How bacteria "talk" - Bonnie Bassler

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  • Опубликовано: 28 июн 2024
  • View full lesson: ed.ted.com/lessons/how-bacteri...
    Bonnie Bassler discovered that bacteria "talk" to each other, using a chemical language that lets them coordinate defense and mount attacks. The find has stunning implications for medicine, industry -- and our understanding of ourselves.
    Talk by Bonnie Bassler.

Комментарии • 408

  • @evanpalmer3594
    @evanpalmer3594 7 лет назад +449

    That was one of the best explained TED talks I've ever heard

    • @soniabarrett
      @soniabarrett 10 месяцев назад

      I absolutely agree with you! Really great job!

  • @Lili-yz6xf
    @Lili-yz6xf 4 года назад +373

    Timestamps/vocab:
    Vibrio Fischeri- 3:09
    Bioluminescence- 4:09
    Quorum sensing- 7:13
    Intraspecies communication- 9:18
    Interspecies communication- 10:49
    Esperanto/ a universal communication molecule- 11:31
    A new approach to antibiotics- 13:45
    Quorum sensing in bacteria- 14:43
    The gang- 17:11

  • @kaitlinmatrix6473
    @kaitlinmatrix6473 2 года назад +92

    The way she speaks about the young researchers is amazing. Genuinely made me tear up! I don't know what I'd do if my PI talked about me like this

  • @anraiduine1483
    @anraiduine1483 7 лет назад +136

    Man that symbiosis with the squid is just wild!!

    • @angelikahainz1665
      @angelikahainz1665 5 лет назад

      Die ganze belebte Welt besteht aus Symbiosen, würden sie sich auflösen, blieben nur noch wenige Einzeller übrig. app.you-publish.com/render/index/guideStaticId/58606d6c62d6789939176d5f/type/pdf?fbclid=IwAR0UbB6irSbNdT7tI_usHAVa9k0Pi-bggaUhKnneavhTj5SRe5sD6kMduss Lesestoff

  • @mientrant3615
    @mientrant3615 4 года назад +37

    Not just the great information she gave but also how incredible she talked smoothly energetic non-stop in the whole speech.

  • @srimansrini
    @srimansrini 10 лет назад +155

    Ms. Bonnie Bassler gives one of the riveting talk about how Bacteria communicate with each, a study that will propel the future of medicine. This is one of the finest studies ever conducted and hats off to the Princeton team of young innovators.

    • @pseudomonas69
      @pseudomonas69 5 лет назад +13

      Doctor Bonnie Bassler........

    • @RitaPizzi
      @RitaPizzi 4 года назад +5

      Prof. Bonnie Bassler

  • @gopikapj4255
    @gopikapj4255 8 лет назад +114

    i love the way she present the topic, it makes curiosity in learning about that subject.

  • @tutentDotCom
    @tutentDotCom 11 лет назад +16

    I got excited about this just from listening to Bonnie talk about it. At first I thought she was nervous, but then I realized it was just her and her excitement for her subject. And her down-to-Earth analogies made it incredibly easy to understand. Thanks so much for sharing this presentation. I learned a lot!

  • @mabelspeaks8019
    @mabelspeaks8019 4 года назад +37

    Thank you for attributing the students who are doing this important work. So often the students who do research as part of a class don’t know that other students are being directed and taught by amazing instructors-some of whom- may not be as diligent about honoring them early on.

  • @DubbedDemon
    @DubbedDemon 7 лет назад +209

    I thought I was watching this at 1.5x speed for a second

    • @hdb80
      @hdb80 5 лет назад +25

      She's passionate, and has a TON of info to give in next to no time.

    • @marieahlin1718
      @marieahlin1718 4 года назад +4

      Yes, I thought about how much she must've practised with a stopwatch to get all info in, in time 😀💪💪💕

    • @ValeriePallaoro
      @ValeriePallaoro 2 года назад +2

      Wow ... I thought it was perfect timing. Gave me everything and conclusions at each steps to allow me to go on to the next step with her. Nicely done.

    • @RondaldJames8
      @RondaldJames8 10 месяцев назад

      I'm watching it on 2x, and it's wonderful, still coming thru clear ❤

  • @ValeriePallaoro
    @ValeriePallaoro 2 года назад +12

    I love the conclusion; that the conversation can go both ways. Her team are developing both - away to stop bacteria from talking to each other (protect us from them) and a way to encourage their conversationability (protect them from us) It could so easily have just gone the one way. Nicely done. And much appreciated.

  • @oinkbaamoo
    @oinkbaamoo 10 лет назад +55

    Fascinating subject. Brilliant speaker.

  • @syncflame
    @syncflame 5 лет назад +50

    Here I am sitting in micro class, imagining bacteria sharing memes :D

  • @patrickfaas2329
    @patrickfaas2329 8 лет назад +44

    Bonnie Bassler is wonderful.

  • @jerkman4jesus
    @jerkman4jesus 6 лет назад +17

    Its the twentieth century and our most breakthrough discoveries are still happening because we saw a light.
    Excellent research, groundbreaking discovery and I hope what will be the foundation of our medical treatment of the future.

  • @kittenforbunny
    @kittenforbunny 9 лет назад +35

    Absolutely f'ing excellent talk!!!!!!!!!

  • @fernandoartiles9875
    @fernandoartiles9875 6 лет назад +9

    Amazing! A very passionate scientist, an incredible and enthusiastic teacher! A "must see"!

  • @gracecy8010
    @gracecy8010 Год назад +6

    wow i didn't know bacteria were so complicated
    this was a very good talk. I understood it well.

  • @oliverlittle5028
    @oliverlittle5028 3 года назад +8

    She adapted the Dazed & Confused quote: "Thats the awesome thing about high school girls; as I get older, they stay the same age". Fantastic speech Ms Bassler!

  • @thenightking7167
    @thenightking7167 Год назад +2

    This must be the absolutely most wonderful presentation in TED's history. Dr. Bassler, you are a remarkable human being, and scientist. Thank you, a quadrillion times, for acknowledging the invaluable contributions of every member in your lab. That was an indescribably beautiful gesture. 🧬🔬

  • @rachelcitizen4703
    @rachelcitizen4703 5 лет назад +2

    Wow!! What a fantastic presenter and she explains it so clearly. Excellent. Thank you heaps for the upload.

  • @JackSparrow-ld6rz
    @JackSparrow-ld6rz 3 года назад +1

    Everything about this speech was superb. I really enjoyed everything she had to say. Really was one of the most entertaining talks that I actually really liked.

  • @HS-wl6bu
    @HS-wl6bu 5 лет назад +2

    I got so touched at the end when she recognised her brilliant "gangs". People sometimes forget to acknowledge but she didn't.

  • @dilliganesh.m.3915
    @dilliganesh.m.3915 6 лет назад +2

    Your lecture is soo energetic. I felt learning something new. Your talk is very informative and it's amazing discovery.

  • @TheStallion1319
    @TheStallion1319 6 лет назад

    great talk enjoyed her enthusiasm and the valuable information and the advancements they achieved

  • @LionTheHeart
    @LionTheHeart 3 года назад +1

    This lovely intelligent lady is definitely in the right career.
    Fascinating!
    Thank you

  • @karencorkery5574
    @karencorkery5574 5 лет назад

    Fascinating how Bonnie can initiate such excitement and curiosity about cellular structure and their existence. Makes me hungry for more.

  • @soniabarrett
    @soniabarrett 10 месяцев назад

    I really loved this, one of the best TED Talks as Bonnie did such an amazing job of explaining the journey of bacteria so simply so that one one can understand it. Really great!

  • @cathysissens9248
    @cathysissens9248 3 года назад +2

    Phenomenal speech! Beautifully explained and riveting! Had me hooked from the intro...

  • @BerkeHitay
    @BerkeHitay 5 лет назад +2

    9:36 Species specifities! My favorite moment in any Ted Talk!

  • @HeCtorCapitalCe
    @HeCtorCapitalCe 11 лет назад

    They don't always give a standing ovation, everyone chooses as (s)he wants.
    It's just a testimony of her speaking abilities and the riveting facts she brought forward.
    You can dislike any speaker and their subject, but for me this format is of so much value.

  • @F00d5tamp
    @F00d5tamp 6 лет назад +1

    Fantastic video!! I love the way bonnie describes things.

  • @diegofernandoecheverrigarc52
    @diegofernandoecheverrigarc52 2 года назад +5

    Prof. Bonnie Bassler and team, thanks a lot for your excellent presentation.
    Is there any evidence or examples of these "communication molecules" in processes (digestion, immunity, vitamin synthesis etc) mediated by the human microbiome? thanks!

  • @rolo1363
    @rolo1363 2 года назад +1

    I'm really surprised this isn't more famous, it's so cool!!

  • @MosesGTC
    @MosesGTC 2 года назад +2

    Realised that there are more bacteria around me, in and on me than my body cells.. and these bacteria interact with the environment, and my cells...hmm where does my "self" begin, and end? Interconnected, inter-dependant, all one organism..?

  • @muhammadsiddiqueafridi8358
    @muhammadsiddiqueafridi8358 5 лет назад +1

    You know what last night I was reading about quorum sensing and read many kinds of stuff to get know about that but in vain, and yes now I got to know what quorum sensing is exactly. thanks for such a mesmerizing way of your explanation

  • @michellewilliams736
    @michellewilliams736 4 года назад

    Her passion is so inspiring!!!

  • @racekarts
    @racekarts 3 года назад

    A super excellent talk Bonnie, thank you

  • @haileywilson6596
    @haileywilson6596 3 года назад +1

    That was the best TED talk I've ever heard

  • @Abominatrix650
    @Abominatrix650 7 лет назад +1

    I have to do an essay on bacterial biofilms and communication plays a big part of it. This video is great at helping me!

  • @Kerrsartisticgifts
    @Kerrsartisticgifts 2 года назад +1

    The best Ted talk ever!

  • @Hemel29
    @Hemel29 2 года назад

    beautifully articulated and amazing persona !! thank you for doing what you do.

  • @superbere
    @superbere 4 года назад

    Wow. I am a few years late to this video but this was one of the most interesting videos Ive come across on youtube. She is fantastic.

  • @ShallowBeThyGames
    @ShallowBeThyGames 11 лет назад +2

    Never thought of other "friendly" bacteria, always thought that "probiotic" stuff, while having an element of validity was blown out of proportion regarding it's benefits. Suppose I should do a little research on it, starting to find this whole immunology and virology quite interesting.
    Thank you very much for setting me straight.

  • @CarolRadway
    @CarolRadway 10 лет назад

    Wonderful, mind expanding talk.

  • @zachrawlings6523
    @zachrawlings6523 2 года назад

    Soo many interesting facets of this talk. Love it

  • @VeVoRose
    @VeVoRose 10 лет назад +7

    Mind is blown love this stuff!

  • @LDWcoment
    @LDWcoment 11 лет назад

    Great talk , best Ted-ed i have seen .And they are all pretty amazing.

  • @salahhe
    @salahhe 11 лет назад +1

    One of the best Ted's. Good job!

  • @ajnjmar1
    @ajnjmar1 11 лет назад

    Amazing! Well done Bonnie and well done Bonnie's gang at Princeton.

  • @fractalico
    @fractalico 6 лет назад

    Lady, you are brilliant and charming...you explained so graciously a fascinating and profound aspect of life!

  • @euneillabrador3154
    @euneillabrador3154 5 лет назад +1

    I am currently learning this in my Microbial Biotechnology class. She made this topic more interesting for me to understand!

  • @squidb8
    @squidb8 11 лет назад +12

    So if we tamper with inter-species communication, would that affect beneficial bacteria also?

  • @lillazyboi
    @lillazyboi 8 лет назад +44

    My question is: Just like how bacteria can build resistance to antibiotics, can they also counter the quorum sensing block?
    Bacteria are very smart

    • @avinashsunder5176
      @avinashsunder5176 8 лет назад +10

      +lillazyboi actually, they have the potential to develop resistance - but it would probably (and hopefully) happen only after widespread commercialization and overuse of the QS blocks. Then we would have to discover the next anti-bacterials..

    • @lillazyboi
      @lillazyboi 8 лет назад

      Thanks!

    • @richardeldridge8335
      @richardeldridge8335 8 лет назад +10

      +lillazyboi I don't think in can be countered. Bacteria immunity is the result of non-immune bacteria dying off. The survivors don't develop resistance, they already have it. As she stated in the video, antibiotics select for immune bacteria. What is happening here is that a molecule is blocking the receptor to the quorum sensing molecules. It would have to develop a brand new receptor, and at the exact same time, develop a brand new communication molecule, and that's never going to happen. And, hypothetically, if it did, you'd only need to block that new receptor.

    • @iluan_
      @iluan_ 7 лет назад +9

      They could by developing mutations that change the type of molecules that control quorum sensing as well as their corresponding receptors. Which is good news since that would require a lot of changes instead of just requiring getting a plasmid or two, which is the case in the resistance mechanism of many current antibiotics.

    • @hdb80
      @hdb80 5 лет назад

      Good question.

  • @haripanditparanjpe30
    @haripanditparanjpe30 4 года назад +4

    This fantastic presentation was around 6 yrs ago but still nowhere near new line of antibiotics. Why ?

    • @TheKillerGamesTkg
      @TheKillerGamesTkg 4 года назад +2

      I'm sorry to say but it has its reasons that anything that involves human trials and such take a really really long time 10, 20 or more years

  • @DaRealFiberOptix
    @DaRealFiberOptix 11 лет назад

    awesome. i love the metaphors you can draw from knowledge about bacterial systems

  • @brianfoley4328
    @brianfoley4328 2 года назад

    I've seen Prof. Bassler on another You Tube channel....she's brilliant.

  • @BxSquared
    @BxSquared 2 года назад

    She is so passionate! Love it!

  • @8906384
    @8906384 6 лет назад

    That was an awesome talk!!

  • @nathanhasbani7877
    @nathanhasbani7877 5 лет назад

    Very interesting and such an articulate speaker

  • @user-gn7yt9fw5n
    @user-gn7yt9fw5n 6 месяцев назад +1

    I think it is the best explanation of Quorum sending i have ever seen thunks a lot

  • @eniamrahc73
    @eniamrahc73 3 года назад

    Really interesting talk! Excellent speaker as well. Would love her to be one of my microbio professors.

  • @bdhome2010
    @bdhome2010 5 лет назад

    Respect from BANGLADESH. Thank you for such explanation.

  • @CarineFrisch
    @CarineFrisch 11 лет назад +2

    Beautiful. Thank-you. And very interesting: stuff I never heard about .....

  • @vinitajagtap1918
    @vinitajagtap1918 2 года назад

    Really awesome talk

  • @shakilDaud
    @shakilDaud 8 лет назад +1

    Great for a understanding, knowledge on the Bacteria and works good for a basic understanding the most important living beings that bless and trouble you by being around you.

  • @wwitsel
    @wwitsel Год назад

    What an excellent explanation

  • @aaliya9652
    @aaliya9652 4 года назад +1

    The best Ted talk ever 👏

  • @rogercorneau4379
    @rogercorneau4379 11 лет назад

    Great talk

  • @santiagogonzalezbenjumea9880
    @santiagogonzalezbenjumea9880 2 года назад

    Amazing talk

  • @Zaris1021
    @Zaris1021 3 года назад

    attentive to the end.. awesome speaking! well done

  • @thisone45
    @thisone45 11 лет назад

    I love this stuff. Just the idea of giving a person with a fatal bacterial disease time enough to fight it off is amazing. I could be wrong but it also seems possible to allow a person to go on living a normal life while suppressing a disease indefinitely if they couldn't beat it outright.

  • @saldasinkope3002
    @saldasinkope3002 8 лет назад +8

    A small update on the fact about the resident microbes and the human cells- It's more like 1:1 ratio between them not 1:10.

    • @lillazyboi
      @lillazyboi 8 лет назад

      +Jānis Galdkājis True. My microbio professor just told us this lol.

    • @nikop4617
      @nikop4617 6 лет назад

      1.3:1

  • @MohammadAhmad-fi3pt
    @MohammadAhmad-fi3pt 14 дней назад

    She seemed so surprised when everyone stood up for her!

  • @CLEANDrumCovers
    @CLEANDrumCovers 11 лет назад

    This was fascinating.

  • @taracheng345
    @taracheng345 6 лет назад

    Fascinating!

  • @mikemeriwether9495
    @mikemeriwether9495 Год назад +1

    This assignment was very balls, I love balls.

  • @elisabetabaltaretu4259
    @elisabetabaltaretu4259 2 месяца назад

    Excellent explains..congratulations

  • @michaelbrown1396
    @michaelbrown1396 8 лет назад

    Absolutely Awesome!!!

  • @jdh9120
    @jdh9120 7 лет назад

    Great video had to share.

  • @qed47
    @qed47 11 лет назад

    excellent argument !!!

  • @stevedunn90
    @stevedunn90 11 лет назад

    TEDtalks is the actual organisation that runs all of these lectures. This channel is an editorial of videos that are educational, so people that are interested in specific areas can get related videos. There are loads of different TED channels, but all are fed from TEDtalks.

  • @alecchvirko6578
    @alecchvirko6578 11 лет назад

    That was fantastic.

  • @AbhilashNairSpartnax
    @AbhilashNairSpartnax Год назад +1

    Impressive how a minute stuff takes on a host million times its size

  • @D3sertst0rm
    @D3sertst0rm 11 лет назад

    Another possible mechanism is what Vincent W, very well said, the enzyme production trigger might be associated not only with quantity but also with density.

  • @yocahuna
    @yocahuna 11 лет назад +1

    Wonderful presentation on so many levels. Naturally, the ones i focus on demonstrate the PANACEA system: the idea of independent holons that make up a holarchies, data exchange, cooperation and emergent effects. The sovereignty of bacterial communities is recognized and a NPV index is assigned to them. (Don't envy who has to count them.)

  • @yasminazaadeh4177
    @yasminazaadeh4177 8 лет назад +9

    Just when I was beginning to think anti biotic resistance would wipe us out.

    • @samreads
      @samreads 6 лет назад

      In any case that would never happen. Just as some bacteria evolve anti-biotic resistance, there would always be some humans who'd be naturally able to resist that bacteria.
      So while the "weak" humans would die off, the survivors would thrive and their future generations would be naturally resistant to that bacteria. And the circle of life would continue exactly as if nothing ever happened.

  • @sandideguzman2378
    @sandideguzman2378 3 года назад

    Are you able to provide a list of what type of bacteria you tested for behavioral modifications when trying to find a different approach to reaching a vaccine?

  • @hdb80
    @hdb80 5 лет назад

    Woah, this is fascinating.

  • @subhamsinha9817
    @subhamsinha9817 4 года назад

    Excellent video 👍👍

  • @h7oslo
    @h7oslo 8 лет назад +1

    Great presentation !
    Tnx to George L. for the link !
    rc

  • @rmt2171
    @rmt2171 7 лет назад

    Love this!

  • @WhiteHoppus
    @WhiteHoppus 11 лет назад

    This was awesome.

  • @senanallahverdiyev5270
    @senanallahverdiyev5270 8 лет назад +1

    stunning.

  • @devil__x2065
    @devil__x2065 2 года назад

    Well explained

  • @amanlitt8386
    @amanlitt8386 3 года назад +1

    for how excited and passionate she was throughout the entirety of her talk, her outro was pretty meek. Thats us science nerds for ya

  • @VegaChastain
    @VegaChastain 9 лет назад +5

    The main thing that scares me about GM and GE foods is that any DNA from them that isn't denatured by our stomach acid (this can be a lot depending on the health of stomach secretions, which tend to be quite unhealthy in an Americanized diet plan) ends up being absorbed by the bacteria that inhabit our intestines. These bacteria are imperative to many processes within us, and are integral to our immune system, vitamin B and K absorption, and many more important processes. It is estimated that these gut flora have around a hundred times as many genes in aggregate as there are in the human genome. This is what you want Monsanto to be experimenting with? :-/

  • @kritikachoudhury2188
    @kritikachoudhury2188 5 лет назад

    MIND=BLOWN!!!

  • @StrawberryStarfish78
    @StrawberryStarfish78 11 лет назад

    Brilliant!

  • @rebekalanska2119
    @rebekalanska2119 7 лет назад

    This is so interesting!