Virtual roundtable: Advancing proteomics in clinical research with the combined strengths...

Presented By: Jochen Schwenk, PhD, Ann-Christine König, PhD. & Hanno Steen, PhD.
Speaker Biography:
Jochen M. Schwenk is a Professor in Translational Proteomics at KTH Royal Institute of Technology in Stockholm, Sweden, and holds a Ph.D. in Biochemistry from the University of Tübingen in Germany. Jochen is an elected member of HUPO's Council, chair of HUPO's Plasma Proteome Project, Scientific Director of SciLifeLab's Affinity Proteomics Unit, and part of the Human Protein Atlas (www.proteinatlas.org)management group. His primary interest is studying the circulating blood proteins to understand human health and disease states. His team works on the novel aspect of the biomarker analysis pipeline, including study design, pre-analytical variables, micro-sampling, assay development, data integration, and emerging translational possibilities. The Schwenk Lab collaborates with various interdisciplinary research projects on different human phenotypes.
Ann-Christine König studied Plant Biology, Cell Biology, and Biochemistry at LMU Munich, earning her PhD in 2014 with a focus on mitochondrial retrograde signaling. She gained her initial postdoctoral experience in the ‘Protein Mass Spectrometry Service’ group at the Max Planck Institute for Plant Breeding Research in Cologne. Since 2017, she has been a member of the Proteomics and Metabolomics Core Facility at Helmholtz Munich.
Hanno Steen, PhD, is a Professor of Pathology at Harvard Medical School, Principal Investigator and Director of Proteomics in the Department of Pathology at Boston Children’s Hospital (BCH). He is a member of the Neurobiology Program and the Precision Vaccines Program at BCH, in addition to various NIAID- and NIDDK-funded research consortium. After studying chemistry in Freiburg/Germany, Manchester/UK (UMIST) and Zurich/Switzerland (ETH), he received his Ph.D. from the University of Southern Denmark (Odense/Denmark) under the supervision of Dr. Matthias Mann. After postdoctoral training in proteomics and quantitative biology in the laboratories of Drs. Steve Gygi and Marc Kirschner at Harvard Medical School, he joined the faculty at Harvard Medical School and BCH in 2004.
Webinar: Virtual roundtable: Advancing proteomics in clinical research with the combined strengths of mass spectrometry and affinity-based methods
Webinar Abstract:
Protein biomarker discovery, validation and utilization require technologies that deliver proteome insights with breadth and depth. Liquid chromatography mass spectrometry (LC-MS), the gold-standard of proteomics, provides unbiased protein coverage and detection of isoforms and post-translational modifications. However, achieving high sensitivity and resolution in complex, clinically relevant samples such as plasma or serum remains challenging and often requires trade-offs in throughput. In contrast, next-generation affinity-based proteomics offers exceptional sensitivity and specificity for low-abundance proteins with high-throughput in these complex matrices. This roundtable discussion will bring together key opinion leaders in proteomics to explore how integrating antibody-based methods, like proximity extension assay (PEA), with LC-MS can expand proteome coverage, facilitate biomarker discovery, and streamline the validation process, ultimately advancing clinical research.
Key Learning Objectives
Discover how next-generation affinity-based proteomics dives into low-abundance proteins in plasma and serum to expand proteome coverage.
Gain insights into the advantages and challenges of integrating affinity-based methods with LC-MS for comprehensive proteomic analysis.
Engage with leading experts and get answers to your questions about combining LC-MS and affinity-based proteomics.
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