understand.
I found a book a few years back that was a 60’s textbook on cancer treatments. It was really interesting seeing how many cancer treatments have evolved, how new some cancer treatments were comparatively, and how old others were!
Side note: It also had pictures, which I wasnt prepared for and that caused me some about of distress when I saw a cancerous eyeball being operated on 🙃
Haven't had to deal with cancer until now, lucky me. And then suddenly, someone you love is diagnosed, and there I am knowing absolutely NOTHING about cancer treatment, except for the fact that "chemo sucks", but not having a clue whether it also HELPS.
Thanks in advance for helping me deal with my beloved stepdad's cancer diagnosis. He's been there for me for as long as I've known him. Now I feel the strong desire to know exactly what he'll be facing, cuz I really won't be able to be there for him if all I know is horror stories. Also, being there for my mom will be easier if I know what cancer treatment is all about.
You forgot how cancerous places like Reddit, Twitter, TikTok, etc can be.
Tumblr....places online where liberals and conservatives are at
Alright, funny. But (imo, whatever that’s worth), not the time.
True
I'd argue that the youtube comment section is by far more cancerous than a lot of the most popular subreddits. But the cancer award definitely goes to the Facebook comment section. Just peeking in there makes you lose IQ points.
meme (in dawkins' sense) can be cancerous
Really amazing video Hank! One minor comment, at 06:31 while talking about mAb trastuzumab/Herceptin, you actually showed the diagram and MoA for the ADC trastuzumab deruxtecan/Enhertu. While both Herceptin and Enhertu certainly target HER2 (the antibody is the same), the mechanism for ADCs is a little different than mAbs in that Enhertu deposits a super cytotoxic chemo-like payload to HER2-expressing cancer cells, while Herceptin simply blocks HER2 signaling to slow cancer growth (as you described). Specifically, the yellow star in the diagram at 06:31 depicts the ADC's payload (which is deruxtecan/"Dxd" here, a topo 1 inhibitor similar to the doxorubicin topo 2 inhibitor chemo that you mentioned you took to treat your lymphoma), and the payload/ADC gets endocytosed where it directly interferes with DNA synthesis in the cell and kills the cancer (like a targeted form of chemo).
Hodgkin's was actually what I battled back in high school myself, Hank! It really does suck, especially when you have to deal with insurance not understanding you half the time. 😅
I started chemo treatment in January 1996 for Hodgkin Lymphoma, I was 23 at the time and in stage 2 going to stage 3. In may 1996 I was cancer free and luckily it never came back. Cancer runs in my family on both sides and it’s not one kind. I still have health problems because of the chemotherapy but I’m still alive and that’s what matters.
I'm so happy to hear you, Hank. May you live 100 hundred years.
I’m happy to see your health improved!😊
Health is truly something that is commonly ignored by many people!
SciShow may be the first channel I subscribed to. Even if not, it is one of the first channels which I subscribed to and that has been making RUclips better ever since a few months after I joined it, because I seem to have joined before it existed, which surprised me.
You look great Hank! Congratulations on your recovery ☺️
"testing treatment causes prevention" sounds like a sentence of its own if you don't hear it in the list format
Hank , my best wishes to you. Im delighted to see that you are doing better.
You're looking great Hank ❤
As someone who only knew vaguely about chemo and radio, all the nifty tricks discussed here put a smile on my face😁
Great presentation. You give us a lot of hope.
I hope you're healing up well. Keep up the amazing work!
You're awesome, life is beautiful and so are you.
May you continue to do well with recovery, Hank!
Everybody’s excited about Cancer: The Movie, and I’m just over here waiting for Cancer: The Lunchbox and Cancer: The Breakfast Cereal
Cancer: The lunchbox would look good next to my Spaceballs lunchbox :)
I'm still waiting for Spaceballs 2, The Search for More Money.
I used this to take the best nap! Fell asleep fairly quickly. Thank you HANK
My GF went through treatment for TNBC over a decade ago. Still with us. The chemo and radiation was not kind to her, long-term. Significant neuropathy in her feet, and she has two small aneurysms in her brain that docs are fairly sure were produced by her treatment. But, she's still with us. I have a friend who underwent treatment for mantle-cell lymphoma about 8 years ago. The treatment was one of those "you're very sick. The probability of you dying from your illness is 100%. The probability of you dying from the treatment? Somewhat less". He survived the treatment. But it was decidedly touch-and-go.
Wonderful compilation! It is wonderful to see how fast the treatment of cancer is growing (ba-dum tish).
Thank you
I hope you are doing great Hank. You are my fav person on the internet.
Just got to the polarized light thing... Now THAT'S way cool!
At 1:13.36… Mind. Blown. Thank you. Wow!
The health benefits of sunlight are not limited to vitamin d. There is also an effect on how the green compounds in leafy greens function in the body. Sunlight in combination with leafy greens actually gives a higher antioxidant effect.
Good Man, tried to make the world cancer free, a better place. God bless you guys.
The most useful video on the RUclips
I survived non-hodgkins lymphoma, specifically atypical Burkett Lymphoma
Lovely to see you back, you are great at what you do.❤
u look much better hank cant even say u ever had cancer really happy for u and thanks for all work
Hank, you are friggin awesome.
Perfect timing! My surgery to find out if i have ovarian cancer (and remove my basketball sized ovarian cyst) is next week
Hopefully I won't need the info in this video
Only Hank would take a cancer diagnosis and say "wow, I could make so much content and learn so many people a thing or two about this BS!" And that's why we love him. Glad the cancer didn't get you Hank, you're my favorite youtube science guy.❤
Hank! Thanks for being awesome!
Hank Green is a treasure. Thanks for all the great videos!
Somehow in the back of my mind I cannot help but "feel" that learning about cancer makes me more prone to get cancer. I have noticed that seeing pictures of cancer tumors makes my body ache in very specific tumor-specific areas. Reading about cancer symptoms,,, well, you get the idea.
Welcome back Hank! you are a brave guy and you are doing a nice job as teacher in the Crash courses and SciShow.
you are very brave person may god keeps you happy always
My doc suspected lung cancer as I was a prior smoker and had only vague symptoms (mostly fatigue). They did a chest CT scan and saw a couple very small but questionable areas, and then did a chest and abdominal PET scan, where, whoopsie! It turned out to be ovarian cancer, and a fairly large tumor at that (11cm).
I'm so happy you made it 😊
Thanks for this, amazing insight
I NEED TO KNOW HOW YOUR HAIR GREW BACK CURLY AFTER CHEMO TREATMENT! but congratulations, i dont know if i could live in a world without your amazing science based humorous narration
Stay well brother glad you are doing well ❤
I'm so glad you're back! I've watched your Sci shows and your crash course vids. You have taught me lots and reignited my passion to learn when I was a young man. Thanks to you I still have the passion. Once again, I am glad to see you back and thank you for being an educational teacher and doing having it out all for free
Thank you for sharing your diagnosis
I am cancer and still waiting for my horoscope.
My dad has been battling with spindle cell soft tissue sarcoma since may. He just had the 12 lb tumor removed from his thigh in January and has been dealing with an infection from the surgery and will be getting two more rounds of chemotherapy at least as soon as he's done with the antibiotic. At removal the tumor was 95% dead and there have been no signs of it spreading anywhere else. This is cancer number for him and has definitely been the absolute most difficult one to deal with and cost him the most. He did lose the muscles in the back of his thigh and he is a hiker so he's going to have to really work to get back to hiking again
I'm so glad you're alive .. idk what i would have done if you disappeared :'c
4:52 fun fact: chronic eosinophilic leukemia caused by FIP1L1-PDGFRA fusion can also be treated with imatinib. My dad has this cancer (he was diagnosed over a decade ago) and was put on imatinib to see if it would work. Lo and behold he’s been basically cancer free for several years now with increasingly lower doses.
Can you list the books you read please.
I had cancer last year too. Unfortunately, they weren't able to figure out which kind it was... t was most definitely highly aggressive and malignant, and metastasized from somewhere else in my body. Due to my very wonky system, it just never showed up on ANY scan, up to and including a PET scan; .so far, im the only person in the whole world who's missing 2 out of the 4 proteins in my DNA that make up my autoimmune system. It sucks being a medical mystery and a medical zebra! I just want to experience what "normal" feels like... my doctors aren't allowed to find anything new unless it's completely fixable!!
So what are they doing for your treatment?
Do an episode about how having knowledge tends to reduce anxiety about a situation. I would start with Richard Nissbit and Timothy Wilson.
Bless you.
VERY INTERESTING, GOOD JOB!
Is there anywhere I can get the list of papers/books used in this episode? Would love to dive deeper myself!
Thank you so much for this video, it is really helpful in so many ways. I was also diagnosed with Hodgkins lymphoma last year and after 6 cycles of chemo, BEACOPP in my case, i am in remission🎉. I have also read a few books on this topic, but i think it would be great if you could also add in the video description, the ones you read too. For me, at least, it would be very interesting. Great job on the video and i wish you good health!
Hey Hank. I really am enjoying your videos. You are looking a lot better. I hope you are feeling good too. Thanx for all the info!
Currently waiting on test results (actually the doctor’s appointment to interpret said results cause I don’t really understand what my flow cytometry results actually mean) to find out if I have cancer or an autoimmune disease, so naturally I’ve been diving deep into the science of cancer to learn as much as possible and be prepared for my appointment next week. I hope it’s not cancer, even though I doubt an autoimmune disease would realistically be a whole lot better, but it’s very reassuring to see how much science understands now and learning all of the new ways to fight cancer now. When I was a kid cancer destroyed my grandpa’s quality of life but didn’t kill him, and I’d always thought that I likely wouldn’t bother with chemo if I got cancer. I wasn’t expecting to be facing a real possibility of having cancer in my 20s though 0.0
Thank you for this video, it’s nice to know I’m not alone in finding knowledge about an illness empowering, and reassuring.
Stay strong mr Green! Godspeed
Glad to see you :)
Hi Hank and co! thanks a million- truly great presentation! Please please please at some future date but not too future explore cancer virology.
Thanks from thailand
Great work
Watching videos about cancer is definitely harder since my cousin passed away last Saturday because of it... Or like, she didn't die because of the cancer but the treatment (cancer came back in the end most likely but they found out one day before they let her die...)
Oh, an extensive case study about the dynamics between cancer researcher and pop-science outlets. Let's see how often certain types of cancer were on the brink of being eradicated throughout this video.
This is so hilarious and so scary at the same time.