Rewinding the biological clock: How to reverse ageing
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- Опубликовано: 6 окт 2024
- Researchers claim to have reversed ageing in mice. It has long been believed that if we understand the causes of ageing, it may be possible to reverse it. New work on mice shows that it is possible to cure vision loss caused by old age or injury. Researchers think that this effect may depend on rewinding the ‘biological clock’ which marks the age of cells, suggesting that the cells in the eye have been made functionally younger.
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This might be the most important area of research in the moment.
You are right. I just wish more research would be done toward this goal of slowing or reversing aging.
Yeah there definitely is going to be high returns in this business...
@@kanakalatahembram1650 if a scientist discovers the medicine,he would perhaps be the first person to become a trillioner.because this is a product that everybody needs and every single drug company would be willing to buy it,even if he gave them 5% of the profit.
Yeah, fantastic.
Yeah, we are soon 8 billions on Earth, but let's prolongate life.
I think this is amazing result and researchers deserve to get Nobel-prize. I'd like to introduce this wonderful result to Korean!
올리신 영상 보고 왔어요ㅎㅎ
David Sinclair looks younger at every new video
Dude's 52 and looks 30
@@gs-nq6mw looks like the test was successful
I want to becomes younger in real Life want to be a an teenager forever. I want to become 16 year old forever turn back the clock reversing the aging process in humans. Fountain of youth in real life shrink make age backwards forever. Turn back the clock ( age regression phyrrisy younger regression) age regression
I want to be teenager forever physically regression. Reversing the aging process in humans turn back the clock fountain of youth .
@@jeremyanderson6789 Researchers claim to have reversed aging in Humans, I want to became younger, younger forever make me younger age regression in humans can we reverse the aging process in humans turn back the clock and time fountain of youth in real life I want to be a 17-year-old forever.
Remember not that many years ago it was a taboo to even suggest in a rigorous scientific publishing that aging might be reversible? Not any more.
Permanent baldness cure has been always projected to be in next 5 years, for 35 years. Yet no cure
@@user-it5po2dq9w That is so true. I need that cure all I have received was empty promises for my scalp. LOL
@@mnkwazi
Have you actually tried anything to fix your baldness?
@@MrNote-lz7lh I have tried finasteride and topical minoxidil. The former has slowed the hair loss but the latter has been useless.
@@mnkwaziGo and get a hair transplant!
Such great information. What would we do without science. Thank you for sharing.
*We need more people working on this instead of being idiotic on TikTok.*
True!
We need this right the heck now! Before our grandparents die.
Nice Thought 👍
@Gonzalo De La Maza Mendizabal dont underestimate China
@Gonzalo De La Maza Mendizabal people will be taking it regardless, safety and the fda be damned. But if they don't want it... Well you can't help that.
cryonics is your best bet
@@saidalas7763 lol
I am from the same field of science. Loved viewing and listening to the video 😊 nice research attempt, I must say
You want a real hero?! Dr. Sinclair is a perfect example!
I'm holding out for a hero 'til the end of the night
I think he does upsell ideas though. I don't always trust him.
@MusiCaninesTheMusicalDogs David Sinclair is a gift to humanity a terrific person and Is such a genuine person that wants the best for mankind I have faith and belief that he will find a way to figure out how to find that backup copy of youthful information in our cells and Reverse Aging and It will be available before It's too late I believe in you David Sinclair Myself and Many people Are rooting for you
This discovery would be a gift to the world. Great minds would never grow old and would contribute infinite potential to life as we know it. Many who never had children can have a chance to experience it due to this miricale.
by this video, he has shown the world that nothing is impossible, great work sir. your biggest fan
What a great piece of work, thanks for linking the paper!
Finally he published his preprint. And reviewers made them do glaucoma experiments. Peer-review is soooo bloody slow.
What does the timeline look for the peer review?
@@faeriedragon348 depends on how many new experiments reviewers ask for. A year from submission to publication seems normal nowdays.
@@faeriedragon348 in some fields, years is the norm.
It's very important that they did though. Those experiments vastly improved the quality of the paper. Peer review is slow unfortunately, but it (usually) works!
@@signalamplifier Yes, it is FREAKING SLOW. But, peer review is important. Because you have to make sure that others agree with how you did your study or your science. Like I did get some peer review for my work, and I got trashed. But, hey, back to drawing board, and my final solution will have a correct result -- which is important to know. THAT YOUR SCIENCE IS REPRODUCIBLE. That's what is important: REPRODUCIBILITY.
Im coming to work for you Mr. Sinclair! just give me 6 years
Mr. Sinclair: "No problem. We offer a 6, 9 or 12 year re-aging therapy, eyevision improvement included."
Wish you good luck! Hope you do well
Bro...I am also his fan and I am studying life Sciences as well...maybe I will see you there.
Good luck! He's has a doctorate, btw.
Good mate
I immediately knew this is about David Sinclair's work :D This dude is 51 years old.
Thanks for the info 👍 I am new to all this....
MrN ... Hey, man, be careful. Treading on ultra-thin ice. Trust me, I don't know how old you are. But, 51 is not that old now. I promise you. It seems that way, but it's not old at all.
@@PoeLemic I know, I'm 30 now and the same is true for that age. However, a being 51 and looking like being mid-30 is darn impressive
@@PoeLemic I have heard the saying these days that "40s is the new 30s..."😉
@@kanakalatahembram1650 Well, I'd say the 50s (now) are even the mid-30's, if you ask me. I'm around that age now, and I feel as good (or better) than when I was younger. For sure, I eat better and have better nutrition, yet only difference, to me, is that my age is a lighter color (like graying or whittening some).
Ty for this awesome video, found it just now
This is an amazing, even scary somehow, achievement. Now, then, the meaning of aging is to be questioned!
And for the moment we are only talking about mice.
Imagine the day when a rejuvenation therapy like this will be successful in humans.
There, no one will be able to question the idea that aging is reversible, so the inevitability of aging loses all its meaning.
It won't make you immortal so eventually you would die anyway but you would have some more decades in good health.
I hope this method is thoroughly tested and works, like any new method it needs a lot of review and testing. The human body is too complex to celebrate recent findings too early because there's too many things that could be going that might nullify the effect or worse, so tests need to be done over long timespans. But I'm very much looking forward not so much to living forever or much longer, but living young until a naturally old age death, that is more important in my view. Imagining my parents and grandparents being young with me would bring me enormous amount of joy.
Death by old age does not exist, we die of the consequences of aging (cancer / infarction ...) but not of aging per se, even if we can die without being old from external causes, or if something in the body immediately stops working.
Aging is not natural but pathological, because it is not genetically programmed and has no benefit for the individual.
According to David, it should begin testing in humans around 2022 if further studies confirm the safety and effectiveness of the method.
The goal of antiaging is to achieve negligible senescence, which means that your health does not deteriorate with age and your risk of dying does not increase with age, for example, at 20 years, your probability of dying is 1/1000, at 170 years for example, they will always be 1/1000.
In nature, many animals (some turtles / whales / sharks / mole rats / salamander / hydra / lobster ...) naturally have negligible senescence.
Treating and preventing aging itself through rejuvenation therapies helps prevent the risk of disease and prevent health from deteriorating.
Hmmm...that makes no sense you die because of age if you reverse age or plainly stop it the potential to be biologically immortal is there kind of like the jelly fish that reverse thier aging process 🤔
Keep the video forever it looks great
We need to re-direct all our resources from solving age related diseases towards curing aging itself, as this has being shown to be a reality!
No one wants to die. Hurry! Research like this needs to get the medias attention
Everyone wants to be immortal.....I hope it will be possible.
I want to age back and get younger again
I really think we will soon see an explosion in life expectancy
Yeah....and we all have to look for real estates on moon and mars now because earth is going to be full...
yep
@@kanakalatahembram1650 the condensation of Mars plan is kinda good for that but that’s going to take time
@@kanakalatahembram1650
Meh. I'd already own my dream house by then.
Please don't forget to support medical research. Cure all diseases, you certainly will live longer and hopefully live long enough for researchers to cure aging.
The human body is easy.
@@jeremyanderson6789 and reverse death.
Thanks, Dr. David Sinclair
Brilliant. Thanks. Followed David Sinclair for sometime now but this is the first time I've seen the mouse experiment. 👍👍👍
The EU has released a social media platform where you can share your ideas for the future of Europe. There is already a suggestion for EU support of longevity. If you are European you can Endorse the idea
futureu.europa.eu/processes/Health/f/3/proposals/94
Aging biologist Attila Csordas has also put forward a similar initiative, please also endorse here: futureu.europa.eu/processes/Health/f/3/proposals/826
And for humans too
@@jeremyanderson6789 turn back the clock making becomes younger ⛲️🧑🦱🧬
@@jeremyanderson6789 age reversal power in humans too.😭
This sounds like great potential!
But some cells get replaced or resorbed after damage leaving scar tissue or empty spaces.. is that possibly treated as well with this therapy?
Perhaps it would be an issue of timing, then.
He reminds me of the dad in ‘ honey I shrunk the kids’!
Y'all need to hurry up and figure this shit out!
Also reverse aging is Possible in humans too
@@jeremyanderson6789 yes
@@leikukuifemaledaughter24 Thanks.
Humans and animal can reverse age and it is possible
I Want to Live to 1000, Learn everything that is possible, and die by my own choice .
I wish the same, but I wonder if our brain is capable of learning stuff along 1000 years.
@@MusiCaninesTheMusicalDogs it is. u will learn things and it will hardwire it. but memory i am guessing will be fading of life events that are not important or not used. its like u will be amazing pianist player and scientist, but if u speak several languages and wont speak 1 for 100 years probably u will have to re learn a bit.
Think bigger, I'd say at least live to infinity.
@@AgingsAProblemFPS :) Infinity would be a torture my man. Thats why existence of god is impossible. he would kill him self quite quickly.
@@AgingsAProblemFPS
"At least" to infinity?
What could be more?
Very excited when I saw this first in his preprint in 2019. Took a year to get published now.
This is critically important in order to end diseases, such as cancer, alzheimer’s, and dementia.
Reason I want this to be so fast and released right now is my father has severe dementia can’t even take care of myself right now.
I just wish they would push this quicker and faster because I’m sick of this. There is no excuses people have to edge get old catch an illness, such as this die painfully like this.
I am tired of hearing people say the ages, something that was supposed to just accept and live with that. I will never accept that and I don’t believe in that.
On December 30th my physical and mental health was going to hell in a handbasket. I lost the will to age get old and die.
Something unexpected happened that shouldn’t have happened, but it did. I started rapidly physically and mentally reversing age. December 30, 2023 up-to-date I reversed over 30+ years of mental and physical age from being 54 years old.
Can’t wait till they start doing this to egg cells. Imagine being able to conceive naturally at 45 or 50. Since we’re living till our 80s these days. Why not.
So how do we reverse ageing?
Stair the black and white lines and that's it
I believe in Immortality for Human Beings
Great work. Looking forward to immortality xd
um,a truck can still hit you so you're not actually immortal.
scientists call this type of immortality,"Amortalitiy" as far as i know
@@sKxapFarbxqjk528khjlwv Yes you are immortal. Just not invincible
@@sKxapFarbxqjk528khjlwv that’s a terrible name because people will think ‘a’ and mortal’ are two separate words
I want to live forevermore
Complete immortality in real life.
Same
It's just a consequence of wanting to be healthy
I want to get younger
It's 3am..
RUclips wanna see rewinding biological clock..
My brain... well well well let's see😂🤦♀️
Good job
we are all immortal until proven wrong
Hearing the time waits for no one is just as bad as getting older.
It's an amazing thing! The idea of being young forever is extremely tempting. However idk why but I'm immediately concerned about population size too....
Birth and death is natural…! Due to reverse aging population grows enormously which causes imbalance in nature…! Going against rule of nature is always dangerous
A global population collapse is upon us.The last thing we need to worry about is over-population also if we find a way to live forever people would literally stop having kids.
Extraordinary ...
Hoping for the cure for the cancer too
By correcting genomic instability (which is one of the causes of aging and the cause of all cancer) the cancer will disappear completely.
And aging too aging in reverse
Now it’s worth getting rich so we can afford to be immortal & live forever!!
I didn't think it that way
My thoughts exactly
How can someone be rich anyway?
Any tips? Lol
Awesome video! I interview longevity experts on my RUclips channel and also host Lifespan News. David is a legend!
True! We need more time,but are you open to the answers you are to find?what if the answer to your question is not science?
For more information about the Buteyko method you can read the following 2 articles:
- Kazarinov V.A. (1990) "The biochemical basis of KP Buteyko's theory of the diseases of deep respiration"
- V.K. Buteyko, M.M. Buteyko (2005) “The Buteyko theory about a key role of breathing for human health: scientific introduction to the Buteyko therapy for experts”
About The Buteyko Method: A Summary of the Pathophysiology of Chronic Hyperventilation by Ira Packman, M.D.
The fact that chronic hyperventilation (CHV) has an effect on the lungs is easily understood and explained. The systemic (whole body) effects however, are physically and physiologically distant from the lungs and therefore are more difficult to understand. The multi-system, wide spread systemic ramifications of chronic hyperventilation are numerous.
These effects are all caused by the initial effect of pulmonary hypocapnia (low CO2) which causes spasm of the airways leading to asthma. The loss of CO2 from the lung on a long term basis causes a compensatory response throughout the body. This concept is called homeostasis which means that the body is always trying to stay in balance and return to its most comfortable state.
A partial list of homeostatic controls would include:
- Constant body temperature
- Constant whole body water volume
- Glucose levels
- Mineral balance including sodium, potassium, magnesium, zinc etc.
- Acid base balance (Ph control)
The acid base/Ph control mechanisms are very sensitive and closely controlled, because the Ph of the body affects the function of every body system. It is this system that is activated when patients chronically hyperventilate.
Understanding this concept, we can follow what happens with CHV.
- The lungs continuously blow off too much CO2 causing local pulmonary hypocapnia (low CO2) and arterial hypocapnia.
- The arterial hypocapnia immediately changes the Ph of the circulating blood causing an increase in the Ph (alkalosis).
- The increase in the Ph causes a decrease in the delivery of Oxygen to all the bodies tissues due to the Bohr Effect (In an alkalotic environment, the hemoglobin molecules in the red cells hold onto the oxygen molecules more tightly and will not release the O2 to the tissues).
- The kidneys see the alkalosis/Ph change and know that it must correct the bodies Ph back towards neutral (neutral Ph is a Ph of 7.40). Once CHV becomes long standing the kidneys response becomes an ongoing process in which the kidneys excrete bicarbonate in an attempt to correct the alkalosis which was created by the CHV.
- The net result is a depletion of the bicarbonate buffers due to continuous over excretion of bicarbonate which also causes the loss of electrolytes including magnesium and phosphorous which are lost with the bicarbonate.
- The loss of phosphorous also decreases the production of ATP (adenosine tri-phosphate) and ADP which are the bodies’ main source of energy.
- This then causes a decrease in the functioning of many organs including the muscles, heart, lungs, bone marrow, immune system and liver.
- These functional changes, coupled with the arterial spasm that occurs directly due to the low CO2 levels in the blood, are expressed in the long term as muscle fatigue, hypertension due to arterial spasm, decrease in the oxygenation of the brain, migraine headaches due to arterial spasm, spasm of the arteries supplying the gut, decrease brain function with memory changes, alterations in the production of proteins and metabolism of lipids in the liver causing elevated cholesterol.
This is just a partial list of the systems, organs and bodily functions which are affected by CHV and the subsequent low CO2 levels in the lungs and blood.
This concept regarding the origins and causes of these diseases is very radically different from the way medical schools teach about these diseases. It is revolutionary and may be too simple for many academicians to accept or understand.
What about neuro brain degeneration. Are there stem cells for brain in order not to lose the neuroplasticity and memory ?
can we halt ageing please keep us at an age so we dont get any older or younger
AGE Regression and AGE Reversal in humans in real life ⛲️🧬🧑🦱🧒♾
How do we get this man more help.
If you're rich - give him money.
If you're not, make society aware of how important this research is.
Talk to your friends or family, try to vote for parties that support scientific research, etc.
Yeah research like this needs to grab the medias attention!
I would like to sign up for clinical trials ASAP! Been waiting a long time for this discovery 🧓🧑👍
Can humans and animals reverse age
How to rewind clock backwards and reverse age back
Wow! Intriguing.
Cancer and telomere shortening are still issues, right?
Well if you have cells in a young enough state I think the telomeres (re)grow anyway🤔
@@MaxDiscere Oh good point, I think telomerase is active in germ cells so that makes sense
Hate cancer.
Humans and animals can do that for reverse age backwards to rewind
Thank you
Humans and animals can allow to reverse aging and the clock too
"Aging leads to, in many cases, death"
I don't want to get older and die
this is very exciting and interesting but will raise many ethical questions.
Well, actually, the main ethical question already exists now, being born out of the desires of others and forced to die without a reason or a purpose. This is a huge ethical problem, to which no one can answer without invoking gods or rhetorical phrases. Among other things, it is the main (if not the only) reason for human anguish.
Yes trying to curing disease raises ethical questions. Do you even listen to yourself when you speak?
It's the opposite. Ethical problems are there as long as there are incurable diseases (including aging, which is the main degenerative disease that causes countless others).
Build ageless sustainable solarpunk immortal utopian resilient safer future without aging, diseases old age, mortality, sicknesses, illnesses, injuries, and death
I want to age back and it will rewind the clock backward
Wow dangerous research..
Well he's trying it on himself first at least.
0:21 The Queen is the not one of the "many cases"
So I will stair the white and black lines and it will make me reverse my age and rewind the clock backward
listened to him on JRE
The forbidden apple huh.
Age Of Man Is Comming Again.
No, that would be the tree of knowledge. Although, it is what has gotten us this far.
@@PulsatingShadow intersting, why is it the tree of knoledge.
It can be argued that the forbidden "tree" of knowledge is DNA itself, because it is knowledge of the secret of life. Also, most depictions of the "snake" look like DNA helix.
@@firefly618 wow nice interpretation
if every cell come from division of previous cell, every cell is as old as the first cell is.
You know, the first living cell is still alive today.
Humans and animals are creatures
Humans and animals can reverse age back and the clock too and year
EPI(geneti)C STUFF!!!
Can I reverse age back when clock is moving back rewind
How to age backward
Please don’t let our parents die of old age and disease
We should be upset that there’s been more money investing this to expand the life of your pets than you and your loved ones.
We need to take a stand against this. Don’t take me wrong. I love to see our pets, live a long time too but why can’t they leave these both treatments at the same time for humans as well.
🤬🤬🤬🤬
Good to see lifespan gap between rich and poor jumps from 15 years to 100 years in the future.
Anyone remember his 'NMN'? It costs a fortune before Chinese started mass production, now it's 95% cheaper but still expensive.
0:18 I think ALL cases of aging leads to death lol
I don't like to be death
Biological immortality, come to papa
I really think if u are as of right now younger than 50 u will probably live way past a 100++
@@draggy6544 I want to live for 8000 years not just 100 years
Complete immortality in real life.
The results out??
I heard u cannot halt the process of ageing..
Well, a simple suggestion.. Try to search it on the brain tissue.. After all, it's where all the memory, dreams, knowledge, different kinda of health response hormone and even subconscious state of mind are stored.. Probably you'll find some "backup data" Or "template" that written down by Subconscious mind... After all our body are just like a computer, there are software running in the background that most of us cannot access.. That all
Thankyou
Don't rush mate, you should know it isn't as simple as that. Btw what you call "brain tissue" is what's generally refered to as neural tissue and this is exactly the main focus of this research.. Plus we don't even know but vaguely with what all the "memory, dreams, knowledge, subconcious" coresponds in the material brain so there's a reason why it perplexes scientists of this level. Still always nice seeing people willing to openly suggest things like that but never rush mate. And keep in mind that suggestions like that on a random RUclips comment section aren't the best way to catch the attention of researchers so no need to make the effort here =P If you're interested and passionated with these subjects better get to studying!
Anyways good luck with whatever you do,
Cheers
david sinclair look younger than before 6 years!
i was sure this video is from 2014, but it's new information that not exist then!
What about the replicative senescence?
Good question. I think going back towards being stem cells reverses the telomeres? Similar to sex cells.
Can I age back and clock too
Long fulfilling life sounds good . Need more people to get on board with this
I am still young and im not old
I don't want to get older
I'm 43 wishing I looked 23.
@@3GPO-bu7bg Become 23 body.
0:13 "leading to suffering and in many cases death" 😂😂😂 in most cases even I dare say ;D
the 36 dislikers are spiritual masters, Gurus and other foolish stuffs
RUclips's algorithm says I'm getting older
Like in the movies and anime episode and cartoon fountain of youth ⛲️🧒 turn back the clock age backwards in humans , immortality.
Fountain?
Yea
Humans and animals can do that
if we can do this in any way possible, then maybe we can even stop
the aging process and reverse the effects of old age in adults or effects of adolescence in teenagers like the growth of facial hair and stuff if it is done I request Mr. Sinclair to make me his first test subject #Ash Ketchum in the making
Younger is good
I want to age back to 5 year old and it will be a great age
For me personally I want to reverse my age to 20 but not 5, I'm officially 43 & I hate it.
Sign me up
Great research, now figure out how will you handle the overpopulation problem.
I love that video
Atleast mice are now immortal , if they don't accidentally get hurt or killed..