Kidney Secrets Unveiled: The Dance of Tubuloglomerular Feedback & G-T Balance! | NEET PG | MBBS |
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- Опубликовано: 4 сен 2024
- Renal mechanisms that maintain fluid and electrolyte balance, thereby ensuring homeostasis.
Dive deep into the intricate world of kidney function as we unravel the secrets of tubuloglomerular feedback and glomerulo-tubular balance. These remarkable mechanisms play a vital role in regulating your body's fluid and electrolyte balance. Join us in this educational journey to understand how your kidneys maintain harmony within your body, ensuring that essential substances are retained while waste is efficiently eliminated. Whether you're a medical student, a healthcare professional, or just eager to comprehend the inner workings of your kidneys, this video offers a glimpse into the delicate balance that keeps you healthy. Don't miss this opportunity to discover the brilliance of renal physiology!
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Awesome explanation sir❤️🔥
Thank you so much, I read a few articles, yet I couldn't understand. Your video helped a lot! Thank you!!!
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Thanku sir it was very helpful..i was breaking my head since an hour because of not understanding this..😇😇😇
There is 1 mcq question..tubuloglomular feedback occurs in-
A.macula densa
B.constant solute load on dct
Ans is given b.
But this doesn't make sense..it should be a right?.
Or else the question should have been feedback occurs due to-
arushi verma yes. The answer should be ‘a’. Or at least, the question should be modified.
Thanku so much sir..🙂🙂
Sir, there is another concept of pressure natriuresis which I am not able to distinguish form TG feedback, both respond to an increased GFR, in tgf, gfr is being reduced while in pressure natriuresis, sodium and water excretion is increased, how it is decided that which mechanism will act when?
One thing that can distinguish between the two is - where exactly the blood flow is increasing primarily. Increase in the blood flow in glomerular capillaries is known to initiate TG feedback. In this, the filtered Na+ is reaching the macula densa. For pressure natriuresis (and diuresis), there is increased blood flow in the medullary blood flow, resulting in increased medullary interstitial hydrostatic factor, which initiates the natriuresis and diuresis (by reducing angiotensin II, and thereby reducing Na+ reabsorption, causing its excretion in urine).
If GFR is increased, G-T balance works,Na+ reabsorption will be increased.. then Na+ in glome. filtrate will be back to normal and then how macula densa will work? how it will regulate the GFR cause we know macula dense sense Na+ level
Yes that's right. But these two mechanisms do not necessarily operate at the same time.
For instance, if there is constriction of efferent arteriole, then Na+ filtration will increase. But protein-rich plasma will not be able to leave the glomerulus (due to efferent artetiole constriction). So it won't be able to reach peritubular capillaries, to exert G-T balance. So, the extra filtered Na+ will then reach the macula densa and T-G feedback can happen.
@@VivekSirsPhysiology Thank you so much Sir..U literally saved me from these confusion.. thank you again
Thank you sir
Welcome
What is myogenic reg
To put it simply - Myogenic regulation involves the smooth muscle in the wall of blood vessel. Increased flow to an organ causes distension, leading to stretch of the vascular smooth muscle. The smooth muscle then contracts, regulating the blood flow.
And i in video studied more reasborption if less gfr
Sir glomerulo tubular feed back applied only to PCT or even asc.LOH,DCT,and CD also??
only at PCT as this is where there is the highest oncotic pressure (increased colloid conc as fluid is filtered out in the bowmans space) that allows for this increased reabsorption of Na+ & H20. At the LOH downwards to DCT & CD, the peritubular capillary has already bypassed the PCT & reabsorbed all the water from there so the Oncotic pressure in the peritubular capillaries will not be significant anymore to draw more water etc
Thankx best explaination which tell me diff between two
But what is myogenic reg
@@lolschoolfrenz but in Ganong the diagram says it affects solute resorption in Thick Ascending Limb of LoH as well. Fig 37-12 in 26th Edition of the book for reference
Superr
Myogenic regulation of arteriole
Map increase arteiole contrract then can u expain in hindi
It is not major regulating factor 4 gfr
Parul Arora That is mainly considered for regulation of blood flow not GFR
@@marshallbasumatary ok thanks
Glomerulo tubulo pct ok but if gfr low then
I here only understand protein flow from efferent to peritubular then regain its content by pct but in notes return if gfr low small amt of filtrate absorbed mean
Saw the msg late. Can you please elaborate on the doubt?
Thanxxx dear sir aap writting kiliye kya use karrahay ho eska naam kya hai aur kis tarah milta hai plz detail
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How about nitric oxide released from macula densa?
Yes. NO is the other mediator involved in TG feedback.
But in pct less reab less gfr
Less GFR , less reabsorption from PCT per unit time. More GFR --> more filtered Na+ & water --> more is reabsorbed from PCT, so that it is not lost into urine. That is how GT balance works.