Appetite: Ghrelin and Leptin Explained
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- Опубликовано: 27 июл 2024
- Leptin: A hormone predominantly produced in adipose tissue that is a key mediator of long-term regulation of food intake and body weight and inhibits hunger.
Ghrelin: A hormone secreted by the stomach that stimulates appetite. Levels increase during fasting states and decrease after intake of food.
Both work for fat regulation and appetite control.
Diet, Exercise, lecture, learning , USMLE, NBME , medical school
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This is a great simplified version what these 2 very important, very complicated hormones do. Good job.
How would someone test for leptin resistance. How is that treated?
Thank you not only for drawing this topic so clearly and breaking everything down, but also for the great learning tipps!
Great video!!! Super informative and very clear.
Please, create more of those :)
I can’t speak for anyone else’s experiences. Everyone’s body is different. But I saw a difference with LEPTIN overnight. I was less hungry. At the same time I was not tired. I think this will help me lose my final 12 pounds. And I think it will help with the food bill.
Thank you!!! I was struggling with Leptin but this finally made it click
happy to help
Excellent explanation of Leptin & Ghrelin hormones. Thanks 😊
Great video
Great pneumonics, easy to understand, thank you!
Very good explained. Thanks.
greatvideo.. thank you so much
With leptin think of ‘lips.’ Imagine closing your lips when you are full and don’t want anymore food. Just another way to remember what leptins do.
Hey guys. I misspelled APPETITE.
Great memory tools for remembering which hormone does what and what area of the hypothalamus 👍🏽
Excellent video.... thank you!!
Very helpful and well done. Thank you!
Very good lesson, thank you!
Thank you! Wonderful video!!
Perfect video...
thanks !!
very helpful video, especially regarding the mnemonic devices provided. but what i find really funny is that people in the medical field are often way too used to looking at things from the anatomical point of view so left becomes right and vice versa. i noticed it when he was presenting those two medical cases at the end of the video.
this often happens to me too so it's nice to see i'm not the only one
Great video! Thanks!
excellent video and ways to remember complicated stuff! thank you :)
Amazing explanation!!
Thank you ❤
great vid
thank you for your great video,
Great!!!!
Thank you for this
Great video!! Thank you!😁
Thanks a lot. A great help.
thank you so much. i really apreiciate your effortd.
Thanks so much!
Thank you so much
Is there a correlation between glucagon with lipolysis and leptin secretion?
thnx sir. ☺️
Thank you
How to master these hormones by getting the benefits of both without the downside? Ghrelin produces HGH and IGF-1 which burns fat, but makes you extremely hungry and lethargic. Leptin is only stimulated by carbohydrates that make fat.
mnemonics were creative
Thank you❤
Thanks ❤
Thank you ... 🙂
Thanks.
Thanks for the mnemonics.
You're a GREAT TEACHER bro.
thanks bro
I feel like this all the time. I feel hungry even if I eat, and eat propertly and enough. Many times after I eat its worse than hunger pangs. Dont know what to do.
Ghrelin for Growth :)
What If the grehlin hormones in the stomach are not being produced or simply put, you have no appetite ? Or you have No desire to eat
What happens to Ghrelin on long fasts? When I fast for 5 days my hunger completely goes away around the 36-48hrs in. What's inhibiting Ghrelin in that case.
Have you found the answer? I'm also having the same problem
i would assume it's ketogenic adaptation, when your blood sugar is stable, insulin is low and ketones have replaced the majority of your energy demands then hunger can be reduced/diminished until your fat stores and trash amino acids are starting to become scarcer. If you think about it, once you tap into your fat storage, your body enters a place where there's like 30-100 days of food in calories depending on if you are 10% or 30% bodyfat, why would it be hungry?
ketogenic diets have a large host of benefits as long as they are nutritionally well rounded and fasting is a great tool for hormonal balance + weight loss.
I try to do keto and have been successful but HUNGRY ALL THE TIME!! I have fasted from Friday dinner to Sunday lunch. Very much a struggle. Im hungry all the time and mentally have to say to myself...u ate already and it was enough. My stomach pains are many times worse than before I eat. Advise? Ive asked the dr but they dont know.
@@CarnivoreNana I have this same problem! Make sure you're drinking enough water and incorporating an adequate amount of protein!
As soon as I started taking leptin I noticed a decrease in my appetite. I think it helped me lose the rest of the pounds I needed to lose so that I could be at my recommended weight.
Taking leptin ? What do you mean I didn't know you can ..
no leptin supplement that i have found. explain!
@@Lauren-vd4qe you’ll just have to try it and see for yourself how it works for you personally.
@@Lauren-vd4qeit’s a bot probably
well his concept is correct but i think hes mistaking that zinc gluconate is the item he took as it does indeed cause leptin to activate and definitely increases saity levels, reducing appetite. @@annav2295
can either of these two hormones cause burning in the upper abdominal area when it’s time to eat?
three or hour hours after a meal, my stomach doesn’t growl, it burns.
Get tested for H. Pylori
@@elijahgavin6706 : did that. Thank you.
How to regulate leptin and reduce the appetite consciously?
How do I increase ghrelin
this makes sense because when i started fasting is when i started yoyoing
HINT: and HOW do you turn leptin ON in your body? take ZINC! i find that zinc gluconate is the best way to do this; I cut the zinc gluc 50mg pills in half (use a pill splitter its great) in a bunch and put them in little container, take 1 half pill in morning with food and 1 half pill with dinner. eat your MAIN meal (dinner type meal) at noon time, then at 5/6 pm have a very light meal, ie mostly veggies, bit of starch, bit of meat, about 1/4 of what u wd normally have. no sugar, coffee, alcohol they destroy your program and your body. works great.
This se ms like me a little. I eat way more than I need to and always want to eat more.
I don't need a bunch of sugars I stick with healthy whole foods meat vegetables that are fresh. No boxed meals nothing like that but I can finish a meal be hurting full and then walk in the other room and want to grab something else to eat. Anybody know a way to stop that?
anyone the citation for the mouse model experiment?
what about the brainstem and hunger regulation
by brain-stem you are referring to hypothalamus
i have a daughter she had -Enterocolitis problems since 1 year old she is 4 now 😢 so we had to do diet
after doing diet she is ok now not vomiting or bad breath but shes feels hungry all the time
do you think this is because she is eating fat free foods diet food, as long as i know fat will help to produce laptin,
i have taken to doctors, unfortunately, they could not give any decent answer so im doing my own reasearch,
i'm thinking may be to give litlle lamb fat after meal so body can get laptin produced ?
if anyone can help with this health issue i would be happy as a father.
also we have gave blood for vitamin analysys doctrs said it's in the norm level.
You can try an elimination diet intriducing foods one by one and seeing what she is sensitive too. Hormone levels also change with age so this may improve with time.Foods higher in protein and fats and fiber are more filling and can produce satiety if that is what you are looking for.
It is good you are doing your own research and getting informed but please double check information you get form online forums.
I have this malady. I am never 'hungry'. It's not about 'appetite'. These words are misleading. I wish they could be replaced with 'metabolic drive and causation' or something of the sort. What I experience is a constant subconscious drive/urge to eat that is driven by the imbalance. Behavior should be replaced with the word 'outcome' etc. Let's frame it correctly and take out any hint at individual person driven decision making. If your body tells you that you are cold you put on a sweater, if your body tells you that your are 'starving' you eat.
QUESTION:
I never feel hungry and if I eat I never feel full no matter how much I eat. Any idea how to get these to work properly? Thanks! 🙏
good protein and fiber intake , lower glycemic foods and good hydration are just some general advice. Best thing would be to see a dietitian.
Dietians...smh. They tell me things my body just doesnt deal well with. I just gain weight cause they say eat these carbs.
@@CarnivoreNana ultimately if you're in a deficit you will lose body fat. It may just be more difficult for you to keep your calorie intake down. But it'll work if you can find a way.
“Appetite”!
So how can you explain about lots of my friends that are lean till age 30 and then get obese and fat after that?
nixland ur friends are getting older and past their prime in regards to their metabolism but they still input calories in a ratio that causes weight gain. time is a sonofabitch.
many reasons, skeletal muscle decrease, due to lack of use, NAFL, excess carb consumption, excess omega 6 FFA and carb consumption combined with lack of sleep, lack of rest, excess fructose consumption. poor lifestyle habits take tears to manifest in obesity and metabolic derangement
There's a good chance they've been having too much sugar in carbs up until that point and they have finally hit a Tipping Point on insulin resistance which has now made it so that they are not only resistant to insulin but also resistant to the effect of leptin. do some research on insulin resistance here on RUclips and you'll find some amazing stuff.
How does insulin interfere with leptin reaching the brain?
not sure sorry
it's synergistic effect , by inhibiting the AGRP/NPY leptin receptor , and stimulate the POMC and CART leptin receptors so we decrease food intake. you can also add CCK along with them.
are you mr morj one piece youtuber?
I can't subscribe right now but I'm interested because I have eye problems and I'm going through some women lead things so please send me your info
I want to increase garline harmone plzz help
What are your sources for this information? Any specific journal articles you used for these examples?
Im just basically reciting stuff i learned in med school no sources sorry
everything was correct , you can check guyton physio.
Well why would I be hungry with bloating? I mean I just ate like an hour ago. I'm scared to eat anymore because I found myself at the ER this morning with painful distension. They did cat scan and other stuff, blood work and all that stuff. Far as they can tell nothing is really wrong. I'm seeing a GI on Tuesday, but........well I was scared to eat what I did today earlier. But I feel hungry as hell. I'm a pretty slim guy not fat or anything. Well anyways you may not obviously know these answers. I'm hungry but scared to really eat again.
If I was you I would eat something small and see how I feel after. Staying well-hydrated can also help. Hope you are ok and able to see your GI soon.
So if fat produces leptin, why don't we feel satisfied if we're fat?
What is the mechanism that prevents fat from suppressing appetite? Because quite obviously, fat people still get ravenous, making the problem worse.
Obesity is a complex disease and likely the hormone response baseline is adjusted in obese people so hormones do not function as they should
Doesn’t obesity often correlate with insulin resistance, and insulin stimulates leptin?
Spelling matters. Two p's in appetite--maybe picayune, but details are important to me for credibility. Good information, anyway.
You're totally right. My mistake. Hopefully, it was informative even with the error
why is pp so important to you
Hay I would like if you could replay to me.
I always say that I like the human body and the way it’s operates but this this is just depressing this is literally say that some people are cursed to have low self esteem and the worst part is people judge and who can blame them they don’t really understand the difficulty of eating and never felling full or not eating and always feel full... can you please tell me if science is working to put an end to this curse?
there are medications and substances that increase and decrease appetite. For example, Caffeine decreases hunger and THC increases it.
You sound just like Kharma Medic
Friendly observation: Suh-TIE-yety.
How to activate my ghrelin
Well if you think the problem is coming from your hormones not being balanced ( because that can cause problems ) I would suggest you look into methi powder ... do you know about that it's fenugreek seeds .
It balances the hormones for both men and women alike and it has been used for thousands of years as a treatment for diabetes .
You can buy it very cheaply at almost any Indian Grocers but the stuff does taste bitter
What are normal leptin levels
Serum leptin (ng/mL): 9. 7 ± 4. 7
Why is it sounding like I need to have brain surgery to finally lose weight?🤕
I fixed it through fasting. People with obesity aren't Leptin sensitive. I would do 48 fasts and then eat one meal a day and gradually as my weight came down i found i couldn't eat the same amount as before. This is why obese people cannot lose weight. The Leptin doesn't work properly because obesity is like a disease that screws all your hormones up. Cutting out sugar also helps. So much of our health problems come from too much sugar.
@@deezeed2817 I agree. Rolling 48's an keepin the carbs low upon refeed to work pretty amazing :D
@@deezeed2817 you might want to look into something that is dirt cheap that has been used for thousands of years and you don't need a prescription ... do you know about methi powder ... it is fenugreek seeds .
And India and that part of the world they have used it for thousands of years as a treatment for diabetes and it balances the hormones for both men and women .
The only problem is it does taste very bitter .
You usually can get it at almost any Indian Grocers ... just mix with water or juice and drink it
As for me..the reasons I
Eat is because I am so....
Sad😥depressed.lonely.
Mad.Anxious.bored and
Did I mention.. ALONE😭
And..NO..I'm not FAT..OR
maybe I'm HUNGRY all the time is because i
Have PARASITES inside of me & eating all the foods I ate..because i am
Always eating & snacking
But not fat.WTF?!!🤔🙄
Go to your doctor. They will likely test your thyroid, and do a blood test. Getting regular checkups is important. As for your mental health your best bet is joining some sort of team or club with people that have similar interests, oh and exercise helps correct hormonal balance which will help you feel better. Hope this helps.
I'm just curious if you ever found out why you are so hungry all the time ... did you get your health checked out ?
haha ur the guy from kharma medic are u not??
you got me !
Great video
Great video thanks