The Mannich Reaction (Mechanism + Rxn Practice)
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- Опубликовано: 26 ноя 2024
- joechem.io/vid... for video on jOeCHEM and attached worksheet + solution (below video on jOeCHEM aka the link).
Worksheet: worksheets.joec...
Worksheet Solution: worksheets.joec...
Worksheet Solution Walkthrough video: joechem.io/vid...
Study Guide: N/a (Joe's working on it!)
In this video, we go through the mechanism behind the Mannich Reaction and get some practice with predicting the product. What's awesome is, if you put in the work back when we worked with imines (joechem.io/vid...) and enols in the aldol condensation (joechem.io/vid...) this will be very familiar and a lovely trip down memory lane.
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Your style is simple.👏👏keep going
Dude I have my Orgo chem 2 finals in a week, and this was one one of the reactions I was having trouble with. Tyvm!
Very well explained! Tomorrow I am doing practically that reaction in the lab,so I needed this for the better understanding. Thank you!!
Great video. You are getting me through my OChem class now that everything is being taught online because of COVID-19. Thank you so much!
Joey! From one Joe to another thank you for the kind words. I'm so glad you're finding the videos helpful. Make sure to check out my most recent live exam review joechem.io/videos/158
And if you'd subscribe to the YT channel (if you haven't already), I'd massively appreciate it. Stay safe and good luck!
This cleared up a lot of confusion. Thank you!!
But how do we know how the enol will be formed?
Hi sir, for 3:20 part, can I say a transfer of hydride ion from NH2CH3 to OH?
Perfect!!
why didnt the hydrogen leave the nitrogen in order to get rid of positive charge?
he mentioned that the positive charge needs to be hold in order to be able to react with the enol
i think usually you would use secondary amine instead of a primary one. like that its not that easy to get rid of the positive charge. otherwise abstracting a proton is usually not that unlikely. however abstracting a positively charged alkyle rest (is that correct in english ? german speaker here) is definitely not very likely thing to happen.
Where did that enol come from
Hi Valerie! I'm assuming you're referring to the enol at 4:42 -- if that is the case, the enol was created because the carbonyl (which here is a ketone) is in an acidic environment, which supports keto-enol tautomerism (aka the ketone flipping back and forth between its enol and keto forms).
Let me know if that does or doesn't make sense?
@@jOeCHEM do you have to show a mechanism from the ketone to enol or can you just show that is the ketone can form an enol because it is in an acidic environment?
Sorry, but I don't understant you😐