When I used lower high melatonin doses 100 mg every 2 hours, it made me tired, but if you keep taking more it will stop. Im up to 400 mg every 2 hours because it has a low half life, according to Dr. Reiter and his co researcher Doris Loh.
6:50 regarding Dr. Reiter, he once made a point that mirrored my experience, that taking 2mg a night might make one groggy, but as you take more (or get more sunlight), and take it throughout the day with a heavier dose in the evening, grogginess likely goes away.
so infrared light helps produce melatonin and blue light (screens/indoor environment) blocks production? or do you just not produce meletonin due to lack of infrared?
We create intracellular, mitochondrial produced melatonin when under solar exposure, likely due to the Red/infrared spectrum, remember the paper has the confounding variables of being outside (full spectrum sun) and while doing exercise. The light (color temperature) and darkness (absence of all light, specifically blue at 465nm) is what is responsible for pineal released nocturnal melatonin into systemic circulation (bloodstream).
I used to stay up all night trying to figure out what was the root cause of my health issues on my computer/phone. Little did I know the effects of blue light and melatonin/melinopsen.
@DrCaseyPeavler Dr Peavler, can you do a short video integrating both the ETC and the krebs cycle? Every chart I have studied shows them as being separate, and I don't quite understand fully the integration. One is electron and proton, and the other is biochemical.
I’ve been taking melatonin every night for many many years. 10mg per night when I was younger, the 50mg per night as I got older. I’m Now taking 500mg per night. No issues with waking, or anything else. Only benefits.
@@DrCaseyPeavler I know a couple of PhDs that take between 1000mg and 5000mg per day. Very interesting effects on ATP and viral infections. I’d have to dig up the data, but as melatonin dose increases ATP follows. The viruses can use some of the additional ATP for their own growth; however, after ATP levels reach a threshold level the viruses are simply dissolved by the ATP.
I am certain you are talking about Dr. Russel Reiter and his colleague lol. Yes they do take boatloads of melatonin. For those who do not have cancer, I do not recommend supplementing, but maximizing what you can produce with darkness and sunlight.
@@DrCaseyPeavler I understand completely. My personal viewpoint and use comes in with the SIRT3 (Melatonin being an activator) for health and longevity. The antiviral mega dosing side (approx 5000mg daily in divided doses) isn’t something I’ve personally utilized, but it is an interesting effect to know and can be utilized similarly to a course of antibiotics (10-14 days at 5000mg). Cheers
Excellent! This presentation is very much matching my concerns. And, even the point about N of 1 experimentation by medical people, to try to get some of the research questions clarified, given that there is so very much funding bias blocking research from trying to answer legitimate questions that doctors and researchers are driven to ask. 'Profit at any cost' is not conducive to pointedly investigative science, censorship abounds, and reluctantly, n of 1 experimentation must sometimes be resorted to, unfortunately.
I honestly don’t have an experience with it. I think we have a ton of good options to improve mitochondrial function and overall health which is encouraging to me
UV radiation from the sun can directly damage the DNA and proteins within mitochondria. Sunlight can also cause heat stress, which can impair mitochondrial function and increase the production of ROS. The increased production of ROS can lead to oxidative stress, which can damage various components of mitochondria, including the mitochondrial membrane, proteins, and DNA. NIR light may be triggering the production of melatonin as a protective mechanism against oxidative stress caused by exposure to sunlight.
Everything you said is correct. But let’s consider humans before 1900. Most were outside in sunlight all day every day. We are designed to be out in the sun all day. Our systems are built to protect us from the UV damage (vitamin D, melatonin, alpha, beta, gamma MSH, beta endorphin, met enkephalin, melanin). We know from epidemiological studies that people at the highest latitudes and less UV exposure have more hypertension, diabetes, autoimmune diseases, psychiatric disorders, heart disease and cancer. Given that information, how could you see what you said as making any sense? It’s a free country (sort of) and I believe in complete personal medical autonomy, so you can do what you want. But there will be a huge biological toll to pay by avoiding the sun. And I would hate to see it happen to you or anyone else.
Sun is not our friend/benefactor, it harms us. It is our own body that does the protection, by producing all those protective chemicals and has evolved all those protective mechanisms. The body doesn't know if someone is out there trying to get sun exposure, it gets distress signals and then tries to protect itself as best it can. I am not against sun exposure, just wanted to bring the other perspective into focus as well. You are doing excellent and valuable work, much respect for that.
I have listened to a lot of Jack Kruse but never got an answer on if we wear blue light blockers in the day inside all the time. How does brightness effect blue light? many thanks in advance
So I don’t want to speak for Uncle Jack but I think in this case I may be able to tell you what he might say. Use yellow blue blockers while inside if there is no way you can have access to natural sunlight. But if you can just open a window or a sliding door and let the light in, less of an issue. The brightness question I am not certain about but my gut tells me it is important. Imagine a very harsh but dim LED vs extremely bright harsh LEDs. I can tell a difference in how I feel, personally. Even with the best blue blockers available on my eyes.
@@DrCaseyPeavler That's very helpful , thank you ! You have a great gift to understand a question and answer it properly. Also to prompt me thinking. Which google and others failed to answer!! Thank you
@@DrCaseyPeavlerYes for me brightness is very important. If I spend a week in the mountains & go out walking or (better still) skiing every day my vision (at least) is markedly better and I feel great.
I may do melatonin once or twice a week. I agree too much of anything and the body shuts down. My approach to circadian rhythms, I strive to complement/counterbalance the challenges of modern living. I find there too many modern variables that can disrupt a classic/from nature circadian rhythm plan.
It’s especially hard since melanopsin receptors are not only located in the eye but everywhere else. Which means your eyes can be covered with blue blocking glasses, sleep mask, etc but if your skin is exposed to light, you are still affected to a lesser degree but affected nonetheless.
Sir, I am currently suffering chronic inflammation in my kidneys and joints. I'm not in the serious stage, but I'm feeling some pain on my body. So Is it worth considering high-dose of melatonin at this time? I'm using 2mg of melatonin for sleeping problem and it works not perfect, but pretty well. Do you think Is it possible to use a high dose for a while and then return to a low dose? If it is possible, Could you recommend dosage for me? I'm 32 years old now. Sorry for broken english, I'm not a english native. Thx for good video!
Melatonin is an unbelievable molecule. I would first and foremost maximize endogenous production of melatonin. Max tolerable sun exposure and max darkness after sunset.
Am I correct in assuming as we age, the body makes less melatonin? I am concerned about genetic dementia. My mother is suffering horribly by this medical condition. I am terrified I too, will suffer from this malady. I am taking 80 mg at bedtime, in hopes it might limit or mitigate the problem of dementia. I don’t know if anyone has a better recommendation for dosage.
It’s hard to answer such a good question on the comments. Needless to say there are a lot of factors that lead to a dementia diagnosis. I am sorry about your mom, it is a horrible disease. I have several family members with dementia myself. So I have a heart for what you are going through and are scared about. Have you heard of Dr. Dale Bredesen?
Thank you, Dr. Peavler, I appreciate your solidarity with other families suffering from the emotional turmoil of dementia diagnosis. I have not heard of Dr. Bredesen. I will research the name. Appreciate your return response. I truly appreciate it.
I don’t thing Dr Bredesen has everything right but it’s better for sure than watching and waiting and feeling powerless. If I were worried about dementia, I would be outside as much as I could stand, as much of my body exposed to the natural light as possible, grounded/earthed, and have a perfect circadian rhythm. Plus I would eat alot of DHA, long chain omega 3, from seafood. You should also look into Dr. Jack Kruse, a brilliant neurosurgeon.
@@DrCaseyPeavler Thank you. I will increase seafood in diet. I already soak up sun rays and hike nearly every weekend. Sleep schedule pretty consistent. I will check into the other doctor info you suggest. I really appreciate you response and assistance.
When you say tunneling do you mean like electron or proton tunneling in quantum mechanics? Or building structures between cells? The melatonin can be exported outside the cell and have an autocrine (same cell effect) or paracrine (adjacent cell effect).
Linked to hair growth also can be absorbed through the skin if mixed with coconut oil. I get some crazy dreams everytime I do one of these skin applications which I combine with some infrared treatments but yeah the effects start almost immediately if you know how it feels when the melatonin kicks in from taking it sublingual you can tell its being absorbed by the skin and getting into the bloodstream by that same feeling. Where my beard was all grey, it's now turning splotchy black again from doing this.
Sounds like you are having some crazy experiences. I would suggest just sticking with IR exposure and complete darkness at night or at least a complete absence of artificial light. Likely a better situation than supplemental formulations. Unless you have cancer, then supplemental melatonin is on the table. Dose/schedule in discussion with your doctor of course.
Interesting, thank you, I’ll take a look. Given the amount of melatonin we make in our skin cell when exposed to UV, red and infrared, I would have to imagine this is unnecessary. But I’ll keep an open mind give your phenomenal results.
@@DrCaseyPeavler Right, so if at some point a persons mitochondria is free of dysfunction, then at another point, dysfunction arises, the question for me would be: is the dysfunction temporary or permanent. If it is temporary, then the issue could resolve itself given the right changes (i.e. dieting). If it is permanent, then introducing new healthy mitochondria, free of defect, should resolve the disorder. Please refer to paper: "Mitochondrial transplantation: an overview of a promising therapeutic approach"
I think it would be beneficial to watch my videos on how to reverse mitochondrial heteroplasmy and heteroplasmy and cancer. Familiarize yourself with autophagy, mitophagy and mitochondrial biogenesis. That will get you started!
That’s better than most people, good for you! You don’t have to be exposed the whole day. The benefits of infrared come from reflection off surfaces, likely through clothing. Plus getting your eyes in natural light is a huge key as much as possible for circadian rhythm.
I know melatonin is in the eyes and for over 50 years my eyes were brown. Now with good diet some supplements increased sunlight my eyes have been turning green for 3 months.
@@DrCaseyPeavler I can see better in the dark, my eyes are still changing i had a lot of melatonin not sure where it is going though. No excess weight, no knee pain no back pain will look like Bruce Lee soon.
There were reports years ago (20 or more years ago?) that MIT had determined that lower doses of melatonin were more effective for promoting sleep than were higher doses. Apparently, 1 mg works better than 10 mg. MIT then got a patent (???) on low-dose melatonin and all other manufacturers had to remove their low dose products and only sell the less effective higher doses. Did I hallucinate this? All universities strive to monetize their research, but this seemed pretty egregious to me.
So we are talking apples and oranges. Melatonin according to Dr. Russel Reiter, world's authority on melatonin, says melatonin does not promote sleep. That seems to have been debunked. However, how much melatonin does a person need to help bring down inflammation, oxidative stress, fix mitochondria, treat cancer. This is open for a large amount of debate. No question it works, but how much? when? exogenous? endogenous?
Paying researchers for their work, I am ok with. Big pharma owning all research for the purpose of siloing everything towards drugs and silencing natural remedies. I also find disgusting.
Ok…. I think a distinction should be made between young and old people. Big difference in endogenous melatonin synthesis.. Yes, anyone under 50 should take the 1 mg. The 80 yr old might benefit from 10-50 mg. The cancer patient, yes, high dose .
When I used lower high melatonin doses 100 mg every 2 hours, it made me tired, but if you keep taking more it will stop. Im up to 400 mg every 2 hours because it has a low half life, according to Dr. Reiter and his co researcher Doris Loh.
Thank you for your insights. Why are you using melatonin? Do you have cancer?
6:50 regarding Dr. Reiter, he once made a point that mirrored my experience, that taking 2mg a night might make one groggy, but as you take more (or get more sunlight), and take it throughout the day with a heavier dose in the evening, grogginess likely goes away.
Interesting…Thank you for sharing your experience!
Thank you for your hard work and contributions in edifying us.
You are very welcome, it is my pleasure.
brilliant presentation
Thank you for your kindness!
so infrared light helps produce melatonin and blue light (screens/indoor environment) blocks production? or do you just not produce meletonin due to lack of infrared?
We create intracellular, mitochondrial produced melatonin when under solar exposure, likely due to the Red/infrared spectrum, remember the paper has the confounding variables of being outside (full spectrum sun) and while doing exercise. The light (color temperature) and darkness (absence of all light, specifically blue at 465nm) is what is responsible for pineal released nocturnal melatonin into systemic circulation (bloodstream).
I used to stay up all night trying to figure out what was the root cause of my health issues on my computer/phone. Little did I know the effects of blue light and melatonin/melinopsen.
Don't feel bad, we all do it. Now you know, now you are armed with this info and can act accordingly.
@DrCaseyPeavler Dr Peavler, can you do a short video integrating both the ETC and the krebs cycle? Every chart I have studied shows them as being separate, and I don't quite understand fully the integration. One is electron and proton, and the other is biochemical.
The first graphic in this paper is pretty good.
pubmed.ncbi.nlm.nih.gov/23168274/
This paper is also amazing integrating in concepts!
www.nature.com/articles/s41467-019-13668-3
@@DrCaseyPeavler Thank you so much.
Thank you for your effort!
You are very welcome!
I’ve been taking melatonin every night for many many years.
10mg per night when I was younger, the 50mg per night as I got older. I’m Now taking 500mg per night.
No issues with waking, or anything else.
Only benefits.
Wow 500mg!
@@DrCaseyPeavler I know a couple of PhDs that take between 1000mg and 5000mg per day.
Very interesting effects on ATP and viral infections. I’d have to dig up the data, but as melatonin dose increases ATP follows. The viruses can use some of the additional ATP for their own growth; however, after ATP levels reach a threshold level the viruses are simply dissolved by the ATP.
I am certain you are talking about Dr. Russel Reiter and his colleague lol. Yes they do take boatloads of melatonin. For those who do not have cancer, I do not recommend supplementing, but maximizing what you can produce with darkness and sunlight.
@@DrCaseyPeavler I understand completely.
My personal viewpoint and use comes in with the SIRT3 (Melatonin being an activator) for health and longevity.
The antiviral mega dosing side (approx 5000mg daily in divided doses) isn’t something I’ve personally utilized, but it is an interesting effect to know and can be utilized similarly to a course of antibiotics (10-14 days at 5000mg).
Cheers
Excellent! This presentation is very much matching my concerns. And, even the point about N of 1 experimentation by medical people, to try to get some of the research questions clarified, given that there is so very much funding bias blocking research from trying to answer legitimate questions that doctors and researchers are driven to ask. 'Profit at any cost' is not conducive to pointedly investigative science, censorship abounds, and reluctantly, n of 1 experimentation must sometimes be resorted to, unfortunately.
Sad but true Ray.
Nichlosamide as a mitochondrial uncoupled creating cell differentiation. Any thoughts?? Thanks for your amazing dedication u need an award!!!
I’ll take your kindness as enough of a reward.
I honestly don’t have an experience with it. I think we have a ton of good options to improve mitochondrial function and overall health which is encouraging to me
UV radiation from the sun can directly damage the DNA and proteins within mitochondria. Sunlight can also cause heat stress, which can impair mitochondrial function and increase the production of ROS. The increased production of ROS can lead to oxidative stress, which can damage various components of mitochondria, including the mitochondrial membrane, proteins, and DNA.
NIR light may be triggering the production of melatonin as a protective mechanism against oxidative stress caused by exposure to sunlight.
Everything you said is correct. But let’s consider humans before 1900. Most were outside in sunlight all day every day. We are designed to be out in the sun all day. Our systems are built to protect us from the UV damage (vitamin D, melatonin, alpha, beta, gamma MSH, beta endorphin, met enkephalin, melanin). We know from epidemiological studies that people at the highest latitudes and less UV exposure have more hypertension, diabetes, autoimmune diseases, psychiatric disorders, heart disease and cancer.
Given that information, how could you see what you said as making any sense?
It’s a free country (sort of) and I believe in complete personal medical autonomy, so you can do what you want. But there will be a huge biological toll to pay by avoiding the sun. And I would hate to see it happen to you or anyone else.
Sun is not our friend/benefactor, it harms us. It is our own body that does the protection, by producing all those protective chemicals and has evolved all those protective mechanisms. The body doesn't know if someone is out there trying to get sun exposure, it gets distress signals and then tries to protect itself as best it can.
I am not against sun exposure, just wanted to bring the other perspective into focus as well. You are doing excellent and valuable work, much respect for that.
Good sir, I will agree to disagree. I appreciate your support of the channel and your kindness.
I have listened to a lot of Jack Kruse but never got an answer on if we wear blue light blockers in the day inside all the time.
How does brightness effect blue light?
many thanks in advance
So I don’t want to speak for Uncle Jack but I think in this case I may be able to tell you what he might say. Use yellow blue blockers while inside if there is no way you can have access to natural sunlight. But if you can just open a window or a sliding door and let the light in, less of an issue.
The brightness question I am not certain about but my gut tells me it is important. Imagine a very harsh but dim LED vs extremely bright harsh LEDs. I can tell a difference in how I feel, personally. Even with the best blue blockers available on my eyes.
@@DrCaseyPeavler That's very helpful , thank you !
You have a great gift to understand a question and answer it properly.
Also to prompt me thinking.
Which google and others failed to answer!!
Thank you
Very kind of you, glad I was able to help!
@@DrCaseyPeavlerYes for me brightness is very important. If I spend a week in the mountains & go out walking or (better still) skiing every day my vision (at least) is markedly better and I feel great.
That is an amazing testimony! Thank you for sharing!
Thank you
You are very welcome
I may do melatonin once or twice a week. I agree too much of anything and the body shuts down. My approach to circadian rhythms, I strive to complement/counterbalance the challenges of modern living. I find there too many modern variables that can disrupt a classic/from nature circadian rhythm plan.
It’s especially hard since melanopsin receptors are not only located in the eye but everywhere else. Which means your eyes can be covered with blue blocking glasses, sleep mask, etc but if your skin is exposed to light, you are still affected to a lesser degree but affected nonetheless.
Sir, I am currently suffering chronic inflammation in my kidneys and joints. I'm not in the serious stage, but I'm feeling some pain on my body. So Is it worth considering high-dose of melatonin at this time? I'm using 2mg of melatonin for sleeping problem and it works not perfect, but pretty well. Do you think Is it possible to use a high dose for a while and then return to a low dose? If it is possible, Could you recommend dosage for me? I'm 32 years old now. Sorry for broken english, I'm not a english native. Thx for good video!
Melatonin is an unbelievable molecule. I would first and foremost maximize endogenous production of melatonin. Max tolerable sun exposure and max darkness after sunset.
I am really sorry to hear about your chronic inflammatory issues.
Am I correct in assuming as we age, the body makes less melatonin? I am concerned about genetic dementia. My mother is suffering horribly by this medical condition. I am terrified I too, will suffer from this malady.
I am taking 80 mg at bedtime, in hopes it might limit or mitigate the problem of dementia. I don’t know if anyone has a better recommendation for dosage.
It’s hard to answer such a good question on the comments. Needless to say there are a lot of factors that lead to a dementia diagnosis. I am sorry about your mom, it is a horrible disease. I have several family members with dementia myself. So I have a heart for what you are going through and are scared about.
Have you heard of Dr. Dale Bredesen?
Thank you, Dr. Peavler, I appreciate your solidarity with other families suffering from the emotional turmoil of dementia diagnosis. I have not heard of Dr. Bredesen. I will research the name.
Appreciate your return response. I truly appreciate it.
I don’t thing Dr Bredesen has everything right but it’s better for sure than watching and waiting and feeling powerless.
If I were worried about dementia, I would be outside as much as I could stand, as much of my body exposed to the natural light as possible, grounded/earthed, and have a perfect circadian rhythm. Plus I would eat alot of DHA, long chain omega 3, from seafood. You should also look into Dr. Jack Kruse, a brilliant neurosurgeon.
@@DrCaseyPeavler
@@DrCaseyPeavler Thank you. I will increase seafood in diet. I already soak up sun rays and hike nearly every weekend. Sleep schedule pretty consistent. I will check into the other doctor info you suggest. I really appreciate you response and assistance.
Is that sharing of melatonin due, at least partially, to “tunneling?”
When you say tunneling do you mean like electron or proton tunneling in quantum mechanics? Or building structures between cells? The melatonin can be exported outside the cell and have an autocrine (same cell effect) or paracrine (adjacent cell effect).
Linked to hair growth also can be absorbed through the skin if mixed with coconut oil. I get some crazy dreams everytime I do one of these skin applications which I combine with some infrared treatments but yeah the effects start almost immediately if you know how it feels when the melatonin kicks in from taking it sublingual you can tell its being absorbed by the skin and getting into the bloodstream by that same feeling. Where my beard was all grey, it's now turning splotchy black again from doing this.
Sounds like you are having some crazy experiences. I would suggest just sticking with IR exposure and complete darkness at night or at least a complete absence of artificial light. Likely a better situation than supplemental formulations. Unless you have cancer, then supplemental melatonin is on the table. Dose/schedule in discussion with your doctor of course.
Whoa! Where do you get your topical melatonin? Or, do you make it yourself?
I have never even heard of topical melatonin. I am also curious
@@DrCaseyPeavler www.ncbi.nlm.nih.gov/pmc/articles/PMC6802208/
Interesting, thank you, I’ll take a look. Given the amount of melatonin we make in our skin cell when exposed to UV, red and infrared, I would have to imagine this is unnecessary. But I’ll keep an open mind give your phenomenal results.
If cancer is produced via metabolic dysfunction, could replenishing them via transplantation offer therapeutic benefit?
I am not exactly sure what you mean. Can you elaborate a bit? Replenish mitochondria?
@@DrCaseyPeavler Right, so if at some point a persons mitochondria is free of dysfunction, then at another point, dysfunction arises, the question for me would be: is the dysfunction temporary or permanent. If it is temporary, then the issue could resolve itself given the right changes (i.e. dieting). If it is permanent, then introducing new healthy mitochondria, free of defect, should resolve the disorder. Please refer to paper: "Mitochondrial transplantation: an overview of a promising therapeutic approach"
I think it would be beneficial to watch my videos on how to reverse mitochondrial heteroplasmy and heteroplasmy and cancer. Familiarize yourself with autophagy, mitophagy and mitochondrial biogenesis. That will get you started!
I take 140mg a night, no drowsiness in the morning., i am 63yrs old.
Thank you for your testimonial. For general health or for some condition you are healing?
I try to be out in the sun every day.
That’s better than most people, good for you! You don’t have to be exposed the whole day. The benefits of infrared come from reflection off surfaces, likely through clothing. Plus getting your eyes in natural light is a huge key as much as possible for circadian rhythm.
Noah! 12,068!
I know melatonin is in the eyes and for over 50 years my eyes were brown.
Now with good diet some supplements increased sunlight my eyes have been turning green for 3 months.
Amazing observation….any observable changes in how you feel or function with that change?
@@DrCaseyPeavler I can see better in the dark, my eyes are still changing i had a lot of melatonin not sure where it is going though.
No excess weight, no knee pain no back pain will look like Bruce Lee soon.
Bruce Lee is a good look ha!
There were reports years ago (20 or more years ago?) that MIT had determined that lower doses of melatonin were more effective for promoting sleep than were higher doses. Apparently, 1 mg works better than 10 mg. MIT then got a patent (???) on low-dose melatonin and all other manufacturers had to remove their low dose products and only sell the less effective higher doses. Did I hallucinate this? All universities strive to monetize their research, but this seemed pretty egregious to me.
So we are talking apples and oranges. Melatonin according to Dr. Russel Reiter, world's authority on melatonin, says melatonin does not promote sleep. That seems to have been debunked. However, how much melatonin does a person need to help bring down inflammation, oxidative stress, fix mitochondria, treat cancer. This is open for a large amount of debate. No question it works, but how much? when? exogenous? endogenous?
Paying researchers for their work, I am ok with. Big pharma owning all research for the purpose of siloing everything towards drugs and silencing natural remedies. I also find disgusting.
Riordan Clinic gives cancer patients 4750 mg intravenous for cancer iirc, an add on therapy to chemo and radiation.
Results?@@DCGreenZone
Ok…. I think a distinction should be made between young and old people. Big difference in endogenous melatonin synthesis.. Yes, anyone under 50 should take the 1 mg. The 80 yr old might benefit from 10-50 mg. The cancer patient, yes, high dose .
5000mg daily for me
For prevention or treatment of some illness?
The grogginess is explained as being caused by melatonin’s detoxifying effects which eventually passes
That is very fascinating, thank you for sharing!
Sorry niclosamide