You are the only person I have ever heard talk about the oxygen problem with opioids.This has been causing me so much pain and then they give me progabyline or lyrica which made me sleep all the time . And every time I got up from sleeping. I was in so much pain because I didn't breathe.Literally starving and no one else is talking about it. In this sweating business.I've been going to a pain center since two thousand eleven
The use of opioids reduces the number of opioid receptors? I thought it reduced the number of presynaptic vesicles, and increased the number of postsynaptic receptors. Will you please clarify?
The two major theories of opioid tolerance involve changes in opioid receptors. One theory purports that receptors undergo changes that result in decreased receptor activation, or desensitization, with prolonged exposure to opioids. This can cause an increase in pain and the need for a higher dose of medication. The other line of evidence suggests that a gradual decrease in the number of available opioid receptors is at least partially responsible for the development of tolerance.
Not everyone responds to opioids the way this guy describes. For many people, the high is not pleasurable and there is no lessening of pain. In fact, the mental and physical suffering is agony. This guys description of the opioud experience really is a fantasy.
You are the only person I have ever heard talk about the oxygen problem with opioids.This has been causing me so much pain and then they give me progabyline or lyrica which made me sleep all the time . And every time I got up from sleeping. I was in so much pain because I didn't breathe.Literally starving and no one else is talking about it. In this sweating business.I've been going to a pain center since two thousand eleven
I’m doing research about fentanyl and this video was the most helpful thing ever, thank you so much
So. So now I know what's wrong with me and I wanted to know more . So why is the video chopped off? Where is the answer? This left me needing more
This talk meant so much to me. Compassion, truth and integrity! Thank you.
salute to that man
Good hearted man
Knowledge through science and emotion finding right answer without pre conceive notions
Right on Chris!!! Love this Ted talk and next time I visit ys we have some catching up to do!!
Excellent information !!!
I can't even take a nap. Because when I wake up. I hurt all over from no oxygen
no high, still in pain and a whole host of problems im illequipped to deal with after 4 years on the stuff perscriptioned by dr
much the same addiction process as alcohol.
The use of opioids reduces the number of opioid receptors?
I thought it reduced the number of presynaptic vesicles, and increased the number of postsynaptic receptors.
Will you please clarify?
The two major theories of opioid tolerance involve changes in opioid receptors. One theory purports that receptors undergo changes that result in decreased receptor activation, or desensitization, with prolonged exposure to opioids. This can cause an increase in pain and the need for a higher dose of medication. The other line of evidence suggests that a gradual decrease in the number of available opioid receptors is at least partially responsible for the development of tolerance.
@@joshbodzin5093 Interesting. I was under the impression of the former, was unaware of the latter.
Thank you.
can one overdose on targin let's say 2- 20mg?
he forgot the Main subject ! PAIN , CHRONIC PAIN , FOREVER PAIN, no one will speak on it !!
Hi I'm currently going through this can I please elaborate and lmk if u find a care PLEASE!! In so much chronic pain
@@jakethomas740 try kratom, it works !
@@EDD519 do u recommend I order and make a tea from it or buy capsule pills form
@@jakethomas740 either way ,it will work !
Not everyone responds to opioids the way this guy describes. For many people, the high is not pleasurable and there is no lessening of pain. In fact, the mental and physical suffering is agony. This guys description of the opioud experience really is a fantasy.
This even have 2000 years