This is another eye-opening video. Thank you, Dr. Peveler. I recently had a PET scan and bone scan in the last month. My PSA has gone up from .1 to 2.0 since July 2024. I have two new lesions on my ribs. And what I imagine is the cancer is Very complacent with my diet and regimen and it’s found another way to attack. So I imagine it’s been looking for a week links in the fence that I’ve built. I feel that my next step to take in my survival is to find an oncologist who is more accepting of the metabolic approach to cancer survival. I’m not saying that I’m unhappy with the care I’ve received, but I think I need to mix it up a little bit. Of course the discussion of certain drugs like metformin ivermectin have caused concern for my family. But this is my life that I am fighting for. So if you have any advice as to where I should go or where to look. I would appreciate it. CMF
"Anticancer properties of sulforaphane: current insights at the molecular level" "Another randomized double-blinded study disclosed that sulforaphane is highly effective in reducing serum prostate-specific antigen (PSA) levels. Serum PSA levels are usually high in men suffering from prostate cancer after radical prostatectomy. The study inferred that the administration of 60 mg SFN in the form of a tablet significantly reduced the PSA progression after at least 3 months of treatment (77)."
Man I’m sorry to hear about the progression of the disease. I think one way to help get your family bought in if they are super conventional medicine/SOC-centric is to just talk about an integrative approach.
I much appreciate the continued building of this toolbox to address cancer. You mentioned that DON, given this burgeoning toolbox, is but one of many that can be used in the Press Pulse Protocol. 1. So, the obvious question with regard to the protocol since the glutamine inhibitor(s) is meant to be “pulsed,” how does one do that from a hypothetical perspective given the myriad of inhibitors at our disposal? 2. Is one of those tools or a combination of those tools just as effective when following the Protocol? How would one verify improvement? I am confirmed Stage IV and would throw all the tools at it, assuming I could get the funds, but I have no idea in what amount and frequency. I attended my intro “chemo” class yesterday and having pushed through much of your content and others, I can tell you that an adjunctive approach as part of the main standard-of-care infrastructure to addressing, managing, halting and/or eliminating cancer remains an outlier given the length of time and content the class instructor spent on it. Sad but not unexpected. And I wasn’t shocked when toured through the infusion room, “snacks” were proudly shown. I wanted to scream. Much work still yet to do, clearly.
I’ll start with what you said last “much work to do”. Essentially at this time we have a starting framework “press pulse”. I will say this: this road is not for the weary. One must be extremely disciplined and bought in. And sadly of financial means because it is all out of pocket. The protocol will take time to be evolved and perfected. Gauging effectiveness will be similar to conventional means: subjective history, physical exam, imaging, tumor markers, etc
Loved your MetCancer video ! Not getting my hopes up but maybe with the message getting out there we can see some momentum towards shifting the paradigm.
With the change of the political guard and fresh faces in top political positions, maybe we can get some eyes on this alternative thinking on how to treat cancer.
Ah yes, another gem Dr. Peavler. I’ve been taking Pentasa (Mesalazine - active ingredient of Sulfasalizine) for years for early signs of UC. Gastro guy said I can go off it as I’m in remission for that. I requested that I continue as it helps my arthritis (no need to take Voltaren which upsets my stomach). Turns out (your info) that it may help fight my cancer too. Please confirm, if you can, that Mesalazine will do the same job as Sulfasalizine in the battle against cancer. Thanks heaps.
Dr Peavier, Would you comment on this discrepancy… Although sulfasalazine has these effects in vitro… it is absorbed in the body and plasma levels are not sulfasalazine but is absorbed from the gut as 2 moieties which do not seem to have the effects described for intact sulfasalazine .
I appreciate your question and concern. There are plenty of things that I will cover which need a ton more research and assistance in overcoming some of these barriers. Does that mean it’s abandoned? Does that mean the structure is changed? The route is changed? Maybe it’s only useful for GI tract cancers. My goal with this channel is to raise awareness and talk about mechanisms and possibilities.
@@DrCaseyPeavler Well, yes! Awareness being elevated! Now, how might awareness be increased for better assessment toward widely used protocol modification in future treatment progressions?!?!
I would like to ask - if cancer cells behave like anaerobic bacteria or anaerobic parasites and they use fermentation to make their energy, then why dont we use repurposed drugs that are used to kill anaerobic bacteria and anaerobic parasites? I see use of mebendazole or doxycycline but no drug for anaerobic bacteria or anaerobic parasites. Can you please share your views. Thanks.
One repurposed “drug” that I use is HBOT. I used to be a vigneron and if there’s one thing that you must keep away from your fermentation it’s oxygen. So there you go. It’s a start.
Mebendazole is proposed to work due to microtubule formation for parasites. However some secondary previously unknown mechanisms are effects on glucose and glutamine. Doxycycline has no effects on anaerobic bacteria unfortunately.
Thank you doctor! Please excuse me if I missed this discussion. How does the use of Metformin and Sulfasalazine preferentially cause cell death in cancer cells. Aren't glucose and glutamine used in normal cells too?
I understand that use of N acetyl cysteine can be an issue. There are some recent reports that say that it causes cancer. I use this medication quite a bit
I highly doubt it causes cancer but maybe overusing it theoretically could causing a reductive stress. However, if I had a cancer diagnosis, I wouldn’t be in the same room as NAC…
I am unsure of that to be honest. Remember this is the metabolic approach to cancer. We are not as concerned with genes compared to conventional oncology.
Thanks you so much doc! I'd love to hear a discussion between you and Dom d' Agostino,it would be quite fantastic in my humble opinion 😊 Greetings from France
Another fantastic video Doc. You are certainly shedding lights on the glutamine pathway and the tools we can use. I’m assuming it was also be a pulsing protocol with sulfasalazine?
My last 2 videos were on artemisia Artemisinin TRIGGERS Ferroptosis in Cancer ruclips.net/video/2usy1OKLiuA/видео.html I’ll be hitting the others in the future!
@@DrCaseyPeavler Yes, hopeful. Research toward 'profit' at the cost of 'first do no harm' functionality data, needs better independence of funding! Perhaps 'government' can actually DO governing for the people, based on the whole scientific method into the future! But, that is only 'pie in the sky'? I have glimmers of hope (starting in El Salvador)?!?
This is a serious issue and question that needs to be worked out. Normal cells don’t rely on glutamine whereas cancer cells bring it in 10-30x more than normal cells. These therapies preferentially damage cancer cells because their metabolic demands are so different
That is a pretty loaded question. Let me think about that, and maybe even do like a top 5 video or something. Betulinic acid is stronger GLS inhibitor than DON.
In the context of cancer? I have not seen any PPI or specifically esomeprazole being floated for cancer yet. Doesn’t mean it won’t pop up on my radar, but not yet
It would be interesting to make a narrow list of supplements (that are safe and well absorbed) and medications (repurposed), that cover most of the cancer metabolic pathways.
@@DrCaseyPeavler she has an online course too, but honestly it's just overwhelming and next to impossible to implement, and I'm not uninterested in nutrition/science
I see. Well that is a problem if it’s too difficult for anyone to implement. But to be fair metabolic therapy as a whole or how I see it, is no easy task. Not cheap sadly.
@DrCaseyPeavler Interesting. Is this the same also for benign kidney tumor? I was diagnosed with one on an ultrasound, a small one, but was confused about what supplements I must avoid? I suspected maybe the NR or NMN I took caused it maybe , because 11 months before the scan I had was clear 🤔 In 11 months my scan showed some fatty liver and that benign tumour.
Strange. Gotta dig deeper in your underlying physiology and environment. Something is up. Find a local intelligent supportive healthcare provider and get digging.
@@DrCaseyPeavler I agree 👍🏻 I appreciate your response sir. Healthcare system England, UK is terrible! I lost weight they thought I may have cancer FIT test and endoscopy were negative..not due to the kidney .. but I had SIBO gut Infection..and lost my parents through medical negligence.. so I thought I'm not going to be their next victim . So did things to help with my gut and liver milk thistle choline etc drink kefir... And started to slowly regain weight as stress reduced also . Since 2020 suffered from long COVID..healed almost in early 2022 then got reinfected that summer, and my long COVID returned this time affecting more body parts not just fatigue but muscle aches etc too calcification in tendon both arms 2 frozen shoulders despite being 38 which unusual my therapist said . Since 2020 march I was never the same. Where is your clinic based ? Many thanks
Such a well-stocked tool bag! How many oncologists really utilize much of this research? And, how does the current political 'science' inhibit use of this apparent wealth of benefit? Mind-boggling, No?!?
I thought this was interesting combinations: Huang QF, Li YH, Huang ZJ, Wu QX, Mei J, Wang W, Gui P, Cheng F, Wang GH. High-performance self-cascade nanoreactors for combined ferroptosis, photothermal therapy, and starving therapy. Eur J Pharm Biopharm. 2024 Aug;201:114367. doi: 10.1016/j.ejpb.2024.114367. Epub 2024 Jun 13. PMID: 38876360.
This is another eye-opening video. Thank you, Dr. Peveler. I recently had a PET scan and bone scan in the last month. My PSA has gone up from .1 to 2.0 since July 2024. I have two new lesions on my ribs. And what I imagine is the cancer is Very complacent with my diet and regimen and it’s found another way to attack. So I imagine it’s been looking for a week links in the fence that I’ve built. I feel that my next step to take in my survival is to find an oncologist who is more accepting of the metabolic approach to cancer survival. I’m not saying that I’m unhappy with the care I’ve received, but I think I need to mix it up a little bit. Of course the discussion of certain drugs like metformin ivermectin have caused concern for my family. But this is my life that I am fighting for. So if you have any advice as to where I should go or where to look. I would appreciate it.
CMF
Can you get Vitamin C 60 grams intravenously it can save your LIFE GOD BLESS 🙏.
"Anticancer properties of sulforaphane: current insights at the molecular level"
"Another randomized double-blinded study disclosed that sulforaphane is highly effective in reducing serum prostate-specific antigen (PSA) levels. Serum PSA levels are usually high in men suffering from prostate cancer after radical prostatectomy. The study inferred that the administration of 60 mg SFN in the form of a tablet significantly reduced the PSA progression after at least 3 months of treatment (77)."
Man I’m sorry to hear about the progression of the disease. I think one way to help get your family bought in if they are super conventional medicine/SOC-centric is to just talk about an integrative approach.
Thank you everyone for supporting him
Fight for your life your way! Lord God I pray for David’s healing and Your guidance of his care.
I much appreciate the continued building of this toolbox to address cancer.
You mentioned that DON, given this burgeoning toolbox, is but one of many that can be used in the Press Pulse Protocol.
1. So, the obvious question with regard to the protocol since the glutamine inhibitor(s) is meant to be “pulsed,” how does one do that from a hypothetical perspective given the myriad of inhibitors at our disposal?
2. Is one of those tools or a combination of those tools just as effective when following the Protocol? How would one verify improvement?
I am confirmed Stage IV and would throw all the tools at it, assuming I could get the funds, but I have no idea in what amount and frequency.
I attended my intro “chemo” class yesterday and having pushed through much of your content and others, I can tell you that an adjunctive approach as part of the main standard-of-care infrastructure to addressing, managing, halting and/or eliminating cancer remains an outlier given the length of time and content the class instructor spent on it. Sad but not unexpected.
And I wasn’t shocked when toured through the infusion room, “snacks” were proudly shown. I wanted to scream.
Much work still yet to do, clearly.
I’ll start with what you said last “much work to do”.
Essentially at this time we have a starting framework “press pulse”.
I will say this: this road is not for the weary. One must be extremely disciplined and bought in. And sadly of financial means because it is all out of pocket.
The protocol will take time to be evolved and perfected.
Gauging effectiveness will be similar to conventional means: subjective history, physical exam, imaging, tumor markers, etc
Loved your MetCancer video ! Not getting my hopes up but maybe with the message getting out there we can see some momentum towards shifting the paradigm.
I pray 🙏 that is the case.
With the change of the political guard and fresh faces in top political positions, maybe we can get some eyes on this alternative thinking on how to treat cancer.
I really want to believe that is possible, but big pharma owns congress no matter R or D so we shall see…
Ah yes, another gem Dr. Peavler. I’ve been taking Pentasa (Mesalazine - active ingredient of Sulfasalizine) for years for early signs of UC. Gastro guy said I can go off it as I’m in remission for that. I requested that I continue as it helps my arthritis (no need to take Voltaren which upsets my stomach). Turns out (your info) that it may help fight my cancer too.
Please confirm, if you can, that Mesalazine will do the same job as Sulfasalizine in the battle against cancer.
Thanks heaps.
I am glad you liked it! I’m guessing you mean mesalamine? Could help yes if you had cancer depending on some factors.
Yes, Mesalazine == mesalamine == 5-aminosalicylic acid (5-ASA) == PentAsa
God bless you for you work man!
It is a lot of work man. But it is my honor to get this information out to you all.
Excellent...I want to know more..... Especially alternatives to Don that are available. Will be watching the previous videos. Thanks
Yes there are many other supplements and medications which affect the glutamine system. I’ve posted quite a few and have several left to share
Dr Peavier, Would you comment on this discrepancy… Although sulfasalazine has these effects in vitro… it is absorbed in the body and plasma levels are not sulfasalazine but is absorbed from the gut as 2 moieties which do not seem to have the effects described for intact sulfasalazine .
I appreciate your question and concern. There are plenty of things that I will cover which need a ton more research and assistance in overcoming some of these barriers. Does that mean it’s abandoned? Does that mean the structure is changed? The route is changed? Maybe it’s only useful for GI tract cancers. My goal with this channel is to raise awareness and talk about mechanisms and possibilities.
@@DrCaseyPeavler Well, yes! Awareness being elevated! Now, how might awareness be increased for better assessment toward widely used protocol modification in future treatment progressions?!?!
Figuring out another route of administration such as IV to achieve plasma levels. Or using for GI tract cancers perhaps…
I would like to ask - if cancer cells behave like anaerobic bacteria or anaerobic parasites and they use fermentation to make their energy, then why dont we use repurposed drugs that are used to kill anaerobic bacteria and anaerobic parasites? I see use of mebendazole or doxycycline but no drug for anaerobic bacteria or anaerobic parasites. Can you please share your views. Thanks.
One repurposed “drug” that I use is HBOT. I used to be a vigneron and if there’s one thing that you must keep away from your fermentation it’s oxygen. So there you go. It’s a start.
Mebendazole is proposed to work due to microtubule formation for parasites. However some secondary previously unknown mechanisms are effects on glucose and glutamine. Doxycycline has no effects on anaerobic bacteria unfortunately.
Thank you doctor! Please excuse me if I missed this discussion. How does the use of Metformin and Sulfasalazine preferentially cause cell death in cancer cells. Aren't glucose and glutamine used in normal cells too?
Yes but to a much lesser degree. 10-30x less and those normal cells do not rely on glucose or glutamine, they are metabolically flexible.
I understand that use of N acetyl cysteine can be an issue. There are some recent reports that say that it causes cancer.
I use this medication quite a bit
I highly doubt it causes cancer but maybe overusing it theoretically could causing a reductive stress. However, if I had a cancer diagnosis, I wouldn’t be in the same room as NAC…
Thank you so much! Do you think blocking Gluthamine can decrease MYB protein level?( which is high in many cancers) Bless you!
I am unsure of that to be honest. Remember this is the metabolic approach to cancer. We are not as concerned with genes compared to conventional oncology.
Thanks! Please keep up the good work.
Thanks, will do!
Thanks you so much doc!
I'd love to hear a discussion between you and Dom d' Agostino,it would be quite fantastic in my humble opinion 😊
Greetings from France
Greetings from Florida. I would love to have that discussion some day also
Nice hit!
Thank you!
Amazing video, thx
You are very welcome!
Excellent Doc !
I am glad you liked it!
This is Great information
I am glad it is useful to you!
Another fantastic video Doc. You are certainly shedding lights on the glutamine pathway and the tools we can use. I’m assuming it was also be a pulsing protocol with sulfasalazine?
TBD, generally Sulfasalazine when given to IBD patients, it’s every day and they tolerate it. But TBD for other uses such as this…
@ TBD ?
To be determined sorry
@@DrCaseyPeavler To be determined?
@ Nothing to apologise for. picnic
Problem in chair not in computer
Artemesia
Fenbendazole
Ivermectine
Methylene blue
My last 2 videos were on artemisia
Artemisinin TRIGGERS Ferroptosis in Cancer
ruclips.net/video/2usy1OKLiuA/видео.html
I’ll be hitting the others in the future!
Does these inhibitors only inhibit the cancer cells or also healthy cells?
My guess is that being a drug it will block irrespective of the cell type. But. This is the Achilles heel of cancer not of normal cells.
@@DrCaseyPeavler Yes, hopeful. Research toward 'profit' at the cost of 'first do no harm' functionality data, needs better independence of funding! Perhaps 'government' can actually DO governing for the people, based on the whole scientific method into the future! But, that is only 'pie in the sky'? I have glimmers of hope (starting in El Salvador)?!?
With RFK…who knows…
What type of dosage are they working with in these papers for the Met Forman?
Great question. I would have to look into the methods of the animal studies but they were mostly in vitro studies to confirm mechanism of action.
Hi
Are you able to comment on this information on NAC. Worried about cancer issues recent research information
Can you please clarify your question a bit? What exactly about NAC are you curious about?
What type of magnesium do you recommend for a cancer patient? I need it for my vitamin D.
Although I appreciate them, these kind of questions are really best between you and your doctor.
I use magnesium bisglycinate, 3 times a day, along with my vitamin D3 and K2 supplement.
Thanks for your input
GLY enhanced GSH levels under GLN starvation, but caused a diminution of GSH content under optimal GLN supply.
Interesting 🤔….
What happens to the regular cell which need glutamine
This is a serious issue and question that needs to be worked out. Normal cells don’t rely on glutamine whereas cancer cells bring it in 10-30x more than normal cells. These therapies preferentially damage cancer cells because their metabolic demands are so different
More on Ivermectin .
I still need to do a deep dive on ivermectin and see how it could fit into metabolic approach…
@@DrCaseyPeavler Thank you .
You are welcome
Can you name the top 3 strongest supplements that block glutamine besides berberine,don,egcg?
That is a pretty loaded question. Let me think about that, and maybe even do like a top 5 video or something. Betulinic acid is stronger GLS inhibitor than DON.
@@DrCaseyPeavler thank you it would really help alot if you can!!
I can see that would be very valuable!
@@DrCaseyPeavler Is DON good at inhibiting GLS or just Glutamine?
GLS stands for glutaminase, a critical enzyme in the utilization of glutamine in cells.
I ever read that sulfasalazin is better when we combain with esomeprazol,,is it true sir
In the context of cancer? I have not seen any PPI or specifically esomeprazole being floated for cancer yet. Doesn’t mean it won’t pop up on my radar, but not yet
@DrCaseyPeavler how about metylen blue injection sir,, thangs
Look up photodynamic therapy
This doesn’t cross BBB… is there another drug/supplement that works on the same pathway in brain?
It would be interesting to make a narrow list of supplements (that are safe and well absorbed) and medications (repurposed), that cover most of the cancer metabolic pathways.
Yes. We need that very badly.
Yes, it gets extremely overwhelming and frustrating, especially trying to work to books like McLellan's
She means well and has done well with no training but or support
@@DrCaseyPeavler she has an online course too, but honestly it's just overwhelming and next to impossible to implement, and I'm not uninterested in nutrition/science
I see. Well that is a problem if it’s too difficult for anyone to implement. But to be fair metabolic therapy as a whole or how I see it, is no easy task. Not cheap sadly.
Thank you Casey
You are very welcome!
Could this be a substitute for DON ?
Perhaps for the right patient. Not a one size fits all. I still think a well thought out combination approach is best.!
Isn't blocking Gluthatione production not ideal?
Context is everything. In cancer glutathione system is hijacked and used to protect itself from chemo, radiation and everything else….
@@DrCaseyPeavler Does it mean I should stop taking NAC and Glycine?
Do you have cancer?
👍❤
Thanks for your support!
thank you doctor
You are very welcome!
I thought glutathione was anti cancer?
Prevention strategies are different from treatment strategies. Unfortunately cancer hijacks our great protectors…
@DrCaseyPeavler Interesting. Is this the same also for benign kidney tumor? I was diagnosed with one on an ultrasound, a small one, but was confused about what supplements I must avoid? I suspected maybe the NR or NMN I took caused it maybe , because 11 months before the scan I had was clear 🤔 In 11 months my scan showed some fatty liver and that benign tumour.
Strange. Gotta dig deeper in your underlying physiology and environment. Something is up. Find a local intelligent supportive healthcare provider and get digging.
@@DrCaseyPeavler I agree 👍🏻 I appreciate your response sir. Healthcare system England, UK is terrible! I lost weight they thought I may have cancer FIT test and endoscopy were negative..not due to the kidney .. but I had SIBO gut Infection..and lost my parents through medical negligence.. so I thought I'm not going to be their next victim . So did things to help with my gut and liver milk thistle choline etc drink kefir... And started to slowly regain weight as stress reduced also .
Since 2020 suffered from long COVID..healed almost in early 2022 then got reinfected that summer, and my long COVID returned this time affecting more body parts not just fatigue but muscle aches etc too calcification in tendon both arms 2 frozen shoulders despite being 38 which unusual my therapist said . Since 2020 march I was never the same.
Where is your clinic based ?
Many thanks
You likely need a radical environmental change my friend. Are you tethered to the UK?
Thanks so much for all the valuable information!!! You are a fantastic doctor.
Thank you for your support fellow mitochondriac!
Such a well-stocked tool bag! How many oncologists really utilize much of this research? And, how does the current political 'science' inhibit use of this apparent wealth of benefit? Mind-boggling, No?!?
No oncologists use this
My videos get shadow banned lol
Nope.
I like you Doc. Those that shadow stink@@DrCaseyPeavler
😂
Thank you 🙏
You are very welcome!
You and Thomas Seyfried should do cancer talk all over the Country. I would definitely attend.
I would love to do something like that
I thought this was interesting combinations: Huang QF, Li YH, Huang ZJ, Wu QX, Mei J, Wang W, Gui P, Cheng F, Wang GH. High-performance self-cascade nanoreactors for combined ferroptosis, photothermal therapy, and starving therapy. Eur J Pharm Biopharm. 2024 Aug;201:114367. doi: 10.1016/j.ejpb.2024.114367. Epub 2024 Jun 13. PMID: 38876360.
Thanks Ray will have to check it out!