Why Dopamine Antagonists Cause Galactorrhea
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- Опубликовано: 16 сен 2024
- From the questions in class: "Why do dopamine antagonists cause galactorrhea?" and "If Parkinson's is sort of the opposite of psychosis, then why don't Parkinson's patients have galactorrhea?"
This video is intended for use by beginning nursing students. It is not a substitute for professional medical advice, diagnosis, or treatment.
Always seek the advice of your physician with any questions you may have regarding a medical condition.
These are well developed video. These are great lessons
Excellent . Thank you
This video was informative and entertaining thank you
I feel so much better when woman tells these.. Also im 15 and this started when I started my new depression meds....
I'm sorry you had that side effect. Hopefully you will find a regimen soon that will lift your mood and be worth the side effects. Stay with it; you just have to hang on until you find the right combination.
Thank you dactor 😃😃😃
Any time
Dopamine antagonist is hell on earth
All drugs (including natural remedies) have side effects, and all drugs are poisons in high enough doses. The question we ask ourselves as care-givers and as patients: is the risk worth the benefit? If you have schizophrenia, is the impact on your life so devastating that you're willing to risk EPS like dystonias or tardive dyskinesia to fight it? Or if, like me, you have multi-treatment-resistant major depression so severe that your life is endangered, then you have to decide if you're willing to put up with the side effects for the chance for a reprieve from hopelessness. The good news is that the second generation (atypical) antipsychotics have less dopamine antagonist action and more serotonin and histamine receptor binding, and that seems to be somewhat protective from the EPS. But the atypicals are a new drug class so they are still not completely understood, imperfect and expensive. Just gotta hold out, my friend, so science catches up in time for us. Hang in there.
@@TaiChiKnees I was forced by the corrupt arrogant psychiatry that can label you whatever they want because it's impossible to prove you arent a schizo.
And then when you complain about flat affect and anhedonia these meds causes they tell you is your "sickness" and not the meds. Some psychs must be in jail.
But yeah, big mistake to trust your brain to big pharma.
Have a nice day c:
Is there a chance than an antagonist binds so strongly to the receptor that never leaves it?
Of course. But that would not be a ligand within the body. That would be defined as an irreversibly-acting agonist/antagonist and would likely be either a naturally occurring or man made poison.
@@TaiChiKnees would't it be usefull to stop drug addiction? No point in taking drugs if the dopamine they produce doesn't do anything.
I'm sure there are consecuences but maybe give it only to the worst addicts
What would happen if this substance is mixed with drugs? We could clean entire cities
This doubt may be irrelevant to this topic but plz someone try to explain me, I don't understand what is the use of antagonizing D2 receptors,well my doubt is D2 like receptors are g inhibitory then in schizophrenia it is said that D2 receptor becomes overactive or they increase in never and cause psychotic symptoms well if D2 like receptors are inhibitory then if we antagonize them it means we are actually getting stimulation of other receptors I mean I can't clear this doubt can someone plz explain it..
So this confuses a lot of students: don't get the concept of "stimulation" or "inhibition" confused with "hyperpolarization" or "depolarization" of the brain... that is, stimulating a receptor, binding and activating the receptor, can often lead to an actual lowering of the firing of that nerve by hyperpolarizing its membrane. Additionally, in the brain there are D1 (activating) and D2 (inhibiting) receptors and pathways, depending on the area of the brain involved. Another way to explain this is that the displaying of psychotic symptoms doesn't mean that all the areas of the brain are being electrically stimulated... that's because some areas of the brain are constantly inhibiting other areas of the brain. (I know, it seems inefficient, but that's the way we are built.). So if there is one part of the brain constantly inhibiting your brain from imagining/dreaming so that you can perceive reality, then a drug that stimulates the "stop dreaming up hallucinations" area of your brain would actually stop psychotic symptoms. Does that make sense? (Sorry for the late response... I didn't notice the channel comments in this area of my dashboard on the channel.)
@@TaiChiKnees thank you so much...that helped a lot. You deserve lots of subscribers
At 5:19. Tardive diskinesia is not low dopamine activity
I think you mean at 7:19 ... Yes you are right out of context, one of the main mechanisms of Tardive Dyskinesia is thought to be due to chronic dopamine receptor blockade by antipsychotics. What I am saying here, in this introductory pharm video, that is that WHEN YOU ARE FIRST LEARNING these medications, you can simplify the way you think about them by thinking about just dopamine and how they are affecting the level of activity levels in the brain. For instance, there is a condition called Neuroleptic Malignant Syndrome (NMS) that can be caused by either starting a patient on a dopamine antagonist drug OR by suddenly stopping a chronically taken dopamine AGONIST.
So this is how to think about this material the first time around. The SECOND time you go through this, you have to do a deeper dive, because antipsychotics do not only affect dopamine receptors, they also affect serotonin and histamine receptors (and as time goes on we are discovering more and more neurotransmitters). In fact, some of the newer atypical antipsychotics (aka SGAs) are so much more active via serotonin and histamine than dopamine you can even use them, in a pinch, in a Parkinson's patient with psychosis. But that is a whole other topic worth its own video...
But thanks for pointing this out. Folks not taking my class would probably be confused.
M having a slight yellow discharge from my right breast. Is it normal? It is corona age ... Afraid to go to hospital for chk ups😞
Call your doctor and explain your symptoms. I understand your concern about going to the hospital but we are likely to be in this situation for a good year and you can't put off your own care because of a small risk of catching COVID from one trip to the doctor. Remember to wear a well-fitting mask, wash your hands and don't touch your face on your trip.
@@TaiChiKnees thank you so much ... Love🙏🏼