It’s amazing how BigPharma and the Medical Industrial Complex hides the benefits of this wonder vitamin. They would be saving patients millions of dollars in expenses if patients knew that just upping their intake of vitamin D (as well as maintaining a healthier lifestyle) would greatly reduce their risks of cancer and other metabolic disorders. Thank you Dr. Peavler!
Every year that go's by I hear of and investigate another cancer cure ..and it only leaves me horrified that big pharma is knowingly killing millions and millions of people..they have killed more than two world wars and the soviet and Chinese revolutions put together.
after watching hundreds of hours of videos trying to learn what it means to be healthy, is it a fair summary to say "get outside, get some excersize, eat whole organic foods, reduce stress and get some good sleep" will prevent most chronic illnesses?
@@DrCaseyPeavler true-avoid toxins (ultra processed "foods", seed oils, hfcs, air pollution, pesticides, herbicides, city water etc et al...). i am primarily carnivour but will eat a small amount of veggies (home grown) in season.
That is extremely kind of you, thank you. If I could put myself out a job by everyone being healthy and not having all this unnecessary suffering everywhere, I would gladly do it. I have become quite the smoothie chef, and could go into that someday perhaps…
Great information! I am a 2 time breast cancer with bone Mets (in remission since 2017). I have a VDR mutation. I take 5,000 min D3 K2. My D level two months ago was 87. I was a little confused (not a science major) about what I can do for the VDR.
Great question. I want to do a video or 2 about VDR polymorphisms or genetic variants in the future. The great news is that Vitamin D has anti-cancer effects on a VRD dependent AND independent mechanisms…
Consider taking more. Vitamin is only toxic in the absence of sufficient amounts of important co factors (Zinc, Vitamin A, Boron, K2, and Magnesium). Also, don’t rely on blood numbers because you can have sufficient blood levels with deficient cellular levels. I would recommend testing intracellularly. There are companies that do that kind of testing. Look up Jeff Bowles and Judson Somerville. I have VDR too and take 30kiu daily with all cofactors. No issues with hypercalcemia.
Amen! 🙏 thank you for your kindness! I will happily put myself out of job, if it means an end to the unnecessary suffering and disease going on everywhere!
Saw a video from over 15 years ago where a lecture was given on Vitamin D and how low levels cause colds and flu and that the higher amount of Vitamin D is actually not toxic and the study that doctors go by was not a scientific study at all. Life guards never keel over from Vitamin D toxicity.
I think it is theoretically possible but I have not personally seen it in clinical practice. What I do see daily, is people with horrific preventable conditions with horribly low vitamin D levels. Which is proxy for low sun exposure, low melatonin, low alpha, beta, gamma MSH, low melanin, low beta-endorphin, low met-enkephalin…
I have seen a lot of information about vitamin D3, this vitamin is toxic only in extremely large amounts (100 thousand IU). I have been taking between 5k-10k IU along with K2, magnesium and zinc and all is well for me! I wish you good health and all the best from Ottawa 🇨🇦
Thank you Dr Peavler for these fascinating insights. I seem to be healthy but who knows what the future holds. I hope Milton did not inconvenience you too greatly. Best regards.
Look forward to your video on melatonin. I have cancer and take 20+20+20+100mg pr day. (in addition to 200microgram Vitamin D). - Considering testing 1.000 miligram melatonin pr day.
I am sorry you are dealing with cancer first off. I know that the second most famous melatonin researcher in the world takes 1000mg per day for disease prevention. Personally I would rather just be exposed to infrared light all day and make my own. I will talk about some of the dosing schedules used by other integrative oncologists for melatonin in the coming videos so stay tuned!
The recommendation for magnesium and k2 is almost only taking about vitamin D’s effect on calcium. These molecules have what they call pleotropic effects. For example magnesium takes part in hundreds of chemical reactions. I do personally do take magnesium and K2 for all of its wonder benefits, including assistance with calcium absorption. I can’t necessarily feel K2 working but I can for sure feel magnesium, it’s a staple for me.
@@DrCaseyPeavler I have been taking Mg and K2mk7, but just before sleeping on an empty stomach. Perhaps better to take these with food earlier to avoid reducing stomach acid levels.
At minimum 60ng/mL, but if I had cancer, I would keep my 25OHD3 as high as I could without causing hypercalcemia. Ideally unsupplemented levels AKA achieving it using sunlight.
Dear Dr. Peavler. THANK you so much for explaining about vitamine d. I'm fighting stage 4 metastatic colon cancer. Listened to Dr. Seyfried. You completed the picture. I will take the supplement up to 4000 IU. I believe and lots of natural Sunlight. Thanks again Dr Peavler.
Dear Dr. Peavler. I have vitamine d supplement 2500UI. The recommend dose per day is 4000 UI. Is it ok to take 2 per day which makes it to 5000UI. And when is it the best time to take. With some kind of fat intake. I will try to get my d level checked. But for now I hope I'm doing the right thing. And how long to get natural Sunlight. THANK you for getting back to me.
High d3 causes low e2 for me. Jacks up free test and lowers aromatase expression. More than 3000 iu a day and I’m up all night urinating and chugging water, dry mucuous membrane in nose, insomnia, irritability Excellent video 👍
Thank you for you interest and your question. I cannot tell you that outside of a doctor patient relationship situation, so I encourage you to talk to your doctor about this. BUT, I can tell you that if I had cancer, I would keep my 25OD3 level as high as I could (> 100ng/mL) without causing any side effects, most commonly hypercalcemia (high blood calcium levels), and I would get it from the sun and a distant second through artificial UV exposure. Last resort would be supplements. I hope that helps!
Seems very plausible yes. www.ncbi.nlm.nih.gov/pmc/articles/PMC7926526/#:~:text=Due%20to%20its%20ability%20to,to%20prevent%20the%20associated%20hypercalcaemia.
@@DrCaseyPeavler thanks for the info Dr Casey. I take 4000 IU’s daily and having convinced my primary doctor to order a vitamin D test which indicated 76. I was satisfied with that but he thought conventionally that it should be lowered. I have had no problems with any blood tests. All readings were normal so I plan to continue the 4000 IU’s with a vitamin K2. I cycle so I should be getting my sum quotient too.
You’re doctor 🤦♂️🤦♂️. My only challenge for you would to be to maintain or even get the level up higher using full spectrum sunlight instead of pills!
Great info! If this is the last focus on D3, for the time being, I have been curious how this all may apply to the physiology of the retina. Warburg might seem to be dominant for benefit enthuse mitochondria? And, if so, how might the D3 presence there affect cost benefit issues? (You know that this question came up in my mind via Jack stating importance of Warburg in the retina.) I'm looking forward to getting my level checked in September, as I have been attentive about getting higher levels of sun all summer than I have for many years. My GP, does not support testing more than once a year, and this may be a deal-breaker with staying in that system locally. I guess, I may need to go to Quest for more frequent testing, especially if I get a UVA/UVB lamp setup, or better yet, on of the combos with NIR! I'm so grateful for the educational opportunities you provide!
You can self-test through quest direct ordering services and it’s like $40 max. Yeah I have heard Jack make the case because there are some cell types like the cornea I believe that rely on Warburg metabolism or RBCs too because mature red blood cells lack mitochondria, then that means Warburg metabolism isn’t bad in other tissues that do have mitochondria and do rely on ox-phos? I can’t follow the logic to be honest. I think it’s a poor argument in my opinion, BUT it’s Dr Kruse, who is admittedly much more intelligent than I. As for now, my opinion stands about Warburg effect and metabolism as being pathologic in the vast majority of cells, and it is the pathological Achilles heel for cancer.
Fact check TRUE. Red and infrared light can lower blood glucose 30% if done before or during eating. Practical take away, try to eat outside whenever possible during the daylight.
@@DrCaseyPeavler And, 30% lower blood glucose! So, glycation pressures in blood must be helped. So, hypoxia pressures in mitochondria may take somewhat of a drop as well? Or, at least tend to?
100% Ray. And to be honest this is in some ways a flawed study. They only used 670nm wavelength LED red light. I would guess that when full spectrum red/IR light is used, possibly UV as well, will have an even more profound effect.
Seems to remember being told that fructose (as opposed to sucrose) is generally converted to fat by the body. Possibly this explains why Bears gorge on fruit before hibernation? Given Vit D is fat soluble do we know how/if Vitamin D stored in fat is released?
Serum levels of 25 OH Vitamin D. Hopefully as more awareness comes out, 1,25 OH and perhaps D3 and L3 analog tests could become available so we can see how the entire system is working….
Thank you for your kindness! My thoughts are it is clearly better than the SAD diet. I think like with most diets there is a continuum of healthiness. For example, I could eat lunch meat all day and be "carnivore" or I could eat grass fed grass fed ribeyes and wild alaskan salmon and be on 2 totally different levels. I mean I love getting rid of processed carbohydrates, but there are substantial benefits to many plant based phytonutrients. What has been your experience with Carnivore?
@@DrCaseyPeavler That's very true!! Grass fed meat only, and organic eggs. I do have berries and avocados. 5 years now! Great blood numbers and in good health
@@DrCaseyPeavler thank you for responding ! i have low level creatin 0,60, and gfr 90! And a lot of protein in urine! After 2-3 months immunotherapy i start high dose vit D 15-20K iu + k2 and mg! I want to increase d3 intake 50-60k iu day! Do you recommend this to me?
For the vast majority of cases, I do not recommend exogenous supplemental melatonin. You can make nearly unlimited quantities in every mitochondria containing cell with exposure to infrared light. Cancer is the only time I would possibly give it to a patient. As with anything, I cannot practice medicine on RUclips, so the dose and schedule would be a discussion between your integrative oncologist and you. Hope that helps!
I eat about 5-6 pasture raised eggs a day. Is that enough vitamin k2 or should i also take a k2 supplement as well? I just started taking d3 5,000 -10,000 ui a day and also know that i need magneseum and zinc supliments together for these to work properly. Could you give me any advice?
I think anything that gets between you and light (Mother Nature) is likely a losing strategy. I think changing my latitude, altitude and supplemental red/infrared light is the only thing I would consider at improving my ability to obtain more UV.
I started taking Vitamin D after I learned that low levels of vitaminD were found in morbid Covid patients…….my winter depression that always set upon me in late November disappeared…I haven’t been sick…since I came down with Covid way back in the beginning….late 2019…..never received the Jabba Jabba either…..my D level last measured 60+…
For general health 60-80ng/mL. If you have cancer, then probably as high as you can get it without side effects. Would be critical to work with a doctor who can check 25OHD3 and CMP regularly.
Hi, so basically if one has tested the 1,25-Hydroxy value and it was fine and one doesn't believe there has been a change in the renal status, one can assume that it should continue to be fine, correct?
Would you happen to know of any fantastic doctors like you in the New York Metro area or northeast that practice metabolic therapy to treat cancer patients?
I do not unfortunately. Dr Seyfried, I believe has a list of colleagues throughout the world that he sends out when you email him. Hippocrates Research Foundation might also have a list. You are welcome to come down to Florida as a last resort!
This was interesting! I have "known" about the anti-cancer effects of vitamin D for a long time, but without mechanisms. And without knowing what blood levels that might require. So, this was helpful, and confirmed my guesses. By the way, I was low in 25(OH)D with 5000 IU of vitamin D3 (with Magnesium and K2, of course).My level was only 113 nmol/l (45.2 ng/ml). So, I probably need something like 10'000 IU, then I'll meassure it again. I live in Stockholm, Sweden and get enough sun only 3 or at most 4 months during the summer.
Thank you for the comments. A couple of things, at that latitude its going to be hard to ever make enough vitamin D as you have realized. Best option would be to move to a lower latitude or possibly supplemental UV....
Some people with kidney disease (CKD/ESRD) will have to. But that doesn’t mean they shouldn’t also get sun. 1,25 hydroxy-vitamin D or calcitriol is the “active” form of vitamin D, but there are dozens of other D3 and L3 analogs which have profound biological effects and benefits that you would miss out on if only taking calcitriol.
Also, since calcitriol itself is a secosteroidal hormone, it would be like taking an active form of estrogen, which is a pharmacological intervention and therefore requires a prescription from a medical provider.
I agree with that but not 100%. My main reason is that you are missing ALL the other benefits of dozens of bioactive analogs along the D system, as well as all the other beneficial non-D bioactive molecules made when exposed to full spectrum sunlight.
10,000 iu of D3 times 3x a day, taken with k2. Could this make the blood thinner and cause bleeding? Could this extend the life if a stage 4 cancer patient?
Fantastic question. I think I’ve made it pretty clear that all of the diseases and cancers do not just resolve or disappear in populations that have “adequate” levels of vitamin D. The reason is because a serum/blood vitamin D level is a proxy for a person’s solar exposure. And the sun exposure confers benefits way above and beyond the cholcalciferol “vitamin D” molecule. For example gene products from POMC that requires UV exposure: alpha, beta, gamma MSH, melanin, beta-endorphin, met-enkephalin. As well as melatonin from red/infrared light. Vitamin K can thin your blood a bit yes. Cause bleeding no. Make it more likely to bleed? Possibly. Probably no more than taking a baby aspirin.
Thanks so much for replying. My husband has stage 4 hpv squamous cell carcinoma. He has a huge fungating tumor on his neck. Seems that everything we find to slow the abnormal cell growth down also thins the blood. He has had 2 bleeding episodes where massive blood loss has occurred. We have no help. Anything at all that you can suggest to slow this beast down? understand that
Very interesting information about vitamin D, thanks! You mentioned that vitamin D from sunlight is preferable to vitamin D from a supplement, which has some intellectual appeal ("all natural") but now I'm curious if this is from a practical basis or if there is a biochemical reason why supplements are less effective. My mom regularly had low vitamin D levels and got booster shots from her doctor. These always seemed to make her feel much better and peppier. Was this just a different way of providing supplementation, like many daily doses of a capsule, or is it a different medication? The shots were always described as just "vitamin D shots". Thanks for all of your educational videos!
Thank you so much for your kindness. I am happy you got something out of it! I try to explain that over the entire vitamin D series and continuously try to remind everyone that yes, getting it from the sun is MUCH better. Essentially there is vitamin D or what we classically this vitamin D (25-OH and 1,25 OH D) however when UV hits the skin, dozens of other D3 and L3 analogs are also synthesized which have diverse effects to promote health. That answers the questions about D, but what about all the other CRITICAL chemicals beta-endorphin, met-enkephalin, alpha, beta, gamma MSH, melatonin, melanin, etc. ALL of these have amazing health promoting effects and cannot be contained inside of a pill. I hope that helps!
Thank you for your research and knowledge. I read from a book about high dose vitamin D (Jeff T. Bowles), he has a speculation that “taking melatonin and D3 together might actually counteract the healing properties of D3 taken alone”. Have you ever come across this idea?
Thank you for your kindness. I think that is likely false. The research is really making things a lot more clear in the last 5 years in particular. And my next melatonin video will put that to bed pretty quickly. Should be out Monday or Tuesday if I can finish the edits.
When giving these videos on vitamins, it is extremely important to be specific. When this presenter talks about the effects of vitamin D on cancer, is he speaking of vitamin D, or vitamin D3. He needs to be specific, especially given all the videos on RUclips on vitamin D3.
The form of "vitamin D" that is naturally synthesized in the human body is cholecalciferol (commonly referred to as "vitamin D3"). Fortification of dairy products is invariably done with cholecalciferol derived from animal sources, while fortification of cow milk "substitutes" typically involves ergocalciferol ("vitamin D2"), which is derived from plant sources. Clinical trials of "vitamin D", on the other hand, typically involve either cholecalciferol, 25-hydroxycholecalciferol (calcidiol), or the active metabolite 1,25-dihydroxycholecalciferol (calcitriol), but second-hand reports unfortunately often don't make this distinction (which is important if for no other reason than that cholecalciferol is the only one of these substances available without a prescription).
@@DrCaseyPeavler Unfortunately, it's a lot easier to slip and say "vitamin D" than it is to say "25-hydroxyvitamin D" or "1,25-dihydroxyvitamin D" (not to mention "1,25-dihydroxycholecalciferol"), which is why I think the term "vitamin D" (which is a misnomer anyway) should be deprecated in favor of the more clinically accurate terms [chole]calciferol, calcidiol, and calcitriol (as in estrogen, estradiol, and estriol).
Thank you for your question. I personally see supplemental either IM or PO vitamin D as the last resort to be honest. I would prioritize full spectrum sunlight, then for a distant second artificial UV-B.
@@RabbiAbe Clinical trials such as those conducted in Europe showing a protective effect against morbidity due to COVID-19 typically involve direct administration of calcitriol (i.e., "1,25-dihydroxyvitamin D3").
I made a whole video about that way back during the pandemic. Don't even get me started on D for COVID...You seem clinical, do you practice somewhere? During the pandemic with a COVID diagnosis initially I would literally diagnosis diabetes and D deficiency just knowing their COVID status. The correlation was insane. Obesity also. At least for the Delta variant wave.
@DrCaseyPeavler I'm a "non-medical" (PhD) epidemiologist by training. Your clinical observations are fascinating. As a public health professional, I was aghast at the lack of interest on the part of certain wannabe public health official(s) in the NIH (who shall remain nameless) in focusing on individuals at high risk of severe morbidity from COVID-19 (due to age, obesity, uncontrolled diabetes, etc., not to mention sub-optimal "vitamin D" status).
I have to admit it’s cool to have PhDs as yourself chiming in. It makes for a great discussion. I know. I could see the shadow vitamin D deficiency pandemic underneath the Covid n pandemic. Now I am seeing that same pandemic play out in tons of people with all kinds of cancers, even kids man 20-30s with metastatic cancers and single digit 25OHD levels…
The storage form of vitamin D has a half-life of a few weeks, but the active form 1.25 (OH2)D3 only has a half-life of 5-8 hours. Many studies have shown that vitamin D administered weekly, monthly or even quarterly has no protective effects on cancer. But with a daily dose. (-12% mortality) Now my question: Would be to prevent z. B. Metastases in a cancer (choroidal melanoma) is it an advantage to divide the daily doses into 3 or 4 individual doses in order to have the active form of vitamin D available around the clock despite the short half-life? Just an idea from me. I would be very happy about an answer.
I would recommend sun exposure as your “dose” of vitamin D. Melanoma is not caused by regular sun exposure, it’s been known for a while. Do not burn yourself, that is the key. People who get least sun/UV have higher mitotic rates, have deeper ulceration, have more aggressive tumors, and have higher morality. Pills and supplements are the last resort. To be very upfront all of the benefit is not conferred by vitamin D, it’s everything (melatonin, alpha, beta, gamma MSH, melanin, beta-endorphin, met-enkephalin, improved mitochondrial function through expansion of EZ water and cytochrome C oxidase) else plus vitamin D, it’s D3 and L3 analogs, etc
Another question you should hold your doctor accountable for is, how did I get cancer? What conditions led to its creation? The doctor should be on a fact finding mission with you of discovery so you change your environment so radically that cancer has no chance of coming back.
While in direct sunlight for cancer prevention, will using sunblock creams, eg, UV 30, 45 etc, lessen the benefits of sun exposure?... recently treated face/head with flurourocel to kill off sun-damaged cells. dr says new cells are "tender"... "use sunblock". I have early stage of suspected barretts esophagus and want to counteract any cancerous cell development as early as possible.. hummm. Thanks for this very informative vid
Dr. Fred Kummerow who lived to age 102 with a Ph.D in food chemistry, never took any vitamins or supplements and he said too much Vitamin D is bad news for your arteries, you only need an adequate amount.
I am not trying to sell anyone on vitamin D as a pill or supplement, to be very up front. Many people are looking for a magic big pharma solution to their problems. The point of this entire series is to say, we have everything we need already when we put ourselves in the right environment.
@@DrCaseyPeavler It's interesting that many breads and breakfast cereals are fortified, some put as much as 100% RDA of some vitamins and minerals but none of them ever put in more than 15% RDA of Vitamin D and Calcium. I wonder why?
@@Jeffs60 Probably sells better if they say it is 'fortified'. But, given rapidly dropping soil fertility (a century ago, even 50 years), and drop in wind-carried rock dust during the ice age fertilization, nutrient density appears to be far more suboptimal now?
Problem is: if they are 'fortifying' only a few things, what are they NOT putting back in that current agriculture has removed or tied up? Not to mention the toxicants put into soil and food, that no one funded adequately for adverse effects potentials?
The kidneys act as a control valve to regulate calcium in the blood. Urine calcium goes up before blood calcium, so anyone that wants to safely take high dose vitamin d at home can use urine test strips to test their urine calcium making sure they dont overdo the vitamin d.
Thank you for that. I do believe that anyone who is trying to maximize their D levels should also get regular BMP/CMP to check calcium levels in the blood. Another reason I prioritize telling people to find a good doctor or practitioner to help guide them on their health journey.
I know it is sadly. But although being a functional medicine doctor doesn’t make you a good doctor, that could be a good place to start. IFM has a directory
Blood levels are also good to monitor with a doctor but urine calcium will go up way before blood calcium does in a human with functioning kidneys, it's the earliest sign of too much vitamin D, and urine strips are very cheap on Amazon. I test urine levels at home weekly, and blood levels twice a year. Great content sir 👏 👌 👍
It’s a very interesting question. I suppose if you ate a very high carbohydrate diet and got no sunlight exposure. Why do I frame it like that? You may notice, It does not inhibit and even enhances fatty acid utilization. If you follow Dr. Jack Kruse at all you might also know that vitamin D downregulates to some degree the proximal Complex I-III, of the electron transport chain as well 🫢. Why might this be? Well the answers are still theoretical at this point BUT I can tell you your body can make ATP and energy in other ways that do not require food. Yes you heard that right and both UV and infrared are the keys. Melanin and water, and water forming EZ or coherent domains which creates an endless supply of de localized electrons to participate in redox chemistry…look into Dr Gerald Pollack, May-wan Ho, etc…it’s an interesting rabbit hole if you’re up for a journey…
But, if that structured water IS really such an energy producer in quantum fashion, as some folk advertise, the water may be even MORE important that the ATP?!? I'm still not diving that deep into that particular water, YET!
But may that help predispose more to utilizing ketone bodies as fueling mitochondria? Perhaps more in line with evolutionary adaptation to living at mid to high latitudes? Given growing seasons, and dietary reliance on meat eating dominance? And, need for using mitochondrial energy to also produce more heat than living at lower latitudes? And given the daylight issues at those latitudes?
Well Dr. Gilbert Ling and Dr. Mae-Wan Ho would agree with Dr. Kruse in this. There are orders of magnitude discrepancies of energy when only taking ATP into account....and as Jack says, that is called pseudoscience to continue to talk only about ATP...and I agree
First off, I am sorry you or someone you love is dealing with metastatic cancer. My heart goes out to you. I cannot practice medicine over RUclips unfortunately. BUT at the end of this video, I go over general recommendations. Have you had your vitamin D level checked ever?
About how much Vit D does one have to take to see calcium increase? Is there some dose threshold (or serum level) above which total calcium "takes off" (highly sensitive to Vit D dose change) and below which barely moves (insensitive to Vit D dose change)?
@@DrCaseyPeavler I was thinking that calcium is controlled by the parathyroid to a narrow range but if you push hard enough with high-dose Vit D you might get to a threshold where the control would break down and you would see a large jump in calcium due to a small increase in Vit D. Just a thought... Maybe it's individual specific too.
Calcium is highly influenced by parathyroid hormone. Usually if calcium is high PTH will suppress naturally. If it’s low will raise naturally. Would be pathological to have high D, high calcium and high PTH.
Well, to add some context, cancer cells uptake 10-30x more glucose and glutamine than normal cells. They are robbing the rest of your body. Vitamin D, melatonin and other things mitigate that. The other normal cells are metabolically flexible, meaning they can live off fats/ketones. Cancer cells cannot. They are a one trick pony, glucose predominantly, and the amino acid glutamine. Shutting down glucose/glutamine uptake and utilization is the major strategy for metabolic therapies.
Impressive, no doubt both what engagement and oversight concerns the way I experience this, now with gratitude. A few points presses still somewhat at the moment, that are hopefully not here lost after a demonstration of what love of sun and of heat might lead to that seems at best to ... well, 10-20 minutes max unprotected should by skin type have been respected, not ignored. Time at times leaves a great urge to advice others in time, of cause, but some sense on cancer relating matters after seing dear one's actually eat their way from cancer as one threatening illness to health and new decades should still be of some value, one's skin type being very different despite. Considering the no doubt soon troublesome task of getting the works of vitamin D going from the point on that the hurry is already about, what about the actual absorbsion, that's (for what I presume) no doubt dependant on a minimum fat metabolism being actual? I can at least attest from my own personal point that there's a clear relation between severe difficulties with digesting cod liver oil and ... how to put it ... a generally on behalf of the liver unconsiderate lifestyle, and in fact to that cod oil and D vitamin additions the likes on my part now demands considerate diets alltogether. Meaning of cause what's now generally called "real foods", no amounts of refined sugars either within foods or from any other source, no avoidable multi unsaturated fats, and of cause the perhaps hardest by a range of reasons as adopted to food searching, fat adoption, and seemingly well grown greens, which is as minimum well functioning to avoid overeating after a generally somewhat prematurely ended fasting. Being within a couple of well established zones involving no doubt together some sum of cancer risks (as father and grandmother), I'll take the liberty to leave another couple of advices to anyone sharing the above mentioned experiences, as even if the here professional level points certainly to a demand for quality, there's also quality in claiming that there's little doubt that food for food ever before enjoyment holds severe importance from pretty much what ever position that's not involving anesthesia or ... well - my automatic jokes despite - this advice is sound: Settle for amounts that seems doable both with vitamin D and an endurable Omega-3 source, and I'll make sure to say and not forget that I'm certain of the value of my 2-3 times a weak of modest intakes (not by my choice, which would be 7/7, was only minimal endurability about), any surpluss comming eventually from sardines, as the smaller fish the lesser of poisons like mercury, lead, and cadmium. Another advice could be a bio-calcium+d3+k2 complex, is one active and milk consuming in particular, while milk seems actually to "draw out of one" calcium judging by my many years of experience, while it's on my part seemingly helping somewhat agains vitamin D deficiency. Got that, doc? Thanks a lot for an obviously concerned and no doubt enlightning contribution anyway, and best wishes for the presently possibly most needed engagement for health that there is the rates of D vitamin deficiency concidered, even if other musts includes banning of sugars containing concentrated fructose and reestablishing fibers within all common foods and clean drinking water containing minimum trace elements rather then ... Well again thanks, and also for leaving some sound thought and some knowledge to trust that's actually also at times bluntly missing among experts, still.
Hey there I presume Douglas. Throughout this series I am very specific as I go through series in the various papers about vitamin D. I try to say if I am talking about 25 hydroxy D3, 1,25 hydroxy, or the D3 and L3 analogs. Vitamin D3 or cholecalciferol, is the chemical made after converted from cholesterol in the skin by UV light. I hope that helps!
I think it’s amazing that vitamin D and its analogs all have both VDR dependent and independent mechanism. The vitamin D analogs up regulate VDR. Will go over soon another important biomolecule that up regulates VDR also…The biochemical synergy symphony is remarkable
Search: Three years on the Lion Diet: a look back. The astonishing visual proof of this man's incredible health and looks transformation will up-end some ideas you may be holding as unassailable truths. You will be glad you took the time, now rather than later.👍💚
@@DrCaseyPeavler Ferrigno's video transformation convinced my 65 year old acupuncturist/Japanese herbalist to go carnivore many months ago and she's never looked back. Eating like a horse, working full time and with long hours in the sun on weekends, her excess lifelong 20 lbs simply went away and especially great, no more need for hats or sunscreen protection ever.👌
At some point, researchers and clinicians need to stop referencing ["the active form of ]vitamin D" and acknowledge that what they are talking about is the properties of the secosteroidal hormone calcitriol (1,25-dihydroxycholecalciferol), which is ultimately synthesized from a cholesterol derivative (7-dehydrocholesterol) in the human skin in the presence of UV radiation from the sun and other sources. Use of the term "vitamin D" to describe the intermediate metabolite cholecalciferol (which is released directly into the bloodstream from the skin, transported and stored in the liver as 25-hydroxycholecalciferol, and then further metabolized by the kidney as needed) implies that it is a standard component of a normal healthy diet (which it is not) and that oral replacement is equivalent to biosynthesis (which may also not be the case).
Lumisterol hydroxyderivatives. Covered it in vitamin D as master antioxidant regulator video. ruclips.net/video/quNUPGYMDnA/видео.htmlsi=4Z9IDoO_DJhn-AYU
Doctor - based on your experience, at which level PTH should be, to signal all is good in Vit D methabolism? I have 25DH at 125 in blood, but PTH at 37, and read somewhere if PTH is not at or below 30, that could signal the Vit D intake is still anyway not sufficient, despite its high level already. Would you agree with this, or which level do you use as indication for PTH, to understand on Vit D levels in blood and if more/less is needed? Please if you could share your view, thank you.
Wow what a great question. Lab ranges vary by lab but less than 30 at my hospital would be considered low. PTH in my experience is more sensitive to calcium than vitamin D status. If your vitamin D level is perfect, and calcium is within normal range, so should PTH. I wish 1,25 vitamin D was cheaper, and easier to get because I would love to look at that conversion for more people, especially with the degree of CKD in the population. Not even end stage CKD, I mean like the stage II-IIIb folks. Because my guess is there is a stepwise decrease in 1 hydroxylase activity with progression. But that isn’t current reality in terms of lab availability and reasonable cost, let alone testing for other D3 and L3 analogs.
@@DrCaseyPeavler Thank you so much for the answer. We as patients, appreciate it so much. Ultimately then - to assess if Vit D levels are too high/toxic, or actually okay, would you use only Calcium as an indicator? i.e. if serum calcium is within ranges, all good with Vit D and perhaps could also be further increased, while if serum calcium too high, then reduce Vit D? Or would there be also other functional markers from blood, you would use to understand if Vit D levels are okay or too high? I'm asking this question, since I unfortunately have auto-immune kind of disease, and seems like upping my Vit D, it helps me with symptoms. And, ideally, would increase it even more beyond 125, which was my latest lab result, just to see what happens. But starting to be bit afraid of possible toxicity now and so that's why the question. To fine tune with dosage.
These are great questions. From what I know today, calcium is really our only marker to know and be concerned with and how we know we may need to pull back. Adding in K2 may help prevent the possibility of hypercalcemia.
@@DrCaseyPeavler I'm very curious if K2mk7 not only transports excess Ca back into bone, but also the bone pool lead (Pb) that is mobilized from bone during physiologic stresses of pregnancy, old age, or illness, might get picked up and transported back? The Pb and Ca travel together through a lot of physiologic pathways, as the body does not seem well able to distinguish between them (since elevated Pb in bone is likely only fairly recent since mining increased this pollution). I have lit searched quite a bit to see if K2mk7 might not distinguish between them, thereby helping remove Pb from soft tissue pools too, but I have not found more supporting papers. Yet.
Those are interesting questions, and I do not readily have an answer to it. But lead and calcium are atomic elements 82 and 20 respectively. It seems a bit hard to believe the body could not distinguish between such difference in atomic mass, charge, and characteristics. But I am willing to try to find an answer.
There are centenarians with Vitamin D levels between 15-25 ng/mL and they are still walking and talking and no bones are crushing in yet. Trump on his White house health report had a Vitamin D level of 20 ng/mL while taking a Centrum muti vitamin and the doctor said that level was fine as he has never had any health problems.
Is Vitamin D not an Anti-Warburg/Anti-cancer rockstar?
It’s amazing how BigPharma and the Medical Industrial Complex hides the benefits of this wonder vitamin. They would be saving patients millions of dollars in expenses if patients knew that just upping their intake of vitamin D (as well as maintaining a healthier lifestyle) would greatly reduce their risks of cancer and other metabolic disorders. Thank you Dr. Peavler!
Every year that go's by I hear of and investigate another cancer cure ..and it only leaves me horrified that big pharma is knowingly killing millions and millions of people..they have killed more than two world wars and the soviet and Chinese revolutions put together.
after watching hundreds of hours of videos trying to learn what it means to be healthy, is it a fair summary to say "get outside, get some excersize, eat whole organic foods, reduce stress and get some good sleep" will prevent most chronic illnesses?
Haha yes absolutely get those things! But then there is also a list of what to avoid, which is longer!
@@DrCaseyPeavler true-avoid toxins (ultra processed "foods", seed oils, hfcs, air pollution, pesticides, herbicides, city water etc et al...). i am primarily carnivour but will eat a small amount of veggies (home grown) in season.
And more important than that! Artificial light, especially at night, as well as non native EMF (ELF, MF, RF)!
@@DrCaseyPeavler Yes!!
Good to hear from you Ray!
Your knowledge and research are uncanny. Thank you for elucidating the complexities so we all can live healthier and simplistic.
That is extremely kind of you, thank you. If I could put myself out a job by everyone being healthy and not having all this unnecessary suffering everywhere, I would gladly do it. I have become quite the smoothie chef, and could go into that someday perhaps…
Great video, power of sunshine
Vitamin D is probably the most well known sun created substance, but this is just the tip of the iceberg….
@@DrCaseyPeavler Let's melt some iceberg!
We are getting there, Melatonin will be next....
Great information! I am a 2 time breast cancer with bone Mets (in remission since 2017). I have a VDR mutation. I take 5,000 min D3 K2. My D level two months ago was 87.
I was a little confused (not a science major) about what I can do for the VDR.
Great question. I want to do a video or 2 about VDR polymorphisms or genetic variants in the future. The great news is that Vitamin D has anti-cancer effects on a VRD dependent AND independent mechanisms…
Consider taking more. Vitamin is only toxic in the absence of sufficient amounts of important co factors (Zinc, Vitamin A, Boron, K2, and Magnesium). Also, don’t rely on blood numbers because you can have sufficient blood levels with deficient cellular levels. I would recommend testing intracellularly. There are companies that do that kind of testing. Look up Jeff Bowles and Judson Somerville. I have VDR too and take 30kiu daily with all cofactors. No issues with hypercalcemia.
Brilliant work Dr you’re amazing thank you for all you are doing to help your fellow humans ❤
Amen! 🙏 thank you for your kindness! I will happily put myself out of job, if it means an end to the unnecessary suffering and disease going on everywhere!
@@DrCaseyPeavler may god bless you.🙏
May God bless you also
Saw a video from over 15 years ago where a lecture was given on Vitamin D and how low levels cause colds and flu and that the higher amount of Vitamin D is actually not toxic and the study that doctors go by was not a scientific study at all. Life guards never keel over from Vitamin D toxicity.
I think it is theoretically possible but I have not personally seen it in clinical practice. What I do see daily, is people with horrific preventable conditions with horribly low vitamin D levels. Which is proxy for low sun exposure, low melatonin, low alpha, beta, gamma MSH, low melanin, low beta-endorphin, low met-enkephalin…
I have seen a lot of information about vitamin D3, this vitamin is toxic only in extremely large amounts (100 thousand IU).
I have been taking between 5k-10k IU along with K2, magnesium and zinc and all is well for me!
I wish you good health and all the best from Ottawa 🇨🇦
Thank you Dr Peavler for these fascinating insights. I seem to be healthy but who knows what the future holds. I hope Milton did not inconvenience you too greatly. Best regards.
Thank you for your concern! No down south where we live, it was pretty uneventful thank God!
Thank you Dr. Peavler for enlithening this huge Topic 😃😃😃😃😃😃😃😃😃😃😃😃😃😃😃😃
You are very welcome! Happy to help!
Thanks for this comprehensive information.
You are very welcome. Glad it was helpful!
Thank you doctor Casey.
You are very welcome!
Thank you !
You are very welcome !
Look forward to your video on melatonin. I have cancer and take 20+20+20+100mg pr day. (in addition to 200microgram Vitamin D). - Considering testing 1.000 miligram melatonin pr day.
I am sorry you are dealing with cancer first off. I know that the second most famous melatonin researcher in the world takes 1000mg per day for disease prevention. Personally I would rather just be exposed to infrared light all day and make my own. I will talk about some of the dosing schedules used by other integrative oncologists for melatonin in the coming videos so stay tuned!
Are you taking Magnesium and Vitamin K2? They are cofactors and help use the Vitamin D?
The recommendation for magnesium and k2 is almost only taking about vitamin D’s effect on calcium. These molecules have what they call pleotropic effects. For example magnesium takes part in hundreds of chemical reactions. I do personally do take magnesium and K2 for all of its wonder benefits, including assistance with calcium absorption. I can’t necessarily feel K2 working but I can for sure feel magnesium, it’s a staple for me.
@@DrCaseyPeavler I have been taking Mg and K2mk7, but just before sleeping on an empty stomach. Perhaps better to take these with food earlier to avoid reducing stomach acid levels.
Mg does well on empty stomach or with food in my experience, and I take a lot of it. K2 makes sense to take it with food since it’s fat soluble.
Thanks doctor keep the good work
Thank you for your kindness and your support! I have a lot left to share!
❤❤❤❤
Too valuable informations
I am so happy you got something out of it and that you enjoyed it!
Thanks. What should be vit D level in blood to exert these anticancer effects???
At minimum 60ng/mL, but if I had cancer, I would keep my 25OHD3 as high as I could without causing hypercalcemia. Ideally unsupplemented levels AKA achieving it using sunlight.
Dear Dr. Peavler. THANK you so much for explaining about vitamine d. I'm fighting stage 4 metastatic colon cancer. Listened to Dr. Seyfried. You completed the picture. I will take the supplement up to 4000 IU. I believe and lots of natural Sunlight. Thanks again Dr Peavler.
You are very welcome! Keep that GKI low and your hope and spirits high. God bless your fight!
@@DrCaseyPeavler THANK YOU FOR RESPONDING. GOD BLESS YOU AND KEEP THE GOOD WORK UP
Thank you 🙏
Dear Dr. Peavler. I have vitamine d supplement 2500UI. The recommend dose per day is 4000 UI. Is it ok to take 2 per day which makes it to 5000UI. And when is it the best time to take. With some kind of fat intake. I will try to get my d level checked. But for now I hope I'm doing the right thing. And how long to get natural Sunlight. THANK you for getting back to me.
Where do you live?
High d3 causes low e2 for me. Jacks up free test and lowers aromatase expression.
More than 3000 iu a day and I’m up all night urinating and chugging water, dry mucuous membrane in nose, insomnia, irritability
Excellent video 👍
Fascinating. Do you mean taking a D3 supplement or getting estimated 3K D via sun exposure?
@@DrCaseyPeavler This is my experience with 4000 iu supplemented for months with very little sun
We might have found a major piece to the puzzle…look into Dr Jack Kruse if you want your mind blown
I take 5-10,000 day, depending on my sun time. & I have none of those issues.
@@liberty8424genes
Dr. Would K2 help controlling excess Calcium accumulated in the arteries?.
What is the proper dosage for a stage 4 cancer patient?
Thank you for you interest and your question. I cannot tell you that outside of a doctor patient relationship situation, so I encourage you to talk to your doctor about this. BUT, I can tell you that if I had cancer, I would keep my 25OD3 level as high as I could (> 100ng/mL) without causing any side effects, most commonly hypercalcemia (high blood calcium levels), and I would get it from the sun and a distant second through artificial UV exposure. Last resort would be supplements. I hope that helps!
@@DrCaseyPeavlerWouldnt Vitamin K2 prevent Hypercalcemia?
Seems very plausible yes.
www.ncbi.nlm.nih.gov/pmc/articles/PMC7926526/#:~:text=Due%20to%20its%20ability%20to,to%20prevent%20the%20associated%20hypercalcaemia.
@@DrCaseyPeavler thanks for the info Dr Casey. I take 4000 IU’s daily and having convinced my primary doctor to order a vitamin D test which indicated 76. I was satisfied with that but he thought conventionally that it should be lowered. I have had no problems with any blood tests. All readings were normal so I plan to continue the 4000 IU’s with a vitamin K2. I cycle so I should be getting my sum quotient too.
You’re doctor 🤦♂️🤦♂️. My only challenge for you would to be to maintain or even get the level up higher using full spectrum sunlight instead of pills!
Great info! If this is the last focus on D3, for the time being, I have been curious how this all may apply to the physiology of the retina. Warburg might seem to be dominant for benefit enthuse mitochondria? And, if so, how might the D3 presence there affect cost benefit issues?
(You know that this question came up in my mind via Jack stating importance of Warburg in the retina.) I'm looking forward to getting my level checked in September, as I have been attentive about getting higher levels of sun all summer than I have for many years. My GP, does not support testing more than once a year, and this may be a deal-breaker with staying in that system locally. I guess, I may need to go to Quest for more frequent testing, especially if I get a UVA/UVB lamp setup, or better yet, on of the combos with NIR! I'm so grateful for the educational opportunities you provide!
You can self-test through quest direct ordering services and it’s like $40 max.
Yeah I have heard Jack make the case because there are some cell types like the cornea I believe that rely on Warburg metabolism or RBCs too because mature red blood cells lack mitochondria, then that means Warburg metabolism isn’t bad in other tissues that do have mitochondria and do rely on ox-phos? I can’t follow the logic to be honest. I think it’s a poor argument in my opinion, BUT it’s Dr Kruse, who is admittedly much more intelligent than I. As for now, my opinion stands about Warburg effect and metabolism as being pathologic in the vast majority of cells, and it is the pathological Achilles heel for cancer.
@@DrCaseyPeavler Yes, my 'take' too, so far.
I am very open to being wrong, but as of right now, I think the evidence is convincing from multiple (centralized) medical literature sources.
If you are going to eat fruit, eat it in the summer time in the sun and you'll have a much smaller insulin spike.
Fact check TRUE. Red and infrared light can lower blood glucose 30% if done before or during eating. Practical take away, try to eat outside whenever possible during the daylight.
@@DrCaseyPeavler And, 30% lower blood glucose! So, glycation pressures in blood must be helped. So, hypoxia pressures in mitochondria may take somewhat of a drop as well? Or, at least tend to?
100% Ray. And to be honest this is in some ways a flawed study. They only used 670nm wavelength LED red light. I would guess that when full spectrum red/IR light is used, possibly UV as well, will have an even more profound effect.
Seems to remember being told that fructose (as opposed to sucrose) is generally converted to fat by the body. Possibly this explains why Bears gorge on fruit before hibernation? Given Vit D is fat soluble do we know how/if Vitamin D stored in fat is released?
Serum levels of 25 OH Vitamin D. Hopefully as more awareness comes out, 1,25 OH and perhaps D3 and L3 analog tests could become available so we can see how the entire system is working….
Can 1,25 OH be measured in blood test?
Absolutely.
Thanks for sharing
You’re welcome!
Great video!!
What are your thoughts on the Carnivore Diet?
Thank you for your kindness! My thoughts are it is clearly better than the SAD diet. I think like with most diets there is a continuum of healthiness. For example, I could eat lunch meat all day and be "carnivore" or I could eat grass fed grass fed ribeyes and wild alaskan salmon and be on 2 totally different levels. I mean I love getting rid of processed carbohydrates, but there are substantial benefits to many plant based phytonutrients.
What has been your experience with Carnivore?
@@DrCaseyPeavler That's very true!!
Grass fed meat only, and organic eggs.
I do have berries and avocados.
5 years now!
Great blood numbers and in good health
Wow that is amazing news! Sounds like you are on the very healthy end of the spectrum!
Hi doctor i have Glomerulonephritis and very low level vit d! I am on the immunotherapy! Do you recommend high dose vit d?
Thank you
Did the glumerulonephritis leave you with elevated creatinine/low GFR?
You may benefit from both 25OH and 1,25OH vitamin D blood tests to see if you can figure out if you need activated vitamin D.
@@DrCaseyPeavler thank you for responding ! i have low level creatin 0,60, and gfr 90! And a lot of protein in urine! After 2-3 months immunotherapy i start high dose vit D 15-20K iu + k2 and mg! I want to increase d3 intake 50-60k iu day!
Do you recommend this to me?
@@DrCaseyPeavler my vit d level was only 6
Uy 6!! You have got to get that up asap. Sun >> artificial UV-B >>> pills. If your GFR is 90 I doubt you would need calcitriol
Pleasr give your take on Melantonin, particularly how many mm per pound?? Hopefully you'll include Dr. Reiter in your discussion? Thx bunches!!
For the vast majority of cases, I do not recommend exogenous supplemental melatonin. You can make nearly unlimited quantities in every mitochondria containing cell with exposure to infrared light. Cancer is the only time I would possibly give it to a patient. As with anything, I cannot practice medicine on RUclips, so the dose and schedule would be a discussion between your integrative oncologist and you. Hope that helps!
I eat about 5-6 pasture raised eggs a day. Is that enough vitamin k2 or should i also take a k2 supplement as well? I just started taking d3 5,000 -10,000 ui a day and also know that i need magneseum and zinc supliments together for these to work properly. Could you give me any advice?
Would applying lanolin oil to your exposed skin help an older person create more activated vitamin d. I find nothing at PubMed on the topic
I think anything that gets between you and light (Mother Nature) is likely a losing strategy. I think changing my latitude, altitude and supplemental red/infrared light is the only thing I would consider at improving my ability to obtain more UV.
I started taking Vitamin D after I learned that low levels of vitaminD were found in morbid Covid patients…….my winter depression that always set upon me in late November disappeared…I haven’t been sick…since I came down with Covid way back in the beginning….late 2019…..never received the Jabba Jabba either…..my D level last measured 60+…
That’s great! I have a new goal for you maintain that 60+ ng/mL without vitamin D supplements using UV exposure..
What if we are in northern Canada, cold and not much sun? Supplement good doses of d throughout winter?
thx for the info
You are very welcome!
Folks with 80-100+ ng/ml did you find were the healthiest?
For general health 60-80ng/mL. If you have cancer, then probably as high as you can get it without side effects. Would be critical to work with a doctor who can check 25OHD3 and CMP regularly.
Any research on Mega Dose Vitamin D for cancer similar to Coimbra protocol?
I’m not a huge fan of supplements.
Sun >>>>pills…
Haha you talk like you live in California or Florida.. many white folks don't
@@DrCaseyPeavler
Get over it!
Hi, so basically if one has tested the 1,25-Hydroxy value and it was fine and one doesn't believe there has been a change in the renal status, one can assume that it should continue to be fine, correct?
I think that is probably a safe assumption yes.
Would continue tracking 25OHD3 more frequently
What is your recommended level vitamin d for cancer patients?
As high as possible (ideally unsupplemented) without causing side effects of hypercalcemia…
@@DrCaseyPeavler
Sun may not be enough to increase vitamin D level
Says who my friend?
@@DrCaseyPeavler
My experience.
You likely need more as you get older. Where do you live?
Would you happen to know of any fantastic doctors like you in the New York Metro area or northeast that practice metabolic therapy to treat cancer patients?
I do not unfortunately. Dr Seyfried, I believe has a list of colleagues throughout the world that he sends out when you email him. Hippocrates Research Foundation might also have a list. You are welcome to come down to Florida as a last resort!
@@DrCaseyPeavler And, any such list might benefit from doctors having knowledge of some level of quantum biology understanding, as you do IMHO.
That might be an even tougher challenge…finding someone who has both characteristics
This was interesting!
I have "known" about the anti-cancer effects of vitamin D for a long time, but without mechanisms. And without knowing what blood levels that might require. So, this was helpful, and confirmed my guesses.
By the way, I was low in 25(OH)D with 5000 IU of vitamin D3 (with Magnesium and K2, of course).My level was only 113 nmol/l (45.2 ng/ml).
So, I probably need something like 10'000 IU, then I'll meassure it again.
I live in Stockholm, Sweden and get enough sun only 3 or at most 4 months during the summer.
Thank you for the comments. A couple of things, at that latitude its going to be hard to ever make enough vitamin D as you have realized. Best option would be to move to a lower latitude or possibly supplemental UV....
Why not take calcitrol directly, instead of vitamin D?
Some people with kidney disease (CKD/ESRD) will have to. But that doesn’t mean they shouldn’t also get sun. 1,25 hydroxy-vitamin D or calcitriol is the “active” form of vitamin D, but there are dozens of other D3 and L3 analogs which have profound biological effects and benefits that you would miss out on if only taking calcitriol.
Also, since calcitriol itself is a secosteroidal hormone, it would be like taking an active form of estrogen, which is a pharmacological intervention and therefore requires a prescription from a medical provider.
I agree with that but not 100%. My main reason is that you are missing ALL the other benefits of dozens of bioactive analogs along the D system, as well as all the other beneficial non-D bioactive molecules made when exposed to full spectrum sunlight.
@@DrCaseyPeavler I want to go with the light when at all possible.
I still have alot of work to do In order to make the case for the sun it seems…Will try to do it one video and biomolecule at a time…
Is calcitriol 125 hydroxy D3 the only form of D that is effective?
Absolutely not. I have a whole video on bioactive vitamin D analogs:
ruclips.net/video/quNUPGYMDnA/видео.htmlsi=NCAJLPjBRd3KLdST
@@DrCaseyPeavler thank you so very very much kind Dr
!
Happy to be of service!
@@DrCaseyPeavler I'll view your videos on melatonin as well
It’s a pretty solid series from an information standpoint. I’ll work on improving quality with time.
Do an upload with Dr Jack Kruze
No, but I’ve been following Jack for 6-7 years as a member of his site. I would consider him a mentor.
10,000 iu of D3 times 3x a day, taken with k2.
Could this make the blood thinner and cause bleeding?
Could this extend the life if a stage 4 cancer patient?
Fantastic question. I think I’ve made it pretty clear that all of the diseases and cancers do not just resolve or disappear in populations that have “adequate” levels of vitamin D. The reason is because a serum/blood vitamin D level is a proxy for a person’s solar exposure. And the sun exposure confers benefits way above and beyond the cholcalciferol “vitamin D” molecule. For example gene products from POMC that requires UV exposure: alpha, beta, gamma MSH, melanin, beta-endorphin, met-enkephalin. As well as melatonin from red/infrared light.
Vitamin K can thin your blood a bit yes. Cause bleeding no. Make it more likely to bleed? Possibly. Probably no more than taking a baby aspirin.
Thanks so much for replying. My husband has stage 4 hpv squamous cell carcinoma. He has a huge fungating tumor on his neck. Seems that everything we find to slow the abnormal cell growth down also thins the blood. He has had 2 bleeding episodes where massive blood loss has occurred. We have no help. Anything at all that you can suggest to slow this beast down? understand that
Email me at admin@integrafunctionalmedicine.com please
Very interesting information about vitamin D, thanks!
You mentioned that vitamin D from sunlight is preferable to vitamin D from a supplement, which has some intellectual appeal ("all natural") but now I'm curious if this is from a practical basis or if there is a biochemical reason why supplements are less effective.
My mom regularly had low vitamin D levels and got booster shots from her doctor. These always seemed to make her feel much better and peppier. Was this just a different way of providing supplementation, like many daily doses of a capsule, or is it a different medication? The shots were always described as just "vitamin D shots".
Thanks for all of your educational videos!
Thank you so much for your kindness. I am happy you got something out of it! I try to explain that over the entire vitamin D series and continuously try to remind everyone that yes, getting it from the sun is MUCH better. Essentially there is vitamin D or what we classically this vitamin D (25-OH and 1,25 OH D) however when UV hits the skin, dozens of other D3 and L3 analogs are also synthesized which have diverse effects to promote health. That answers the questions about D, but what about all the other CRITICAL chemicals beta-endorphin, met-enkephalin, alpha, beta, gamma MSH, melatonin, melanin, etc. ALL of these have amazing health promoting effects and cannot be contained inside of a pill. I hope that helps!
@@DrCaseyPeavler
That answers a heck of a lot, thanks!
I am happy that it does!
@@DrCaseyPeavler And, can there be added risk of quality control issues in pill manufacture, such as no attention to deuterium levels?
Yeah so that is another issue. I am not sure how far-reaching that could be. Boggles the mind really...
Thank you for your research and knowledge. I read from a book about high dose vitamin D (Jeff T. Bowles), he has a speculation that “taking melatonin and D3 together might actually counteract the healing properties of D3 taken alone”. Have you ever come across this idea?
Thank you for your kindness. I think that is likely false. The research is really making things a lot more clear in the last 5 years in particular. And my next melatonin video will put that to bed pretty quickly. Should be out Monday or Tuesday if I can finish the edits.
@@DrCaseyPeavlerthank you so much. Can’t wait for your melatonin insight.
It’s pretty exciting to be honest. Melatonin may be even more impressive than vitamin D…
When giving these videos on vitamins, it is extremely important to be specific. When this presenter talks about the effects of vitamin D on cancer, is he speaking of vitamin D, or vitamin D3. He needs to be specific, especially given all the videos on RUclips on vitamin D3.
The form of "vitamin D" that is naturally synthesized in the human body is cholecalciferol (commonly referred to as "vitamin D3"). Fortification of dairy products is invariably done with cholecalciferol derived from animal sources, while fortification of cow milk "substitutes" typically involves ergocalciferol ("vitamin D2"), which is derived from plant sources. Clinical trials of "vitamin D", on the other hand, typically involve either cholecalciferol, 25-hydroxycholecalciferol (calcidiol), or the active metabolite 1,25-dihydroxycholecalciferol (calcitriol), but second-hand reports unfortunately often don't make this distinction (which is important if for no other reason than that cholecalciferol is the only one of these substances available without a prescription).
Thank you for your feedback. However, I did throughout the series try to be very specific with my language saying 25OH or 1,25OH vs D3 and L3 analogs.
@@DrCaseyPeavler Unfortunately, it's a lot easier to slip and say "vitamin D" than it is to say "25-hydroxyvitamin D" or "1,25-dihydroxyvitamin D" (not to mention "1,25-dihydroxycholecalciferol"), which is why I think the term "vitamin D" (which is a misnomer anyway) should be deprecated in favor of the more clinically accurate terms [chole]calciferol, calcidiol, and calcitriol (as in estrogen, estradiol, and estriol).
Agreed, its kind of simplified for the masses, who then think oh this pill or injection is equivalent to being in the sun, which it isn't.
Doses would be helpful
What about Injectable Vitamin D3 IM. 100,000 iu per/cc ?
Thank you for your question. I personally see supplemental either IM or PO vitamin D as the last resort to be honest. I would prioritize full spectrum sunlight, then for a distant second artificial UV-B.
@@RabbiAbe Clinical trials such as those conducted in Europe showing a protective effect against morbidity due to COVID-19 typically involve direct administration of calcitriol (i.e., "1,25-dihydroxyvitamin D3").
I made a whole video about that way back during the pandemic. Don't even get me started on D for COVID...You seem clinical, do you practice somewhere? During the pandemic with a COVID diagnosis initially I would literally diagnosis diabetes and D deficiency just knowing their COVID status. The correlation was insane. Obesity also. At least for the Delta variant wave.
@DrCaseyPeavler I'm a "non-medical" (PhD) epidemiologist by training. Your clinical observations are fascinating. As a public health professional, I was aghast at the lack of interest on the part of certain wannabe public health official(s) in the NIH (who shall remain nameless) in focusing on individuals at high risk of severe morbidity from COVID-19 (due to age, obesity, uncontrolled diabetes, etc., not to mention sub-optimal "vitamin D" status).
I have to admit it’s cool to have PhDs as yourself chiming in. It makes for a great discussion.
I know. I could see the shadow vitamin D deficiency pandemic underneath the Covid n pandemic. Now I am seeing that same pandemic play out in tons of people with all kinds of cancers, even kids man 20-30s with metastatic cancers and single digit 25OHD levels…
The storage form of vitamin D has a half-life of a few weeks, but the active form 1.25 (OH2)D3 only has a half-life of 5-8 hours. Many studies have shown that vitamin D administered weekly, monthly or even quarterly has no protective effects on cancer. But with a daily dose. (-12% mortality) Now my question:
Would be to prevent z. B. Metastases in a cancer (choroidal melanoma) is it an advantage to divide the daily doses into 3 or 4 individual doses in order to have the active form of vitamin D available around the clock despite the short half-life? Just an idea from me.
I would be very happy about an answer.
I would recommend sun exposure as your “dose” of vitamin D. Melanoma is not caused by regular sun exposure, it’s been known for a while. Do not burn yourself, that is the key. People who get least sun/UV have higher mitotic rates, have deeper ulceration, have more aggressive tumors, and have higher morality. Pills and supplements are the last resort.
To be very upfront all of the benefit is not conferred by vitamin D, it’s everything (melatonin, alpha, beta, gamma MSH, melanin, beta-endorphin, met-enkephalin, improved mitochondrial function through expansion of EZ water and cytochrome C oxidase) else plus vitamin D, it’s D3 and L3 analogs, etc
Another question you should hold your doctor accountable for is, how did I get cancer? What conditions led to its creation? The doctor should be on a fact finding mission with you of discovery so you change your environment so radically that cancer has no chance of coming back.
While in direct sunlight for cancer prevention, will using sunblock creams, eg, UV 30, 45 etc, lessen the benefits of sun exposure?... recently treated face/head with flurourocel to kill off sun-damaged cells. dr says new cells are "tender"... "use sunblock". I have early stage of suspected barretts esophagus and want to counteract any cancerous cell development as early as possible.. hummm. Thanks for this very informative vid
Dr. Fred Kummerow who lived to age 102 with a Ph.D in food chemistry, never took any vitamins or supplements and he said too much Vitamin D is bad news for your arteries, you only need an adequate amount.
I am not trying to sell anyone on vitamin D as a pill or supplement, to be very up front. Many people are looking for a magic big pharma solution to their problems. The point of this entire series is to say, we have everything we need already when we put ourselves in the right environment.
@@DrCaseyPeavler It's interesting that many breads and breakfast cereals are fortified, some put as much as 100% RDA of some vitamins and minerals but none of them ever put in more than 15% RDA of Vitamin D and Calcium. I wonder why?
My guess is that it would probably throw off the taste to add so many things.
@@Jeffs60 Probably sells better if they say it is 'fortified'. But, given rapidly dropping soil fertility (a century ago, even 50 years), and drop in wind-carried rock dust during the ice age fertilization, nutrient density appears to be far more suboptimal now?
Problem is: if they are 'fortifying' only a few things, what are they NOT putting back in that current agriculture has removed or tied up?
Not to mention the toxicants put into soil and food, that no one funded adequately for adverse effects potentials?
The kidneys act as a control valve to regulate calcium in the blood. Urine calcium goes up before blood calcium, so anyone that wants to safely take high dose vitamin d at home can use urine test strips to test their urine calcium making sure they dont overdo the vitamin d.
Thank you for that. I do believe that anyone who is trying to maximize their D levels should also get regular BMP/CMP to check calcium levels in the blood. Another reason I prioritize telling people to find a good doctor or practitioner to help guide them on their health journey.
@@DrCaseyPeavler Easier said than done.
I know it is sadly. But although being a functional medicine doctor doesn’t make you a good doctor, that could be a good place to start. IFM has a directory
Blood levels are also good to monitor with a doctor but urine calcium will go up way before blood calcium does in a human with functioning kidneys, it's the earliest sign of too much vitamin D, and urine strips are very cheap on Amazon. I test urine levels at home weekly, and blood levels twice a year. Great content sir 👏 👌 👍
I may have to get some strips and check it out. Use them with and without K2 and do some self investigations…
I wonder if low D3 is related to higher incidence prostate cancer for dark skinned men in northern hemisphere
100%
Would vitamin D affect our cell energy level though, if it inhibits glucose uptake to the cell from the blood?
It’s a very interesting question. I suppose if you ate a very high carbohydrate diet and got no sunlight exposure. Why do I frame it like that? You may notice, It does not inhibit and even enhances fatty acid utilization. If you follow Dr. Jack Kruse at all you might also know that vitamin D downregulates to some degree the proximal Complex I-III, of the electron transport chain as well 🫢. Why might this be? Well the answers are still theoretical at this point BUT I can tell you your body can make ATP and energy in other ways that do not require food. Yes you heard that right and both UV and infrared are the keys. Melanin and water, and water forming EZ or coherent domains which creates an endless supply of de localized electrons to participate in redox chemistry…look into Dr Gerald Pollack, May-wan Ho, etc…it’s an interesting rabbit hole if you’re up for a journey…
@@DrCaseyPeavler Yah, that water stuff is DEEP! Better be ready to swim?
But, if that structured water IS really such an energy producer in quantum fashion, as some folk advertise, the water may be even MORE important that the ATP?!? I'm still not diving that deep into that particular water, YET!
But may that help predispose more to utilizing ketone bodies as fueling mitochondria? Perhaps more in line with evolutionary adaptation to living at mid to high latitudes? Given growing seasons, and dietary reliance on meat eating dominance? And, need for using mitochondrial energy to also produce more heat than living at lower latitudes? And given the daylight issues at those latitudes?
Well Dr. Gilbert Ling and Dr. Mae-Wan Ho would agree with Dr. Kruse in this. There are orders of magnitude discrepancies of energy when only taking ATP into account....and as Jack says, that is called pseudoscience to continue to talk only about ATP...and I agree
How many IU of vitamin D3 should a patient with cancer metastasis use daily? Should it be taken with K2..Please give me some advice🙏
First off, I am sorry you or someone you love is dealing with metastatic cancer. My heart goes out to you. I cannot practice medicine over RUclips unfortunately. BUT at the end of this video, I go over general recommendations. Have you had your vitamin D level checked ever?
I do think eating foods high in K2 or K2 supplements are necessary yes.
1000units per day ......oily form gel
Tab bio d3 max .......1/ day ....
About how much Vit D does one have to take to see calcium increase? Is there some dose threshold (or serum level) above which total calcium "takes off" (highly sensitive to Vit D dose change) and below which barely moves (insensitive to Vit D dose change)?
I cannot see an obvious cutoff in practice. Which is frustrating but it is what it is, and just needs to be tracked along side D levels.
@@DrCaseyPeavler I was thinking that calcium is controlled by the parathyroid to a narrow range but if you push hard enough with high-dose Vit D you might get to a threshold where the control would break down and you would see a large jump in calcium due to a small increase in Vit D. Just a thought... Maybe it's individual specific too.
Calcium is highly influenced by parathyroid hormone. Usually if calcium is high PTH will suppress naturally. If it’s low will raise naturally. Would be pathological to have high D, high calcium and high PTH.
@@bobthrasher8226 Hmmmm, good point.
The level of discussion on these comments is amazing!
“INHIBITS Glucose Uptake & Metabolism”
Just wondering (being a layman) if the brain is happy about that?
Well, to add some context, cancer cells uptake 10-30x more glucose and glutamine than normal cells. They are robbing the rest of your body. Vitamin D, melatonin and other things mitigate that. The other normal cells are metabolically flexible, meaning they can live off fats/ketones. Cancer cells cannot. They are a one trick pony, glucose predominantly, and the amino acid glutamine. Shutting down glucose/glutamine uptake and utilization is the major strategy for metabolic therapies.
@@DrCaseyPeavler Thanks for the explanation.
Of course, I am happy to be of service!
Impressive, no doubt both what engagement and oversight concerns the way I experience this, now with gratitude. A few points presses still somewhat at the moment, that are hopefully not here lost after a demonstration of what love of sun and of heat might lead to that seems at best to ... well, 10-20 minutes max unprotected should by skin type have been respected, not ignored. Time at times leaves a great urge to advice others in time, of cause, but some sense on cancer relating matters after seing dear one's actually eat their way from cancer as one threatening illness to health and new decades should still be of some value, one's skin type being very different despite.
Considering the no doubt soon troublesome task of getting the works of vitamin D going from the point on that the hurry is already about, what about the actual absorbsion, that's (for what I presume) no doubt dependant on a minimum fat metabolism being actual? I can at least attest from my own personal point that there's a clear relation between severe difficulties with digesting cod liver oil and ... how to put it ... a generally on behalf of the liver unconsiderate lifestyle, and in fact to that cod oil and D vitamin additions the likes on my part now demands considerate diets alltogether. Meaning of cause what's now generally called "real foods", no amounts of refined sugars either within foods or from any other source, no avoidable multi unsaturated fats, and of cause the perhaps hardest by a range of reasons as adopted to food searching, fat adoption, and seemingly well grown greens, which is as minimum well functioning to avoid overeating after a generally somewhat prematurely ended fasting. Being within a couple of well established zones involving no doubt together some sum of cancer risks (as father and grandmother), I'll take the liberty to leave another couple of advices to anyone sharing the above mentioned experiences, as even if the here professional level points certainly to a demand for quality, there's also quality in claiming that there's little doubt that food for food ever before enjoyment holds severe importance from pretty much what ever position that's not involving anesthesia or ... well - my automatic jokes despite - this advice is sound: Settle for amounts that seems doable both with vitamin D and an endurable Omega-3 source, and I'll make sure to say and not forget that I'm certain of the value of my 2-3 times a weak of modest intakes (not by my choice, which would be 7/7, was only minimal endurability about), any surpluss comming eventually from sardines, as the smaller fish the lesser of poisons like mercury, lead, and cadmium. Another advice could be a bio-calcium+d3+k2 complex, is one active and milk consuming in particular, while milk seems actually to "draw out of one" calcium judging by my many years of experience, while it's on my part seemingly helping somewhat agains vitamin D deficiency. Got that, doc? Thanks a lot for an obviously concerned and no doubt enlightning contribution anyway, and best wishes for the presently possibly most needed engagement for health that there is the rates of D vitamin deficiency concidered, even if other musts includes banning of sugars containing concentrated fructose and reestablishing fibers within all common foods and clean drinking water containing minimum trace elements rather then ... Well again thanks, and also for leaving some sound thought and some knowledge to trust that's actually also at times bluntly missing among experts, still.
Wow that is a lot to digest! Thank you for your kindness and input!
Vitamind lamp
Probably next best option after the sun. Far better than pills.
After reading all the comments, I'm still confused, are we talking about D3???
Hey there I presume Douglas. Throughout this series I am very specific as I go through series in the various papers about vitamin D. I try to say if I am talking about 25 hydroxy D3, 1,25 hydroxy, or the D3 and L3 analogs. Vitamin D3 or cholecalciferol, is the chemical made after converted from cholesterol in the skin by UV light. I hope that helps!
Often overlooked is that calcifediol has physiological activity on the vitamin D3 receptor. Its concentration is significantly higher than calcitriol.
I think it’s amazing that vitamin D and its analogs all have both VDR dependent and independent mechanism. The vitamin D analogs up regulate VDR. Will go over soon another important biomolecule that up regulates VDR also…The biochemical synergy symphony is remarkable
Vitamin D inhibits ferroptosis
Likely in non cancer cells. My guess it enhances it in cancer cells given its effect on glucose, glutamine, as well as SLC7A11…
Search: Three years on the Lion Diet: a look back. The astonishing visual proof of this man's incredible health and looks transformation will up-end some ideas you may be holding as unassailable truths. You will be glad you took the time, now rather than later.👍💚
I will do thank you for the heads up. I’ve heard of the diet of course but not that story in particular
@@DrCaseyPeavler Ferrigno's video transformation convinced my 65 year old acupuncturist/Japanese herbalist to go carnivore many months ago and she's never looked back. Eating like a horse, working full time and with long hours in the sun on weekends, her excess lifelong 20 lbs simply went away and especially great, no more need for hats or sunscreen protection ever.👌
Amazing results! Where do you guys live in the world out of curiosity?
At some point, researchers and clinicians need to stop referencing ["the active form of ]vitamin D" and acknowledge that what they are talking about is the properties of the secosteroidal hormone calcitriol (1,25-dihydroxycholecalciferol), which is ultimately synthesized from a cholesterol derivative (7-dehydrocholesterol) in the human skin in the presence of UV radiation from the sun and other sources. Use of the term "vitamin D" to describe the intermediate metabolite cholecalciferol (which is released directly into the bloodstream from the skin, transported and stored in the liver as 25-hydroxycholecalciferol, and then further metabolized by the kidney as needed) implies that it is a standard component of a normal healthy diet (which it is not) and that oral replacement is equivalent to biosynthesis (which may also not be the case).
I could not agree more! Even to say that 1,25 is the only "active" Vitamin D is hogwash. All of the D3 and L3 analogs have profound biologic activity!
@@DrCaseyPeavler !!!!
Thank you for your support Ray!
@@DrCaseyPeavler What's a "L3" analog?
Lumisterol hydroxyderivatives. Covered it in vitamin D as master antioxidant regulator video.
ruclips.net/video/quNUPGYMDnA/видео.htmlsi=4Z9IDoO_DJhn-AYU
This is from 2017.
What do you mean? Not following. The articles cited?
Doctor - based on your experience, at which level PTH should be, to signal all is good in Vit D methabolism? I have 25DH at 125 in blood, but PTH at 37, and read somewhere if PTH is not at or below 30, that could signal the Vit D intake is still anyway not sufficient, despite its high level already. Would you agree with this, or which level do you use as indication for PTH, to understand on Vit D levels in blood and if more/less is needed? Please if you could share your view, thank you.
Wow what a great question. Lab ranges vary by lab but less than 30 at my hospital would be considered low. PTH in my experience is more sensitive to calcium than vitamin D status. If your vitamin D level is perfect, and calcium is within normal range, so should PTH. I wish 1,25 vitamin D was cheaper, and easier to get because I would love to look at that conversion for more people, especially with the degree of CKD in the population. Not even end stage CKD, I mean like the stage II-IIIb folks. Because my guess is there is a stepwise decrease in 1 hydroxylase activity with progression. But that isn’t current reality in terms of lab availability and reasonable cost, let alone testing for other D3 and L3 analogs.
@@DrCaseyPeavler Thank you so much for the answer. We as patients, appreciate it so much. Ultimately then - to assess if Vit D levels are too high/toxic, or actually okay, would you use only Calcium as an indicator? i.e. if serum calcium is within ranges, all good with Vit D and perhaps could also be further increased, while if serum calcium too high, then reduce Vit D? Or would there be also other functional markers from blood, you would use to understand if Vit D levels are okay or too high? I'm asking this question, since I unfortunately have auto-immune kind of disease, and seems like upping my Vit D, it helps me with symptoms. And, ideally, would increase it even more beyond 125, which was my latest lab result, just to see what happens. But starting to be bit afraid of possible toxicity now and so that's why the question. To fine tune with dosage.
These are great questions. From what I know today, calcium is really our only marker to know and be concerned with and how we know we may need to pull back. Adding in K2 may help prevent the possibility of hypercalcemia.
@@DrCaseyPeavler I'm very curious if K2mk7 not only transports excess Ca back into bone, but also the bone pool lead (Pb) that is mobilized from bone during physiologic stresses of pregnancy, old age, or illness, might get picked up and transported back? The Pb and Ca travel together through a lot of physiologic pathways, as the body does not seem well able to distinguish between them (since elevated Pb in bone is likely only fairly recent since mining increased this pollution). I have lit searched quite a bit to see if K2mk7 might not distinguish between them, thereby helping remove Pb from soft tissue pools too, but I have not found more supporting papers. Yet.
Those are interesting questions, and I do not readily have an answer to it. But lead and calcium are atomic elements 82 and 20 respectively. It seems a bit hard to believe the body could not distinguish between such difference in atomic mass, charge, and characteristics. But I am willing to try to find an answer.
There are centenarians with Vitamin D levels between 15-25 ng/mL and they are still walking and talking and no bones are crushing in yet. Trump on his White house health report had a Vitamin D level of 20 ng/mL while taking a Centrum muti vitamin and the doctor said that level was fine as he has never had any health problems.
I love Trump, but I do not see him as a picture of health. Nor would I go to him for health advice…
@@DrCaseyPeavler You lost me at "I love Trump" Unsubscribed.
I try to love everyone thanks. God bless!
@@DrCaseyPeavler subscribed
Welcome fellow mitochondriac!
💪🔥🙏
Thank you for your encouragement!
This guy talks as though he is a robot..........
Lol thank you….
I am listening to the video at a reduced speed (0,75), then I can better follow the incredibly dens content. 🙂
He is conveying a lot of information, and it needs to be put out without digressing; i.e. this doctor is smart!
Trying to allow the listeners like you to get max benefit/information with minimum time! Thank you for your kindness!
Thank you for your support and kindness, it’s an honor and privilege to get this critical information out!