00:00:34 - The Horvath clock explained: Methylation patterns at unique areas of our DNA involved in gene regulation predict a person's age within four to five years. 00:06:42 - The effect of HEREDITY on the epigenetic clock rate (determines as much as 40 percent of rate). 00:12:48 - How the stability of epigenetic information has potential implications in forensic science. 00:26:08 - How diet, exercise, education, and lifestyle factors effect the epigenetic clock. 00:31:59 - How transplanting young cells into an old body may slow epigenetic aging of the recipient. 00:47:23 - Reprogramming pluripotent stem cells by activating specific genes can reset the epigenetic clock. 00:50:56 - Do epigenetic changes drive aging, or are they the result of aging (just the "face of the clock")? 01:02:32 - How poor sleep speeds up the epigenetic clock. 01:12:12 - *Super silly outro easter egg* This episode has a lot of amazing studies and figures included in the slides, which are available to FoundMyFitness Premium Members, in a convenient presentation! To find out more about becoming a Premium Member, visit: www.foundmyfitness.com/premium (Premium membership helps us make more videos and is a great experience for members! 👆❤️)
Thanks for all of your hard work making time stamps, cutting and pasting research articles, etc. I have learned so much from your youtube channel! Your passion and dedication is helping people's lives!
life/death cycle happening any 1000's infinite years isn't reality sharing as my inner liquid chemistry inreality transforms into infinitespeed its speed @an accelerated rate my belly transforms into a furnace and air-oxygen to hydrogen-helium further shifts to plasma fields am moving towards gaining freedom from any remaining health issues as well freedom from the process of degeneration of my cells still have no faith in humans managing institutions am experiencing vibration/waves auto-nomous/matic spontaneous stabilizes settles asat plasma fields high time science needs to update and move ahead and away from the process of degeneration of cells and search for human chemistry fields' real purpose in life
One question, I do not remember anything mentioning that, if a person's Biological age is lower than his or her Chronological age, does that person LOOKS younger? If so, could it be there a person's appearance is a simple and direct judgment?
Definitely one of the most entertaining hours of 2020... awesome idea showing citations for clinicians and researchers who are interested in learning more about these topics!
I love the way you add the literature excerpts during the interview. It adds new dimensions to the presentation & gives me new rabbit holes to run toward & through.
We evaluated the impact of a 1-year Mediterranean-like diet in a pilot study including 120 elderly healthy subjects from the NU-AGE study (60 Italians, 60 Poles) by measuring the changes in their epigenetic age, assessed by Horvath's clock. We observed a trend towards epigenetic rejuvenation of participants after nutritional intervention.
thank you so much Rhonda, without people like you we wouldnt bring important topics like aging to the general public. for some reason the average guy doesnt care about aging, only later in life when its already too late. its truly one of the most important topics in the modern times tho
those member benefits... *they're spicy!* 01:12:12 😊 Like and subscribe with notifications on for a ton of great episodes AND FoundMyFitness coming out in the new year. Thank you for watching!
Your energy and passion gives me the biggest grin possible. I just can’t describe how much appreciation I have for you, your work and the people you interview’s work. On a side note - do you have any books you recommend for someone trying to eat a diet for longevity and health? Thanks Rhonda, hope you’re doing well!
Thank you both for sharing such level of interesting information which usually kept in the labs..Thank you and may God bless you in your biological age of longevity and wellness.
I don’t really understand when Steve says that a healthy life style doesn’t affect the epigenetic ageing, if that was the case what on earth is David Sinclair doing . I am a tad confused
I think he's wrong. He doesn't sound like he fully understands nutrition, for example. He thinks vegetarian is healthier than non vegetarian without specifying if he means vegan and the importance of b12, for example. And he has a category of 'vegetables' rather than specific quantities of micronutrients. Often in the University of California campuses faculty tend to be a little egg headed. 🤷🏻 He was brilliant enough to build the clock, but still doesn't understand nutrition. 🤷🏻 Legend has it Bertrand Russell couldn't figure out how to use a coffee maker. Similar sort of thing.
@@robertwilsoniii2048 my husband is very smart. Math is his forte. But I am often shocked at what he doesn't get. Brings me to mind of the Big Bang Theory TV show. 😂😂 Though we are far from Penny and Leonard. And definitely not as funny...🤨
Good quest Bob. See legendary frenchwoman Jeanne Calment: she smoked, drank Portwine, and so on and got to 120 years !! So: the genetic/genes (100%) Others eat meticulously - and die stunning e a r l y ! Sinclair for sure is taking a whole BUNCH of great stuff (like ALA,. Resveratrol, NMN and so on - just lo live uo to an age when the immortality pill f i n a l l y is available. (Maybe I could help you a little bit sir)
@@FoundMyFitness Dr. Rhonda Patrick, humans are rapid aging 10 times as fast as our lifespans 13,000 years ago according to historical texts. I found out why in my theory of aging. It's carbon-14. No logical study was EVER done on this. In order to do this, we need the answer to the problem. The answer might be creating a molecule to bind with that radioactive carbon atom to put it in a state where DNA doesn't use it as food and possibly even dispose of it as waste. They recently created pills to do this with radioactive metals. Thank God they did that because it gave me the idea for dealing with carbon-14. I messaged your website detailing further into my theory and how it explains everything related to lifespan variations within the last 13,000 years in history.
Great to see you again Steve. You were my boyfriend's roomate (Rick de Mattos) at UNC CHAPEL HILL over 30 yrs ago! YOU have not AGED MUCH AT ALL YOURSELF! Great interview. Andi Sloan de Mattos. Rick enjoyed seeing you in this video!
Probably my live-style interventions will not prolong so much my health span but I'm feeling so well that I would continue doing them: 1 or 2 hours exercise outside during sunrise, semi-naked, after 16 hours fasting, CT and two meals a day high-fat low carb.
Thanks. @32 on parabiosis - recently, the Conboy lab performed a variation (not really parabiosis though) in which 50% of plasma in older mice was replaced with saline and albumin. They saw tissue regeneration in 3 tissues, the liver, muscle, and hippocampus. Lots of changes in many plasma proteins. Would be interesting to know how long this effect persists and if epigenome is affected.
Resveratrol increases the lifespan of several model organisms by regulating oxidative stress, energy metabolism, nutrient sensing, and epigenetics, primarily by activating sirtuin 1.
If at 16 years old you stored some of your own bone marrow. Could you in fact store it for long periods of time 10-50 years and then inject your own bone marrow 10-50 years later, would it age while stored? Would it eliminate graph vs host issues if it was your own bone marrow? Just curious.
There is a Beijing company doing exactly this. I came across them a couple of years ago in ZhongGuanCun Life Science Park (www.sciencemag.org/advertorials/set-success-introduction-zhongguancun-life-science-park), but I don't have their web address. You can try searching from here: www.zgcgroup.com.cn/zgcadminen/home/index/index.html My personal opinion is that 20 or 30 years from now there will be better rejuvenation options available.
Assuming we could store the 16 year old's marrow in a state of suspended animation, that would be a very sensible thing to do in case we discover within the next 10-50 years that our own juvenile cells can regress our elderly cells. I asked one of the prominent ageing scientists (one in mitochondria) this question and if this was something we should be doing anticipating a need for those cells. His response was that cell storage for that long period was the impediment.
Statistically somebody is bound to accidentally click dislike even when they meant to click like or not click at all. Also, then you inevitably get some crazy people who are either very religious or have strange beliefs, and who got this video in their suggestion and something said - or the idea of curing aging itself - has triggered them. There's such an enormous range of people. Truly no matter what you say someone will dislike it for whatever reason. This is why I love Internet. Once you use it long enough you understand that no matter what you do, you will find people to like or dislike it. Some people will purely dislike you just because you are of some nationality. There are places where people will try to kill you just because you are a foreigner and have white skin. We just forget how diverse humans are.
@@CrumbleLives That is interesting, thanks. Eh, I have a feeling it won't be enough or require too much of it. Really hoping they will come up with molecules that have very high affinity and require low dosage.
That's the distinction between researchers and doctors; %99+ of doctors don't know shit so they just prescribe stuff as they were instructed in Medical School without ever even bothering themselves to update their knowledge with lastest research.
Because despite 50+ years researching longevity, there is still F all you can do. No single compound has been identified with proof it will extend your life.
Thanks for the great info, I suspect that since there is so much to this science that we cannot oversee or micromanage, the best that we can do is to give our bodies the best food to take care of itself, it is divinely programmed to do a much better job at staying young than we can ever hope to do by meddling in its work, All we can do is to understand our organism and not abuse it and give it what needs to repair itself and stay young, cheers
Great interview -- from the beginning to the end!!! However, I realy wonder what the these two doctors think about the current, and soon be be a common, mRNA "vaccines"/drug delivery system/s and their potential effects on human epigenetics?
Okay, I'm good. Keeping an eye on the latest data and theory, but I should be good for another four decades. (1949) 🐃 the strength of the walls is laid in their foundations.
Good points. To the sentence “ Double the exercise” is not always good haha it all depends the level of exercise the person is doing and if it fits their requirements. Because exercise is personal. Not one size fits all. Personal trainers are the adequate professionals in charge of prescribing it. Unfortunately everyone talks about exercise incorrectly and ignoring the methods for exercise prescription to produce excellent effects on health and aging.
I think cannabinoids are better antioxidants than fish oil .,Aust health minister just called for ideas to grow industry, so I sent him this video and suggested he look at cannabinoids and molecular aging ..the u telomere shape and aging was a learning curve for me as I was thinking of it re skin photoaging analysis..brilliant cutting edge conversation, much appreciated..looking forward to learning more
The U-shaped effect appears to apply to stress as well. Too much or too little stress isn’t good either. Fasting produces stress that activates autophagy.
To be honest, we spent a hilarious amount of time centering the roman numeral clock and the phone in the frame. But doesn't it look cool? Steve has great taste in decor. Clean, spartan, specific in a way that seems to "say" something.
Great interview. We definitely need a follow up with Dr. Horvath in a year or two. It's clear this field is moving _fast_! At 00:27:39, if I'm reading this correctly, it appears that carotenoid consumption has a much greater impact on GrimAge than fruits & vegetables or exercise. Also, reducing C-reactive protein seems to have a profound effect as well. Traditional health advice is focused on diet & exercise, but would it have a bigger impact to increase carotenoid consumption and reduce CRP (through L-Carnitine or curcumin)?
Very close, but it's not technically carotenoid ''consumption'' as much as it is having circulating traces of carotenoids. Of course, one would assume eating more carotenoids would increase circulating traces of carotenoids, but there are other factors at play that can make it a tad more complex than that.
In that the discussion considered hormone levels predictive, it is odd that the hormone ‘Vit D’ has no place in their measurements. I know, …they are not nutritionists nor endocrinologists.
I don't have any evidence, but I think it could be related but not necessarily. I have been graying since I was 19 and so has my sister, but I look a decade younger than I am. There are also more people than we realize who begin graying as children but they obviously aren't aging faster. And yet, sometimes it seems very much to be a marker of faster aging.
Exactly! Although later they discuss EPIGENETIC REPROGRAMMING. Dr Sinclair did have an intervention that repaired eyesight in mice that removed the accumulated "methyl tags on DNA, reversing the clock of aging and allowing the cells to survive and grow like a newborn’s" (quoted parts from Dr Sinclair's book LifeSpan).
@@AndrewDavidBoyd Thanks for mentioning it. I was curious how it was related to Sinclaire's work and I haven't read the book, yet - so this comment was interesting to read.
What is the definition of Hispanic used in the study? After all Hispanic is defined linguistically, and it is frecuently a person of European descent? Is it a definition of Hispanic pertaining only to the US or is it a more broad definition of people of Iberian Descent, which would include people in India and the Philippines. Also, how is the relationship between the Horvath clock and the association with a culture, as suggested in the study. After all, there are many Hispanics of Caucasian origin? So, I am very confused by the study, it would tend to imply there is room for improvement in the testing and definition. As it is stated it would appear to be based on some form of classification that lacks substance.
According to my DNA test from National Geographic all Indigenous people in North and South America are of the same descent. American Indians and Hispanics. These people did not come from Europe.
Dietary polyphenols play a key role in modulating these modifications thereby delaying aging and extending longevity. In this review, we summarize recent advancements linking epigenetics, polyphenols and aging as well as critical findings related to the various dietary polyphenols in different fruits and vegetables.
Another issue is the long list of deficiencies that add up with age and largely go unmeasured in the population. Vitamin D is about the only one of dozens that actually gets measured and studied much. Are we just measuring the combined effects if 20 or so deficiencies in one clock and methylation process?
Hi Rhonda I've been a long time fan of yours and I'd love to see you talk about human growth hormone and its connections to aging then dive into how we can take action to have proper/optimal levels of HGH!
An integrative metabolo-epigenetic outlook supports a new model whereby metformin operates as a guardian of cell identity, capable of retarding cellular aging by preventing the loss of the information-theoretic nature of the epigenome. The ultimate anti-aging mechanism of metformin might involve the global preservation of the epigenome architecture, thereby ensuring cell fate commitment and phenotypic outcomes despite the challenging effects of aging noise. Metformin might therefore inspire the development of new gerotherapeutics capable of preserving the epigenome architecture for cell identity.
the Horvath clock can hardly be changed by lifestyle interventions?... and yet there is overwhelming evidence that a healthy lifestyle makes people living longer (and healthier). is this not contradictory?
A healthy life style just makes you live to your maximum age. What he is saying is that it will not extend that. An unhealthy lifestyle means you will not reach your maximum age and die before then.
He did mention that this is only in blood. He didn't observe other tissues. So, in blood, at least, exercise makes little difference but exercise does more things like increasing BDNF, increasing ketones, activating sirtuins, etc. which are probably not measured in blood cells.
He did also say that fish oil slows down the aging process the most. He also mentioned a few other interventions that could slow down aging but more research needs to be done in humans to confirm. Both of those statements directly contradict his original statement that the epigenetic age cannot be altered by lifestyle choices. I’m a little confused.
Surely positive lifestyle factors must have a positive effect on epigenetics/healthspan. To say 'not really', in otherwise healthy individuals, is counter intuitive..
Newborns with positive age acceleration were more likely to be female and have greater body fatness. Maternal intakes of saturated fat [6.2 wk epigenetic age acceleration (95% CI: 1.0, 11.3) per 5% of energy; P = 0.02] and monounsaturated fat [12.4 wk (95% CI: 4.2, 20.5) per 5% of energy; P = 0.003] were associated with higher epigenetic age acceleration in the newborn. The strongest association of individual fatty acids were for palmitoleic acid (25.3 wk; 95% CI: 11.4, 39.2; P = 0.0004), oleic acid (2.2 wk; 95% CI: 0.8, 3.6; P = 0.002), and palmitic acid (2.9 wk; 95% CI: 1.0, 4.9; P = 0.004) per 1% of energy intake. Vitamin D supplementation was associated with lower epigenetic age acceleration (-8.1 wk; 95% CI: -14.5, -1.7; P = 0.01).
I liked this podcast, but one thing that annoys me about research, is how they put all types of exercise under one umbrella. Cause strength training is vastly different than cardio. And when you look at the elderly population, you see muscle mass or strength as a correlation, to longevity. But you don't see the same with cardio. In cancer treatment, muscle loss is a huge correlate on how well you respond to treatment, and how long you'll live with the cancer. Cardio doesn't do much at all. But for some reason there's is barely any research on lifting and cancer treatment. Even though lifting is more muscle sparring than steroids.
Very interesting stuff... but a lot of contradiction too. Lifestyle doesn't make much difference...except it might in specific tissues being an example. Will be watching this field with great interest. I would guess many people wouldn't want to get these tests out of fear.
I would love to see a cross-sectional correlation between GrimAge and lifestyle factors for low-carb and fasting cohorts. I am assuming his data was from nHANES or some other SAD-based cohort.
Hi Dr. Rhonda. Any update on the CHORI-Bar? The last article I read said it was going to be available summer 2019, but I cannot find anything else out about it.
this was so interesting, but also rather depressing. So my take from this is that we almost have a predetermined lifespan and there is seemingly little we can do about it. Diet and exercise he claimed has minimal effect on increasing our lifespan. So if we have a father who died at 64 from heart attack and a mother who lived to age 90, it would appear we can only keep our fingers crossed that we inherited our mothers epigenetic age markers?
There is research that shows that calorie restriction and fasting increases lifespan. But he is saying that lifestyle changes have effect on epigenetic clock, how does that work?
No effect if you are already healthy. I think it means doubling Down on healthy Living is not necessary; healthy people have already “undergone” lifestyle changes (most of them unconsciously)
Thank you, Rhonda, for your added explanatory and elaborative notes. They are a great help to me. But! I can't understand the charts for Young Finns study nor the Vitality 90+study! (@9:38) The text on on the right gives us the gist, but how do the charts show the aging rates over time? shouldn't any one dot either be two as seen at different times, or does each dot show that there is no movement in rate? Is each stationary over time? What am I missing? If there is NO difference in rate and each dot is stationary over time, then all I see in the charts is the distribution of some unknown number of different subjects who live at a slower or faster DNAm aging.
Not commented upon, but after smoking, a high CRP in the long list of measurements, and lifestyle data, seems to be a rather important factor. Reversely, I reckon having a very low CRP, is a good thing to have, as I do (statins + ace inhibitors + omega 3), and I am happy about it.
I am curious to what you are attributing your low CRP to, besides a good intake of Omega 3’s? (I noted on the chart you are referencing that LDL levels had 0.0 impact - HDL had positive associations. Interesting…)
I would like to think that lifestyle intervention plays a much more significant role in life span then Dr. Horvath believes. Firstly, it’s ambiguous at best. Because for me I take 2000mg of resveratrol every day, don’t smoke, lift weights, take plenty of vitamins. But maybe someone else simply eats the Mediterranean diet. It can mean so much but varied boredom to person is my point. Do we really know the perfect lifestyle to live to increase lifespan? Probably not! Once we do know, it should play a significant role.
![GEEK TIMË [OFFICIAL AUDIO]](http://i.ytimg.com/vi/ry-6RvkH880/mqdefault.jpg)
00:00:34 - The Horvath clock explained: Methylation patterns at unique areas of our DNA involved in gene regulation predict a person's age within four to five years.
00:06:42 - The effect of HEREDITY on the epigenetic clock rate (determines as much as 40 percent of rate).
00:12:48 - How the stability of epigenetic information has potential implications in forensic science.
00:26:08 - How diet, exercise, education, and lifestyle factors effect the epigenetic clock.
00:31:59 - How transplanting young cells into an old body may slow epigenetic aging of the recipient.
00:47:23 - Reprogramming pluripotent stem cells by activating specific genes can reset the epigenetic clock.
00:50:56 - Do epigenetic changes drive aging, or are they the result of aging (just the "face of the clock")?
01:02:32 - How poor sleep speeds up the epigenetic clock.
01:12:12 - *Super silly outro easter egg*
This episode has a lot of amazing studies and figures included in the slides, which are available to FoundMyFitness Premium Members, in a convenient presentation! To find out more about becoming a Premium Member, visit:
www.foundmyfitness.com/premium
(Premium membership helps us make more videos and is a great experience for members! 👆❤️)
Thanks for all of your hard work making time stamps, cutting and pasting research articles, etc. I have learned so much from your youtube channel! Your passion and dedication is helping people's lives!
Can individuals have the epigenetic /biological age measured at Prof Horvaths Lab ?
life/death cycle happening any 1000's infinite years isn't reality
sharing as my inner liquid chemistry inreality transforms into infinitespeed its speed @an accelerated rate
my belly transforms into a furnace and air-oxygen to hydrogen-helium further shifts to plasma fields
am moving towards gaining freedom from any remaining health issues as well freedom from the process of degeneration of my cells
still have no faith in humans managing institutions
am experiencing vibration/waves auto-nomous/matic spontaneous stabilizes settles asat plasma fields
high time science needs to update and move ahead and away from the process of degeneration of cells and search for human chemistry fields' real purpose in life
One question, I do not remember anything mentioning that, if a person's Biological age is lower than his or her Chronological age, does that person LOOKS younger? If so, could it be there a person's appearance is a simple and direct judgment?
Steve is a legend. Thank you for having him on!
Definitely one of the most entertaining hours of 2020... awesome idea showing citations for clinicians and researchers who are interested in learning more about these topics!
A great interview and guest. I watched it while pedaling on a stationary bicycle. Rhonda is simply a nice human being 😊
I love the way you add the literature excerpts during the interview. It adds new dimensions to the presentation & gives me new rabbit holes to run toward & through.
We evaluated the impact of a 1-year Mediterranean-like diet in a pilot study including 120 elderly healthy subjects from the NU-AGE study (60 Italians, 60 Poles) by measuring the changes in their epigenetic age, assessed by Horvath's clock. We observed a trend towards epigenetic rejuvenation of participants after nutritional intervention.
thank you so much Rhonda, without people like you we wouldnt bring important topics like aging to the general public. for some reason the average guy doesnt care about aging, only later in life when its already too late. its truly one of the most important topics in the modern times tho
‘Some reason’ could well be our Western culture which stratifies age groups away from one another. Equals ageism : (
those member benefits... *they're spicy!* 01:12:12 😊
Like and subscribe with notifications on for a ton of great episodes AND FoundMyFitness coming out in the new year. Thank you for watching!
❤️
Your energy and passion gives me the biggest grin possible. I just can’t describe how much appreciation I have for you, your work and the people you interview’s work. On a side note - do you have any books you recommend for someone trying to eat a diet for longevity and health? Thanks Rhonda, hope you’re doing well!
Thank you both for sharing such level of interesting information which usually kept in the labs..Thank you and may God bless you in your biological age of longevity and wellness.
I don’t really understand when Steve says that a healthy life style doesn’t affect the epigenetic ageing, if that was the case what on earth is David Sinclair doing . I am a tad confused
I think he's wrong. He doesn't sound like he fully understands nutrition, for example. He thinks vegetarian is healthier than non vegetarian without specifying if he means vegan and the importance of b12, for example. And he has a category of 'vegetables' rather than specific quantities of micronutrients. Often in the University of California campuses faculty tend to be a little egg headed. 🤷🏻 He was brilliant enough to build the clock, but still doesn't understand nutrition. 🤷🏻 Legend has it Bertrand Russell couldn't figure out how to use a coffee maker. Similar sort of thing.
@@robertwilsoniii2048 my husband is very smart. Math is his forte. But I am often shocked at what he doesn't get.
Brings me to mind of the Big Bang Theory TV show. 😂😂
Though we are far from Penny and Leonard. And definitely not as funny...🤨
Good quest Bob. See legendary frenchwoman Jeanne Calment: she smoked, drank Portwine, and so on and got to 120 years !! So: the genetic/genes (100%) Others eat meticulously - and die stunning e a r l y ! Sinclair for sure is taking a whole BUNCH of great stuff (like ALA,. Resveratrol, NMN and so on - just lo live uo to an age when the immortality pill f i n a l l y is available. (Maybe I could help you a little bit sir)
Rhonda can hardly contain her excitement! :)
It's so fun having genuine enthusiasm for these interactions. I'm glad it comes off.
@@FoundMyFitness 👌
She displays all the enthusiasm of a kid in a candy store.
So what? She's a woman, she has needs.
@@FoundMyFitness Dr. Rhonda Patrick, humans are rapid aging 10 times as fast as our lifespans 13,000 years ago according to historical texts. I found out why in my theory of aging. It's carbon-14. No logical study was EVER done on this. In order to do this, we need the answer to the problem. The answer might be creating a molecule to bind with that radioactive carbon atom to put it in a state where DNA doesn't use it as food and possibly even dispose of it as waste. They recently created pills to do this with radioactive metals. Thank God they did that because it gave me the idea for dealing with carbon-14. I messaged your website detailing further into my theory and how it explains everything related to lifespan variations within the last 13,000 years in history.
Ah this is so cool, thanks for the interview!! :)
This podcasts follows such a natural but still hardcore biology involved flow, I love it.
Great to see you again Steve. You were my boyfriend's roomate (Rick de Mattos) at UNC CHAPEL HILL over 30 yrs ago! YOU have not AGED MUCH AT ALL YOURSELF! Great interview. Andi Sloan de Mattos. Rick enjoyed seeing you in this video!
Great, insightful discussion, thank you, Rhonda!
Dr Rhonda Thank you. Spread the Love❤️ Faith in God. You bring light into the world in your own little ways. Thank you Rhonda
Greatly appreciated for bringing such research studies to the public domain
👍👍👍👍👍!!!
Speaking of age, why is there an old rotary phone sitting on the desk ? Other than that, very advanced ground breaking information. Fascinating!!!
Awesome content! Thank you SO much for your devotion to this field, much much appreciated.
Extremely interesting and fascinating. Thank you very much for this interview!
Probably my live-style interventions will not prolong so much my health span but I'm feeling so well that I would continue doing them: 1 or 2 hours exercise outside during sunrise, semi-naked, after 16 hours fasting, CT and two meals a day high-fat low carb.
What is CT?
@@Kitdzn Cold Thermogenesis. If you want to read about: www.neuroathletics.com.au/cte-/concussion/coldthermogenesis
Vielen Dank Steve für deine herausragende Arbeit, welche den Durchbruch brachte! 🙏🏻☀️
Thanks. @32 on parabiosis - recently, the Conboy lab performed a variation (not really parabiosis though) in which 50% of plasma in older mice was replaced with saline and albumin. They saw tissue regeneration in 3 tissues, the liver, muscle, and hippocampus. Lots of changes in many plasma proteins. Would be interesting to know how long this effect persists and if epigenome is affected.
Resveratrol increases the lifespan of several model organisms by regulating oxidative stress, energy metabolism, nutrient sensing, and epigenetics, primarily by activating sirtuin 1.
I am discovering many instances of people who sleep 5 hours or so , lately.
Thank you for this presentation.
Great interview!
Really appreciate the effort you put in to put infographics on as well!
If at 16 years old you stored some of your own bone marrow. Could you in fact store it for long periods of time 10-50 years and then inject your own bone marrow 10-50 years later, would it age while stored? Would it eliminate graph vs host issues if it was your own bone marrow? Just curious.
There is a Beijing company doing exactly this. I came across them a couple of years ago in ZhongGuanCun Life Science Park (www.sciencemag.org/advertorials/set-success-introduction-zhongguancun-life-science-park), but I don't have their web address. You can try searching from here: www.zgcgroup.com.cn/zgcadminen/home/index/index.html
My personal opinion is that 20 or 30 years from now there will be better rejuvenation options available.
Bone marrow transplant in later life is said to reset the age of the blood but does it affect other organs as well?
Assuming we could store the 16 year old's marrow in a state of suspended animation, that would be a very sensible thing to do in case we discover within the next 10-50 years that our own juvenile cells can regress our elderly cells. I asked one of the prominent ageing scientists (one in mitochondria) this question and if this was something we should be doing anticipating a need for those cells. His response was that cell storage for that long period was the impediment.
Except that it's a risky operation, and you might die sooner than if you let it be.
Good news is they are rapidly developing nanorobotics technology faster was predicted.
😂😂 I was not expecting that sudden promotion at the end. I was completely caught off guard and laughed my ass off. 😂😂
The information in this video amazes me. I had to rewatch it twice 💜
This was way too short . Can we invite him once a month and delve into deeper areas you touched upon please ?
🤣🤣🤣
Was really looking forward to this so thank you 🤗
You really have to wonder who dislike Dr Patrick’s videos.
big brother/ and big pharma:)
Statistically somebody is bound to accidentally click dislike even when they meant to click like or not click at all.
Also, then you inevitably get some crazy people who are either very religious or have strange beliefs, and who got this video in their suggestion and something said - or the idea of curing aging itself - has triggered them.
There's such an enormous range of people. Truly no matter what you say someone will dislike it for whatever reason. This is why I love Internet. Once you use it long enough you understand that no matter what you do, you will find people to like or dislike it. Some people will purely dislike you just because you are of some nationality. There are places where people will try to kill you just because you are a foreigner and have white skin.
We just forget how diverse humans are.
This dude is from Frankfurt my home town😂👍🏻
And his surname is Hungarian, horváth in Hungarian means from Croatia. :D So his family probably originated from the Hungarian-Croatian border.
@@katalinbodnar9475 🤣🤣🤣
Magyarul elmondhatnà.....
Világosan
❤
@@77MAGYAR Meg is mondom. :D
One proud dude😅
I've been on a ketogenic diet study binge as of late and i wound up here :)
I really appreciate it Rhonda,
Looking forward to a new interview with David Sinclair
Maybe on how oleic acid, sitting in your press in the form of Olive oil, trumps resveratrol in activating SIRT1. ;)
@@CrumbleLives That is interesting, thanks. Eh, I have a feeling it won't be enough or require too much of it. Really hoping they will come up with molecules that have very high affinity and require low dosage.
Rhonda! Can you do a video on aging and hair? What foods to eat to support hair as you age etc? Love you bye
Why don't we hear this information on our annual doctor visits? All I get is prescriptions pushed on me
That's the distinction between researchers and doctors; %99+ of doctors don't know shit so they just prescribe stuff as they were instructed in Medical School without ever even bothering themselves to update their knowledge with lastest research.
No money in health, need illness to make money
Because despite 50+ years researching longevity, there is still F all you can do. No single compound has been identified with proof it will extend your life.
Thanks for the great info, I suspect that since there is so much to this science that we cannot oversee or micromanage, the best that we can do is to give our bodies the best food to take care of itself, it is divinely programmed to do a much better job at staying young than we can ever hope to do by meddling in its work, All we can do is to understand our organism and not abuse it and give it what needs to repair itself and stay young, cheers
Great interview -- from the beginning to the end!!! However, I realy wonder what the these two doctors think about the current, and soon be be a common, mRNA "vaccines"/drug delivery system/s and their potential effects on human epigenetics?
Thanks Rhonda, another great interview!
@40:50 great point indeed Rhonda, proud of you
Okay, I'm good. Keeping an eye on the latest data and theory, but I should be good for another four decades. (1949) 🐃 the strength of the walls is laid in their foundations.
Absolutely brilliant.
Good points. To the sentence “ Double the exercise” is not always good haha it all depends the level of exercise the person is doing and if it fits their requirements. Because exercise is personal. Not one size fits all. Personal trainers are the adequate professionals in charge of prescribing it. Unfortunately everyone talks about exercise incorrectly and ignoring the methods for exercise prescription to produce excellent effects on health and aging.
Good explanation 👍
I think cannabinoids are better antioxidants than fish oil .,Aust health minister just called for ideas to grow industry, so I sent him this video and suggested he look at cannabinoids and molecular aging ..the u telomere shape and aging was a learning curve for me as I was thinking of it re skin photoaging analysis..brilliant cutting edge conversation, much appreciated..looking forward to learning more
I love the interview format with the key researchers instead of another flat presentation that spends too much time on the introduction.
what a delicious conversation!
The U-shaped effect appears to apply to stress as well. Too much or too little stress isn’t good either. Fasting produces stress that activates autophagy.
what a legend!
Did anybody notice the rotary dial phone?
To be honest, we spent a hilarious amount of time centering the roman numeral clock and the phone in the frame. But doesn't it look cool? Steve has great taste in decor. Clean, spartan, specific in a way that seems to "say" something.
I did. I had one recently. It didn’t work well.
John
Great interview. We definitely need a follow up with Dr. Horvath in a year or two. It's clear this field is moving _fast_!
At 00:27:39, if I'm reading this correctly, it appears that carotenoid consumption has a much greater impact on GrimAge than fruits & vegetables or exercise. Also, reducing C-reactive protein seems to have a profound effect as well.
Traditional health advice is focused on diet & exercise, but would it have a bigger impact to increase carotenoid consumption and reduce CRP (through L-Carnitine or curcumin)?
Very close, but it's not technically carotenoid ''consumption'' as much as it is having circulating traces of carotenoids. Of course, one would assume eating more carotenoids would increase circulating traces of carotenoids, but there are other factors at play that can make it a tad more complex than that.
In that the discussion considered hormone levels predictive, it is odd that the hormone ‘Vit D’ has no place in their measurements.
I know, …they are not nutritionists nor endocrinologists.
Love that telephone!!!
Rhonda, would you know of any information pertaining to if graying early is correlated with higher or lower epigenetic clock?
I don't have any evidence, but I think it could be related but not necessarily. I have been graying since I was 19 and so has my sister, but I look a decade younger than I am. There are also more people than we realize who begin graying as children but they obviously aren't aging faster. And yet, sometimes it seems very much to be a marker of faster aging.
from 27:15 to 31:50 one of the most interesting point ;)
Exactly! Although later they discuss EPIGENETIC REPROGRAMMING. Dr Sinclair did have an intervention that repaired eyesight in mice that removed the accumulated "methyl tags on DNA, reversing the clock of aging and allowing the cells to survive and grow like a newborn’s" (quoted parts from Dr Sinclair's book LifeSpan).
They mention TET at 41:40 The TET enzymes are what Dr Sinclair used.
@@AndrewDavidBoyd Thanks for mentioning it. I was curious how it was related to Sinclaire's work and I haven't read the book, yet - so this comment was interesting to read.
What is the definition of Hispanic used in the study? After all Hispanic is defined linguistically, and it is frecuently a person of European descent? Is it a definition of Hispanic pertaining only to the US or is it a more broad definition of people of Iberian Descent, which would include people in India and the Philippines. Also, how is the relationship between the Horvath clock and the association with a culture, as suggested in the study. After all, there are many Hispanics of Caucasian origin? So, I am very confused by the study, it would tend to imply there is room for improvement in the testing and definition. As it is stated it would appear to be based on some form of classification that lacks substance.
According to my DNA test from National Geographic all Indigenous people in North and South America are of the same descent. American Indians and Hispanics. These people did not come from Europe.
Non europeans, in this case those prone to diabetes.
Thanks so much for being you Rhonda, I'm hoping you will comment soon on the epigenetic reset of a mouse eye
Dietary polyphenols play a key role in modulating these modifications thereby delaying aging and extending longevity. In this review, we summarize recent advancements linking epigenetics, polyphenols and aging as well as critical findings related to the various dietary polyphenols in different fruits and vegetables.
Off topic: what are your thoughts on using powder versions of green vegetables in smoothies
Another issue is the long list of deficiencies that add up with age and largely go unmeasured in the population. Vitamin D is about the only one of dozens that actually gets measured and studied much. Are we just measuring the combined effects if 20 or so deficiencies in one clock and methylation process?
And yet no hormone D measurement in his ‘clock’ data. Curious.
Hi Rhonda I've been a long time fan of yours and I'd love to see you talk about human growth hormone and its connections to aging then dive into how we can take action to have proper/optimal levels of HGH!
An integrative metabolo-epigenetic outlook supports a new model whereby metformin operates as a guardian of cell identity, capable of retarding cellular aging by preventing the loss of the information-theoretic nature of the epigenome. The ultimate anti-aging mechanism of metformin might involve the global preservation of the epigenome architecture, thereby ensuring cell fate commitment and phenotypic outcomes despite the challenging effects of aging noise. Metformin might therefore inspire the development of new gerotherapeutics capable of preserving the epigenome architecture for cell identity.
First 🍏 .. I 💚 these fitness dialogues 👼
the Horvath clock can hardly be changed by lifestyle interventions?... and yet there is overwhelming evidence that a healthy lifestyle makes people living longer (and healthier). is this not contradictory?
A healthy life style just makes you live to your maximum age. What he is saying is that it will not extend that. An unhealthy lifestyle means you will not reach your maximum age and die before then.
He did mention that this is only in blood. He didn't observe other tissues. So, in blood, at least, exercise makes little difference but exercise does more things like increasing BDNF, increasing ketones, activating sirtuins, etc. which are probably not measured in blood cells.
He did also say that fish oil slows down the aging process the most. He also mentioned a few other interventions that could slow down aging but more research needs to be done in humans to confirm. Both of those statements directly contradict his original statement that the epigenetic age cannot be altered by lifestyle choices. I’m a little confused.
Surely positive lifestyle factors must have a positive effect on epigenetics/healthspan. To say 'not really', in otherwise healthy individuals, is counter intuitive..
Newborns with positive age acceleration were more likely to be female and have greater body fatness. Maternal intakes of saturated fat [6.2 wk epigenetic age acceleration (95% CI: 1.0, 11.3) per 5% of energy; P = 0.02] and monounsaturated fat [12.4 wk (95% CI: 4.2, 20.5) per 5% of energy; P = 0.003] were associated with higher epigenetic age acceleration in the newborn. The strongest association of individual fatty acids were for palmitoleic acid (25.3 wk; 95% CI: 11.4, 39.2; P = 0.0004), oleic acid (2.2 wk; 95% CI: 0.8, 3.6; P = 0.002), and palmitic acid (2.9 wk; 95% CI: 1.0, 4.9; P = 0.004) per 1% of energy intake. Vitamin D supplementation was associated with lower epigenetic age acceleration (-8.1 wk; 95% CI: -14.5, -1.7; P = 0.01).
Love the phone, and great work.
I liked this podcast, but one thing that annoys me about research, is how they put all types of exercise under one umbrella.
Cause strength training is vastly different than cardio. And when you look at the elderly population, you see muscle mass or strength as a correlation, to longevity. But you don't see the same with cardio.
In cancer treatment, muscle loss is a huge correlate on how well you respond to treatment, and how long you'll live with the cancer. Cardio doesn't do much at all. But for some reason there's is barely any research on lifting and cancer treatment. Even though lifting is more muscle sparring than steroids.
I also wanna add, that most lifting regiments, in research, are baf. And do not make sense.
Very interesting stuff... but a lot of contradiction too. Lifestyle doesn't make much difference...except it might in specific tissues being an example. Will be watching this field with great interest. I would guess many people wouldn't want to get these tests out of fear.
I did a the test I’m 2 years younger than my chronicle age !
@@garygjl9036 true diagnostic
Quisiera participar en estudios sobre la longevidad y epigenetica, me podrías orientar al respecto?
Just look for his lab in the internet !!
When will the Horvath clock test be available for purchase? And where?
I would love to see a cross-sectional correlation between GrimAge and lifestyle factors for low-carb and fasting cohorts. I am assuming his data was from nHANES or some other SAD-based cohort.
Hi Dr. Rhonda. Any update on the CHORI-Bar? The last article I read said it was going to be available summer 2019, but I cannot find anything else out about it.
Wonderful podcast
this was so interesting, but also rather depressing. So my take from this is that we almost have a predetermined lifespan and there is seemingly little we can do about it. Diet and exercise he claimed has minimal effect on increasing our lifespan. So if we have a father who died at 64 from heart attack and a mother who lived to age 90, it would appear we can only keep our fingers crossed that we inherited our mothers epigenetic age markers?
Fantastic interview!
Sounds like we're on the cusp of something really big, wrt to the epigenetics of different cell types.
There is research that shows that calorie restriction and fasting increases lifespan. But he is saying that lifestyle changes have effect on epigenetic clock, how does that work?
No effect if you are already healthy. I think it means doubling Down on healthy Living is not necessary; healthy people have already “undergone” lifestyle changes (most of them unconsciously)
The geek in me thanks you! 🤓🙏💞
I find it funny that the centerpoint of their setup on the back wall is a clock.
We should avoid drinking from plastic cups☺️
That's why a dishwasher exists. Use a reusable bottle. I have 3 of them. Water bottles
Can this test be conducted by a doctors office or a reputable online service? I saw several online but nothing endorsed by Dr Horvath,
I love how she “fangirls” at the opening. Too cute 😊
Would like to see the effects of fasting on Methylation
Fantastic video. I'm just wondering what supplements Dr Horvath is taking?
@@onlyhis5870 hi, isnt B17 illegal?
@@onlyhis5870 Thank you very much for taking the time to reply to me.🙏🏻❣️
Dr Horvath mentioned a Yamanaka cocktail. Am I spelling this correctly. Does anyone know what this cocktail is?
John
Also discussed with David Sinclair here...
ruclips.net/video/cr1iRlSPSTA/видео.html
Thank you, Rhonda, for your added explanatory and elaborative notes. They are a great help to me. But! I can't understand the charts for Young Finns study nor the Vitality 90+study! (@9:38) The text on on the right gives us the gist, but how do the charts show the aging rates over time? shouldn't any one dot either be two as seen at different times, or does each dot show that there is no movement in rate? Is each stationary over time? What am I missing? If there is NO difference in rate and each dot is stationary over time, then all I see in the charts is the distribution of some unknown number of different subjects who live at a slower or faster DNAm aging.
High fat diet means only high fat or is it the combination of high fat and high carbs? Would keto be a high fat diet?
What does Steve think about Lipo CaAKG supplement?
I am a patient here, to age testing what is the hospital name?
Watched the entire video. This was super interesting even though im not a scientist (:
how does fasting effect these aging and disease clock predictions
Not commented upon, but after smoking, a high CRP in the long list of measurements, and lifestyle data, seems to be a rather important factor. Reversely, I reckon having a very low CRP, is a good thing to have, as I do (statins + ace inhibitors + omega 3), and I am happy about it.
I am curious to what you are attributing your low CRP to, besides a good intake of Omega 3’s?
(I noted on the chart you are referencing that LDL levels had 0.0 impact - HDL had positive associations. Interesting…)
Could a 20 yr old extract and store bone marrow for his own use in 30yr time?
Do it, if you can afford to have it stored properly. In 30 years the technology to use it will be incredible. And, it could save your life.
@@WorldCommander Damn, I am learning so much even from comments. Thanks for commenting, guys!
Wow, that's a B500 telephone on the desk! That's what we used in the 70s before rotary dial phones went out of vogue...
Hey Rhonda, do you know what the test-retest variability is for the original pan tissue clock?
I would like to think that lifestyle intervention plays a much more significant role in life span then Dr. Horvath believes.
Firstly, it’s ambiguous at best. Because for me I take 2000mg of resveratrol every day, don’t smoke, lift weights, take plenty of vitamins. But maybe someone else simply eats the Mediterranean diet.
It can mean so much but varied boredom to person is my point. Do we really know the perfect lifestyle to live to increase lifespan? Probably not! Once we do know, it should play a significant role.
Very interesting. Thanks!