Supurb information Dr Babak, thank you so very much .... I am just beginning this journey and already have been thrown by the attitude of 2 doctors who have been reluctant to refer me back to the enocrinologist. I have very high B/P and now on meds.... no kidney stones but soft tissue damage and significant osteoporosis. It's the mental, (cognitive dysfunction), emotional, (anxiety) symptoms, chronic fatigue, gut problems, lactose and gluten intolerance. and total alopecia universalis which compromise my life the most. I realise from listening to your great advice that I need to be more proactive and carefully follow my blood tests. I am now 70years and have endured many of these symptoms for 40 years from the time I birthed my 4 children.
Been trying to no avail to find the relationship been acid base status and PTH; acidosis leads to increased free ionized calcuim AND result in secretion of PTH which will result into excretion of phosphate for buffering tubular acid excretion. The reverse happens with alkalosis, ie, alkalosis lead to decreased calcuim and reduced PTH and therefore phosphate retention. High calcium suppress PTH, and reduced phosphate stimulate 1-alpha hydroxylase and therefore increase calcitriol which suppresses PTH. It therefore seems acid base status overrides PTH control by calcium and phosphate. What's the significance of this arrangement..
No wonder doctors are angels . Specially the good ones
Supurb information Dr Babak, thank you so very much .... I am just beginning this journey and already have been thrown by the attitude of 2 doctors who have been reluctant to refer me back to the enocrinologist. I have very high B/P and now on meds.... no kidney stones but soft tissue damage and significant osteoporosis. It's the mental, (cognitive dysfunction), emotional, (anxiety) symptoms, chronic fatigue, gut problems, lactose and gluten intolerance. and total alopecia universalis which compromise my life the most. I realise from listening to your great advice that I need to be more proactive and carefully follow my blood tests. I am now 70years and have endured many of these symptoms for 40 years from the time I birthed my 4 children.
Dr, I can tell you are a consummate professional. Thanks for all you do!
I wish you where here close to the East Coast. I need your help...
Been trying to no avail to find the relationship been acid base status and PTH; acidosis leads to increased free ionized calcuim AND result in secretion of PTH which will result into excretion of phosphate for buffering tubular acid excretion. The reverse happens with alkalosis, ie, alkalosis lead to decreased calcuim and reduced PTH and therefore phosphate retention. High calcium suppress PTH, and reduced phosphate stimulate 1-alpha hydroxylase and therefore increase calcitriol which suppresses PTH. It therefore seems acid base status overrides PTH control by calcium and phosphate. What's the significance of this arrangement..