I was diagnosed with ‘nervous bladder’ (it was one of those bladder infections that the common urine test strip doesn’t catch). The doctor offered me some medication that was supposed to reduce my urine output (side effect: persistent perception of thirst that should not be sated). I asked hin how long I would need to take it. The answer was pretty much ‘for the rest of your life’. I politely declined. He was offended.
The corporations pushing drugs like this should beheld accountable. Any doctor falling for this kind of shuck and jive BS should lose their license to practice!
I'm not aware of a single physician who was for this trial, except for the authors! I think part of this is b/c this trial moved into the space of Radiation Oncologists and Urologists who are more of critical of this rather than many (not all) medical oncologists who tend to except these "PFS" benefits
Would you be able to take the slides and move them to fullscreen, and then put your video feed in the corner or side? I watch this on my phone and its just too small to see the slides! You are very handsome, so don't feel bad, but I would appreciate if you increased the screen real-estate dedicated to the visual aids. Also, I'm a postbac applying for MSTP right now. I love the show and it's helping me form an interest in oncology and health policy. I really like how you seem so honest. Lots of medical and science news seems stuffy and obscure, but your attitude is so infectious that I can't help but get excited about sticking it to the man and doing really good studies one day. Btw, when I'm writing papers, I'm never ever going to use a medical writer!
something you didn't go over that I think is worth mentioning, this study enrolled over 200 people, the cost must have been incredibly high given how expensive this medicine is.
I truly admire your persistence. It seems prudent to offer you credence given your motive is highly laudable. Perhaps you should take a leap into the cell structure of a particle wave as it relates to the replication sequence. Water flowing from a tap may look crystal clear but would it not be a fatal leap to state it is void of contaminants? Examine the dilution rate as it pertains to the enhancement of an antibody in the structural depth of a vaccine. The war is already over doctor. Our lives are vacuous of substance and enrichment because we choose to live this way.
You’re definitely not too hard on these people, the truth is the truth. The villain in this situation is politicians who do anything they can to encourage pharmaceutical companies to explore insane ideas for profit. You hit the nail on the head when an easy analysis of the cost benefit should have ended this study. Thank you for what you do. Allen
(Vinay Prasad did not kill himself.) …….. Dr. Vin, you are a lighthouse in a foggy and tempestuous sea. Thank you for laying it down hot. Your intellect, judgement and courage in pursuit of objective humanity is very much appreciated. Let us know how we can help.
Are medical writers the same as "face checkers"? Thank-you for exposing the "fraud" and encouraging folks to take their health in their own hands (exercise, eat healthy, spiritual life...) Covid was an eye opener...
No, medical writers don't judge the results interpretations they just write. for this paper Pharma was involved in analysis & interpretation so problematic
The statistical entity you want to know about is called “number needed to treat” (NNT). You can look up the numbers for widely-used medications using that phrase. I don’t know the NNT for statins off the top of my head, or I would share!
Even if the benefit of this drug does not justify the $100k cost as of the time of this study, is it not true that competition with a similar androgen inhibitor / economies of scale in production of the drug / generic versions being produced will eventually lower the cost massively? At least in theory it makes sense to approve a drug (that is actually effective/safe) without regards to cost, because once the drug is approved, there will eventually be market forces that bring down the cost.
I tried to share this with co-workers, but this one is also Restricted, which means our corporate IT department won't let it through. I teach EBM to clinicians who create clinical decision support content, and would LOVE to be able to share links to your videos to flesh out what I'm teaching (without everyone just getting error messages). Anything you can do to keep these from being restricted by RUclips would be very greatly appreciated!
Don't most doctors today use a "diagnose my patient" app, where they enter in their customers symptoms and the app recommends which drugs to prescribe? Treating symptoms versus cause?
Thank you for your videos. A criticism of the recent ones: the way you show slides does not work. They are too small to read, whether on a laptop or on a 42" TV screen. Please: you small (or gone), slides big.
I'm sure there was a good idea behind this drug. But if it doesn't work well, why doesn't big pharma figure out how to improve it's mechanism of action and reduce side effects, or if that cannot be accomplished, drop it? I'm sure I'm guilty of oversimplification, but I looked up this drug, and the side effects look pretty bad and it doesn't cure prostate cancer, it appears to just hold it off at significant cost.
It works well in other contexts. It's typically used for castration-resistant prostate cancer. Almost all chemotherapeutics have bad adverse effects. You have to realize that we are using antibiotics that target human cells, so this is inevitable.
Plagiarism is allowed now, so I don't see how having someone else write a paper should be frowned on. If you don't like it, just get your medical care in a country where they don't do that kind of thing.
What is the most common age for developing prostate cancer? I'm not in the medical field. My only experience with this cancer is a relative who was diagnosed in his 70s, in the 1970s, and died from it at age 85, in the 1980s. At that time, as his children told me then, there was no treatment, but it was slow growing, so he just continued living his life, enjoying every moment, and putting his affairs in order. I was also told that it was most common in elderly men. If that's the case, then why pursue immortality? I don't mean to be crass, but death comes to all, one way or other. That doesn't mean forget all medical care or healthy practices. It just means that at some point it's a quixotic exercise of futility trying to stay alive, especially considering the negative side effects that severely impact quality of life. Maybe some Howard Hughes zillionaire wants to live forever...let that one buy this drug.
The solution is simple. NEW START acronym for Nutrition (whole food-plant based diet, free from everything injurious like, coffee, sugar, alcohol, meat, dairy, processed foods) Exercise, Water, Sunshine, Temperance, Air, Rest, Trust in God. "Love the Lord your God with all your heart, all your mind, and all your strength and your neighbor as your self." Please read THE GREAT CONTROVERSY. Blessings.
"Smell cash" and "doesn't make a lick of sense." Hmmm...kinda like vaccinating children and young, healthy adults for the 'vid? Or vaccinating folks with natural immunity?
I was diagnosed with ‘nervous bladder’ (it was one of those bladder infections that the common urine test strip doesn’t catch). The doctor offered me some medication that was supposed to reduce my urine output (side effect: persistent perception of thirst that should not be sated). I asked hin how long I would need to take it. The answer was pretty much ‘for the rest of your life’. I politely declined. He was offended.
The corporations pushing drugs like this should beheld accountable. Any doctor falling for this kind of shuck and jive BS should lose their license to practice!
I'm not aware of a single physician who was for this trial, except for the authors! I think part of this is b/c this trial moved into the space of Radiation Oncologists and Urologists who are more of critical of this rather than many (not all) medical oncologists who tend to except these "PFS" benefits
I am a radiation oncologist, and this did not fool me. Pharma-run trials are , by definition, suspect.
It makes sense when informed consent is gone. Mandates are here. This will apply to things beyond the flu of unknown origin.
I so enjoy listening to your review of studies. I am laughing out loud in my office
There was a placebo arm and there was a drug+personal masseuse+steak dinner arm, and guess which arm won?
Get 'em , doc. I admire you so much. Keep up the great work
I enjoy watching you. You present the information so that I can understand your analysis. Keep up the good work.
Would you be able to take the slides and move them to fullscreen, and then put your video feed in the corner or side? I watch this on my phone and its just too small to see the slides! You are very handsome, so don't feel bad, but I would appreciate if you increased the screen real-estate dedicated to the visual aids.
Also, I'm a postbac applying for MSTP right now. I love the show and it's helping me form an interest in oncology and health policy. I really like how you seem so honest. Lots of medical and science news seems stuffy and obscure, but your attitude is so infectious that I can't help but get excited about sticking it to the man and doing really good studies one day. Btw, when I'm writing papers, I'm never ever going to use a medical writer!
Thank you, Dr. Prasad.
Thank you again. Your efforts give us a perspective that most of us could not otherwise get. So needed.
I LOVE YOUR REVIEWS AND HONEST/DIRECT VERBIAGE....KEEP TELLING TRUTH TO POWER DR. YOU ARE APPRECIATED IMMENSELY!
something you didn't go over that I think is worth mentioning, this study enrolled over 200 people, the cost must have been incredibly high given how expensive this medicine is.
I truly admire your persistence. It seems prudent to offer you credence given your motive is highly laudable. Perhaps you should take a leap into the cell structure of a particle wave as it relates to the replication sequence. Water flowing from a tap may look crystal clear but would it not be a fatal leap to state it is void of contaminants? Examine the dilution rate as it pertains to the enhancement of an antibody in the structural depth of a vaccine. The war is already over doctor. Our lives are vacuous of substance and enrichment because we choose to live this way.
You’re definitely not too hard on these people, the truth is the truth. The villain in this situation is politicians who do anything they can to encourage pharmaceutical companies to explore insane ideas for profit. You hit the nail on the head when an easy analysis of the cost benefit should have ended this study. Thank you for what you do. Allen
most outstanding presentation. Your candide analyis is brillant.
keep going. You are a gift to society.
You are getting wiser by the minute doc!!!
(Vinay Prasad did not kill himself.) …….. Dr. Vin, you are a lighthouse in a foggy and tempestuous sea. Thank you for laying it down hot. Your intellect, judgement and courage in pursuit of objective humanity is very much appreciated. Let us know how we can help.
No money for doctors and stockholders if people are HEALTHY. 🤑
Exactly, no money in health!
Are medical writers the same as "face checkers"?
Thank-you for exposing the "fraud" and encouraging folks to take their health in their own hands (exercise, eat healthy, spiritual life...)
Covid was an eye opener...
No, medical writers don't judge the results interpretations they just write. for this paper Pharma was involved in analysis & interpretation so problematic
Kept hearing “thalidomide” 😳
Isn't this exactly what happens with statin drugs? You have to treat so many people to get even one person who's life might be saved?
The statistical entity you want to know about is called “number needed to treat” (NNT). You can look up the numbers for widely-used medications using that phrase. I don’t know the NNT for statins off the top of my head, or I would share!
BMJ has a paper saying one in 400 gets a life saving benefit, the other 399 miss out.
The NNV (number needed to vaccinate) for COVID jabs is pretty abysmal as well. Ideally the number is 1. You give 1 dose, you get benefit in 1 patient.
Hey from Tahoe, nice shirt ;)
Even if the benefit of this drug does not justify the $100k cost as of the time of this study, is it not true that competition with a similar androgen inhibitor / economies of scale in production of the drug / generic versions being produced will eventually lower the cost massively? At least in theory it makes sense to approve a drug (that is actually effective/safe) without regards to cost, because once the drug is approved, there will eventually be market forces that bring down the cost.
Market forces wont apply until it comes off patent.
I tried to share this with co-workers, but this one is also Restricted, which means our corporate IT department won't let it through. I teach EBM to clinicians who create clinical decision support content, and would LOVE to be able to share links to your videos to flesh out what I'm teaching (without everyone just getting error messages). Anything you can do to keep these from being restricted by RUclips would be very greatly appreciated!
Don't most doctors today use a "diagnose my patient" app, where they enter in their customers symptoms and the app recommends which drugs to prescribe? Treating symptoms versus cause?
Thank you for your videos. A criticism of the recent ones: the way you show slides does not work. They are too small to read, whether on a laptop or on a 42" TV screen. Please: you small (or gone), slides big.
Stop holding back, tell us how you really feel.
Pushing Skittles for a more chromatic outcome.
I like how the experimental arm is called enza + AS 😂 this ain’t surveillance anymore
do not say you are "harsh". this is not correct. you are scientific and commenting accordingly. please keep helping society
I wonder if any of the men taking this drug fathered children, and if those children had any birth defects?
Remember thalidomide?
You're not too bright.
Please, please, please change your editing so that your slides take up a bigger portion of your screen and your scenery less.
I know you can't touch this topic without being censored, but I wonder what you think about the claim that Lupron is safe for children.
I'm sure there was a good idea behind this drug. But if it doesn't work well, why doesn't big pharma figure out how to improve it's mechanism of action and reduce side effects, or if that cannot be accomplished, drop it? I'm sure I'm guilty of oversimplification, but I looked up this drug, and the side effects look pretty bad and it doesn't cure prostate cancer, it appears to just hold it off at significant cost.
I think you know what the 'good idea' was behind thi$$$$$$$$$$$$ drug.
It works well in other contexts. It's typically used for castration-resistant prostate cancer.
Almost all chemotherapeutics have bad adverse effects. You have to realize that we are using antibiotics that target human cells, so this is inevitable.
Plagiarism is allowed now, so I don't see how having someone else write a paper should be frowned on. If you don't like it, just get your medical care in a country where they don't do that kind of thing.
They should put you on the news every night.
What is the most common age for developing prostate cancer? I'm not in the medical field. My only experience with this cancer is a relative who was diagnosed in his 70s, in the 1970s, and died from it at age 85, in the 1980s. At that time, as his children told me then, there was no treatment, but it was slow growing, so he just continued living his life, enjoying every moment, and putting his affairs in order. I was also told that it was most common in elderly men. If that's the case, then why pursue immortality? I don't mean to be crass, but death comes to all, one way or other. That doesn't mean forget all medical care or healthy practices. It just means that at some point it's a quixotic exercise of futility trying to stay alive, especially considering the negative side effects that severely impact quality of life. Maybe some Howard Hughes zillionaire wants to live forever...let that one buy this drug.
Exactly, he would have been better off not knowing.
The solution is simple. NEW START acronym for Nutrition (whole food-plant based diet, free from everything injurious like, coffee, sugar, alcohol, meat, dairy, processed foods) Exercise, Water, Sunshine, Temperance, Air, Rest, Trust in God. "Love the Lord your God with all your heart, all your mind, and all your strength and your neighbor as your self." Please read THE GREAT CONTROVERSY. Blessings.
"Smell cash" and "doesn't make a lick of sense." Hmmm...kinda like vaccinating children and young, healthy adults for the 'vid? Or vaccinating folks with natural immunity?