Coagulation cascade | Human anatomy and physiology | Health & Medicine | Khan Academy
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- Опубликовано: 14 окт 2024
- Created by Patrick van Nieuwenhuizen.
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I studied Robbin's pathology, I studied guyton and believe me, these 14 minutes have stood more valuable for me than those 20 pages of textbooks
Exactly! Those who really know how complicated this whole coagulation thing is have great respect for this presentation. Of course, this presentation is targeted towards an entry-level allied health students: nurses, paramedics, respiratory therapists, etc. I am a nurse (now retired, thank God) with an extensive background teaching allied health students, and many years of experience in ICU, PACU, ER, and Med-Surg. and I’ve forwarded these coag. videos to colleagues who’ve enjoyed them as I have.
World needs more teachers like you...
Nicely broken down and very easy to follow! I swear, I spend an hour just trying to read about this stuff, but watching a 15 minute video and I completely grasp the concept now! Thanks a lot!
10 years out of college and I tried to learn it in multiple occasions from so many different textbooks and you did it in 14 minutes. Thanks 🤣😍
Studying this cascade from the pov of different subjects at college and never been able to carack it doen like today
It's just wonderful how you organize notes so that it can be easily remembered! Love your videos!
A living legend...man u dont know how much u help...i can only say God bless u
Been studying this sh*t for ages and you taught me the easiest way to remember it! I like how you said about the numbers (factors) ultimately leading to the 'goal.' And yes it worked for me because I'm bad at counting lmao
"Assuming you have those friends" LOL
Lol. I can relate
You have helped me understand this thru the past several months. It took a while, but it's all coming together. Thank you.
I’m about to cry this video helped me more than I could imagine
I felt less dumb after watching this video, my lecturer talked like a machine gun
our lecturers always have
Extremely clear explanation!! amazing
This was fascinating. I am learning about anti-coagulants in nursing school, and this really helped me with the foundation as to WHY we bother with PTT, PT/INR lab values. Thank you!
honestly, after the complement system this is like a walk in the park
It's the opposite for me? But this was still pretty easy to understand. Guess it depends on who u r learning from as well
@@gh-ps5es how is it easy for you I am dying trying to learn them 😂💔
Fell in love with the explanation, its saving the life out of me. Thank you sm❤️❤️❤️
"lets say you weren't very good at counting" omg that entire part brought my sides into orbit
Omg …. This video is so good. I had to pause it halfway to give a thumbs up and comment. I am phlebotomist, and I have been wondering how anti Xa works. With all the video I have gone through online. This video, I believe is the best. The cascade is well explained with tricks to help me remember. I will love to explain to some of my patients this amazing biological process in our human body. Thank you for this amazing 🤩 video 🙏
No way i can describe how much of a great helpful and intelligent human being you are
This was so so very well explained!
And I love the little things to help us remember it!
Thank you very much sir .. Thats how medicine should be explained to doctors .. 👍
this video helped me alot ....i really spent days to try to understand this part :( .....but now everything is clear for me....thank u so much
i really spent 2 to three fcking days to get used to insertions and origins of the muscles as well as the lumpy bits
Wow! Amazing explanation - I have heard or read over a dozen lectures or articles on the clotting cascade, and I feel as though I finally understand it and can retain it.
This is very helpful and easy to understand ,also loved the tricks to memorize it better
This was amazing! I was struggling to fully understand my uni lecture on coagulation but this video made it so much easier by going thru the steps diagrammatically and vvv simply! v relevant + to the point too, no waffle!!
I clicked on your video by accident. But your video and explanation skills were so good, I subscribed. Thank you for the information, this is great!
God bless you!! You explain this so well and oh my gosh I needed this!
This is the absolute BEST video I've watched on intrinsic/extrinsic pathways! Such a clear understanding now! THANK YOU!
thanks! I have to study 140 pages of notes on anticoagulant, anti-platelet, and fibrinolytic drugs. This is going to help me a bunch.
This video deserves noble prize in education
Videos like this make me love RUclips. Great job! I loved the visuals.
then is one of the best videos ive ever watch in my whole medical school. THANX ALOT
Which medical school do you go too?
Ha080 it is in Turkiye, Ankara, yildirim beyazit university
Thank you. This was much easier to follow than the first two I watched.
this is amazing...you are God's sent. my teacher makes it look so complicated...
Most beautifully explained - thank you!
Best best vedio on coagulation cascade I've come across
Wow - great little story to remember the factors :) thanks!!
Almost a decade later and still the best video on the net to learn clotting factors
It's not easy getting your head around this but you did a great job of explaining all the pathways. Thanks.
I tried to learn this a couple of years ago for my exams and I must confess, I could not answer the question. Listening to this video and watching you create such a complex concept so simply is so good, thank you
Clotting factor 2 is actually Prothrombin, not thrombin. Thrombin is 2a. Great Video!
Easiest way to remember it, thank you so much!
i just love the way you teach along side how to remember it. i wish my teachers were like this! :/ thanks
Brilliant delivery. Thank you!
Just Khan Academy saving the day again. thanks!
thank god for this channel... about to singlehandedly save my degree!!
One of the best coagulation videos out there!
Great video, greetings from Colombia Armenia U. Humboldt
You did such a magnificent work over here
Well done
I alway look for videos from Khan academy .. always useful .. many thanks ❤️
amazing... i am an egyptian vet and i love your videos so much 💙💙💙
The best explanation I ever had in coagulation cascade I wish you where our lecturer 🥹
such a good teacher. thanks for making this!
You made this sound so easy and it made so simple to understand. Thank you so much!!!
Great explanation!
Wow, thanks! My lecturers are shit! You explained in 15 minutes what my lecturer could not in an hour.
What's heparin? I hear that comes into play when breaking down a clot or something.
Heparin is basically a natural anti coagulant protein . Natural because is made in your body. You can use it before performing a cannulation , you put some heparin on the tip of the needle to prevent blood clots from forming and eventually close the tip of that needle, which would make injecting drugs into the vein harder.. :P
Heparin promotes Antithrombin 3 (a serine protease). Antithrombin 3 inactivates Factors 2 and 10.
Doktor One True, only heparin is NOT a protein but a GAG (glicoseaminoglican) polymer.
PonzooonTheGreat it's an anticoagulant made by liver which keeps the blood in liquid form when the blood capillaries are not hurt
Does Prekallekrein and HMW Kininogen also includes in the intrinsic pathway? Please explain anyone. Thankyou.
Thank you so much for your efforts in doing this video!! God bless you
Wow this explanation was amazing
omg, you are my hero, god bless you, im gona smash this knowledge right to my profesor face, thank you so much!!!
I-
I finally understand. Thank you so much! Incredible video. You made the topic really easy to memorize!
thank you Patrick for the very informative lecture :)
it's REALLY helpful, thanks.
Zymogen forms are one of the most amazing things in the body, in my view. Your body is locked and loaded to do so many things, it's very efficient. Especially in this case, when something soluble is turning into something insoluble.
wow this video is super good! im gonna leave a comment here!
...and then i saw who published it; OH! KHAN! i knew it. thanks khan academy ;)
best video? no best video EVER!!!
you just explained in 15 minutes what my lecturer failed to do in 3 hours
it's just awesome! you simplified it like a boss
"you'd become one large walking clot" HAHAHAHAH
Great summary, really useful; but you said the first step would be the platelets aggregating to the site of injury, but wouldn't the first step be vasoconstriction? This would significantly slow down the blood flow
I think it is because he is talking only about the clotting cascade with platelets and such, even though that would be the first part.
obviously...
@@user-rj8wm8oj1c If it was obvious then why bring it up? A little bit of a contradiction here lol.
Three years too late.. but vasoconstriction will be the first thing to occur in PRIMARY hemostasis. The coagulation cascade occurs in SECONDARY hemostasis. He shouldnt have worded it that way, but for this portion of hemostasis it makes sense.
this was beautifully done. it made so much sense. if my lecturer only showed this video instead of talking for an hour
Brilliant Lecture.
Thank you for the excellent lesson. The amplification sequence explanation (07:16) was very helpful in understanding the significance of the activation process.
Seriously, this video is amazing.
Wow! You really helped me learn this material. I was so confused by my professor. Thank you !!
This video is an A for brilliant explanation
Very simple to understand it by these little cute drawings .
Thanks a lot .
such a clear simple explanation thank u!!
im so happy i found your page!
Loved it. Thankyou so much man! ✨🔥💯
Helpfull in understnaging and memorizing too ...!!! Thank you ....!!!
Thanks for existing
What a great video. Thank you :) I would love to see a video like this and include how heparin, Coumadin, aspirin, etc works on this pathway. :)
yup
+Katelin Gates Subscribe to my channel, I will be posting the cntent in a matter of moments
That would make this video pretty lengthy and kind of long shot. Aspirin inhibits formation of TXA2 (thromboxane2) which is part of the primary hemostasis process. Coumadin inhibits epoxide reductase which activates Vitamin K. Vitamin K is necessary for gamma carboxylation of factors II, VII, IX, X and proteins C and S. And heparin inactivates thrombin (IIa) and Xa through another mechanism known as antithrombin dependent mechanism..
Maybe in a different video it would be helpful
Katelin Gates ]b
thank you so much for this video, so easy to follow
this literally just rewired my whole brain
Thanks for this amazing explanation!!
Incredibly helpful! Thank you!
Thank you so much, I always come in this channel for help and you guys never disappoint me
Fantastic. This is just incredible. Great job.
"...while evolution was designing us". Wow! Such an intelligent designer evolution is. How people can believe this masterpiece just came together with no design is beyond human comprehension or reason.
They're stubborn
I thought the same thing! Such a betrayal of their own beliefs to personify a seemingly meaningless and random process!
Awesome video! Maan... That helped me a lot! Thank you.
Very helpful video, a small thing is maybe you could explain when the thrombin activates its negative feedback. Is it when there is too much thrombin in the blood?
This was so helpful! Thank you so much.
This is exactly what I'm looking for! This is very helpful!
you have just saved me !!! thank you so much for the video
This video is pretty good, thank you so much really
Great help. Big thanks
this guy is just awesome..
I love you and this video, thank you so much
Thank you. Really made a big difference 👏🏽
thank you so much for this!! this really helped me!
Thank you for this great explanation .. You guys are awesome